Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
wolf-screen-ratio-mammosphere-adherent | 0.924 | 4.18e-15 | 3.10e-03 | 4.71e-02 |
Gene Symbol | Entrez Gene ID | Frequency | wolf-screen-ratio-mammosphere-adherent gene score | Best subnetwork score | Degree | wolf adherent-list Hits GI | wolf mammosphere no adherent-list Hits GI |
---|---|---|---|---|---|---|---|
RBX1 | 9978 | 97 | 1.185 | 1.151 | 139 | Yes | - |
PHB2 | 11331 | 9 | 0.829 | 1.076 | 140 | Yes | - |
PSMA2 | 5683 | 60 | 1.093 | 1.106 | 89 | Yes | - |
PSMB7 | 5695 | 48 | 0.982 | 1.052 | 57 | Yes | - |
PSMA1 | 5682 | 61 | 0.996 | 1.052 | 123 | Yes | - |
ATP6V1B2 | 526 | 44 | 0.881 | 1.076 | 278 | - | - |
RPSA | 3921 | 156 | 1.327 | 1.151 | 152 | Yes | - |
PSMD2 | 5708 | 3 | 0.463 | 0.961 | 386 | Yes | - |
ACO2 | 50 | 50 | 1.000 | 1.076 | 191 | Yes | - |
EEF2 | 1938 | 27 | 0.890 | 1.043 | 301 | Yes | - |
PSMD3 | 5709 | 57 | 0.986 | 1.106 | 146 | Yes | - |
RPS11 | 6205 | 36 | 0.993 | 1.113 | 175 | Yes | - |
RPL14 | 9045 | 42 | 1.250 | 1.113 | 143 | Yes | - |
[ ABCB1 ] | 5243 | 1 | 0.222 | 0.924 | 21 | Yes | - |
PSMB2 | 5690 | 18 | 0.877 | 1.026 | 117 | Yes | - |
RNF2 | 6045 | 2 | 0.423 | 0.926 | 106 | - | - |
PSMD11 | 5717 | 121 | 1.095 | 1.106 | 183 | Yes | - |
ACTB | 60 | 167 | 1.153 | 1.151 | 587 | Yes | - |
HSPD1 | 3329 | 35 | 0.913 | 1.035 | 286 | Yes | - |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
PSMA2 | 5683 | PSMD2 | 5708 | pp | -- | int.I2D: BioGrid_Yeast |
ACTB | 60 | PSMB2 | 5690 | pp | -- | int.I2D: BioGrid_Yeast |
PSMA1 | 5682 | PSMD2 | 5708 | pp | -- | int.I2D: BioGrid, BioGrid_Yeast |
PSMD3 | 5709 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG |
PSMA1 | 5682 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast, YeastMedium |
PSMD2 | 5708 | RPL14 | 9045 | pp | -- | int.I2D: BioGrid_Yeast |
ACTB | 60 | PSMB7 | 5695 | pp | -- | int.I2D: BioGrid_Yeast |
ATP6V1B2 | 526 | PHB2 | 11331 | pp | -- | int.I2D: IntAct_Yeast |
PSMD2 | 5708 | PHB2 | 11331 | pp | -- | int.I2D: IntAct_Yeast |
PSMA1 | 5682 | PSMA2 | 5683 | pp | -- | int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh; int.HPRD: yeast 2-hybrid |
PSMB2 | 5690 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct |
ACTB | 60 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast |
RPSA | 3921 | RPS11 | 6205 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast |
HSPD1 | 3329 | PHB2 | 11331 | pp | -- | int.I2D: IntAct_Yeast |
ACTB | 60 | ATP6V1B2 | 526 | pp | -- | int.I2D: BioGrid_Yeast |
ATP6V1B2 | 526 | RPSA | 3921 | pp | -- | int.I2D: IntAct_Yeast |
PSMB2 | 5690 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
PSMD2 | 5708 | RPS11 | 6205 | pp | -- | int.I2D: BioGrid_Yeast |
PSMD2 | 5708 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast, MINT_Yeast, IntAct_Yeast, Krogan_Core, YeastLow |
PSMA2 | 5683 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast |
RPSA | 3921 | PHB2 | 11331 | pp | -- | int.I2D: IntAct_Yeast |
ACTB | 60 | PSMA1 | 5682 | pp | -- | int.I2D: BioGrid_Yeast |
ACO2 | 50 | PSMD11 | 5717 | pp | -- | int.I2D: YeastLow |
EEF2 | 1938 | HSPD1 | 3329 | pp | -- | int.I2D: YeastLow, YeastMedium |
ABCB1 | 5243 | PSMD2 | 5708 | pp | -- | int.I2D: BioGrid_Yeast |
RPSA | 3921 | PSMD11 | 5717 | pp | -- | int.I2D: IntAct_Yeast |
HSPD1 | 3329 | RPSA | 3921 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast |
ACTB | 60 | PSMD2 | 5708 | pp | -- | int.I2D: BioGrid_Yeast |
PSMA2 | 5683 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
ACTB | 60 | EEF2 | 1938 | pp | -- | int.I2D: YeastLow, IntAct_Yeast |
PSMA1 | 5682 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
ACTB | 60 | RPSA | 3921 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct |
PSMA2 | 5683 | PSMB2 | 5690 | pp | -- | int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core |
RPS11 | 6205 | RPL14 | 9045 | pp | -- | int.I2D: BioGrid_Yeast |
EEF2 | 1938 | PHB2 | 11331 | pp | -- | int.I2D: IntAct_Yeast |
ACTB | 60 | PHB2 | 11331 | pp | -- | int.I2D: IntAct_Yeast |
ACO2 | 50 | HSPD1 | 3329 | pp | -- | int.I2D: IntAct_Yeast |
PSMA1 | 5682 | PSMB2 | 5690 | pp | -- | int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastHigh; int.HPRD: yeast 2-hybrid |
ABCB1 | 5243 | PSMB2 | 5690 | pp | -- | int.I2D: BioGrid_Yeast |
ABCB1 | 5243 | RNF2 | 6045 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: BCI, IntAct, HPRD; int.HPRD: in vivo, yeast 2-hybrid |
PSMA2 | 5683 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
PSMA1 | 5682 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast |
ACTB | 60 | RBX1 | 9978 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB2 | 5690 | PSMD2 | 5708 | pp | -- | int.I2D: BioGrid_Yeast |
ACTB | 60 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
ACO2 | 50 | PSMD2 | 5708 | pp | -- | int.I2D: YeastLow |
EEF2 | 1938 | PSMD2 | 5708 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB7 | 5695 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB2 | 5690 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast, YeastMedium |
EEF2 | 1938 | PSMD3 | 5709 | pp | -- | int.I2D: Krogan_NonCore |
ACTB | 60 | HSPD1 | 3329 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct, YeastLow |
PSMB7 | 5695 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast |
PSMD2 | 5708 | RBX1 | 9978 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow |
ABCB1 | 5243 | PHB2 | 11331 | pp | -- | int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct |
PSMD2 | 5708 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastLow |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0016071 | mRNA metabolic process | 5.22e-14 | 7.53e-10 | 5.089 | 10 | 31 | 223 |
GO:0016070 | RNA metabolic process | 1.46e-13 | 2.11e-09 | 4.942 | 10 | 32 | 247 |
GO:0006521 | regulation of cellular amino acid metabolic process | 1.90e-13 | 2.73e-09 | 6.732 | 7 | 17 | 50 |
GO:0016032 | viral process | 2.34e-13 | 3.37e-09 | 4.092 | 12 | 55 | 534 |
GO:0000502 | proteasome complex | 5.67e-13 | 8.18e-09 | 6.518 | 7 | 17 | 58 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 1.17e-12 | 1.68e-08 | 6.376 | 7 | 19 | 64 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.31e-12 | 1.89e-08 | 6.353 | 7 | 22 | 65 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 2.24e-12 | 3.23e-08 | 6.246 | 7 | 22 | 70 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 2.75e-12 | 3.97e-08 | 6.206 | 7 | 20 | 72 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 3.36e-12 | 4.84e-08 | 6.166 | 7 | 22 | 74 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 3.70e-12 | 5.34e-08 | 6.147 | 7 | 20 | 75 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 5.39e-12 | 7.77e-08 | 6.072 | 7 | 23 | 79 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 1.61e-11 | 2.33e-07 | 5.852 | 7 | 21 | 92 |
GO:0000209 | protein polyubiquitination | 8.43e-11 | 1.22e-06 | 5.518 | 7 | 20 | 116 |
GO:0010467 | gene expression | 1.06e-10 | 1.53e-06 | 3.642 | 11 | 59 | 669 |
GO:0070062 | extracellular vesicular exosome | 1.93e-10 | 2.79e-06 | 2.339 | 16 | 104 | 2400 |
GO:0000082 | G1/S transition of mitotic cell cycle | 4.95e-10 | 7.14e-06 | 5.156 | 7 | 32 | 149 |
GO:0042981 | regulation of apoptotic process | 5.19e-10 | 7.48e-06 | 5.147 | 7 | 24 | 150 |
GO:0034641 | cellular nitrogen compound metabolic process | 1.30e-09 | 1.88e-05 | 4.958 | 7 | 20 | 171 |
GO:0005839 | proteasome core complex | 6.50e-09 | 9.38e-05 | 7.398 | 4 | 8 | 18 |
GO:0005829 | cytosol | 6.93e-09 | 9.99e-05 | 2.190 | 15 | 132 | 2496 |
GO:0004298 | threonine-type endopeptidase activity | 8.23e-09 | 1.19e-04 | 7.320 | 4 | 8 | 19 |
GO:0000278 | mitotic cell cycle | 1.58e-08 | 2.28e-04 | 3.957 | 8 | 48 | 391 |
GO:0043066 | negative regulation of apoptotic process | 2.97e-08 | 4.29e-04 | 3.840 | 8 | 31 | 424 |
GO:0005654 | nucleoplasm | 2.68e-07 | 3.86e-03 | 2.811 | 10 | 76 | 1082 |
GO:0005838 | proteasome regulatory particle | 4.23e-07 | 6.10e-03 | 7.568 | 3 | 7 | 12 |
GO:0022624 | proteasome accessory complex | 1.30e-06 | 1.88e-02 | 7.066 | 3 | 8 | 17 |
GO:0016020 | membrane | 1.62e-06 | 2.33e-02 | 2.312 | 11 | 90 | 1681 |
GO:0006915 | apoptotic process | 4.05e-06 | 5.84e-02 | 3.259 | 7 | 33 | 555 |
GO:0006414 | translational elongation | 5.83e-06 | 8.41e-02 | 5.029 | 4 | 13 | 93 |
GO:0044281 | small molecule metabolic process | 8.57e-06 | 1.24e-01 | 2.496 | 9 | 58 | 1211 |
GO:0019773 | proteasome core complex, alpha-subunit complex | 4.58e-05 | 6.61e-01 | 7.568 | 2 | 4 | 8 |
GO:0030234 | enzyme regulator activity | 1.27e-04 | 1.00e+00 | 6.868 | 2 | 3 | 13 |
GO:0019083 | viral transcription | 1.55e-04 | 1.00e+00 | 4.813 | 3 | 10 | 81 |
GO:0005515 | protein binding | 1.85e-04 | 1.00e+00 | 1.012 | 16 | 184 | 6024 |
GO:0006415 | translational termination | 1.92e-04 | 1.00e+00 | 4.710 | 3 | 10 | 87 |
GO:0042176 | regulation of protein catabolic process | 1.95e-04 | 1.00e+00 | 6.568 | 2 | 3 | 16 |
GO:0006412 | translation | 2.02e-04 | 1.00e+00 | 3.723 | 4 | 20 | 230 |
GO:0044267 | cellular protein metabolic process | 2.98e-04 | 1.00e+00 | 3.001 | 5 | 29 | 474 |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 3.24e-04 | 1.00e+00 | 4.453 | 3 | 10 | 104 |
GO:0005844 | polysome | 4.09e-04 | 1.00e+00 | 6.045 | 2 | 4 | 23 |
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 4.25e-04 | 1.00e+00 | 4.320 | 3 | 11 | 114 |
GO:0019058 | viral life cycle | 4.36e-04 | 1.00e+00 | 4.308 | 3 | 13 | 115 |
GO:0006413 | translational initiation | 6.38e-04 | 1.00e+00 | 4.120 | 3 | 17 | 131 |
GO:0003735 | structural constituent of ribosome | 7.27e-04 | 1.00e+00 | 4.055 | 3 | 10 | 137 |
GO:0022627 | cytosolic small ribosomal subunit | 1.18e-03 | 1.00e+00 | 5.283 | 2 | 4 | 39 |
GO:0002842 | positive regulation of T cell mediated immune response to tumor cell | 1.32e-03 | 1.00e+00 | 9.568 | 1 | 1 | 1 |
GO:0036353 | histone H2A-K119 monoubiquitination | 1.32e-03 | 1.00e+00 | 9.568 | 1 | 1 | 1 |
GO:0048291 | isotype switching to IgG isotypes | 1.32e-03 | 1.00e+00 | 9.568 | 1 | 1 | 1 |
GO:0002368 | B cell cytokine production | 1.32e-03 | 1.00e+00 | 9.568 | 1 | 1 | 1 |
GO:0051538 | 3 iron, 4 sulfur cluster binding | 2.63e-03 | 1.00e+00 | 8.568 | 1 | 1 | 2 |
GO:0000461 | endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 2.63e-03 | 1.00e+00 | 8.568 | 1 | 1 | 2 |
GO:0003994 | aconitate hydratase activity | 2.63e-03 | 1.00e+00 | 8.568 | 1 | 1 | 2 |
GO:0005055 | laminin receptor activity | 2.63e-03 | 1.00e+00 | 8.568 | 1 | 1 | 2 |
GO:0006407 | rRNA export from nucleus | 2.63e-03 | 1.00e+00 | 8.568 | 1 | 1 | 2 |
GO:0006458 | 'de novo' protein folding | 3.95e-03 | 1.00e+00 | 7.983 | 1 | 1 | 3 |
GO:0008559 | xenobiotic-transporting ATPase activity | 3.95e-03 | 1.00e+00 | 7.983 | 1 | 1 | 3 |
GO:0030135 | coated vesicle | 3.95e-03 | 1.00e+00 | 7.983 | 1 | 1 | 3 |
GO:0071535 | RING-like zinc finger domain binding | 3.95e-03 | 1.00e+00 | 7.983 | 1 | 1 | 3 |
GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 5.26e-03 | 1.00e+00 | 7.568 | 1 | 1 | 4 |
GO:0030686 | 90S preribosome | 5.26e-03 | 1.00e+00 | 7.568 | 1 | 1 | 4 |
GO:0031467 | Cul7-RING ubiquitin ligase complex | 5.26e-03 | 1.00e+00 | 7.568 | 1 | 1 | 4 |
GO:0019788 | NEDD8 ligase activity | 5.26e-03 | 1.00e+00 | 7.568 | 1 | 1 | 4 |
GO:0043234 | protein complex | 6.44e-03 | 1.00e+00 | 2.949 | 3 | 18 | 295 |
GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex | 6.57e-03 | 1.00e+00 | 7.246 | 1 | 3 | 5 |
GO:0031461 | cullin-RING ubiquitin ligase complex | 6.57e-03 | 1.00e+00 | 7.246 | 1 | 1 | 5 |
GO:0043248 | proteasome assembly | 6.57e-03 | 1.00e+00 | 7.246 | 1 | 1 | 5 |
GO:0046696 | lipopolysaccharide receptor complex | 6.57e-03 | 1.00e+00 | 7.246 | 1 | 1 | 5 |
GO:0006102 | isocitrate metabolic process | 6.57e-03 | 1.00e+00 | 7.246 | 1 | 1 | 5 |
GO:0030891 | VCB complex | 6.57e-03 | 1.00e+00 | 7.246 | 1 | 2 | 5 |
GO:0033600 | negative regulation of mammary gland epithelial cell proliferation | 6.57e-03 | 1.00e+00 | 7.246 | 1 | 1 | 5 |
GO:0042908 | xenobiotic transport | 6.57e-03 | 1.00e+00 | 7.246 | 1 | 1 | 5 |
GO:0003688 | DNA replication origin binding | 7.88e-03 | 1.00e+00 | 6.983 | 1 | 2 | 6 |
GO:0000791 | euchromatin | 7.88e-03 | 1.00e+00 | 6.983 | 1 | 1 | 6 |
GO:0030957 | Tat protein binding | 7.88e-03 | 1.00e+00 | 6.983 | 1 | 3 | 6 |
GO:0060744 | mammary gland branching involved in thelarche | 7.88e-03 | 1.00e+00 | 6.983 | 1 | 1 | 6 |
GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex | 7.88e-03 | 1.00e+00 | 6.983 | 1 | 1 | 6 |
GO:0006101 | citrate metabolic process | 7.88e-03 | 1.00e+00 | 6.983 | 1 | 1 | 6 |
GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis | 7.88e-03 | 1.00e+00 | 6.983 | 1 | 1 | 6 |
GO:0031466 | Cul5-RING ubiquitin ligase complex | 7.88e-03 | 1.00e+00 | 6.983 | 1 | 1 | 6 |
GO:0033180 | proton-transporting V-type ATPase, V1 domain | 9.19e-03 | 1.00e+00 | 6.761 | 1 | 2 | 7 |
GO:0072089 | stem cell proliferation | 9.19e-03 | 1.00e+00 | 6.761 | 1 | 1 | 7 |
GO:0000028 | ribosomal small subunit assembly | 9.19e-03 | 1.00e+00 | 6.761 | 1 | 1 | 7 |
GO:0001739 | sex chromatin | 9.19e-03 | 1.00e+00 | 6.761 | 1 | 1 | 7 |
GO:0031462 | Cul2-RING ubiquitin ligase complex | 9.19e-03 | 1.00e+00 | 6.761 | 1 | 2 | 7 |
GO:0030529 | ribonucleoprotein complex | 9.38e-03 | 1.00e+00 | 3.761 | 2 | 8 | 112 |
GO:0044822 | poly(A) RNA binding | 1.02e-02 | 1.00e+00 | 1.846 | 5 | 49 | 1056 |
GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex | 1.05e-02 | 1.00e+00 | 6.568 | 1 | 2 | 8 |
GO:0070688 | MLL5-L complex | 1.05e-02 | 1.00e+00 | 6.568 | 1 | 1 | 8 |
GO:0045116 | protein neddylation | 1.05e-02 | 1.00e+00 | 6.568 | 1 | 2 | 8 |
GO:0051604 | protein maturation | 1.05e-02 | 1.00e+00 | 6.568 | 1 | 1 | 8 |
GO:0008494 | translation activator activity | 1.18e-02 | 1.00e+00 | 6.398 | 1 | 1 | 9 |
GO:0006855 | drug transmembrane transport | 1.31e-02 | 1.00e+00 | 6.246 | 1 | 1 | 10 |
GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway | 1.31e-02 | 1.00e+00 | 6.246 | 1 | 1 | 10 |
GO:0043032 | positive regulation of macrophage activation | 1.31e-02 | 1.00e+00 | 6.246 | 1 | 1 | 10 |
GO:0032727 | positive regulation of interferon-alpha production | 1.44e-02 | 1.00e+00 | 6.109 | 1 | 1 | 11 |
GO:0035518 | histone H2A monoubiquitination | 1.44e-02 | 1.00e+00 | 6.109 | 1 | 3 | 11 |
GO:0035102 | PRC1 complex | 1.57e-02 | 1.00e+00 | 5.983 | 1 | 1 | 12 |
GO:0005634 | nucleus | 1.59e-02 | 1.00e+00 | 0.873 | 11 | 136 | 4559 |
GO:0042273 | ribosomal large subunit biogenesis | 1.70e-02 | 1.00e+00 | 5.868 | 1 | 4 | 13 |
GO:0001530 | lipopolysaccharide binding | 1.70e-02 | 1.00e+00 | 5.868 | 1 | 3 | 13 |
GO:0051131 | chaperone-mediated protein complex assembly | 1.70e-02 | 1.00e+00 | 5.868 | 1 | 1 | 13 |
GO:0035267 | NuA4 histone acetyltransferase complex | 1.83e-02 | 1.00e+00 | 5.761 | 1 | 4 | 14 |
GO:0009948 | anterior/posterior axis specification | 1.83e-02 | 1.00e+00 | 5.761 | 1 | 2 | 14 |
GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 1.96e-02 | 1.00e+00 | 5.661 | 1 | 3 | 15 |
GO:0060749 | mammary gland alveolus development | 1.96e-02 | 1.00e+00 | 5.661 | 1 | 2 | 15 |
GO:0042026 | protein refolding | 1.96e-02 | 1.00e+00 | 5.661 | 1 | 2 | 15 |
GO:0046034 | ATP metabolic process | 1.96e-02 | 1.00e+00 | 5.661 | 1 | 1 | 15 |
GO:0050998 | nitric-oxide synthase binding | 2.09e-02 | 1.00e+00 | 5.568 | 1 | 1 | 16 |
GO:0010243 | response to organonitrogen compound | 2.22e-02 | 1.00e+00 | 5.481 | 1 | 3 | 17 |
GO:0050870 | positive regulation of T cell activation | 2.22e-02 | 1.00e+00 | 5.481 | 1 | 1 | 17 |
GO:0003746 | translation elongation factor activity | 2.22e-02 | 1.00e+00 | 5.481 | 1 | 3 | 17 |
GO:0015078 | hydrogen ion transmembrane transporter activity | 2.48e-02 | 1.00e+00 | 5.320 | 1 | 3 | 19 |
GO:0032733 | positive regulation of interleukin-10 production | 2.48e-02 | 1.00e+00 | 5.320 | 1 | 1 | 19 |
GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 2.48e-02 | 1.00e+00 | 5.320 | 1 | 1 | 19 |
GO:0048863 | stem cell differentiation | 2.48e-02 | 1.00e+00 | 5.320 | 1 | 1 | 19 |
GO:0042100 | B cell proliferation | 2.73e-02 | 1.00e+00 | 5.176 | 1 | 1 | 21 |
GO:0001702 | gastrulation with mouth forming second | 2.73e-02 | 1.00e+00 | 5.176 | 1 | 2 | 21 |
GO:0030863 | cortical cytoskeleton | 2.86e-02 | 1.00e+00 | 5.109 | 1 | 1 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 2.86e-02 | 1.00e+00 | 5.109 | 1 | 4 | 22 |
GO:0043044 | ATP-dependent chromatin remodeling | 2.99e-02 | 1.00e+00 | 5.045 | 1 | 4 | 23 |
GO:0031463 | Cul3-RING ubiquitin ligase complex | 2.99e-02 | 1.00e+00 | 5.045 | 1 | 3 | 23 |
GO:0043236 | laminin binding | 2.99e-02 | 1.00e+00 | 5.045 | 1 | 1 | 23 |
GO:0006513 | protein monoubiquitination | 2.99e-02 | 1.00e+00 | 5.045 | 1 | 1 | 23 |
GO:0042113 | B cell activation | 3.24e-02 | 1.00e+00 | 4.924 | 1 | 2 | 25 |
GO:0032735 | positive regulation of interleukin-12 production | 3.24e-02 | 1.00e+00 | 4.924 | 1 | 1 | 25 |
GO:0031519 | PcG protein complex | 3.24e-02 | 1.00e+00 | 4.924 | 1 | 4 | 25 |
GO:0015991 | ATP hydrolysis coupled proton transport | 3.37e-02 | 1.00e+00 | 4.868 | 1 | 4 | 26 |
GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 3.37e-02 | 1.00e+00 | 4.868 | 1 | 3 | 26 |
GO:0042626 | ATPase activity, coupled to transmembrane movement of substances | 3.37e-02 | 1.00e+00 | 4.868 | 1 | 1 | 26 |
GO:0030331 | estrogen receptor binding | 3.50e-02 | 1.00e+00 | 4.813 | 1 | 2 | 27 |
GO:0019843 | rRNA binding | 3.50e-02 | 1.00e+00 | 4.813 | 1 | 3 | 27 |
GO:0043022 | ribosome binding | 3.50e-02 | 1.00e+00 | 4.813 | 1 | 3 | 27 |
GO:0071339 | MLL1 complex | 3.50e-02 | 1.00e+00 | 4.813 | 1 | 3 | 27 |
GO:0031492 | nucleosomal DNA binding | 3.50e-02 | 1.00e+00 | 4.813 | 1 | 4 | 27 |
GO:0005759 | mitochondrial matrix | 3.57e-02 | 1.00e+00 | 2.735 | 2 | 14 | 228 |
GO:0006099 | tricarboxylic acid cycle | 3.63e-02 | 1.00e+00 | 4.761 | 1 | 4 | 28 |
GO:0019894 | kinesin binding | 3.63e-02 | 1.00e+00 | 4.761 | 1 | 1 | 28 |
GO:0019005 | SCF ubiquitin ligase complex | 3.75e-02 | 1.00e+00 | 4.710 | 1 | 1 | 29 |
GO:0015992 | proton transport | 3.75e-02 | 1.00e+00 | 4.710 | 1 | 3 | 29 |
GO:0033572 | transferrin transport | 3.88e-02 | 1.00e+00 | 4.661 | 1 | 5 | 30 |
GO:0016604 | nuclear body | 4.01e-02 | 1.00e+00 | 4.614 | 1 | 2 | 31 |
GO:0051701 | interaction with host | 4.13e-02 | 1.00e+00 | 4.568 | 1 | 4 | 32 |
GO:0004842 | ubiquitin-protein transferase activity | 4.37e-02 | 1.00e+00 | 2.574 | 2 | 6 | 255 |
GO:0001895 | retina homeostasis | 4.39e-02 | 1.00e+00 | 4.481 | 1 | 1 | 34 |
GO:0051539 | 4 iron, 4 sulfur cluster binding | 4.51e-02 | 1.00e+00 | 4.439 | 1 | 3 | 35 |
GO:0034332 | adherens junction organization | 4.64e-02 | 1.00e+00 | 4.398 | 1 | 1 | 36 |
GO:0032755 | positive regulation of interleukin-6 production | 4.64e-02 | 1.00e+00 | 4.398 | 1 | 2 | 36 |
GO:0090382 | phagosome maturation | 4.64e-02 | 1.00e+00 | 4.398 | 1 | 5 | 36 |
GO:0051084 | 'de novo' posttranslational protein folding | 4.77e-02 | 1.00e+00 | 4.359 | 1 | 4 | 37 |
GO:0005902 | microvillus | 4.89e-02 | 1.00e+00 | 4.320 | 1 | 2 | 38 |
GO:0070527 | platelet aggregation | 4.89e-02 | 1.00e+00 | 4.320 | 1 | 2 | 38 |
GO:0032729 | positive regulation of interferon-gamma production | 5.02e-02 | 1.00e+00 | 4.283 | 1 | 2 | 39 |
GO:0005743 | mitochondrial inner membrane | 5.07e-02 | 1.00e+00 | 2.454 | 2 | 8 | 277 |
GO:0042110 | T cell activation | 5.39e-02 | 1.00e+00 | 4.176 | 1 | 3 | 42 |
GO:0014070 | response to organic cyclic compound | 5.52e-02 | 1.00e+00 | 4.142 | 1 | 4 | 43 |
GO:0006200 | ATP catabolic process | 5.57e-02 | 1.00e+00 | 2.378 | 2 | 15 | 292 |
GO:0021762 | substantia nigra development | 5.64e-02 | 1.00e+00 | 4.109 | 1 | 2 | 44 |
GO:0045727 | positive regulation of translation | 5.64e-02 | 1.00e+00 | 4.109 | 1 | 3 | 44 |
GO:0005730 | nucleolus | 5.66e-02 | 1.00e+00 | 1.210 | 5 | 69 | 1641 |
GO:0022625 | cytosolic large ribosomal subunit | 6.27e-02 | 1.00e+00 | 3.953 | 1 | 6 | 49 |
GO:0006091 | generation of precursor metabolites and energy | 6.39e-02 | 1.00e+00 | 3.924 | 1 | 3 | 50 |
GO:0006986 | response to unfolded protein | 6.39e-02 | 1.00e+00 | 3.924 | 1 | 2 | 50 |
GO:0005905 | coated pit | 6.39e-02 | 1.00e+00 | 3.924 | 1 | 3 | 50 |
GO:0019901 | protein kinase binding | 6.44e-02 | 1.00e+00 | 2.260 | 2 | 21 | 317 |
GO:0006879 | cellular iron ion homeostasis | 6.51e-02 | 1.00e+00 | 3.896 | 1 | 4 | 51 |
GO:0003725 | double-stranded RNA binding | 6.64e-02 | 1.00e+00 | 3.868 | 1 | 5 | 52 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 6.76e-02 | 1.00e+00 | 3.840 | 1 | 5 | 53 |
GO:0002244 | hematopoietic progenitor cell differentiation | 6.88e-02 | 1.00e+00 | 3.813 | 1 | 1 | 54 |
GO:0045216 | cell-cell junction organization | 6.88e-02 | 1.00e+00 | 3.813 | 1 | 2 | 54 |
GO:0000932 | cytoplasmic mRNA processing body | 6.88e-02 | 1.00e+00 | 3.813 | 1 | 3 | 54 |
GO:0002039 | p53 binding | 7.01e-02 | 1.00e+00 | 3.787 | 1 | 7 | 55 |
GO:0012505 | endomembrane system | 7.13e-02 | 1.00e+00 | 3.761 | 1 | 2 | 56 |
GO:0003723 | RNA binding | 7.36e-02 | 1.00e+00 | 2.150 | 2 | 20 | 342 |
GO:0005840 | ribosome | 7.37e-02 | 1.00e+00 | 3.710 | 1 | 1 | 58 |
GO:0051087 | chaperone binding | 7.50e-02 | 1.00e+00 | 3.686 | 1 | 6 | 59 |
GO:0030141 | secretory granule | 7.86e-02 | 1.00e+00 | 3.614 | 1 | 2 | 62 |
GO:0000151 | ubiquitin ligase complex | 7.99e-02 | 1.00e+00 | 3.591 | 1 | 1 | 63 |
GO:0005925 | focal adhesion | 8.27e-02 | 1.00e+00 | 2.052 | 2 | 19 | 366 |
GO:0005524 | ATP binding | 8.51e-02 | 1.00e+00 | 1.226 | 4 | 60 | 1298 |
GO:0034329 | cell junction assembly | 8.59e-02 | 1.00e+00 | 3.481 | 1 | 1 | 68 |
GO:0003697 | single-stranded DNA binding | 8.59e-02 | 1.00e+00 | 3.481 | 1 | 5 | 68 |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 9.32e-02 | 1.00e+00 | 3.359 | 1 | 6 | 74 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 9.44e-02 | 1.00e+00 | 3.339 | 1 | 2 | 75 |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 9.68e-02 | 1.00e+00 | 3.301 | 1 | 7 | 77 |
GO:0009986 | cell surface | 9.71e-02 | 1.00e+00 | 1.917 | 2 | 11 | 402 |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | 1.00e-01 | 1.00e+00 | 3.246 | 1 | 3 | 80 |
GO:0001726 | ruffle | 1.00e-01 | 1.00e+00 | 3.246 | 1 | 4 | 80 |
GO:0050821 | protein stabilization | 1.10e-01 | 1.00e+00 | 3.109 | 1 | 2 | 88 |
GO:0055085 | transmembrane transport | 1.11e-01 | 1.00e+00 | 1.803 | 2 | 10 | 435 |
GO:0042470 | melanosome | 1.13e-01 | 1.00e+00 | 3.060 | 1 | 9 | 91 |
GO:0016363 | nuclear matrix | 1.13e-01 | 1.00e+00 | 3.060 | 1 | 12 | 91 |
GO:0006928 | cellular component movement | 1.13e-01 | 1.00e+00 | 3.060 | 1 | 7 | 91 |
GO:0005200 | structural constituent of cytoskeleton | 1.13e-01 | 1.00e+00 | 3.060 | 1 | 8 | 91 |
GO:0001649 | osteoblast differentiation | 1.15e-01 | 1.00e+00 | 3.045 | 1 | 6 | 92 |
GO:0071456 | cellular response to hypoxia | 1.15e-01 | 1.00e+00 | 3.045 | 1 | 6 | 92 |
GO:0051082 | unfolded protein binding | 1.16e-01 | 1.00e+00 | 3.029 | 1 | 5 | 93 |
GO:0006364 | rRNA processing | 1.17e-01 | 1.00e+00 | 3.014 | 1 | 6 | 94 |
GO:0014069 | postsynaptic density | 1.30e-01 | 1.00e+00 | 2.854 | 1 | 3 | 105 |
GO:0005506 | iron ion binding | 1.30e-01 | 1.00e+00 | 2.854 | 1 | 4 | 105 |
GO:0015630 | microtubule cytoskeleton | 1.35e-01 | 1.00e+00 | 2.787 | 1 | 4 | 110 |
GO:0072562 | blood microparticle | 1.37e-01 | 1.00e+00 | 2.774 | 1 | 3 | 111 |
GO:0005739 | mitochondrion | 1.40e-01 | 1.00e+00 | 1.190 | 3 | 28 | 998 |
GO:0044237 | cellular metabolic process | 1.43e-01 | 1.00e+00 | 2.698 | 1 | 5 | 117 |
GO:0006325 | chromatin organization | 1.45e-01 | 1.00e+00 | 2.686 | 1 | 5 | 118 |
GO:0007219 | Notch signaling pathway | 1.47e-01 | 1.00e+00 | 2.661 | 1 | 5 | 120 |
GO:0006511 | ubiquitin-dependent protein catabolic process | 1.54e-01 | 1.00e+00 | 2.591 | 1 | 5 | 126 |
GO:0009615 | response to virus | 1.54e-01 | 1.00e+00 | 2.591 | 1 | 5 | 126 |
GO:0000790 | nuclear chromatin | 1.57e-01 | 1.00e+00 | 2.557 | 1 | 9 | 129 |
GO:0005215 | transporter activity | 1.58e-01 | 1.00e+00 | 2.546 | 1 | 2 | 130 |
GO:0000086 | G2/M transition of mitotic cell cycle | 1.65e-01 | 1.00e+00 | 2.481 | 1 | 9 | 136 |
GO:0016887 | ATPase activity | 1.69e-01 | 1.00e+00 | 2.439 | 1 | 7 | 140 |
GO:0008286 | insulin receptor signaling pathway | 1.71e-01 | 1.00e+00 | 2.418 | 1 | 7 | 142 |
GO:0006457 | protein folding | 1.73e-01 | 1.00e+00 | 2.408 | 1 | 7 | 143 |
GO:0061024 | membrane organization | 1.75e-01 | 1.00e+00 | 2.388 | 1 | 7 | 145 |
GO:0010628 | positive regulation of gene expression | 1.76e-01 | 1.00e+00 | 2.378 | 1 | 5 | 146 |
GO:0005769 | early endosome | 1.82e-01 | 1.00e+00 | 2.320 | 1 | 2 | 152 |
GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 1.96e-01 | 1.00e+00 | 2.202 | 1 | 7 | 165 |
GO:0030424 | axon | 1.98e-01 | 1.00e+00 | 2.193 | 1 | 4 | 166 |
GO:0031625 | ubiquitin protein ligase binding | 2.10e-01 | 1.00e+00 | 2.092 | 1 | 14 | 178 |
GO:0032403 | protein complex binding | 2.16e-01 | 1.00e+00 | 2.052 | 1 | 10 | 183 |
GO:0003924 | GTPase activity | 2.30e-01 | 1.00e+00 | 1.946 | 1 | 12 | 197 |
GO:0005765 | lysosomal membrane | 2.36e-01 | 1.00e+00 | 1.903 | 1 | 5 | 203 |
GO:0006184 | GTP catabolic process | 2.47e-01 | 1.00e+00 | 1.827 | 1 | 12 | 214 |
GO:0016874 | ligase activity | 2.47e-01 | 1.00e+00 | 1.827 | 1 | 1 | 214 |
GO:0006810 | transport | 2.75e-01 | 1.00e+00 | 1.649 | 1 | 1 | 242 |
GO:0006281 | DNA repair | 2.93e-01 | 1.00e+00 | 1.540 | 1 | 18 | 261 |
GO:0043065 | positive regulation of apoptotic process | 3.00e-01 | 1.00e+00 | 1.502 | 1 | 10 | 268 |
GO:0042493 | response to drug | 3.15e-01 | 1.00e+00 | 1.418 | 1 | 13 | 284 |
GO:0005856 | cytoskeleton | 3.21e-01 | 1.00e+00 | 1.383 | 1 | 12 | 291 |
GO:0016567 | protein ubiquitination | 3.25e-01 | 1.00e+00 | 1.364 | 1 | 5 | 295 |
GO:0005525 | GTP binding | 3.38e-01 | 1.00e+00 | 1.292 | 1 | 12 | 310 |
GO:0043231 | intracellular membrane-bounded organelle | 3.45e-01 | 1.00e+00 | 1.255 | 1 | 9 | 318 |
GO:0007411 | axon guidance | 3.46e-01 | 1.00e+00 | 1.251 | 1 | 13 | 319 |
GO:0003682 | chromatin binding | 3.53e-01 | 1.00e+00 | 1.215 | 1 | 11 | 327 |
GO:0005813 | centrosome | 3.53e-01 | 1.00e+00 | 1.219 | 1 | 14 | 326 |
GO:0005615 | extracellular space | 3.62e-01 | 1.00e+00 | 0.666 | 2 | 17 | 957 |
GO:0008270 | zinc ion binding | 3.82e-01 | 1.00e+00 | 0.607 | 2 | 12 | 997 |
GO:0007155 | cell adhesion | 3.89e-01 | 1.00e+00 | 1.041 | 1 | 6 | 369 |
GO:0045892 | negative regulation of transcription, DNA-templated | 4.24e-01 | 1.00e+00 | 0.878 | 1 | 15 | 413 |
GO:0005886 | plasma membrane | 4.50e-01 | 1.00e+00 | 0.234 | 4 | 45 | 2582 |
GO:0007596 | blood coagulation | 4.56e-01 | 1.00e+00 | 0.738 | 1 | 18 | 455 |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 5.35e-01 | 1.00e+00 | 0.413 | 1 | 16 | 570 |
GO:0045087 | innate immune response | 5.52e-01 | 1.00e+00 | 0.349 | 1 | 24 | 596 |
GO:0005737 | cytoplasm | 5.79e-01 | 1.00e+00 | 0.011 | 5 | 110 | 3767 |
GO:0006351 | transcription, DNA-templated | 5.81e-01 | 1.00e+00 | 0.070 | 2 | 31 | 1446 |
GO:0016021 | integral component of membrane | 7.57e-01 | 1.00e+00 | -0.385 | 2 | 27 | 1982 |