int-snw-5879

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.985 1.74e-17 8.04e-04 1.75e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-5879 subnetwork

Genes (11)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
ACO2 50 501.0001.076191Yes-
RBX1 9978 971.1851.151139Yes-
PPP2R1A 5518 90.6440.985249Yes-
CLTC 1213 350.8841.138247Yes-
[ RAC1 ] 5879 10.1030.985245Yes-
RPL14 9045 421.2501.113143Yes-
ACTB 60 1671.1531.151587Yes-
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-
RPS3A 6189 110.8351.069166Yes-

Interactions (14)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ACTB 60 RAC1 5879 pp -- int.I2D: BCI, BioGrid, HPRD;
int.HPRD: in vitro, in vivo
PGD 5226 PPP2R1A 5518 pp -- int.I2D: YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
RPS3A 6189 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
ACTB 60 CLTC 1213 pp -- int.I2D: IntAct_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
PPP2R1A 5518 RAC1 5879 pp -- int.I2D: BioGrid_Fly
ACTB 60 RPS3A 6189 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 PPP2R1A 5518 pp -- int.I2D: BioGrid_Yeast
ACO2 50 RAC1 5879 pp -- int.I2D: SOURAV_MAPK_LOW, IntAct
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
RAC1 5879 RPS3A 6189 pp -- int.I2D: IntAct, SOURAV_MAPK_LOW
ACO2 50 PGD 5226 pp -- int.I2D: YeastLow
CLTC 1213 RAC1 5879 pp -- int.I2D: BioGrid_Fly, BIND_Fly, FlyEmbryo, IntAct_Fly

Related GO terms (270)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.17e-061.69e-025.524411114
GO:0005829cytosol5.40e-067.79e-022.24191322496
GO:0016071mRNA metabolic process1.69e-052.43e-014.556431223
GO:0016070RNA metabolic process2.52e-053.64e-014.408432247
GO:0016032viral process2.62e-053.78e-013.618555534
GO:0019083viral transcription2.73e-053.93e-015.60231081
GO:0006415translational termination3.38e-054.87e-015.49931087
GO:0006414translational elongation4.13e-055.95e-015.40231393
GO:0006614SRP-dependent cotranslational protein targeting to membrane5.76e-058.31e-015.241310104
GO:0070062extracellular vesicular exosome5.96e-058.59e-012.12881042400
GO:0019058viral life cycle7.78e-051.00e+005.096313115
GO:0006413translational initiation1.15e-041.00e+004.908317131
GO:0005925focal adhesion1.17e-041.00e+003.841419366
GO:0036464cytoplasmic ribonucleoprotein granule1.21e-041.00e+006.8972422
GO:0003735structural constituent of ribosome1.31e-041.00e+004.844310137
GO:0044267cellular protein metabolic process3.16e-041.00e+003.468429474
GO:0022627cytosolic small ribosomal subunit3.86e-041.00e+006.0712439
GO:0006412translation6.01e-041.00e+004.096320230
GO:0016020membrane6.82e-041.00e+002.2276901681
GO:0045216cell-cell junction organization7.41e-041.00e+005.6022254
GO:0021831embryonic olfactory bulb interneuron precursor migration7.63e-041.00e+0010.357111
GO:0048532anatomical structure arrangement7.63e-041.00e+0010.357111
GO:0070262peptidyl-serine dephosphorylation7.63e-041.00e+0010.357111
GO:0019521D-gluconate metabolic process7.63e-041.00e+0010.357111
GO:0010467gene expression1.17e-031.00e+002.971459669
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis1.39e-031.00e+005.1472674
GO:0019901protein kinase binding1.52e-031.00e+003.633321317
GO:00515383 iron, 4 sulfur cluster binding1.52e-031.00e+009.357112
GO:0051668localization within membrane1.52e-031.00e+009.357112
GO:0043652engulfment of apoptotic cell1.52e-031.00e+009.357112
GO:0003994aconitate hydratase activity1.52e-031.00e+009.357112
GO:0006407rRNA export from nucleus1.52e-031.00e+009.357112
GO:0032707negative regulation of interleukin-23 production1.52e-031.00e+009.357112
GO:0051022Rho GDP-dissociation inhibitor binding1.52e-031.00e+009.357112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.52e-031.00e+009.357112
GO:0019322pentose biosynthetic process1.52e-031.00e+009.357122
GO:0005055laminin receptor activity1.52e-031.00e+009.357112
GO:0002093auditory receptor cell morphogenesis1.52e-031.00e+009.357112
GO:0042470melanosome2.09e-031.00e+004.8492991
GO:0006928cellular component movement2.09e-031.00e+004.8492791
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.29e-031.00e+008.772113
GO:1900126negative regulation of hyaluronan biosynthetic process2.29e-031.00e+008.772123
GO:0009051pentose-phosphate shunt, oxidative branch2.29e-031.00e+008.772123
GO:0071439clathrin complex2.29e-031.00e+008.772123
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.05e-031.00e+008.357114
GO:003068690S preribosome3.05e-031.00e+008.357114
GO:0010310regulation of hydrogen peroxide metabolic process3.05e-031.00e+008.357114
GO:0032051clathrin light chain binding3.05e-031.00e+008.357114
GO:0019788NEDD8 ligase activity3.05e-031.00e+008.357114
GO:0002551mast cell chemotaxis3.05e-031.00e+008.357114
GO:0060263regulation of respiratory burst3.05e-031.00e+008.357114
GO:0031467Cul7-RING ubiquitin ligase complex3.05e-031.00e+008.357114
GO:1903077negative regulation of protein localization to plasma membrane3.05e-031.00e+008.357114
GO:0030529ribonucleoprotein complex3.14e-031.00e+004.54928112
GO:0031465Cul4B-RING E3 ubiquitin ligase complex3.81e-031.00e+008.035135
GO:0019932second-messenger-mediated signaling3.81e-031.00e+008.035115
GO:0042518negative regulation of tyrosine phosphorylation of Stat3 protein3.81e-031.00e+008.035115
GO:2000001regulation of DNA damage checkpoint3.81e-031.00e+008.035115
GO:0031461cullin-RING ubiquitin ligase complex3.81e-031.00e+008.035115
GO:0006102isocitrate metabolic process3.81e-031.00e+008.035115
GO:0030891VCB complex3.81e-031.00e+008.035125
GO:0000730DNA recombinase assembly3.81e-031.00e+008.035115
GO:0002181cytoplasmic translation4.57e-031.00e+007.772116
GO:0030130clathrin coat of trans-Golgi network vesicle4.57e-031.00e+007.772136
GO:0006101citrate metabolic process4.57e-031.00e+007.772116
GO:0030118clathrin coat4.57e-031.00e+007.772126
GO:0031466Cul5-RING ubiquitin ligase complex4.57e-031.00e+007.772116
GO:0048261negative regulation of receptor-mediated endocytosis4.57e-031.00e+007.772116
GO:0030957Tat protein binding4.57e-031.00e+007.772136
GO:0097178ruffle assembly4.57e-031.00e+007.772116
GO:0061024membrane organization5.20e-031.00e+004.17727145
GO:0000028ribosomal small subunit assembly5.33e-031.00e+007.549117
GO:0031462Cul2-RING ubiquitin ligase complex5.33e-031.00e+007.549127
GO:0030132clathrin coat of coated pit5.33e-031.00e+007.549127
GO:0021799cerebral cortex radially oriented cell migration5.33e-031.00e+007.549127
GO:0031464Cul4A-RING E3 ubiquitin ligase complex6.09e-031.00e+007.357128
GO:0070688MLL5-L complex6.09e-031.00e+007.357118
GO:0045116protein neddylation6.09e-031.00e+007.357128
GO:0044822poly(A) RNA binding6.21e-031.00e+002.3124491056
GO:0003382epithelial cell morphogenesis6.85e-031.00e+007.187119
GO:0006972hyperosmotic response6.85e-031.00e+007.187119
GO:0006098pentose-phosphate shunt7.60e-031.00e+007.0351410
GO:0060071Wnt signaling pathway, planar cell polarity pathway7.60e-031.00e+007.0351210
GO:0010569regulation of double-strand break repair via homologous recombination7.60e-031.00e+007.0351110
GO:0007084mitotic nuclear envelope reassembly7.60e-031.00e+007.0351110
GO:0035025positive regulation of Rho protein signal transduction7.60e-031.00e+007.0351110
GO:0031625ubiquitin protein ligase binding7.74e-031.00e+003.881214178
GO:0005515protein binding8.30e-031.00e+000.97091846024
GO:0031571mitotic G1 DNA damage checkpoint8.36e-031.00e+006.8971411
GO:0010592positive regulation of lamellipodium assembly8.36e-031.00e+006.8971111
GO:0006275regulation of DNA replication9.12e-031.00e+006.7721212
GO:0030111regulation of Wnt signaling pathway9.12e-031.00e+006.7721112
GO:0071542dopaminergic neuron differentiation9.12e-031.00e+006.7721112
GO:0006672ceramide metabolic process9.87e-031.00e+006.6561113
GO:0042273ribosomal large subunit biogenesis9.87e-031.00e+006.6561413
GO:0005662DNA replication factor A complex9.87e-031.00e+006.6561113
GO:0001891phagocytic cup9.87e-031.00e+006.6561213
GO:0035267NuA4 histone acetyltransferase complex1.06e-021.00e+006.5491414
GO:0031996thioesterase binding1.06e-021.00e+006.5491114
GO:0048870cell motility1.14e-021.00e+006.4501115
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand1.14e-021.00e+006.4501215
GO:0031529ruffle organization1.14e-021.00e+006.4501115
GO:0050998nitric-oxide synthase binding1.21e-021.00e+006.3571116
GO:0030742GTP-dependent protein binding1.29e-021.00e+006.2691117
GO:0051894positive regulation of focal adhesion assembly1.36e-021.00e+006.1871118
GO:0035861site of double-strand break1.36e-021.00e+006.1871118
GO:0090023positive regulation of neutrophil chemotaxis1.36e-021.00e+006.1871118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.44e-021.00e+006.1091119
GO:0071526semaphorin-plexin signaling pathway1.44e-021.00e+006.1091119
GO:0045453bone resorption1.44e-021.00e+006.1091219
GO:0019897extrinsic component of plasma membrane1.52e-021.00e+006.0351220
GO:0008601protein phosphatase type 2A regulator activity1.52e-021.00e+006.0351220
GO:0090103cochlea morphogenesis1.52e-021.00e+006.0351220
GO:0006298mismatch repair1.52e-021.00e+006.0351320
GO:0000159protein phosphatase type 2A complex1.52e-021.00e+006.0351220
GO:0045595regulation of cell differentiation1.59e-021.00e+005.9641121
GO:0000718nucleotide-excision repair, DNA damage removal1.59e-021.00e+005.9641421
GO:0030041actin filament polymerization1.59e-021.00e+005.9641321
GO:0032201telomere maintenance via semi-conservative replication1.59e-021.00e+005.9641521
GO:0006281DNA repair1.61e-021.00e+003.329218261
GO:0003823antigen binding1.67e-021.00e+005.8971122
GO:0006297nucleotide-excision repair, DNA gap filling1.67e-021.00e+005.8971322
GO:0030863cortical cytoskeleton1.67e-021.00e+005.8971122
GO:1900026positive regulation of substrate adhesion-dependent cell spreading1.74e-021.00e+005.8331223
GO:0031463Cul3-RING ubiquitin ligase complex1.74e-021.00e+005.8331323
GO:0043236laminin binding1.74e-021.00e+005.8331123
GO:0006513protein monoubiquitination1.74e-021.00e+005.8331123
GO:0043044ATP-dependent chromatin remodeling1.74e-021.00e+005.8331423
GO:0019899enzyme binding1.80e-021.00e+003.243212277
GO:0000722telomere maintenance via recombination1.89e-021.00e+005.7131525
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.97e-021.00e+005.6561326
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity1.97e-021.00e+005.6561226
GO:0043234protein complex2.03e-021.00e+003.152218295
GO:0010033response to organic substance2.04e-021.00e+005.6021227
GO:0050661NADP binding2.04e-021.00e+005.6021227
GO:0000188inactivation of MAPK activity2.04e-021.00e+005.6021127
GO:0050690regulation of defense response to virus by virus2.04e-021.00e+005.6021427
GO:0043022ribosome binding2.04e-021.00e+005.6021327
GO:0031492nucleosomal DNA binding2.04e-021.00e+005.6021427
GO:0006099tricarboxylic acid cycle2.12e-021.00e+005.5491428
GO:0030669clathrin-coated endocytic vesicle membrane2.12e-021.00e+005.5491428
GO:0019894kinesin binding2.12e-021.00e+005.5491128
GO:0019005SCF ubiquitin ligase complex2.19e-021.00e+005.4991129
GO:0030032lamellipodium assembly2.19e-021.00e+005.4991229
GO:0033572transferrin transport2.27e-021.00e+005.4501530
GO:0006271DNA strand elongation involved in DNA replication2.27e-021.00e+005.4501730
GO:0048813dendrite morphogenesis2.27e-021.00e+005.4501130
GO:0010811positive regulation of cell-substrate adhesion2.34e-021.00e+005.4021231
GO:0031623receptor internalization2.34e-021.00e+005.4021231
GO:0007411axon guidance2.35e-021.00e+003.039213319
GO:0032588trans-Golgi network membrane2.56e-021.00e+005.2691234
GO:0001895retina homeostasis2.56e-021.00e+005.2691134
GO:0030838positive regulation of actin filament polymerization2.56e-021.00e+005.2691234
GO:00515394 iron, 4 sulfur cluster binding2.64e-021.00e+005.2271335
GO:0003723RNA binding2.68e-021.00e+002.939220342
GO:0034332adherens junction organization2.71e-021.00e+005.1871136
GO:0034446substrate adhesion-dependent cell spreading2.71e-021.00e+005.1871236
GO:0045740positive regulation of DNA replication2.71e-021.00e+005.1871236
GO:0051084'de novo' posttranslational protein folding2.79e-021.00e+005.1471437
GO:0006284base-excision repair2.79e-021.00e+005.1471337
GO:0051496positive regulation of stress fiber assembly2.86e-021.00e+005.1091238
GO:0070527platelet aggregation2.86e-021.00e+005.1091238
GO:0072659protein localization to plasma membrane2.94e-021.00e+005.0711139
GO:0000781chromosome, telomeric region2.94e-021.00e+005.0711339
GO:0007155cell adhesion3.08e-021.00e+002.82926369
GO:0030136clathrin-coated vesicle3.16e-021.00e+004.9641442
GO:0004722protein serine/threonine phosphatase activity3.16e-021.00e+004.9641142
GO:0030155regulation of cell adhesion3.16e-021.00e+004.9641242
GO:0006892post-Golgi vesicle-mediated transport3.23e-021.00e+004.9301343
GO:0021762substantia nigra development3.31e-021.00e+004.8971244
GO:0005884actin filament3.31e-021.00e+004.8971244
GO:0000278mitotic cell cycle3.43e-021.00e+002.746248391
GO:0006283transcription-coupled nucleotide-excision repair3.45e-021.00e+004.8331746
GO:0022625cytosolic large ribosomal subunit3.68e-021.00e+004.7421649
GO:0003684damaged DNA binding3.68e-021.00e+004.7421749
GO:0006091generation of precursor metabolites and energy3.75e-021.00e+004.7131350
GO:0000775chromosome, centromeric region3.75e-021.00e+004.7131250
GO:0040008regulation of growth3.75e-021.00e+004.7131550
GO:0030334regulation of cell migration3.75e-021.00e+004.7131250
GO:0003725double-stranded RNA binding3.90e-021.00e+004.6561552
GO:0009611response to wounding3.90e-021.00e+004.6561152
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3.97e-021.00e+004.6291553
GO:0000724double-strand break repair via homologous recombination4.12e-021.00e+004.5751355
GO:0000723telomere maintenance4.19e-021.00e+004.5491656
GO:0005654nucleoplasm4.41e-021.00e+001.8623761082
GO:0007596blood coagulation4.52e-021.00e+002.527218455
GO:0007059chromosome segregation4.63e-021.00e+004.4021462
GO:0006302double-strand break repair4.63e-021.00e+004.4021462
GO:0019903protein phosphatase binding4.63e-021.00e+004.4021462
GO:0031295T cell costimulation4.85e-021.00e+004.3341265
GO:0006289nucleotide-excision repair5.07e-021.00e+004.26911168
GO:0003697single-stranded DNA binding5.07e-021.00e+004.2691568
GO:0034329cell junction assembly5.07e-021.00e+004.2691168
GO:0032587ruffle membrane5.21e-021.00e+004.2271370
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process5.58e-021.00e+004.1281275
GO:0017137Rab GTPase binding5.65e-021.00e+004.1091276
GO:0007160cell-matrix adhesion6.08e-021.00e+003.9991382
GO:0009653anatomical structure morphogenesis6.15e-021.00e+003.9821383
GO:0006898receptor-mediated endocytosis6.23e-021.00e+003.9641384
GO:0047485protein N-terminus binding6.37e-021.00e+003.9301586
GO:0016605PML body6.51e-021.00e+003.8971388
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II6.66e-021.00e+003.8651790
GO:0005200structural constituent of cytoskeleton6.73e-021.00e+003.8491891
GO:0001649osteoblast differentiation6.80e-021.00e+003.8331692
GO:0071456cellular response to hypoxia6.80e-021.00e+003.8331692
GO:0006364rRNA processing6.94e-021.00e+003.8021694
GO:0006470protein dephosphorylation7.23e-021.00e+003.7421198
GO:0045087innate immune response7.32e-021.00e+002.137224596
GO:0001934positive regulation of protein phosphorylation7.65e-021.00e+003.65616104
GO:0014069postsynaptic density7.73e-021.00e+003.64213105
GO:0005506iron ion binding7.73e-021.00e+003.64214105
GO:0005802trans-Golgi network8.08e-021.00e+003.57512110
GO:0030308negative regulation of cell growth8.08e-021.00e+003.57516110
GO:0015630microtubule cytoskeleton8.08e-021.00e+003.57514110
GO:0006461protein complex assembly8.15e-021.00e+003.56216111
GO:0072562blood microparticle8.15e-021.00e+003.56213111
GO:0005819spindle8.22e-021.00e+003.54917112
GO:0097190apoptotic signaling pathway8.29e-021.00e+003.53616113
GO:0044237cellular metabolic process8.57e-021.00e+003.48615117
GO:0006325chromatin organization8.64e-021.00e+003.47415118
GO:0007219Notch signaling pathway8.78e-021.00e+003.45015120
GO:0006260DNA replication8.85e-021.00e+003.43819121
GO:0030036actin cytoskeleton organization8.99e-021.00e+003.41415123
GO:0030027lamellipodium9.13e-021.00e+003.39114125
GO:0000790nuclear chromatin9.41e-021.00e+003.34519129
GO:0031982vesicle9.55e-021.00e+003.32319131
GO:0005634nucleus9.78e-021.00e+000.78761364559
GO:0000086G2/M transition of mitotic cell cycle9.90e-021.00e+003.26919136
GO:0006457protein folding1.04e-011.00e+003.19717143
GO:0000082G1/S transition of mitotic cell cycle1.08e-011.00e+003.137132149
GO:0005198structural molecule activity1.09e-011.00e+003.12815150
GO:0008543fibroblast growth factor receptor signaling pathway1.13e-011.00e+003.07119156
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.19e-011.00e+002.99017165
GO:0030424axon1.20e-011.00e+002.98214166
GO:0038095Fc-epsilon receptor signaling pathway1.21e-011.00e+002.964112168
GO:0006886intracellular protein transport1.23e-011.00e+002.93915171
GO:0032403protein complex binding1.31e-011.00e+002.841110183
GO:0005737cytoplasm1.33e-011.00e+000.79951103767
GO:0003924GTPase activity1.40e-011.00e+002.735112197
GO:0030168platelet activation1.46e-011.00e+002.677110205
GO:0006184GTP catabolic process1.52e-011.00e+002.615112214
GO:0007067mitotic nuclear division1.60e-011.00e+002.530114227
GO:0005759mitochondrial matrix1.61e-011.00e+002.524114228
GO:0008380RNA splicing1.61e-011.00e+002.524111228
GO:0005739mitochondrion1.74e-011.00e+001.394228998
GO:0005975carbohydrate metabolic process1.77e-011.00e+002.37419253
GO:0004842ubiquitin-protein transferase activity1.78e-011.00e+002.36216255
GO:0043065positive regulation of apoptotic process1.86e-011.00e+002.291110268
GO:0048011neurotrophin TRK receptor signaling pathway1.87e-011.00e+002.285115269
GO:0006954inflammatory response1.92e-011.00e+002.24317277
GO:0007264small GTPase mediated signal transduction1.93e-011.00e+002.23314279
GO:0007186G-protein coupled receptor signaling pathway2.00e-011.00e+002.18217289
GO:0005856cytoskeleton2.01e-011.00e+002.172112291
GO:0016567protein ubiquitination2.03e-011.00e+002.15215295
GO:0030154cell differentiation2.07e-011.00e+002.12315301
GO:0035556intracellular signal transduction2.08e-011.00e+002.11319303
GO:0005525GTP binding2.13e-011.00e+002.081112310
GO:0008283cell proliferation2.24e-011.00e+001.999114328
GO:0044281small molecule metabolic process2.35e-011.00e+001.1152581211
GO:0000139Golgi membrane2.43e-011.00e+001.86113361
GO:0046982protein heterodimerization activity2.55e-011.00e+001.787113380
GO:0055114oxidation-reduction process2.78e-011.00e+001.642112420
GO:0043066negative regulation of apoptotic process2.80e-011.00e+001.629131424
GO:0005886plasma membrane3.13e-011.00e+000.6073452582
GO:0006915apoptotic process3.51e-011.00e+001.240133555
GO:0005730nucleolus3.61e-011.00e+000.6762691641
GO:0005615extracellular space5.30e-011.00e+000.454117957
GO:0006355regulation of transcription, DNA-templated5.45e-011.00e+000.395118997
GO:0008270zinc ion binding5.45e-011.00e+000.395112997
GO:0005524ATP binding6.46e-011.00e+000.0151601298