int-snw-5048

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 1.076 1.87e-21 7.59e-05 2.74e-03
wolf-screen-ratio-mammosphere-adherent-int-snw-5048 subnetwork

Genes (7)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
RBX1 9978 971.1851.151139Yes-
[ PAFAH1B1 ] 5048 60.6911.07671Yes-
PHB2 11331 90.8291.076140Yes-
RPSA 3921 1561.3271.151152Yes-

Interactions (9)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RPSA 3921 PHB2 11331 pp -- int.I2D: IntAct_Yeast
ACTB 60 PHB2 11331 pp -- int.I2D: IntAct_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ACTB 60 PAFAH1B1 5048 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PAFAH1B1 5048 PHB2 11331 pp -- int.I2D: BioGrid_Yeast

Related GO terms (214)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0000235astral microtubule4.85e-041.00e+0011.009111
GO:0051660establishment of centrosome localization4.85e-041.00e+0011.009111
GO:0046469platelet activating factor metabolic process4.85e-041.00e+0011.009111
GO:0000278mitotic cell cycle6.38e-041.00e+003.983348391
GO:0005654nucleoplasm9.17e-041.00e+002.9294761082
GO:0051081nuclear envelope disassembly9.70e-041.00e+0010.009122
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)9.70e-041.00e+0010.009112
GO:0005055laminin receptor activity9.70e-041.00e+0010.009112
GO:0006407rRNA export from nucleus9.70e-041.00e+0010.009112
GO:0021540corpus callosum morphogenesis9.70e-041.00e+0010.009112
GO:0036035osteoclast development9.70e-041.00e+0010.009122
GO:0045505dynein intermediate chain binding1.46e-031.00e+009.424113
GO:0016032viral process1.58e-031.00e+003.533355534
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.94e-031.00e+009.009114
GO:003068690S preribosome1.94e-031.00e+009.009114
GO:0031467Cul7-RING ubiquitin ligase complex1.94e-031.00e+009.009114
GO:0019788NEDD8 ligase activity1.94e-031.00e+009.009114
GO:0070062extracellular vesicular exosome1.98e-031.00e+002.10251042400
GO:0000082G1/S transition of mitotic cell cycle2.15e-031.00e+004.790232149
GO:0005515protein binding2.21e-031.00e+001.26071846024
GO:0005829cytosol2.38e-031.00e+002.04551322496
GO:0031465Cul4B-RING E3 ubiquitin ligase complex2.42e-031.00e+008.687135
GO:0031461cullin-RING ubiquitin ligase complex2.42e-031.00e+008.687115
GO:0043248proteasome assembly2.42e-031.00e+008.687115
GO:0030891VCB complex2.42e-031.00e+008.687125
GO:0033600negative regulation of mammary gland epithelial cell proliferation2.42e-031.00e+008.687115
GO:0000730DNA recombinase assembly2.42e-031.00e+008.687115
GO:2000001regulation of DNA damage checkpoint2.42e-031.00e+008.687115
GO:0031023microtubule organizing center organization2.42e-031.00e+008.687115
GO:0030424axon2.66e-031.00e+004.63424166
GO:0008090retrograde axon cargo transport2.91e-031.00e+008.424126
GO:0007097nuclear migration2.91e-031.00e+008.424116
GO:0030957Tat protein binding2.91e-031.00e+008.424136
GO:0034452dynactin binding2.91e-031.00e+008.424116
GO:0060744mammary gland branching involved in thelarche2.91e-031.00e+008.424116
GO:0001667ameboidal-type cell migration2.91e-031.00e+008.424116
GO:0060762regulation of branching involved in mammary gland duct morphogenesis2.91e-031.00e+008.424116
GO:0031466Cul5-RING ubiquitin ligase complex2.91e-031.00e+008.424116
GO:0031625ubiquitin protein ligase binding3.05e-031.00e+004.533214178
GO:0001961positive regulation of cytokine-mediated signaling pathway3.39e-031.00e+008.201117
GO:0000028ribosomal small subunit assembly3.39e-031.00e+008.201117
GO:0017145stem cell division3.39e-031.00e+008.201117
GO:0031462Cul2-RING ubiquitin ligase complex3.39e-031.00e+008.201127
GO:0031512motile primary cilium3.88e-031.00e+008.009118
GO:0031464Cul4A-RING E3 ubiquitin ligase complex3.88e-031.00e+008.009128
GO:0070688MLL5-L complex3.88e-031.00e+008.009118
GO:0045116protein neddylation3.88e-031.00e+008.009128
GO:0032319regulation of Rho GTPase activity4.36e-031.00e+007.839129
GO:0021895cerebral cortex neuron differentiation4.36e-031.00e+007.839119
GO:0016071mRNA metabolic process4.75e-031.00e+004.208231223
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway4.84e-031.00e+007.6871110
GO:0010569regulation of double-strand break repair via homologous recombination4.84e-031.00e+007.6871110
GO:0001675acrosome assembly4.84e-031.00e+007.6871110
GO:0045502dynein binding5.33e-031.00e+007.5491211
GO:0031571mitotic G1 DNA damage checkpoint5.33e-031.00e+007.5491411
GO:0021819layer formation in cerebral cortex5.33e-031.00e+007.5491111
GO:0016070RNA metabolic process5.80e-031.00e+004.060232247
GO:0005838proteasome regulatory particle5.81e-031.00e+007.4241712
GO:0047496vesicle transport along microtubule5.81e-031.00e+007.4241212
GO:0005662DNA replication factor A complex6.29e-031.00e+007.3081113
GO:0006281DNA repair6.45e-031.00e+003.981218261
GO:0035267NuA4 histone acetyltransferase complex6.78e-031.00e+007.2011414
GO:0019226transmission of nerve impulse6.78e-031.00e+007.2011114
GO:0048854brain morphogenesis7.26e-031.00e+007.1021115
GO:0060749mammary gland alveolus development7.26e-031.00e+007.1021215
GO:0050998nitric-oxide synthase binding7.74e-031.00e+007.0091116
GO:0007405neuroblast proliferation7.74e-031.00e+007.0091116
GO:0043274phospholipase binding7.74e-031.00e+007.0091116
GO:0000132establishment of mitotic spindle orientation7.74e-031.00e+007.0091116
GO:0043234protein complex8.18e-031.00e+003.804218295
GO:0022624proteasome accessory complex8.22e-031.00e+006.9211817
GO:0045773positive regulation of axon extension8.71e-031.00e+006.8391418
GO:0035861site of double-strand break8.71e-031.00e+006.8391118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process9.19e-031.00e+006.7611119
GO:0048863stem cell differentiation9.19e-031.00e+006.7611119
GO:0009306protein secretion9.67e-031.00e+006.6871120
GO:0006298mismatch repair9.67e-031.00e+006.6871320
GO:0032201telomere maintenance via semi-conservative replication1.01e-021.00e+006.6161521
GO:0000718nucleotide-excision repair, DNA damage removal1.01e-021.00e+006.6161421
GO:0006297nucleotide-excision repair, DNA gap filling1.06e-021.00e+006.5491322
GO:0030863cortical cytoskeleton1.06e-021.00e+006.5491122
GO:0036464cytoplasmic ribonucleoprotein granule1.06e-021.00e+006.5491422
GO:0046329negative regulation of JNK cascade1.11e-021.00e+006.4851123
GO:0043044ATP-dependent chromatin remodeling1.11e-021.00e+006.4851423
GO:0031463Cul3-RING ubiquitin ligase complex1.11e-021.00e+006.4851323
GO:0043236laminin binding1.11e-021.00e+006.4851123
GO:0006513protein monoubiquitination1.11e-021.00e+006.4851123
GO:0000722telomere maintenance via recombination1.21e-021.00e+006.3651525
GO:0045931positive regulation of mitotic cell cycle1.26e-021.00e+006.3081126
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.26e-021.00e+006.3081326
GO:0030331estrogen receptor binding1.30e-021.00e+006.2541227
GO:0007017microtubule-based process1.30e-021.00e+006.2541327
GO:0043022ribosome binding1.30e-021.00e+006.2541327
GO:0031492nucleosomal DNA binding1.30e-021.00e+006.2541427
GO:0031252cell leading edge1.35e-021.00e+006.2011428
GO:0010977negative regulation of neuron projection development1.35e-021.00e+006.2011228
GO:0005875microtubule associated complex1.35e-021.00e+006.2011228
GO:0019894kinesin binding1.35e-021.00e+006.2011128
GO:0019005SCF ubiquitin ligase complex1.40e-021.00e+006.1511129
GO:0006271DNA strand elongation involved in DNA replication1.45e-021.00e+006.1021730
GO:0051219phosphoprotein binding1.54e-021.00e+006.0091232
GO:0001895retina homeostasis1.64e-021.00e+005.9211134
GO:0007611learning or memory1.64e-021.00e+005.9211234
GO:0034332adherens junction organization1.73e-021.00e+005.8391136
GO:0051084'de novo' posttranslational protein folding1.78e-021.00e+005.7991437
GO:0006284base-excision repair1.78e-021.00e+005.7991337
GO:0021766hippocampus development1.83e-021.00e+005.7611438
GO:0070527platelet aggregation1.83e-021.00e+005.7611238
GO:0022627cytosolic small ribosomal subunit1.88e-021.00e+005.7231439
GO:0000781chromosome, telomeric region1.88e-021.00e+005.7231339
GO:0050885neuromuscular process controlling balance1.93e-021.00e+005.6871140
GO:0021987cerebral cortex development2.02e-021.00e+005.6161342
GO:0044267cellular protein metabolic process2.03e-021.00e+003.120229474
GO:0021762substantia nigra development2.12e-021.00e+005.5491244
GO:0008344adult locomotory behavior2.12e-021.00e+005.5491144
GO:0005871kinesin complex2.12e-021.00e+005.5491344
GO:0006283transcription-coupled nucleotide-excision repair2.21e-021.00e+005.4851746
GO:0016042lipid catabolic process2.31e-021.00e+005.4241248
GO:0003684damaged DNA binding2.35e-021.00e+005.3941749
GO:0006521regulation of cellular amino acid metabolic process2.40e-021.00e+005.36511750
GO:0000226microtubule cytoskeleton organization2.50e-021.00e+005.3081352
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding2.54e-021.00e+005.2811553
GO:0045216cell-cell junction organization2.59e-021.00e+005.2541254
GO:0000724double-strand break repair via homologous recombination2.64e-021.00e+005.2271355
GO:0000723telomere maintenance2.69e-021.00e+005.2011656
GO:0000502proteasome complex2.78e-021.00e+005.15111758
GO:0019903protein phosphatase binding2.97e-021.00e+005.0551462
GO:0006302double-strand break repair2.97e-021.00e+005.0551462
GO:0000776kinetochore3.02e-021.00e+005.0311463
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest3.07e-021.00e+005.00911964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.11e-021.00e+004.98612265
GO:0006289nucleotide-excision repair3.25e-021.00e+004.92111168
GO:0034329cell junction assembly3.25e-021.00e+004.9211168
GO:0003697single-stranded DNA binding3.25e-021.00e+004.9211568
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.35e-021.00e+004.87912270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent3.44e-021.00e+004.83912072
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis3.54e-021.00e+004.7991674
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.54e-021.00e+004.79912274
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process3.58e-021.00e+004.7801275
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I3.58e-021.00e+004.78012075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process3.77e-021.00e+004.70512379
GO:0016020membrane3.85e-021.00e+001.8793901681
GO:0010467gene expression3.86e-021.00e+002.623259669
GO:0019083viral transcription3.87e-021.00e+004.66911081
GO:0047485protein N-terminus binding4.10e-021.00e+004.5821586
GO:0006415translational termination4.15e-021.00e+004.56611087
GO:0016605PML body4.19e-021.00e+004.5491388
GO:0016363nuclear matrix4.33e-021.00e+004.50111291
GO:0006928cellular component movement4.33e-021.00e+004.5011791
GO:0005200structural constituent of cytoskeleton4.33e-021.00e+004.5011891
GO:0071456cellular response to hypoxia4.38e-021.00e+004.4851692
GO:0002474antigen processing and presentation of peptide antigen via MHC class I4.38e-021.00e+004.48512192
GO:0006414translational elongation4.43e-021.00e+004.47011393
GO:0001764neuron migration4.43e-021.00e+004.4701393
GO:0030426growth cone4.57e-021.00e+004.4241596
GO:0006614SRP-dependent cotranslational protein targeting to membrane4.94e-021.00e+004.308110104
GO:0005938cell cortex4.94e-021.00e+004.30813104
GO:0014069postsynaptic density4.99e-021.00e+004.29413105
GO:0072562blood microparticle5.27e-021.00e+004.21413111
GO:0030529ribonucleoprotein complex5.31e-021.00e+004.20118112
GO:0005635nuclear envelope5.36e-021.00e+004.18916113
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay5.40e-021.00e+004.176111114
GO:0019058viral life cycle5.45e-021.00e+004.163113115
GO:0000209protein polyubiquitination5.50e-021.00e+004.151120116
GO:0006325chromatin organization5.59e-021.00e+004.12615118
GO:0007219Notch signaling pathway5.68e-021.00e+004.10215120
GO:0006260DNA replication5.73e-021.00e+004.09019121
GO:0008201heparin binding5.77e-021.00e+004.07814122
GO:0030036actin cytoskeleton organization5.82e-021.00e+004.06615123
GO:0006511ubiquitin-dependent protein catabolic process5.96e-021.00e+004.03115126
GO:0000790nuclear chromatin6.10e-021.00e+003.99819129
GO:0006413translational initiation6.19e-021.00e+003.975117131
GO:0000086G2/M transition of mitotic cell cycle6.42e-021.00e+003.92119136
GO:0003735structural constituent of ribosome6.46e-021.00e+003.911110137
GO:0006457protein folding6.74e-021.00e+003.84917143
GO:0061024membrane organization6.83e-021.00e+003.82917145
GO:0008017microtubule binding6.92e-021.00e+003.80916147
GO:0042981regulation of apoptotic process7.06e-021.00e+003.780124150
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding7.74e-021.00e+003.64217165
GO:0031965nuclear membrane7.88e-021.00e+003.61613168
GO:0034641cellular nitrogen compound metabolic process8.01e-021.00e+003.591120171
GO:0032403protein complex binding8.55e-021.00e+003.493110183
GO:0007067mitotic nuclear division1.05e-011.00e+003.182114227
GO:0006412translation1.06e-011.00e+003.163120230
GO:0043025neuronal cell body1.13e-011.00e+003.07219245
GO:0004842ubiquitin-protein transferase activity1.17e-011.00e+003.01416255
GO:0005743mitochondrial inner membrane1.27e-011.00e+002.89518277
GO:0019899enzyme binding1.27e-011.00e+002.895112277
GO:0005856cytoskeleton1.33e-011.00e+002.824112291
GO:0016567protein ubiquitination1.35e-011.00e+002.80415295
GO:0019901protein kinase binding1.44e-011.00e+002.700121317
GO:0007411axon guidance1.45e-011.00e+002.691113319
GO:0005634nucleus1.48e-011.00e+000.85441364559
GO:0005813centrosome1.48e-011.00e+002.660114326
GO:0007268synaptic transmission1.50e-011.00e+002.63416332
GO:0005925focal adhesion1.65e-011.00e+002.493119366
GO:0007155cell adhesion1.66e-011.00e+002.48116369
GO:0045892negative regulation of transcription, DNA-templated1.84e-011.00e+002.319115413
GO:0043066negative regulation of apoptotic process1.89e-011.00e+002.281131424
GO:0007596blood coagulation2.01e-011.00e+002.179118455
GO:0048471perinuclear region of cytoplasm2.20e-011.00e+002.037113502
GO:0006915apoptotic process2.40e-011.00e+001.892133555
GO:0042803protein homodimerization activity2.55e-011.00e+001.792112595
GO:0045087innate immune response2.56e-011.00e+001.790124596
GO:0005615extracellular space3.82e-011.00e+001.106117957
GO:0008270zinc ion binding3.94e-011.00e+001.047112997
GO:0005739mitochondrion3.95e-011.00e+001.046128998
GO:0044822poly(A) RNA binding4.13e-011.00e+000.9641491056
GO:0044281small molecule metabolic process4.59e-011.00e+000.7671581211
GO:0005524ATP binding4.83e-011.00e+000.6671601298
GO:0006351transcription, DNA-templated5.23e-011.00e+000.5111311446
GO:0005730nucleolus5.71e-011.00e+000.3281691641
GO:0005737cytoplasm5.83e-011.00e+000.13021103767
GO:0005886plasma membrane7.49e-011.00e+00-0.3261452582