int-snw-4175

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.962 1.47e-16 1.37e-03 2.60e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-4175 subnetwork

Genes (14)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
PES1 23481 20.5130.976163Yes-
RSL24D1 51187 361.3001.02059Yes-
PSMA3 5684 120.5331.026218Yes-
[ MCM6 ] 4175 1-0.0890.96286--
PSMD13 5719 160.8481.029104Yes-
MCM5 4174 40.5780.992121Yes-
HNRNPC 3183 201.8121.026119Yes-
PSMB7 5695 480.9821.05257Yes-
PSMA1 5682 610.9961.052123Yes-
ACTB 60 1671.1531.151587Yes-
ATP6V1B2 526 440.8811.076278--
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-

Interactions (27)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PGD 5226 PES1 23481 pp -- int.I2D: YeastLow
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ATP6V1B2 526 MCM6 4175 pp -- int.I2D: IntAct_Yeast
MCM5 4174 PSMD13 5719 pp -- int.I2D: YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PSMA1 5682 PSMA3 5684 pp -- int.Intact: MI:0914(association), MI:0915(physical association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, CE_DATA, HPRD, IntAct, IntAct_Fly, IntAct_Mouse, IntAct_Worm, IntAct_Yeast, MINT_Worm, BioGrid, BioGrid_Fly, BIND_Fly, BIND_Yeast, FlyHigh, Krogan_Core, MINT_Fly, MINT_Yeast, YeastHigh, Yu_GoldStd;
int.HPRD: in vitro
ACTB 60 MCM5 4174 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMD13 5719 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: IntAct, YeastMedium, BioGrid, BioGrid_Yeast, IntAct_Yeast
MCM6 4175 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
HNRNPC 3183 PSMA3 5684 pp -- int.I2D: BioGrid
MCM6 4175 PSMA3 5684 pp -- int.I2D: BioGrid
PSMA3 5684 PSMD13 5719 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: IntAct, BioGrid
ATP6V1B2 526 RPSA 3921 pp -- int.I2D: IntAct_Yeast
ACTB 60 ATP6V1B2 526 pp -- int.I2D: BioGrid_Yeast
MCM5 4174 RPA2 6118 pp -- int.I2D: BioGrid, HPRD;
int.HPRD: yeast 2-hybrid
MCM6 4175 PSMA1 5682 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, BioGrid, HPRD, MINT, VidalHuman_core;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
MCM6 4175 PSMD13 5719 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastLow
PES1 23481 RSL24D1 51187 pp -- int.I2D: BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MIPS, YeastLow
ATP6V1B2 526 MCM5 4174 pp -- int.I2D: IntAct_Yeast
ACTB 60 PSMD13 5719 pp -- int.I2D: BioGrid_Yeast
MCM6 4175 PES1 23481 pp -- int.I2D: BioGrid_Yeast
PSMA3 5684 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast, IntAct_Mouse, MINT_Yeast, YeastLow, Krogan_Core
MCM5 4174 MCM6 4175 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, BioGrid_Yeast, IntAct_Fly, IntAct_Yeast, INTEROLOG, IntAct, MINT_Yeast, YeastLow
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMA3 5684 pp -- int.I2D: BioGrid, BioGrid_Yeast

Related GO terms (186)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0000082G1/S transition of mitotic cell cycle3.52e-115.08e-075.597732149
GO:0005654nucleoplasm4.11e-095.93e-053.25110761082
GO:0000278mitotic cell cycle2.97e-084.29e-044.205748391
GO:0006521regulation of cellular amino acid metabolic process1.25e-071.80e-036.36541750
GO:0000502proteasome complex2.29e-073.30e-036.15141758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest3.41e-074.92e-036.00941964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.63e-075.24e-035.98642265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.91e-077.08e-035.87942270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent5.50e-077.94e-035.83942072
GO:0005839proteasome core complex5.89e-078.50e-037.4243818
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.15e-078.87e-035.79942274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I6.49e-079.36e-035.78042075
GO:0004298threonine-type endopeptidase activity6.99e-071.01e-027.3463819
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process8.00e-071.15e-025.70542379
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.48e-062.13e-025.48542192
GO:0016071mRNA metabolic process1.51e-062.18e-024.530531223
GO:0016070RNA metabolic process2.50e-063.60e-024.382532247
GO:0006271DNA strand elongation involved in DNA replication2.91e-064.20e-026.6873730
GO:0000209protein polyubiquitination3.74e-065.39e-025.151420116
GO:0042981regulation of apoptotic process1.04e-051.50e-014.780424150
GO:0034641cellular nitrogen compound metabolic process1.74e-052.51e-014.591420171
GO:0010467gene expression2.12e-053.06e-013.208659669
GO:0019773proteasome core complex, alpha-subunit complex2.44e-053.52e-018.009248
GO:0042555MCM complex3.14e-054.53e-017.839229
GO:0005730nucleolus4.40e-056.35e-012.3288691641
GO:0070062extracellular vesicular exosome8.64e-051.00e+001.95091042400
GO:0016032viral process1.04e-041.00e+003.270555534
GO:0005829cytosol1.19e-041.00e+001.89391322496
GO:0006260DNA replication1.96e-041.00e+004.67539121
GO:0006270DNA replication initiation2.00e-041.00e+006.5492622
GO:0043044ATP-dependent chromatin remodeling2.19e-041.00e+006.4852423
GO:0031492nucleosomal DNA binding3.03e-041.00e+006.2542427
GO:0043066negative regulation of apoptotic process5.83e-041.00e+003.281431424
GO:0019521D-gluconate metabolic process9.71e-041.00e+0010.009111
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1.17e-031.00e+005.2812553
GO:0006915apoptotic process1.60e-031.00e+002.892433555
GO:0003697single-stranded DNA binding1.92e-031.00e+004.9212568
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.94e-031.00e+009.009112
GO:0019322pentose biosynthetic process1.94e-031.00e+009.009122
GO:0005055laminin receptor activity1.94e-031.00e+009.009112
GO:0006407rRNA export from nucleus1.94e-031.00e+009.009112
GO:0000466maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.94e-031.00e+009.009112
GO:0007127meiosis I1.94e-031.00e+009.009112
GO:0005634nucleus2.58e-031.00e+001.176101364559
GO:0070545PeBoW complex2.91e-031.00e+008.424113
GO:0009051pentose-phosphate shunt, oxidative branch2.91e-031.00e+008.424123
GO:0000463maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.91e-031.00e+008.424113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.91e-031.00e+008.424113
GO:0030687preribosome, large subunit precursor2.91e-031.00e+008.424113
GO:0016020membrane3.25e-031.00e+001.8796901681
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.88e-031.00e+008.009114
GO:003068690S preribosome3.88e-031.00e+008.009114
GO:0007000nucleolus organization3.88e-031.00e+008.009114
GO:0044281small molecule metabolic process4.35e-031.00e+002.0895581211
GO:0000730DNA recombinase assembly4.84e-031.00e+007.687115
GO:2000001regulation of DNA damage checkpoint4.84e-031.00e+007.687115
GO:0030957Tat protein binding5.81e-031.00e+007.424136
GO:0000790nuclear chromatin6.73e-031.00e+003.99829129
GO:0033180proton-transporting V-type ATPase, V1 domain6.78e-031.00e+007.201127
GO:0000028ribosomal small subunit assembly6.78e-031.00e+007.201117
GO:0070688MLL5-L complex7.74e-031.00e+007.009118
GO:0006098pentose-phosphate shunt9.67e-031.00e+006.6871410
GO:0006268DNA unwinding involved in DNA replication9.67e-031.00e+006.6871110
GO:0010569regulation of double-strand break repair via homologous recombination9.67e-031.00e+006.6871110
GO:0031571mitotic G1 DNA damage checkpoint1.06e-021.00e+006.5491411
GO:0045120pronucleus1.06e-021.00e+006.5491211
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.08e-021.00e+003.64227165
GO:00709353'-UTR-mediated mRNA stabilization1.16e-021.00e+006.4241212
GO:0005838proteasome regulatory particle1.16e-021.00e+006.4241712
GO:0042273ribosomal large subunit biogenesis1.26e-021.00e+006.3081413
GO:0005662DNA replication factor A complex1.26e-021.00e+006.3081113
GO:0008266poly(U) RNA binding1.26e-021.00e+006.3081113
GO:0035267NuA4 histone acetyltransferase complex1.35e-021.00e+006.2011414
GO:0046961proton-transporting ATPase activity, rotational mechanism1.45e-021.00e+006.1021315
GO:0046034ATP metabolic process1.45e-021.00e+006.1021115
GO:0050998nitric-oxide synthase binding1.54e-021.00e+006.0091116
GO:0033365protein localization to organelle1.54e-021.00e+006.0091116
GO:0003678DNA helicase activity1.64e-021.00e+005.9211317
GO:0022624proteasome accessory complex1.64e-021.00e+005.9211817
GO:0035861site of double-strand break1.73e-021.00e+005.8391118
GO:0015078hydrogen ion transmembrane transporter activity1.83e-021.00e+005.7611319
GO:0006298mismatch repair1.92e-021.00e+005.6871320
GO:0043021ribonucleoprotein complex binding2.02e-021.00e+005.6161121
GO:0000793condensed chromosome2.02e-021.00e+005.6161121
GO:0032201telomere maintenance via semi-conservative replication2.02e-021.00e+005.6161521
GO:0000718nucleotide-excision repair, DNA damage removal2.02e-021.00e+005.6161421
GO:0006297nucleotide-excision repair, DNA gap filling2.12e-021.00e+005.5491322
GO:0030863cortical cytoskeleton2.12e-021.00e+005.5491122
GO:0036464cytoplasmic ribonucleoprotein granule2.12e-021.00e+005.5491422
GO:0005844polysome2.21e-021.00e+005.4851423
GO:0043236laminin binding2.21e-021.00e+005.4851123
GO:0000722telomere maintenance via recombination2.40e-021.00e+005.3651525
GO:0005515protein binding2.44e-021.00e+000.774101846024
GO:0003730mRNA 3'-UTR binding2.50e-021.00e+005.3081226
GO:0015991ATP hydrolysis coupled proton transport2.50e-021.00e+005.3081426
GO:0004003ATP-dependent DNA helicase activity2.59e-021.00e+005.2541227
GO:0043022ribosome binding2.59e-021.00e+005.2541327
GO:0050661NADP binding2.59e-021.00e+005.2541227
GO:0019894kinesin binding2.69e-021.00e+005.2011128
GO:0015992proton transport2.78e-021.00e+005.1511329
GO:0042254ribosome biogenesis2.87e-021.00e+005.1021130
GO:0033572transferrin transport2.87e-021.00e+005.1021530
GO:0051701interaction with host3.06e-021.00e+005.0091432
GO:0005524ATP binding3.14e-021.00e+001.6674601298
GO:0043234protein complex3.23e-021.00e+002.804218295
GO:0001895retina homeostasis3.25e-021.00e+004.9211134
GO:0034332adherens junction organization3.44e-021.00e+004.8391136
GO:0090382phagosome maturation3.44e-021.00e+004.8391536
GO:0051084'de novo' posttranslational protein folding3.53e-021.00e+004.7991437
GO:0006284base-excision repair3.53e-021.00e+004.7991337
GO:0005902microvillus3.63e-021.00e+004.7611238
GO:0070527platelet aggregation3.63e-021.00e+004.7611238
GO:0022627cytosolic small ribosomal subunit3.72e-021.00e+004.7231439
GO:0000781chromosome, telomeric region3.72e-021.00e+004.7231339
GO:0032508DNA duplex unwinding3.91e-021.00e+004.6511341
GO:0021762substantia nigra development4.19e-021.00e+004.5491244
GO:0003723RNA binding4.23e-021.00e+002.591220342
GO:0006283transcription-coupled nucleotide-excision repair4.38e-021.00e+004.4851746
GO:0003684damaged DNA binding4.65e-021.00e+004.3941749
GO:0006879cellular iron ion homeostasis4.84e-021.00e+004.3361451
GO:0045216cell-cell junction organization5.12e-021.00e+004.2541254
GO:0000724double-strand break repair via homologous recombination5.21e-021.00e+004.2271355
GO:0000723telomere maintenance5.30e-021.00e+004.2011656
GO:0012505endomembrane system5.30e-021.00e+004.2011256
GO:0019903protein phosphatase binding5.86e-021.00e+004.0551462
GO:0006302double-strand break repair5.86e-021.00e+004.0551462
GO:0006289nucleotide-excision repair6.40e-021.00e+003.92111168
GO:0034329cell junction assembly6.40e-021.00e+003.9211168
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis6.95e-021.00e+003.7991674
GO:0071013catalytic step 2 spliceosome7.31e-021.00e+003.7231478
GO:0001726ruffle7.49e-021.00e+003.6871480
GO:0044267cellular protein metabolic process7.56e-021.00e+002.120229474
GO:0019083viral transcription7.59e-021.00e+003.66911081
GO:0044822poly(A) RNA binding7.77e-021.00e+001.5493491056
GO:0005681spliceosomal complex7.77e-021.00e+003.6341483
GO:0042802identical protein binding7.84e-021.00e+002.090220484
GO:0047485protein N-terminus binding8.04e-021.00e+003.5821586
GO:0006415translational termination8.13e-021.00e+003.56611087
GO:0016605PML body8.21e-021.00e+003.5491388
GO:0042470melanosome8.48e-021.00e+003.5011991
GO:0006928cellular component movement8.48e-021.00e+003.5011791
GO:0005200structural constituent of cytoskeleton8.48e-021.00e+003.5011891
GO:0001649osteoblast differentiation8.57e-021.00e+003.4851692
GO:0006414translational elongation8.66e-021.00e+003.47011393
GO:0006364rRNA processing8.75e-021.00e+003.4541694
GO:0051726regulation of cell cycle9.02e-021.00e+003.4091597
GO:0006614SRP-dependent cotranslational protein targeting to membrane9.64e-021.00e+003.308110104
GO:0014069postsynaptic density9.73e-021.00e+003.29413105
GO:0015630microtubule cytoskeleton1.02e-011.00e+003.22714110
GO:0030529ribonucleoprotein complex1.03e-011.00e+003.20118112
GO:0072562blood microparticle1.03e-011.00e+003.21413111
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.05e-011.00e+003.176111114
GO:0019058viral life cycle1.06e-011.00e+003.163113115
GO:0006325chromatin organization1.09e-011.00e+003.12615118
GO:0006413translational initiation1.20e-011.00e+002.975117131
GO:0003735structural constituent of ribosome1.25e-011.00e+002.911110137
GO:0008286insulin receptor signaling pathway1.29e-011.00e+002.85917142
GO:0006457protein folding1.30e-011.00e+002.84917143
GO:0061024membrane organization1.32e-011.00e+002.82917145
GO:0000398mRNA splicing, via spliceosome1.48e-011.00e+002.65118164
GO:0030424axon1.50e-011.00e+002.63414166
GO:0031625ubiquitin protein ligase binding1.60e-011.00e+002.533114178
GO:0005765lysosomal membrane1.80e-011.00e+002.34315203
GO:0008380RNA splicing2.00e-011.00e+002.176111228
GO:0006412translation2.02e-011.00e+002.163120230
GO:0005975carbohydrate metabolic process2.20e-011.00e+002.02619253
GO:0000166nucleotide binding2.24e-011.00e+001.99215259
GO:0006281DNA repair2.26e-011.00e+001.981118261
GO:0019899enzyme binding2.38e-011.00e+001.895112277
GO:0005856cytoskeleton2.48e-011.00e+001.824112291
GO:0019901protein kinase binding2.67e-011.00e+001.700121317
GO:0043231intracellular membrane-bounded organelle2.68e-011.00e+001.69619318
GO:0007411axon guidance2.69e-011.00e+001.691113319
GO:0005813centrosome2.74e-011.00e+001.660114326
GO:0008283cell proliferation2.75e-011.00e+001.651114328
GO:0005925focal adhesion3.02e-011.00e+001.493119366
GO:0007155cell adhesion3.04e-011.00e+001.48116369
GO:0055114oxidation-reduction process3.39e-011.00e+001.294112420
GO:0055085transmembrane transport3.49e-011.00e+001.244110435
GO:0007596blood coagulation3.62e-011.00e+001.179118455
GO:0045087innate immune response4.46e-011.00e+000.790124596
GO:0005737cytoplasm5.18e-011.00e+000.13041103767
GO:0005615extracellular space6.18e-011.00e+000.106117957
GO:0003677DNA binding7.09e-011.00e+00-0.2421281218
GO:0005886plasma membrane7.44e-011.00e+00-0.3262452582
GO:0016021integral component of membrane8.74e-011.00e+00-0.9441271982