int-snw-55143

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.934 1.73e-15 2.51e-03 4.05e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-55143 subnetwork

Genes (13)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
CAD 790 170.8071.007333--
ACO2 50 501.0001.076191Yes-
RUVBL1 8607 170.7201.013343Yes-
PSMA2 5683 601.0931.10689Yes-
PSMD3 5709 570.9861.106146Yes-
SUMO2 6613 3-0.4660.983199--
[ CDCA8 ] 55143 10.3170.93416--
PSMB7 5695 480.9821.05257Yes-
PSMA1 5682 610.9961.052123Yes-
ACTB 60 1671.1531.151587Yes-
PSMD11 5717 1211.0951.106183Yes-
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-

Interactions (30)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ACO2 50 RUVBL1 8607 pp -- int.I2D: YeastLow
PSMD11 5717 SUMO2 6613 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
CAD 790 SUMO2 6613 pp -- int.I2D: BioGrid
CAD 790 RPSA 3921 pp -- int.I2D: IntAct_Yeast
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
CAD 790 RUVBL1 8607 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
PSMA2 5683 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PGD 5226 PSMD3 5709 pp -- int.I2D: YeastLow
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMA2 5683 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
SUMO2 6613 CDCA8 55143 pp -- int.I2D: BioGrid
ACTB 60 CAD 790 pp -- int.I2D: IntAct_Yeast
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
SUMO2 6613 RUVBL1 8607 pp -- int.I2D: BioGrid
ACO2 50 PSMD11 5717 pp -- int.I2D: YeastLow
ACTB 60 RUVBL1 8607 pp -- int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
PSMD11 5717 RUVBL1 8607 pp -- int.I2D: YeastLow
ACO2 50 PGD 5226 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast

Related GO terms (195)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0006521regulation of cellular amino acid metabolic process5.14e-107.41e-066.79451750
GO:0000502proteasome complex1.11e-091.60e-056.58051758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.84e-092.65e-056.43851964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.99e-092.87e-056.41552265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.91e-094.19e-056.30852270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent3.36e-094.84e-056.26852072
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.86e-095.57e-056.22852274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I4.14e-095.97e-056.20952075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process5.39e-097.78e-056.13452379
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.17e-081.69e-045.91452192
GO:0016071mRNA metabolic process2.00e-082.89e-044.900631223
GO:0016070RNA metabolic process3.68e-085.31e-044.752632247
GO:0000209protein polyubiquitination3.77e-085.44e-045.580520116
GO:0000082G1/S transition of mitotic cell cycle1.32e-071.91e-035.218532149
GO:0042981regulation of apoptotic process1.37e-071.98e-035.209524150
GO:0034641cellular nitrogen compound metabolic process2.63e-073.80e-035.020520171
GO:0005839proteasome core complex4.63e-076.68e-037.5313818
GO:0004298threonine-type endopeptidase activity5.50e-077.93e-037.4533819
GO:0000278mitotic cell cycle5.58e-078.05e-034.090648391
GO:0005654nucleoplasm8.95e-071.29e-023.0368761082
GO:0044281small molecule metabolic process2.12e-063.06e-022.8748581211
GO:0070062extracellular vesicular exosome2.81e-064.05e-022.209101042400
GO:0016032viral process3.44e-064.96e-023.640655534
GO:0005829cytosol4.07e-065.87e-022.152101322496
GO:0005634nucleus9.08e-061.31e-011.546121364559
GO:0010467gene expression1.26e-051.82e-013.315659669
GO:0019773proteasome core complex, alpha-subunit complex2.09e-053.02e-018.116248
GO:0043066negative regulation of apoptotic process2.27e-053.28e-013.710531424
GO:0005838proteasome regulatory particle4.92e-057.10e-017.5312712
GO:0035267NuA4 histone acetyltransferase complex6.78e-059.78e-017.3082414
GO:0006915apoptotic process8.25e-051.00e+003.321533555
GO:0022624proteasome accessory complex1.01e-041.00e+007.0282817
GO:0004151dihydroorotase activity9.01e-041.00e+0010.116111
GO:0019521D-gluconate metabolic process9.01e-041.00e+0010.116111
GO:0004070aspartate carbamoyltransferase activity9.01e-041.00e+0010.116111
GO:0004088carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity9.01e-041.00e+0010.116111
GO:0070335aspartate binding9.01e-041.00e+0010.116111
GO:00515383 iron, 4 sulfur cluster binding1.80e-031.00e+009.116112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.80e-031.00e+009.116112
GO:0019322pentose biosynthetic process1.80e-031.00e+009.116122
GO:0003994aconitate hydratase activity1.80e-031.00e+009.116112
GO:0005055laminin receptor activity1.80e-031.00e+009.116112
GO:0006407rRNA export from nucleus1.80e-031.00e+009.116112
GO:0070409carbamoyl phosphate biosynthetic process1.80e-031.00e+009.116112
GO:0016020membrane2.06e-031.00e+001.9866901681
GO:0043234protein complex2.08e-031.00e+003.496318295
GO:0009051pentose-phosphate shunt, oxidative branch2.70e-031.00e+008.531123
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.70e-031.00e+008.531113
GO:0044205'de novo' UMP biosynthetic process2.70e-031.00e+008.531113
GO:0006207'de novo' pyrimidine nucleobase biosynthetic process2.70e-031.00e+008.531113
GO:0016363nuclear matrix2.94e-031.00e+004.60821291
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.60e-031.00e+008.116114
GO:003068690S preribosome3.60e-031.00e+008.116114
GO:0006543glutamine catabolic process3.60e-031.00e+008.116114
GO:0032133chromosome passenger complex3.60e-031.00e+008.116114
GO:0030529ribonucleoprotein complex4.41e-031.00e+004.30828112
GO:0051414response to cortisol4.50e-031.00e+007.794115
GO:0043248proteasome assembly4.50e-031.00e+007.794115
GO:0006102isocitrate metabolic process4.50e-031.00e+007.794115
GO:0006325chromatin organization4.88e-031.00e+004.23325118
GO:0030957Tat protein binding5.40e-031.00e+007.531136
GO:0046134pyrimidine nucleoside biosynthetic process5.40e-031.00e+007.531116
GO:0006101citrate metabolic process5.40e-031.00e+007.531116
GO:0000028ribosomal small subunit assembly6.29e-031.00e+007.308117
GO:0070688MLL5-L complex7.19e-031.00e+007.116118
GO:0000812Swr1 complex7.19e-031.00e+007.116138
GO:0044267cellular protein metabolic process7.89e-031.00e+002.812329474
GO:0006228UTP biosynthetic process8.09e-031.00e+006.946119
GO:0014075response to amine8.09e-031.00e+006.946119
GO:0031000response to caffeine8.09e-031.00e+006.946129
GO:0006098pentose-phosphate shunt8.98e-031.00e+006.7941410
GO:0019789SUMO ligase activity9.87e-031.00e+006.6561111
GO:0010369chromocenter9.87e-031.00e+006.6561111
GO:0043968histone H2A acetylation1.08e-021.00e+006.5311312
GO:0005730nucleolus1.11e-021.00e+001.7575691641
GO:0007080mitotic metaphase plate congression1.17e-021.00e+006.4151213
GO:0030234enzyme regulator activity1.17e-021.00e+006.4151313
GO:0031011Ino80 complex1.26e-021.00e+006.3081314
GO:0050998nitric-oxide synthase binding1.43e-021.00e+006.1161116
GO:0042176regulation of protein catabolic process1.43e-021.00e+006.1161316
GO:0051276chromosome organization1.43e-021.00e+006.1161316
GO:0006541glutamine metabolic process1.52e-021.00e+006.0281117
GO:0003678DNA helicase activity1.52e-021.00e+006.0281317
GO:0017144drug metabolic process1.61e-021.00e+005.9461118
GO:0048863stem cell differentiation1.70e-021.00e+005.8681119
GO:0071364cellular response to epidermal growth factor stimulus1.88e-021.00e+005.7231121
GO:0006206pyrimidine nucleobase metabolic process1.97e-021.00e+005.6561222
GO:0033574response to testosterone1.97e-021.00e+005.6561222
GO:0030863cortical cytoskeleton1.97e-021.00e+005.6561122
GO:0036464cytoplasmic ribonucleoprotein granule1.97e-021.00e+005.6561422
GO:0043044ATP-dependent chromatin remodeling2.05e-021.00e+005.5921423
GO:0005844polysome2.05e-021.00e+005.5921423
GO:0043236laminin binding2.05e-021.00e+005.5921123
GO:0034080CENP-A containing nucleosome assembly2.23e-021.00e+005.4721125
GO:0016925protein sumoylation2.23e-021.00e+005.4721125
GO:0043022ribosome binding2.41e-021.00e+005.3611327
GO:0050661NADP binding2.41e-021.00e+005.3611227
GO:0071339MLL1 complex2.41e-021.00e+005.3611327
GO:0043967histone H4 acetylation2.41e-021.00e+005.3611327
GO:0031492nucleosomal DNA binding2.41e-021.00e+005.3611427
GO:0006099tricarboxylic acid cycle2.50e-021.00e+005.3081428
GO:0019894kinesin binding2.50e-021.00e+005.3081128
GO:0045171intercellular bridge2.67e-021.00e+005.2091230
GO:0001895retina homeostasis3.02e-021.00e+005.0281134
GO:00515394 iron, 4 sulfur cluster binding3.11e-021.00e+004.9861335
GO:0034332adherens junction organization3.20e-021.00e+004.9461136
GO:0018107peptidyl-threonine phosphorylation3.29e-021.00e+004.9061437
GO:0051084'de novo' posttranslational protein folding3.29e-021.00e+004.9061437
GO:0070527platelet aggregation3.37e-021.00e+004.8681238
GO:0022627cytosolic small ribosomal subunit3.46e-021.00e+004.8301439
GO:0007595lactation3.46e-021.00e+004.8301239
GO:0043195terminal bouton3.63e-021.00e+004.7581141
GO:0032508DNA duplex unwinding3.63e-021.00e+004.7581341
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process3.90e-021.00e+004.6561344
GO:0021762substantia nigra development3.90e-021.00e+004.6561244
GO:0005515protein binding4.29e-021.00e+000.72991846024
GO:0035690cellular response to drug4.33e-021.00e+004.5011249
GO:0006091generation of precursor metabolites and energy4.42e-021.00e+004.4721350
GO:0000775chromosome, centromeric region4.42e-021.00e+004.4721250
GO:0031100organ regeneration4.42e-021.00e+004.4721450
GO:0040008regulation of growth4.42e-021.00e+004.4721550
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.68e-021.00e+004.3881553
GO:0045216cell-cell junction organization4.76e-021.00e+004.3611254
GO:0000932cytoplasmic mRNA processing body4.76e-021.00e+004.3611354
GO:0042995cell projection5.28e-021.00e+004.2091660
GO:0006310DNA recombination5.71e-021.00e+004.0931265
GO:0034329cell junction assembly5.96e-021.00e+004.0281168
GO:0055086nucleobase-containing small molecule metabolic process6.13e-021.00e+003.9861270
GO:0006334nucleosome assembly6.30e-021.00e+003.9461272
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis6.47e-021.00e+003.9061674
GO:0001889liver development6.72e-021.00e+003.8491477
GO:0007565female pregnancy6.81e-021.00e+003.8301178
GO:0019083viral transcription7.06e-021.00e+003.77611081
GO:0006415translational termination7.57e-021.00e+003.67311087
GO:0016605PML body7.65e-021.00e+003.6561388
GO:0006928cellular component movement7.90e-021.00e+003.6081791
GO:0005200structural constituent of cytoskeleton7.90e-021.00e+003.6081891
GO:0006414translational elongation8.07e-021.00e+003.57611393
GO:0006614SRP-dependent cotranslational protein targeting to membrane8.98e-021.00e+003.415110104
GO:0014069postsynaptic density9.07e-021.00e+003.40113105
GO:0005506iron ion binding9.07e-021.00e+003.40114105
GO:0030496midbody9.31e-021.00e+003.36115108
GO:0005815microtubule organizing center9.39e-021.00e+003.34715109
GO:0015630microtubule cytoskeleton9.48e-021.00e+003.33414110
GO:0072562blood microparticle9.56e-021.00e+003.32113111
GO:0005819spindle9.64e-021.00e+003.30817112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay9.81e-021.00e+003.283111114
GO:0019058viral life cycle9.89e-021.00e+003.270113115
GO:0044237cellular metabolic process1.01e-011.00e+003.24515117
GO:0005524ATP binding1.05e-011.00e+001.3593601298
GO:0006511ubiquitin-dependent protein catabolic process1.08e-011.00e+003.13815126
GO:0009615response to virus1.08e-011.00e+003.13815126
GO:0000790nuclear chromatin1.10e-011.00e+003.10419129
GO:0006413translational initiation1.12e-011.00e+003.082117131
GO:0003735structural constituent of ribosome1.17e-011.00e+003.018110137
GO:0007507heart development1.18e-011.00e+002.99717139
GO:0016887ATPase activity1.19e-011.00e+002.98617140
GO:0006457protein folding1.22e-011.00e+002.95617143
GO:0061024membrane organization1.23e-011.00e+002.93617145
GO:0046777protein autophosphorylation1.33e-011.00e+002.81217158
GO:0043687post-translational protein modification1.37e-011.00e+002.77615162
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.39e-011.00e+002.74917165
GO:0030424axon1.40e-011.00e+002.74114166
GO:0004672protein kinase activity1.48e-011.00e+002.64816177
GO:0031625ubiquitin protein ligase binding1.49e-011.00e+002.640114178
GO:0007067mitotic nuclear division1.86e-011.00e+002.289114227
GO:0005759mitochondrial matrix1.87e-011.00e+002.283114228
GO:0006412translation1.89e-011.00e+002.270120230
GO:0043025neuronal cell body2.00e-011.00e+002.17919245
GO:0005975carbohydrate metabolic process2.06e-011.00e+002.13319253
GO:0006281DNA repair2.11e-011.00e+002.088118261
GO:0007283spermatogenesis2.12e-011.00e+002.08218262
GO:0006357regulation of transcription from RNA polymerase II promoter2.14e-011.00e+002.07118264
GO:0019899enzyme binding2.23e-011.00e+002.002112277
GO:0005856cytoskeleton2.33e-011.00e+001.931112291
GO:0044822poly(A) RNA binding2.46e-011.00e+001.0712491056
GO:0019901protein kinase binding2.51e-011.00e+001.807121317
GO:0043231intracellular membrane-bounded organelle2.52e-011.00e+001.80319318
GO:0007411axon guidance2.52e-011.00e+001.798113319
GO:0005813centrosome2.57e-011.00e+001.767114326
GO:0003723RNA binding2.68e-011.00e+001.698120342
GO:0005925focal adhesion2.84e-011.00e+001.600119366
GO:0007155cell adhesion2.86e-011.00e+001.58816369
GO:0055114oxidation-reduction process3.19e-011.00e+001.401112420
GO:0007596blood coagulation3.41e-011.00e+001.286118455
GO:0042802identical protein binding3.58e-011.00e+001.197120484
GO:0045087innate immune response4.22e-011.00e+000.896124596
GO:0005794Golgi apparatus4.30e-011.00e+000.863115610
GO:0005737cytoplasm4.53e-011.00e+000.23641103767
GO:0045944positive regulation of transcription from RNA polymerase II promoter5.19e-011.00e+000.492119789
GO:0005615extracellular space5.91e-011.00e+000.213117957
GO:0005739mitochondrion6.06e-011.00e+000.153128998
GO:0008270zinc ion binding6.06e-011.00e+000.154112997
GO:0006351transcription, DNA-templated7.47e-011.00e+00-0.3821311446
GO:0005886plasma membrane9.23e-011.00e+00-1.2191452582