int-snw-5792

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.953 3.19e-16 1.66e-03 3.00e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-5792 subnetwork

Genes (12)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
[ PTPRF ] 5792 1-0.3440.95328--
CDC16 8881 250.9501.02080Yes-
RBX1 9978 971.1851.151139Yes-
PSMD3 5709 570.9861.106146Yes-
RET 5979 1-0.7140.95340--
PSMB7 5695 480.9821.05257Yes-
PSMA1 5682 610.9961.052123Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
BCAR1 9564 2-0.4540.95381-Yes
RPSA 3921 1561.3271.151152Yes-

Interactions (18)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
PTPRF 5792 RET 5979 pp -- int.I2D: BioGrid
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
ACTB 60 CDC16 8881 pp -- int.I2D: YeastLow
PTPRF 5792 BCAR1 9564 pp -- int.I2D: HPRD;
int.HPRD: in vivo
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 BCAR1 9564 pp -- int.I2D: MINT
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast

Related GO terms (231)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.23e-091.77e-056.53152265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.80e-092.59e-056.42452270
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.39e-093.44e-056.34452274
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process3.33e-094.81e-056.24952379
GO:0006521regulation of cellular amino acid metabolic process6.20e-088.94e-046.58741750
GO:0000082G1/S transition of mitotic cell cycle8.22e-081.19e-035.334532149
GO:0042981regulation of apoptotic process8.50e-081.23e-035.324524150
GO:0000502proteasome complex1.14e-071.64e-036.37341758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.70e-072.45e-036.23141964
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent2.74e-073.95e-036.06142072
GO:0000278mitotic cell cycle3.07e-074.44e-034.205648391
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I3.23e-074.67e-036.00242075
GO:0005654nucleoplasm3.69e-075.32e-033.1528761082
GO:0016071mRNA metabolic process6.13e-078.84e-034.752531223
GO:0002474antigen processing and presentation of peptide antigen via MHC class I7.38e-071.06e-025.70842192
GO:0016070RNA metabolic process1.02e-061.46e-024.605532247
GO:0000209protein polyubiquitination1.87e-062.70e-025.373420116
GO:0016032viral process1.91e-062.76e-023.755655534
GO:0034641cellular nitrogen compound metabolic process8.77e-061.26e-014.813420171
GO:0005829cytosol1.83e-052.63e-012.11691322496
GO:0005838proteasome regulatory particle4.17e-056.01e-017.6462712
GO:0022624proteasome accessory complex8.57e-051.00e+007.1442817
GO:0005839proteasome core complex9.64e-051.00e+007.0612818
GO:0004298threonine-type endopeptidase activity1.08e-041.00e+006.9832819
GO:0010467gene expression1.28e-041.00e+003.167559669
GO:0043066negative regulation of apoptotic process3.02e-041.00e+003.503431424
GO:0006915apoptotic process8.39e-041.00e+003.115433555
GO:0070062extracellular vesicular exosome1.27e-031.00e+001.81071042400
GO:0097021lymphocyte migration into lymphoid organs1.66e-031.00e+009.231112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.66e-031.00e+009.231112
GO:0005055laminin receptor activity1.66e-031.00e+009.231112
GO:0006407rRNA export from nucleus1.66e-031.00e+009.231112
GO:0007497posterior midgut development1.66e-031.00e+009.231112
GO:0001838embryonic epithelial tube formation1.66e-031.00e+009.231112
GO:1900121negative regulation of receptor binding2.49e-031.00e+008.646113
GO:0061146Peyer's patch morphogenesis2.49e-031.00e+008.646113
GO:0014042positive regulation of neuron maturation2.49e-031.00e+008.646113
GO:0072300positive regulation of metanephric glomerulus development2.49e-031.00e+008.646113
GO:0007155cell adhesion3.08e-031.00e+003.28936369
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.32e-031.00e+008.231114
GO:003068690S preribosome3.32e-031.00e+008.231114
GO:0031467Cul7-RING ubiquitin ligase complex3.32e-031.00e+008.231114
GO:0019788NEDD8 ligase activity3.32e-031.00e+008.231114
GO:0035799ureter maturation3.32e-031.00e+008.231114
GO:0005515protein binding4.10e-031.00e+000.997101846024
GO:0031465Cul4B-RING E3 ubiquitin ligase complex4.15e-031.00e+007.909135
GO:0031461cullin-RING ubiquitin ligase complex4.15e-031.00e+007.909115
GO:0043248proteasome assembly4.15e-031.00e+007.909115
GO:0030891VCB complex4.15e-031.00e+007.909125
GO:0033619membrane protein proteolysis4.15e-031.00e+007.909115
GO:0050851antigen receptor-mediated signaling pathway4.15e-031.00e+007.909115
GO:0000730DNA recombinase assembly4.15e-031.00e+007.909115
GO:2000001regulation of DNA damage checkpoint4.15e-031.00e+007.909115
GO:0030335positive regulation of cell migration4.79e-031.00e+004.24227127
GO:0016477cell migration4.87e-031.00e+004.23125128
GO:0048012hepatocyte growth factor receptor signaling pathway4.98e-031.00e+007.646116
GO:0030957Tat protein binding4.98e-031.00e+007.646136
GO:0031466Cul5-RING ubiquitin ligase complex4.98e-031.00e+007.646116
GO:0000028ribosomal small subunit assembly5.81e-031.00e+007.424117
GO:0035729cellular response to hepatocyte growth factor stimulus5.81e-031.00e+007.424117
GO:0007185transmembrane receptor protein tyrosine phosphatase signaling pathway5.81e-031.00e+007.424117
GO:0031462Cul2-RING ubiquitin ligase complex5.81e-031.00e+007.424127
GO:0019773proteasome core complex, alpha-subunit complex6.64e-031.00e+007.231148
GO:0031464Cul4A-RING E3 ubiquitin ligase complex6.64e-031.00e+007.231128
GO:0070688MLL5-L complex6.64e-031.00e+007.231118
GO:0045116protein neddylation6.64e-031.00e+007.231128
GO:0045793positive regulation of cell size7.47e-031.00e+007.061129
GO:0005730nucleolus7.54e-031.00e+001.8735691641
GO:0048484enteric nervous system development8.29e-031.00e+006.9091110
GO:0010569regulation of double-strand break repair via homologous recombination8.29e-031.00e+006.9091110
GO:0042551neuron maturation8.29e-031.00e+006.9091110
GO:0031571mitotic G1 DNA damage checkpoint9.12e-031.00e+006.7721411
GO:0033630positive regulation of cell adhesion mediated by integrin9.12e-031.00e+006.7721111
GO:0031625ubiquitin protein ligase binding9.22e-031.00e+003.755214178
GO:0032403protein complex binding9.72e-031.00e+003.715210183
GO:0060384innervation9.94e-031.00e+006.6461112
GO:0005662DNA replication factor A complex1.08e-021.00e+006.5311113
GO:0007158neuron cell-cell adhesion1.08e-021.00e+006.5311113
GO:0030234enzyme regulator activity1.08e-021.00e+006.5311313
GO:0035267NuA4 histone acetyltransferase complex1.16e-021.00e+006.4241414
GO:0048265response to pain1.16e-021.00e+006.4241114
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand1.24e-021.00e+006.3241215
GO:0050998nitric-oxide synthase binding1.32e-021.00e+006.2311116
GO:0042176regulation of protein catabolic process1.32e-021.00e+006.2311316
GO:0044281small molecule metabolic process1.42e-021.00e+001.9894581211
GO:0007088regulation of mitosis1.49e-021.00e+006.0611118
GO:0005001transmembrane receptor protein tyrosine phosphatase activity1.49e-021.00e+006.0611118
GO:0035861site of double-strand break1.49e-021.00e+006.0611118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.57e-021.00e+005.9831119
GO:0048863stem cell differentiation1.57e-021.00e+005.9831119
GO:0048010vascular endothelial growth factor receptor signaling pathway1.65e-021.00e+005.9091120
GO:0005680anaphase-promoting complex1.65e-021.00e+005.9091420
GO:0006298mismatch repair1.65e-021.00e+005.9091320
GO:0032201telomere maintenance via semi-conservative replication1.73e-021.00e+005.8391521
GO:0000718nucleotide-excision repair, DNA damage removal1.73e-021.00e+005.8391421
GO:0006297nucleotide-excision repair, DNA gap filling1.82e-021.00e+005.7721322
GO:0030863cortical cytoskeleton1.82e-021.00e+005.7721122
GO:0036464cytoplasmic ribonucleoprotein granule1.82e-021.00e+005.7721422
GO:0043044ATP-dependent chromatin remodeling1.90e-021.00e+005.7081423
GO:0005844polysome1.90e-021.00e+005.7081423
GO:0031463Cul3-RING ubiquitin ligase complex1.90e-021.00e+005.7081323
GO:0043236laminin binding1.90e-021.00e+005.7081123
GO:0006513protein monoubiquitination1.90e-021.00e+005.7081123
GO:0006281DNA repair1.91e-021.00e+003.203218261
GO:0000722telomere maintenance via recombination2.06e-021.00e+005.5871525
GO:0070979protein K11-linked ubiquitination2.14e-021.00e+005.5311626
GO:0050770regulation of axonogenesis2.14e-021.00e+005.5311126
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.14e-021.00e+005.5311326
GO:0048008platelet-derived growth factor receptor signaling pathway2.22e-021.00e+005.4761227
GO:0043022ribosome binding2.22e-021.00e+005.4761327
GO:0031492nucleosomal DNA binding2.22e-021.00e+005.4761427
GO:0001755neural crest cell migration2.31e-021.00e+005.4241228
GO:0019894kinesin binding2.31e-021.00e+005.4241128
GO:0019005SCF ubiquitin ligase complex2.39e-021.00e+005.3731129
GO:0050853B cell receptor signaling pathway2.39e-021.00e+005.3731129
GO:0006271DNA strand elongation involved in DNA replication2.47e-021.00e+005.3241730
GO:0004714transmembrane receptor protein tyrosine kinase activity2.47e-021.00e+005.3241230
GO:0007094mitotic spindle assembly checkpoint2.55e-021.00e+005.2771431
GO:0019901protein kinase binding2.75e-021.00e+002.923221317
GO:0001895retina homeostasis2.79e-021.00e+005.1441134
GO:0005876spindle microtubule2.79e-021.00e+005.1441234
GO:0005813centrosome2.89e-021.00e+002.882214326
GO:0008283cell proliferation2.93e-021.00e+002.874214328
GO:0034332adherens junction organization2.96e-021.00e+005.0611136
GO:0051084'de novo' posttranslational protein folding3.04e-021.00e+005.0221437
GO:0007015actin filament organization3.04e-021.00e+005.0221237
GO:0006284base-excision repair3.04e-021.00e+005.0221337
GO:0001657ureteric bud development3.12e-021.00e+004.9831138
GO:0070527platelet aggregation3.12e-021.00e+004.9831238
GO:0010595positive regulation of endothelial cell migration3.12e-021.00e+004.9831138
GO:0022627cytosolic small ribosomal subunit3.20e-021.00e+004.9461439
GO:0000781chromosome, telomeric region3.20e-021.00e+004.9461339
GO:0030155regulation of cell adhesion3.44e-021.00e+004.8391242
GO:0005925focal adhesion3.58e-021.00e+002.715219366
GO:0021762substantia nigra development3.60e-021.00e+004.7721244
GO:0006283transcription-coupled nucleotide-excision repair3.76e-021.00e+004.7081746
GO:0003684damaged DNA binding4.00e-021.00e+004.6161749
GO:0060326cell chemotaxis4.08e-021.00e+004.5871250
GO:0060041retina development in camera-type eye4.16e-021.00e+004.5591251
GO:0016020membrane4.22e-021.00e+001.5164901681
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.32e-021.00e+004.5031553
GO:0045216cell-cell junction organization4.40e-021.00e+004.4761254
GO:0071300cellular response to retinoic acid4.48e-021.00e+004.4501255
GO:0000724double-strand break repair via homologous recombination4.48e-021.00e+004.4501355
GO:0000723telomere maintenance4.56e-021.00e+004.4241656
GO:0010976positive regulation of neuron projection development4.72e-021.00e+004.3731158
GO:0001558regulation of cell growth4.96e-021.00e+004.3001261
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway4.96e-021.00e+004.3001261
GO:0019903protein phosphatase binding5.04e-021.00e+004.2771462
GO:0006302double-strand break repair5.04e-021.00e+004.2771462
GO:0007596blood coagulation5.32e-021.00e+002.401218455
GO:0006289nucleotide-excision repair5.52e-021.00e+004.14411168
GO:0034329cell junction assembly5.52e-021.00e+004.1441168
GO:0003697single-stranded DNA binding5.52e-021.00e+004.1441568
GO:0044267cellular protein metabolic process5.72e-021.00e+002.342229474
GO:0000165MAPK cascade5.83e-021.00e+004.0611272
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis5.99e-021.00e+004.0221674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.07e-021.00e+004.0021275
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process6.22e-021.00e+003.9641777
GO:0004725protein tyrosine phosphatase activity6.30e-021.00e+003.9461178
GO:0007229integrin-mediated signaling pathway6.30e-021.00e+003.9461278
GO:0001726ruffle6.46e-021.00e+003.9091480
GO:0051301cell division6.54e-021.00e+003.8911581
GO:0019083viral transcription6.54e-021.00e+003.89111081
GO:0004713protein tyrosine kinase activity6.62e-021.00e+003.8741582
GO:0050852T cell receptor signaling pathway6.85e-021.00e+003.8221485
GO:0047485protein N-terminus binding6.93e-021.00e+003.8051586
GO:0006415translational termination7.01e-021.00e+003.78811087
GO:0016605PML body7.08e-021.00e+003.7721388
GO:0006928cellular component movement7.32e-021.00e+003.7231791
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules7.32e-021.00e+003.7231191
GO:0005200structural constituent of cytoskeleton7.32e-021.00e+003.7231891
GO:0071456cellular response to hypoxia7.39e-021.00e+003.7081692
GO:0035335peptidyl-tyrosine dephosphorylation7.39e-021.00e+003.7081192
GO:0006414translational elongation7.47e-021.00e+003.69211393
GO:0043235receptor complex7.94e-021.00e+003.6021299
GO:0006614SRP-dependent cotranslational protein targeting to membrane8.32e-021.00e+003.531110104
GO:0014069postsynaptic density8.40e-021.00e+003.51713105
GO:0015630microtubule cytoskeleton8.78e-021.00e+003.45014110
GO:0072562blood microparticle8.86e-021.00e+003.43713111
GO:0030529ribonucleoprotein complex8.93e-021.00e+003.42418112
GO:0005819spindle8.93e-021.00e+003.42417112
GO:0017124SH3 domain binding9.01e-021.00e+003.41113113
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay9.09e-021.00e+003.398111114
GO:0019058viral life cycle9.16e-021.00e+003.386113115
GO:0006325chromatin organization9.39e-021.00e+003.34815118
GO:0007219Notch signaling pathway9.54e-021.00e+003.32415120
GO:0006260DNA replication9.62e-021.00e+003.31219121
GO:0008201heparin binding9.69e-021.00e+003.30014122
GO:0030027lamellipodium9.92e-021.00e+003.26514125
GO:0006511ubiquitin-dependent protein catabolic process1.00e-011.00e+003.25415126
GO:0000790nuclear chromatin1.02e-011.00e+003.22019129
GO:0006413translational initiation1.04e-011.00e+003.198117131
GO:0018108peptidyl-tyrosine phosphorylation1.04e-011.00e+003.18717132
GO:0003735structural constituent of ribosome1.08e-011.00e+003.133110137
GO:0008286insulin receptor signaling pathway1.12e-011.00e+003.08117142
GO:0006457protein folding1.13e-011.00e+003.07117143
GO:0061024membrane organization1.14e-011.00e+003.05117145
GO:0010008endosome membrane1.19e-011.00e+002.99317151
GO:0045121membrane raft1.22e-011.00e+002.94618156
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.29e-011.00e+002.86517165
GO:0030424axon1.30e-011.00e+002.85614166
GO:0005634nucleus1.45e-011.00e+000.66261364559
GO:0004872receptor activity1.46e-011.00e+002.66912189
GO:0007173epidermal growth factor receptor signaling pathway1.46e-011.00e+002.669112189
GO:0030168platelet activation1.58e-011.00e+002.552110205
GO:0004871signal transducer activity1.60e-011.00e+002.53114208
GO:0005887integral component of plasma membrane1.66e-011.00e+001.43726888
GO:0007067mitotic nuclear division1.73e-011.00e+002.405114227
GO:0006412translation1.75e-011.00e+002.386120230
GO:0005737cytoplasm1.81e-011.00e+000.67451103767
GO:0004842ubiquitin-protein transferase activity1.93e-011.00e+002.23716255
GO:0048011neurotrophin TRK receptor signaling pathway2.02e-011.00e+002.160115269
GO:0019899enzyme binding2.08e-011.00e+002.117112277
GO:0042493response to drug2.12e-011.00e+002.081113284
GO:0007186G-protein coupled receptor signaling pathway2.16e-011.00e+002.05617289
GO:0005856cytoskeleton2.17e-011.00e+002.046112291
GO:0043234protein complex2.20e-011.00e+002.027118295
GO:0016567protein ubiquitination2.20e-011.00e+002.02715295
GO:0007411axon guidance2.35e-011.00e+001.914113319
GO:0003723RNA binding2.50e-011.00e+001.813120342
GO:0005524ATP binding2.95e-011.00e+000.8892601298
GO:0006468protein phosphorylation3.22e-011.00e+001.386118460
GO:0045893positive regulation of transcription, DNA-templated3.33e-011.00e+001.330113478
GO:0005509calcium ion binding3.63e-011.00e+001.17915531
GO:0045087innate immune response3.97e-011.00e+001.012124596
GO:0007165signal transduction5.41e-011.00e+000.406124907
GO:0005615extracellular space5.61e-011.00e+000.329117957
GO:0008270zinc ion binding5.77e-011.00e+000.270112997
GO:0044822poly(A) RNA binding5.99e-011.00e+000.1871491056
GO:0005886plasma membrane6.61e-011.00e+00-0.1032452582