int-snw-5898

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.921 5.26e-15 3.28e-03 4.90e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-5898 subnetwork

Genes (8)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
[ RALA ] 5898 10.3760.92142--
CCND1 595 1-0.4900.92186-Yes
TSC2 7249 10.4950.92162--
RBX1 9978 971.1851.151139Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
RPSA 3921 1561.3271.151152Yes-

Interactions (9)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CCND1 595 RBX1 9978 pp -- int.I2D: BioGrid, HPRD;
int.HPRD: in vivo
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
CCND1 595 RALA 5898 pp -- int.Intact: MI:0403(colocalization)
RALA 5898 TSC2 7249 pp -- int.I2D: BioGrid
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
CCND1 595 TSC2 7249 pp -- int.I2D: BioGrid, HPRD;
int.HPRD: in vitro

Related GO terms (252)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0031571mitotic G1 DNA damage checkpoint1.48e-052.13e-018.3572411
GO:0000082G1/S transition of mitotic cell cycle5.83e-058.40e-015.182332149
GO:0005654nucleoplasm1.09e-041.00e+003.0595761082
GO:0016032viral process1.15e-041.00e+003.755455534
GO:0030178negative regulation of Wnt signaling pathway1.59e-041.00e+006.6872235
GO:0005829cytosol5.44e-041.00e+002.11661322496
GO:0051665membrane raft localization5.55e-041.00e+0010.816111
GO:0016020membrane8.83e-041.00e+002.4235901681
GO:0005515protein binding9.24e-041.00e+001.26081846024
GO:0000278mitotic cell cycle1.00e-031.00e+003.790348391
GO:0031755Edg-2 lysophosphatidic acid receptor binding1.11e-031.00e+009.816112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.11e-031.00e+009.816112
GO:0005055laminin receptor activity1.11e-031.00e+009.816112
GO:0006407rRNA export from nucleus1.11e-031.00e+009.816112
GO:0070141response to UV-A1.66e-031.00e+009.231113
GO:0000320re-entry into mitotic cell cycle1.66e-031.00e+009.231123
GO:0033596TSC1-TSC2 complex1.66e-031.00e+009.231113
GO:0046626regulation of insulin receptor signaling pathway1.66e-031.00e+009.231113
GO:0007219Notch signaling pathway1.86e-031.00e+004.90925120
GO:0033601positive regulation of mammary gland epithelial cell proliferation2.22e-031.00e+008.816114
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.22e-031.00e+008.816114
GO:003068690S preribosome2.22e-031.00e+008.816114
GO:0031467Cul7-RING ubiquitin ligase complex2.22e-031.00e+008.816114
GO:0019788NEDD8 ligase activity2.22e-031.00e+008.816114
GO:0061024membrane organization2.70e-031.00e+004.63627145
GO:0031465Cul4B-RING E3 ubiquitin ligase complex2.77e-031.00e+008.494135
GO:0031461cullin-RING ubiquitin ligase complex2.77e-031.00e+008.494115
GO:0043248proteasome assembly2.77e-031.00e+008.494115
GO:0030891VCB complex2.77e-031.00e+008.494125
GO:0000730DNA recombinase assembly2.77e-031.00e+008.494115
GO:2000001regulation of DNA damage checkpoint2.77e-031.00e+008.494115
GO:0030957Tat protein binding3.32e-031.00e+008.231136
GO:0031466Cul5-RING ubiquitin ligase complex3.32e-031.00e+008.231116
GO:0000028ribosomal small subunit assembly3.88e-031.00e+008.009117
GO:0031462Cul2-RING ubiquitin ligase complex3.88e-031.00e+008.009127
GO:0031625ubiquitin protein ligase binding4.04e-031.00e+004.340214178
GO:0032403protein complex binding4.26e-031.00e+004.300210183
GO:0031464Cul4A-RING E3 ubiquitin ligase complex4.43e-031.00e+007.816128
GO:0000307cyclin-dependent protein kinase holoenzyme complex4.43e-031.00e+007.816118
GO:0030857negative regulation of epithelial cell differentiation4.43e-031.00e+007.816118
GO:0070688MLL5-L complex4.43e-031.00e+007.816118
GO:0045116protein neddylation4.43e-031.00e+007.816128
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity4.98e-031.00e+007.646119
GO:0033598mammary gland epithelial cell proliferation4.98e-031.00e+007.646119
GO:0045792negative regulation of cell size4.98e-031.00e+007.646119
GO:0033197response to vitamin E4.98e-031.00e+007.646119
GO:0010569regulation of double-strand break repair via homologous recombination5.53e-031.00e+007.4941110
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity6.09e-031.00e+007.3571111
GO:0014067negative regulation of phosphatidylinositol 3-kinase signaling6.09e-031.00e+007.3571111
GO:0010971positive regulation of G2/M transition of mitotic cell cycle6.09e-031.00e+007.3571211
GO:0016071mRNA metabolic process6.27e-031.00e+004.015231223
GO:0071157negative regulation of cell cycle arrest6.64e-031.00e+007.2311112
GO:0033327Leydig cell differentiation6.64e-031.00e+007.2311112
GO:0010039response to iron ion6.64e-031.00e+007.2311112
GO:0032026response to magnesium ion6.64e-031.00e+007.2311112
GO:0005838proteasome regulatory particle6.64e-031.00e+007.2311712
GO:0005662DNA replication factor A complex7.19e-031.00e+007.1161113
GO:0016070RNA metabolic process7.64e-031.00e+003.868232247
GO:0035267NuA4 histone acetyltransferase complex7.74e-031.00e+007.0091414
GO:0048009insulin-like growth factor receptor signaling pathway7.74e-031.00e+007.0091114
GO:0060749mammary gland alveolus development8.29e-031.00e+006.9091215
GO:0006281DNA repair8.50e-031.00e+003.788218261
GO:0050998nitric-oxide synthase binding8.84e-031.00e+006.8161116
GO:0048011neurotrophin TRK receptor signaling pathway9.01e-031.00e+003.745215269
GO:0010243response to organonitrogen compound9.39e-031.00e+006.7291317
GO:0022624proteasome accessory complex9.39e-031.00e+006.7291817
GO:0019899enzyme binding9.53e-031.00e+003.702212277
GO:0017157regulation of exocytosis9.94e-031.00e+006.6461218
GO:0030100regulation of endocytosis9.94e-031.00e+006.6461118
GO:007188914-3-3 protein binding9.94e-031.00e+006.6461118
GO:0070064proline-rich region binding9.94e-031.00e+006.6461218
GO:0035861site of double-strand break9.94e-031.00e+006.6461118
GO:0005856cytoskeleton1.05e-021.00e+003.631212291
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.05e-021.00e+006.5681119
GO:0010165response to X-ray1.05e-021.00e+006.5681319
GO:0048863stem cell differentiation1.05e-021.00e+006.5681119
GO:0032007negative regulation of TOR signaling1.10e-021.00e+006.4941120
GO:0006298mismatch repair1.10e-021.00e+006.4941320
GO:0051491positive regulation of filopodium assembly1.16e-021.00e+006.4241121
GO:0014065phosphatidylinositol 3-kinase signaling1.16e-021.00e+006.4241221
GO:0032201telomere maintenance via semi-conservative replication1.16e-021.00e+006.4241521
GO:0000718nucleotide-excision repair, DNA damage removal1.16e-021.00e+006.4241421
GO:0006297nucleotide-excision repair, DNA gap filling1.21e-021.00e+006.3571322
GO:0030863cortical cytoskeleton1.21e-021.00e+006.3571122
GO:0036464cytoplasmic ribonucleoprotein granule1.21e-021.00e+006.3571422
GO:0019901protein kinase binding1.24e-021.00e+003.508221317
GO:0043044ATP-dependent chromatin remodeling1.27e-021.00e+006.2931423
GO:0046627negative regulation of insulin receptor signaling pathway1.27e-021.00e+006.2931123
GO:0031463Cul3-RING ubiquitin ligase complex1.27e-021.00e+006.2931323
GO:0043236laminin binding1.27e-021.00e+006.2931123
GO:0006513protein monoubiquitination1.27e-021.00e+006.2931123
GO:0051412response to corticosterone1.32e-021.00e+006.2311124
GO:0000722telomere maintenance via recombination1.38e-021.00e+006.1721525
GO:0030030cell projection organization1.43e-021.00e+006.1161126
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.43e-021.00e+006.1161326
GO:0051898negative regulation of protein kinase B signaling1.49e-021.00e+006.0611127
GO:0043022ribosome binding1.49e-021.00e+006.0611327
GO:0031492nucleosomal DNA binding1.49e-021.00e+006.0611427
GO:0019894kinesin binding1.54e-021.00e+006.0091128
GO:0019005SCF ubiquitin ligase complex1.60e-021.00e+005.9581129
GO:0005925focal adhesion1.63e-021.00e+003.300219366
GO:0006606protein import into nucleus1.65e-021.00e+005.9091230
GO:0006271DNA strand elongation involved in DNA replication1.65e-021.00e+005.9091730
GO:0050918positive chemotaxis1.65e-021.00e+005.9091130
GO:0043407negative regulation of MAP kinase activity1.76e-021.00e+005.8161232
GO:0032320positive regulation of Ras GTPase activity1.76e-021.00e+005.8161232
GO:0043491protein kinase B signaling1.76e-021.00e+005.8161232
GO:0001895retina homeostasis1.87e-021.00e+005.7291134
GO:0006953acute-phase response1.93e-021.00e+005.6871235
GO:0034332adherens junction organization1.98e-021.00e+005.6461136
GO:0051084'de novo' posttranslational protein folding2.03e-021.00e+005.6071437
GO:0006284base-excision repair2.03e-021.00e+005.6071337
GO:0070527platelet aggregation2.09e-021.00e+005.5681238
GO:0032154cleavage furrow2.09e-021.00e+005.5681238
GO:0022627cytosolic small ribosomal subunit2.14e-021.00e+005.5311439
GO:0000781chromosome, telomeric region2.14e-021.00e+005.5311339
GO:0007595lactation2.14e-021.00e+005.5311239
GO:0031532actin cytoskeleton reorganization2.25e-021.00e+005.4591141
GO:0019902phosphatase binding2.31e-021.00e+005.4241242
GO:0021762substantia nigra development2.42e-021.00e+005.3571244
GO:0030139endocytic vesicle2.42e-021.00e+005.3571144
GO:0006283transcription-coupled nucleotide-excision repair2.52e-021.00e+005.2931746
GO:0045444fat cell differentiation2.58e-021.00e+005.2611247
GO:0044267cellular protein metabolic process2.65e-021.00e+002.927229474
GO:0003684damaged DNA binding2.69e-021.00e+005.2011749
GO:0006521regulation of cellular amino acid metabolic process2.74e-021.00e+005.17211750
GO:0031100organ regeneration2.74e-021.00e+005.1721450
GO:0000910cytokinesis2.79e-021.00e+005.1441251
GO:0050680negative regulation of epithelial cell proliferation2.79e-021.00e+005.1441151
GO:0017053transcriptional repressor complex2.79e-021.00e+005.1441251
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding2.90e-021.00e+005.0881553
GO:0045216cell-cell junction organization2.96e-021.00e+005.0611254
GO:0051592response to calcium ion3.01e-021.00e+005.0351355
GO:0000724double-strand break repair via homologous recombination3.01e-021.00e+005.0351355
GO:0070062extracellular vesicular exosome3.05e-021.00e+001.58741042400
GO:0008104protein localization3.06e-021.00e+005.0091356
GO:0051291protein heterooligomerization3.06e-021.00e+005.0091256
GO:0000723telomere maintenance3.06e-021.00e+005.0091656
GO:0043627response to estrogen3.06e-021.00e+005.0091256
GO:0000502proteasome complex3.17e-021.00e+004.95811758
GO:0019903protein phosphatase binding3.39e-021.00e+004.8621462
GO:0005901caveola3.39e-021.00e+004.8621562
GO:0006302double-strand break repair3.39e-021.00e+004.8621462
GO:0006887exocytosis3.50e-021.00e+004.8161164
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest3.50e-021.00e+004.81611964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.55e-021.00e+004.79412265
GO:0006469negative regulation of protein kinase activity3.55e-021.00e+004.7941465
GO:0006289nucleotide-excision repair3.71e-021.00e+004.72911168
GO:0034329cell junction assembly3.71e-021.00e+004.7291168
GO:0003697single-stranded DNA binding3.71e-021.00e+004.7291568
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.82e-021.00e+004.68712270
GO:0042826histone deacetylase binding3.93e-021.00e+004.6461272
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent3.93e-021.00e+004.64612072
GO:0001843neural tube closure4.03e-021.00e+004.6071474
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis4.03e-021.00e+004.6071674
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.03e-021.00e+004.60712274
GO:0045087innate immune response4.05e-021.00e+002.597224596
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process4.09e-021.00e+004.5871275
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I4.09e-021.00e+004.58712075
GO:0060070canonical Wnt signaling pathway4.09e-021.00e+004.5871375
GO:0007265Ras protein signal transduction4.09e-021.00e+004.5871275
GO:0001889liver development4.19e-021.00e+004.5491477
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process4.30e-021.00e+004.51212379
GO:0030968endoplasmic reticulum unfolded protein response4.30e-021.00e+004.5121479
GO:0051301cell division4.41e-021.00e+004.4761581
GO:0019083viral transcription4.41e-021.00e+004.47611081
GO:0047485protein N-terminus binding4.67e-021.00e+004.3901586
GO:0045471response to ethanol4.67e-021.00e+004.3901386
GO:0005923tight junction4.67e-021.00e+004.3901186
GO:0006415translational termination4.73e-021.00e+004.37311087
GO:0016605PML body4.78e-021.00e+004.3571388
GO:0006928cellular component movement4.94e-021.00e+004.3081791
GO:0005200structural constituent of cytoskeleton4.94e-021.00e+004.3081891
GO:0071456cellular response to hypoxia4.99e-021.00e+004.2931692
GO:0002474antigen processing and presentation of peptide antigen via MHC class I4.99e-021.00e+004.29312192
GO:0010467gene expression4.99e-021.00e+002.430259669
GO:0006414translational elongation5.04e-021.00e+004.27711393
GO:0030426growth cone5.20e-021.00e+004.2311596
GO:0051726regulation of cell cycle5.26e-021.00e+004.2161597
GO:0030659cytoplasmic vesicle membrane5.47e-021.00e+004.15812101
GO:0005096GTPase activator activity5.52e-021.00e+004.14411102
GO:0006614SRP-dependent cotranslational protein targeting to membrane5.63e-021.00e+004.116110104
GO:0001934positive regulation of protein phosphorylation5.63e-021.00e+004.11616104
GO:0014069postsynaptic density5.68e-021.00e+004.10213105
GO:0006935chemotaxis5.68e-021.00e+004.10213105
GO:0006897endocytosis5.73e-021.00e+004.08818106
GO:0030496midbody5.84e-021.00e+004.06115108
GO:0072562blood microparticle5.99e-021.00e+004.02213111
GO:0030529ribonucleoprotein complex6.05e-021.00e+004.00918112
GO:0048015phosphatidylinositol-mediated signaling6.15e-021.00e+003.98317114
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay6.15e-021.00e+003.983111114
GO:0019058viral life cycle6.20e-021.00e+003.971113115
GO:0000209protein polyubiquitination6.26e-021.00e+003.958120116
GO:0016192vesicle-mediated transport6.31e-021.00e+003.94611117
GO:0006325chromatin organization6.36e-021.00e+003.93315118
GO:0006260DNA replication6.52e-021.00e+003.89719121
GO:0007050cell cycle arrest6.68e-021.00e+003.86219124
GO:0006511ubiquitin-dependent protein catabolic process6.78e-021.00e+003.83915126
GO:0000790nuclear chromatin6.94e-021.00e+003.80519129
GO:0006413translational initiation7.04e-021.00e+003.783117131
GO:0005634nucleus7.14e-021.00e+000.98451364559
GO:0003735structural constituent of ribosome7.35e-021.00e+003.718110137
GO:0007507heart development7.46e-021.00e+003.69717139
GO:0008286insulin receptor signaling pathway7.61e-021.00e+003.66617142
GO:0006457protein folding7.66e-021.00e+003.65617143
GO:0051260protein homooligomerization7.77e-021.00e+003.63612145
GO:0001666response to hypoxia7.97e-021.00e+003.59715149
GO:0042981regulation of apoptotic process8.03e-021.00e+003.587124150
GO:0006974cellular response to DNA damage stimulus8.08e-021.00e+003.57818151
GO:0008543fibroblast growth factor receptor signaling pathway8.33e-021.00e+003.53119156
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding8.80e-021.00e+003.45017165
GO:0030424axon8.85e-021.00e+003.44114166
GO:0038095Fc-epsilon receptor signaling pathway8.95e-021.00e+003.424112168
GO:0034641cellular nitrogen compound metabolic process9.10e-021.00e+003.398120171
GO:0004672protein kinase activity9.41e-021.00e+003.34816177
GO:0003714transcription corepressor activity9.46e-021.00e+003.34018178
GO:0007173epidermal growth factor receptor signaling pathway1.00e-011.00e+003.254112189
GO:0003924GTPase activity1.04e-011.00e+003.194112197
GO:0005622intracellular1.09e-011.00e+003.12316207
GO:0006184GTP catabolic process1.13e-011.00e+003.075112214
GO:0030425dendrite1.21e-011.00e+002.97113230
GO:0006412translation1.21e-011.00e+002.971120230
GO:0008134transcription factor binding1.27e-011.00e+002.89718242
GO:0043025neuronal cell body1.28e-011.00e+002.87919245
GO:0004842ubiquitin-protein transferase activity1.33e-011.00e+002.82216255
GO:0042493response to drug1.47e-011.00e+002.666113284
GO:0043234protein complex1.52e-011.00e+002.612118295
GO:0016567protein ubiquitination1.52e-011.00e+002.61215295
GO:0005525GTP binding1.60e-011.00e+002.540112310
GO:0007411axon guidance1.64e-011.00e+002.499113319
GO:0008285negative regulation of cell proliferation1.80e-011.00e+002.353111353
GO:0007155cell adhesion1.87e-011.00e+002.28916369
GO:0046982protein heterodimerization activity1.92e-011.00e+002.246113380
GO:0009986cell surface2.02e-011.00e+002.165111402
GO:0043066negative regulation of apoptotic process2.12e-011.00e+002.088131424
GO:0007596blood coagulation2.26e-011.00e+001.986118455
GO:0006468protein phosphorylation2.28e-011.00e+001.971118460
GO:0005730nucleolus2.29e-011.00e+001.1362691641
GO:0048471perinuclear region of cytoplasm2.47e-011.00e+001.845113502
GO:0006915apoptotic process2.69e-011.00e+001.700133555
GO:0000122negative regulation of transcription from RNA polymerase II promoter2.76e-011.00e+001.661116570
GO:0042803protein homodimerization activity2.86e-011.00e+001.599112595
GO:0005794Golgi apparatus2.92e-011.00e+001.563115610
GO:0005737cytoplasm3.49e-011.00e+000.52231103767
GO:0007165signal transduction4.05e-011.00e+000.991124907
GO:0005615extracellular space4.23e-011.00e+000.914117957
GO:0005886plasma membrane4.34e-011.00e+000.4822452582
GO:0008270zinc ion binding4.36e-011.00e+000.855112997
GO:0044822poly(A) RNA binding4.56e-011.00e+000.7721491056
GO:0044281small molecule metabolic process5.04e-011.00e+000.5741581211
GO:0005524ATP binding5.30e-011.00e+000.4741601298
GO:0006351transcription, DNA-templated5.71e-011.00e+000.3181311446