int-snw-5049

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.981 2.37e-17 8.68e-04 1.85e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-5049 subnetwork

Genes (9)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
PHB2 11331 90.8291.076140Yes-
PAFAH1B1 5048 60.6911.07671Yes-
RBX1 9978 971.1851.151139Yes-
PSMA1 5682 610.9961.052123Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
[ PAFAH1B2 ] 5049 10.3050.98124--
RPSA 3921 1561.3271.151152Yes-

Interactions (12)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PAFAH1B1 5048 pp -- int.I2D: BioGrid_Yeast
PAFAH1B1 5048 PAFAH1B2 5049 pp -- int.I2D: BCI, BioGrid, BIND, HPRD;
int.HPRD: in vitro, yeast 2-hybrid
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PAFAH1B1 5048 PHB2 11331 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 PHB2 11331 pp -- int.I2D: IntAct_Yeast
ACTB 60 PHB2 11331 pp -- int.I2D: IntAct_Yeast
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast

Related GO terms (225)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0000278mitotic cell cycle6.02e-058.68e-014.035448391
GO:0000082G1/S transition of mitotic cell cycle8.67e-051.00e+005.012332149
GO:0070062extracellular vesicular exosome9.23e-051.00e+002.22571042400
GO:0005829cytosol1.20e-041.00e+002.16871322496
GO:0016032viral process2.02e-041.00e+003.585455534
GO:0005654nucleoplasm2.30e-041.00e+002.8895761082
GO:0016071mRNA metabolic process2.86e-041.00e+004.430331223
GO:0016042lipid catabolic process3.85e-041.00e+006.0612248
GO:0016070RNA metabolic process3.86e-041.00e+004.283332247
GO:0006521regulation of cellular amino acid metabolic process4.17e-041.00e+006.00221750
GO:0000502proteasome complex5.62e-041.00e+005.78821758
GO:0000235astral microtubule6.24e-041.00e+0010.646111
GO:0051660establishment of centrosome localization6.24e-041.00e+0010.646111
GO:0046469platelet activating factor metabolic process6.24e-041.00e+0010.646111
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest6.84e-041.00e+005.64621964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle7.05e-041.00e+005.62422265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle8.18e-041.00e+005.51722270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent8.65e-041.00e+005.47622072
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle9.13e-041.00e+005.43722274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I9.38e-041.00e+005.41722075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.04e-031.00e+005.34222379
GO:0051081nuclear envelope disassembly1.25e-031.00e+009.646122
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.25e-031.00e+009.646112
GO:0005055laminin receptor activity1.25e-031.00e+009.646112
GO:0006407rRNA export from nucleus1.25e-031.00e+009.646112
GO:0021540corpus callosum morphogenesis1.25e-031.00e+009.646112
GO:0036035osteoclast development1.25e-031.00e+009.646122
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.41e-031.00e+005.12322192
GO:00038471-alkyl-2-acetylglycerophosphocholine esterase activity1.87e-031.00e+009.061113
GO:0045505dynein intermediate chain binding1.87e-031.00e+009.061113
GO:0000209protein polyubiquitination2.23e-031.00e+004.788220116
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.49e-031.00e+008.646114
GO:003068690S preribosome2.49e-031.00e+008.646114
GO:0031467Cul7-RING ubiquitin ligase complex2.49e-031.00e+008.646114
GO:0019788NEDD8 ligase activity2.49e-031.00e+008.646114
GO:0031465Cul4B-RING E3 ubiquitin ligase complex3.12e-031.00e+008.324135
GO:0031461cullin-RING ubiquitin ligase complex3.12e-031.00e+008.324115
GO:0043248proteasome assembly3.12e-031.00e+008.324115
GO:0030891VCB complex3.12e-031.00e+008.324125
GO:0033600negative regulation of mammary gland epithelial cell proliferation3.12e-031.00e+008.324115
GO:0000730DNA recombinase assembly3.12e-031.00e+008.324115
GO:2000001regulation of DNA damage checkpoint3.12e-031.00e+008.324115
GO:0031023microtubule organizing center organization3.12e-031.00e+008.324115
GO:0042981regulation of apoptotic process3.69e-031.00e+004.417224150
GO:0008090retrograde axon cargo transport3.74e-031.00e+008.061126
GO:0007097nuclear migration3.74e-031.00e+008.061116
GO:0030957Tat protein binding3.74e-031.00e+008.061136
GO:0034452dynactin binding3.74e-031.00e+008.061116
GO:0060744mammary gland branching involved in thelarche3.74e-031.00e+008.061116
GO:0001667ameboidal-type cell migration3.74e-031.00e+008.061116
GO:0060762regulation of branching involved in mammary gland duct morphogenesis3.74e-031.00e+008.061116
GO:0031466Cul5-RING ubiquitin ligase complex3.74e-031.00e+008.061116
GO:0001961positive regulation of cytokine-mediated signaling pathway4.36e-031.00e+007.839117
GO:0000028ribosomal small subunit assembly4.36e-031.00e+007.839117
GO:0017145stem cell division4.36e-031.00e+007.839117
GO:0031462Cul2-RING ubiquitin ligase complex4.36e-031.00e+007.839127
GO:0030424axon4.50e-031.00e+004.27124166
GO:0034641cellular nitrogen compound metabolic process4.76e-031.00e+004.228220171
GO:0031512motile primary cilium4.98e-031.00e+007.646118
GO:0019773proteasome core complex, alpha-subunit complex4.98e-031.00e+007.646148
GO:0031464Cul4A-RING E3 ubiquitin ligase complex4.98e-031.00e+007.646128
GO:0070688MLL5-L complex4.98e-031.00e+007.646118
GO:0045116protein neddylation4.98e-031.00e+007.646128
GO:0031625ubiquitin protein ligase binding5.15e-031.00e+004.170214178
GO:0005515protein binding5.23e-031.00e+001.09081846024
GO:0032319regulation of Rho GTPase activity5.60e-031.00e+007.476129
GO:0021895cerebral cortex neuron differentiation5.60e-031.00e+007.476119
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway6.22e-031.00e+007.3241110
GO:0010569regulation of double-strand break repair via homologous recombination6.22e-031.00e+007.3241110
GO:0001675acrosome assembly6.22e-031.00e+007.3241110
GO:0010467gene expression6.76e-031.00e+002.845359669
GO:0045502dynein binding6.85e-031.00e+007.1871211
GO:0031571mitotic G1 DNA damage checkpoint6.85e-031.00e+007.1871411
GO:0021819layer formation in cerebral cortex6.85e-031.00e+007.1871111
GO:0016239positive regulation of macroautophagy7.47e-031.00e+007.0611112
GO:0005838proteasome regulatory particle7.47e-031.00e+007.0611712
GO:0047496vesicle transport along microtubule7.47e-031.00e+007.0611212
GO:0005662DNA replication factor A complex8.09e-031.00e+006.9461113
GO:0035267NuA4 histone acetyltransferase complex8.70e-031.00e+006.8391414
GO:0019226transmission of nerve impulse8.70e-031.00e+006.8391114
GO:0048854brain morphogenesis9.32e-031.00e+006.7391115
GO:0060749mammary gland alveolus development9.32e-031.00e+006.7391215
GO:0050998nitric-oxide synthase binding9.94e-031.00e+006.6461116
GO:0007405neuroblast proliferation9.94e-031.00e+006.6461116
GO:0043274phospholipase binding9.94e-031.00e+006.6461116
GO:0000132establishment of mitotic spindle orientation9.94e-031.00e+006.6461116
GO:0022624proteasome accessory complex1.06e-021.00e+006.5591817
GO:0006281DNA repair1.08e-021.00e+003.618218261
GO:0045773positive regulation of axon extension1.12e-021.00e+006.4761418
GO:0035861site of double-strand break1.12e-021.00e+006.4761118
GO:0005839proteasome core complex1.12e-021.00e+006.4761818
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.18e-021.00e+006.3981119
GO:0048863stem cell differentiation1.18e-021.00e+006.3981119
GO:0004298threonine-type endopeptidase activity1.18e-021.00e+006.3981819
GO:0009306protein secretion1.24e-021.00e+006.3241120
GO:0006298mismatch repair1.24e-021.00e+006.3241320
GO:0032201telomere maintenance via semi-conservative replication1.30e-021.00e+006.2541521
GO:0000718nucleotide-excision repair, DNA damage removal1.30e-021.00e+006.2541421
GO:0006297nucleotide-excision repair, DNA gap filling1.36e-021.00e+006.1871322
GO:0030863cortical cytoskeleton1.36e-021.00e+006.1871122
GO:0036464cytoplasmic ribonucleoprotein granule1.36e-021.00e+006.1871422
GO:0043234protein complex1.37e-021.00e+003.442218295
GO:0046329negative regulation of JNK cascade1.43e-021.00e+006.1231123
GO:0043044ATP-dependent chromatin remodeling1.43e-021.00e+006.1231423
GO:0005844polysome1.43e-021.00e+006.1231423
GO:0031463Cul3-RING ubiquitin ligase complex1.43e-021.00e+006.1231323
GO:0043236laminin binding1.43e-021.00e+006.1231123
GO:0006513protein monoubiquitination1.43e-021.00e+006.1231123
GO:0000722telomere maintenance via recombination1.55e-021.00e+006.0021525
GO:0045931positive regulation of mitotic cell cycle1.61e-021.00e+005.9461126
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.61e-021.00e+005.9461326
GO:0005813centrosome1.65e-021.00e+003.297214326
GO:0030331estrogen receptor binding1.67e-021.00e+005.8911227
GO:0007017microtubule-based process1.67e-021.00e+005.8911327
GO:0043022ribosome binding1.67e-021.00e+005.8911327
GO:0031492nucleosomal DNA binding1.67e-021.00e+005.8911427
GO:0031252cell leading edge1.73e-021.00e+005.8391428
GO:0010977negative regulation of neuron projection development1.73e-021.00e+005.8391228
GO:0005875microtubule associated complex1.73e-021.00e+005.8391228
GO:0019894kinesin binding1.73e-021.00e+005.8391128
GO:0019005SCF ubiquitin ligase complex1.80e-021.00e+005.7881129
GO:0006271DNA strand elongation involved in DNA replication1.86e-021.00e+005.7391730
GO:0051219phosphoprotein binding1.98e-021.00e+005.6461232
GO:0001895retina homeostasis2.10e-021.00e+005.5591134
GO:0007611learning or memory2.10e-021.00e+005.5591234
GO:0034332adherens junction organization2.22e-021.00e+005.4761136
GO:0051084'de novo' posttranslational protein folding2.29e-021.00e+005.4371437
GO:0006284base-excision repair2.29e-021.00e+005.4371337
GO:0021766hippocampus development2.35e-021.00e+005.3981438
GO:0070527platelet aggregation2.35e-021.00e+005.3981238
GO:0022627cytosolic small ribosomal subunit2.41e-021.00e+005.3611439
GO:0000781chromosome, telomeric region2.41e-021.00e+005.3611339
GO:0050885neuromuscular process controlling balance2.47e-021.00e+005.3241140
GO:0021987cerebral cortex development2.59e-021.00e+005.2541342
GO:0021762substantia nigra development2.71e-021.00e+005.1871244
GO:0008344adult locomotory behavior2.71e-021.00e+005.1871144
GO:0043066negative regulation of apoptotic process2.71e-021.00e+002.918231424
GO:0005871kinesin complex2.71e-021.00e+005.1871344
GO:0006283transcription-coupled nucleotide-excision repair2.83e-021.00e+005.1231746
GO:0003684damaged DNA binding3.02e-021.00e+005.0311749
GO:0000226microtubule cytoskeleton organization3.20e-021.00e+004.9461352
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3.26e-021.00e+004.9181553
GO:0045216cell-cell junction organization3.32e-021.00e+004.8911254
GO:0044267cellular protein metabolic process3.33e-021.00e+002.757229474
GO:0000724double-strand break repair via homologous recombination3.38e-021.00e+004.8651355
GO:0000723telomere maintenance3.44e-021.00e+004.8391656
GO:0019903protein phosphatase binding3.80e-021.00e+004.6921462
GO:0006302double-strand break repair3.80e-021.00e+004.6921462
GO:0000776kinetochore3.86e-021.00e+004.6691463
GO:0006289nucleotide-excision repair4.17e-021.00e+004.55911168
GO:0034329cell junction assembly4.17e-021.00e+004.5591168
GO:0003697single-stranded DNA binding4.17e-021.00e+004.5591568
GO:0006915apoptotic process4.45e-021.00e+002.530233555
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis4.53e-021.00e+004.4371674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process4.59e-021.00e+004.4171275
GO:0019083viral transcription4.94e-021.00e+004.30611081
GO:0042803protein homodimerization activity5.05e-021.00e+002.429212595
GO:0047485protein N-terminus binding5.24e-021.00e+004.2201586
GO:0006415translational termination5.30e-021.00e+004.20311087
GO:0016605PML body5.36e-021.00e+004.1871388
GO:0006629lipid metabolic process5.48e-021.00e+004.1541590
GO:0016363nuclear matrix5.54e-021.00e+004.13811291
GO:0006928cellular component movement5.54e-021.00e+004.1381791
GO:0005200structural constituent of cytoskeleton5.54e-021.00e+004.1381891
GO:0071456cellular response to hypoxia5.60e-021.00e+004.1231692
GO:0006414translational elongation5.66e-021.00e+004.10711393
GO:0001764neuron migration5.66e-021.00e+004.1071393
GO:0030426growth cone5.83e-021.00e+004.0611596
GO:0006614SRP-dependent cotranslational protein targeting to membrane6.31e-021.00e+003.946110104
GO:0005938cell cortex6.31e-021.00e+003.94613104
GO:0014069postsynaptic density6.37e-021.00e+003.93213105
GO:0072562blood microparticle6.72e-021.00e+003.85213111
GO:0030529ribonucleoprotein complex6.78e-021.00e+003.83918112
GO:0005635nuclear envelope6.84e-021.00e+003.82616113
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay6.89e-021.00e+003.813111114
GO:0019058viral life cycle6.95e-021.00e+003.801113115
GO:0006325chromatin organization7.13e-021.00e+003.76415118
GO:0007219Notch signaling pathway7.25e-021.00e+003.73915120
GO:0005730nucleolus7.30e-021.00e+001.5513691641
GO:0006260DNA replication7.30e-021.00e+003.72719121
GO:0008201heparin binding7.36e-021.00e+003.71514122
GO:0030036actin cytoskeleton organization7.42e-021.00e+003.70415123
GO:0006511ubiquitin-dependent protein catabolic process7.60e-021.00e+003.66915126
GO:0016020membrane7.75e-021.00e+001.5163901681
GO:0000790nuclear chromatin7.77e-021.00e+003.63519129
GO:0006413translational initiation7.89e-021.00e+003.613117131
GO:0000086G2/M transition of mitotic cell cycle8.18e-021.00e+003.55919136
GO:0003735structural constituent of ribosome8.23e-021.00e+003.548110137
GO:0006457protein folding8.58e-021.00e+003.48617143
GO:0061024membrane organization8.69e-021.00e+003.46617145
GO:0008017microtubule binding8.81e-021.00e+003.44616147
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding9.84e-021.00e+003.28017165
GO:0007420brain development9.95e-021.00e+003.26212167
GO:0031965nuclear membrane1.00e-011.00e+003.25413168
GO:0032403protein complex binding1.09e-011.00e+003.130110183
GO:0005634nucleus1.20e-011.00e+000.81451364559
GO:0007067mitotic nuclear division1.33e-011.00e+002.820114227
GO:0006412translation1.35e-011.00e+002.801120230
GO:0043025neuronal cell body1.43e-011.00e+002.71019245
GO:0004842ubiquitin-protein transferase activity1.48e-011.00e+002.65216255
GO:0007283spermatogenesis1.52e-011.00e+002.61318262
GO:0005743mitochondrial inner membrane1.60e-011.00e+002.53218277
GO:0019899enzyme binding1.60e-011.00e+002.532112277
GO:0005856cytoskeleton1.68e-011.00e+002.461112291
GO:0016567protein ubiquitination1.70e-011.00e+002.44215295
GO:0044281small molecule metabolic process1.71e-011.00e+001.4042581211
GO:0019901protein kinase binding1.81e-011.00e+002.338121317
GO:0007411axon guidance1.82e-011.00e+002.329113319
GO:0007268synaptic transmission1.89e-011.00e+002.27116332
GO:0003723RNA binding1.94e-011.00e+002.228120342
GO:0005925focal adhesion2.07e-011.00e+002.130119366
GO:0007155cell adhesion2.08e-011.00e+002.11916369
GO:0046982protein heterodimerization activity2.14e-011.00e+002.076113380
GO:0045892negative regulation of transcription, DNA-templated2.30e-011.00e+001.956115413
GO:0007596blood coagulation2.51e-011.00e+001.816118455
GO:0048471perinuclear region of cytoplasm2.73e-011.00e+001.675113502
GO:0045087innate immune response3.16e-011.00e+001.427124596
GO:0005737cytoplasm4.31e-011.00e+000.35231103767
GO:0005615extracellular space4.61e-011.00e+000.744117957
GO:0008270zinc ion binding4.75e-011.00e+000.685112997
GO:0005739mitochondrion4.76e-011.00e+000.683128998
GO:0044822poly(A) RNA binding4.96e-011.00e+000.6021491056
GO:0005886plasma membrane4.98e-011.00e+000.3122452582
GO:0005524ATP binding5.72e-011.00e+000.3041601298
GO:0006351transcription, DNA-templated6.14e-011.00e+000.1481311446