| Dataset | Score | p-value 1 | p-value 2 | p-value 3 | 
|---|---|---|---|---|
| wolf-screen-ratio-mammosphere-adherent | 0.921 | 5.46e-15 | 3.31e-03 | 4.93e-02 | 

| Gene Symbol | Entrez Gene ID | Frequency | wolf-screen-ratio-mammosphere-adherent gene score | Best subnetwork score | Degree | wolf adherent-list Hits GI | wolf mammosphere no adherent-list Hits GI | 
|---|---|---|---|---|---|---|---|
| RPA2 | 6118 | 98 | 1.250 | 1.151 | 69 | Yes | - | 
| [ GSTK1 ] | 373156 | 1 | -0.185 | 0.921 | 97 | - | - | 
| CDC16 | 8881 | 25 | 0.950 | 1.020 | 80 | Yes | - | 
| RBX1 | 9978 | 97 | 1.185 | 1.151 | 139 | Yes | - | 
| PSMD3 | 5709 | 57 | 0.986 | 1.106 | 146 | Yes | - | 
| EFTUD2 | 9343 | 7 | 0.883 | 0.969 | 78 | Yes | - | 
| PSMB7 | 5695 | 48 | 0.982 | 1.052 | 57 | Yes | - | 
| LRPPRC | 10128 | 3 | -0.558 | 1.095 | 61 | - | Yes | 
| PSMA1 | 5682 | 61 | 0.996 | 1.052 | 123 | Yes | - | 
| PSMD11 | 5717 | 121 | 1.095 | 1.106 | 183 | Yes | - | 
| ACTB | 60 | 167 | 1.153 | 1.151 | 587 | Yes | - | 
| RPSA | 3921 | 156 | 1.327 | 1.151 | 152 | Yes | - | 
| DCTN1 | 1639 | 2 | 0.423 | 0.933 | 86 | Yes | - | 
| Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources | 
|---|---|---|---|---|---|---|
| PSMD3 | 5709 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG | 
| ACTB | 60 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast | 
| LRPPRC | 10128 | GSTK1 | 373156 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct, BioGrid | 
| PSMB7 | 5695 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast | 
| PSMB7 | 5695 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast | 
| ACTB | 60 | PSMA1 | 5682 | pp | -- | int.I2D: BioGrid_Yeast | 
| EFTUD2 | 9343 | GSTK1 | 373156 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct, BioGrid | 
| ACTB | 60 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast | 
| PSMA1 | 5682 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast, YeastMedium | 
| ACTB | 60 | LRPPRC | 10128 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct | 
| RPSA | 3921 | PSMD11 | 5717 | pp | -- | int.I2D: IntAct_Yeast | 
| PSMA1 | 5682 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow | 
| ACTB | 60 | RPSA | 3921 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct | 
| PSMA1 | 5682 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast | 
| ACTB | 60 | RBX1 | 9978 | pp | -- | int.I2D: BioGrid_Yeast | 
| ACTB | 60 | PSMB7 | 5695 | pp | -- | int.I2D: BioGrid_Yeast | 
| ACTB | 60 | CDC16 | 8881 | pp | -- | int.I2D: YeastLow | 
| DCTN1 | 1639 | GSTK1 | 373156 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct, BioGrid | 
| ACTB | 60 | RPA2 | 6118 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct | 
| Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes | 
|---|---|---|---|---|---|---|---|
| GO:0005654 | nucleoplasm | 1.26e-09 | 1.82e-05 | 3.358 | 10 | 76 | 1082 | 
| GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.99e-09 | 2.87e-05 | 6.415 | 5 | 22 | 65 | 
| GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 2.91e-09 | 4.19e-05 | 6.308 | 5 | 22 | 70 | 
| GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 3.86e-09 | 5.57e-05 | 6.228 | 5 | 22 | 74 | 
| GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 5.39e-09 | 7.78e-05 | 6.134 | 5 | 23 | 79 | 
| GO:0000278 | mitotic cell cycle | 1.52e-08 | 2.19e-04 | 4.312 | 7 | 48 | 391 | 
| GO:0006521 | regulation of cellular amino acid metabolic process | 8.93e-08 | 1.29e-03 | 6.472 | 4 | 17 | 50 | 
| GO:0000082 | G1/S transition of mitotic cell cycle | 1.32e-07 | 1.91e-03 | 5.218 | 5 | 32 | 149 | 
| GO:0000502 | proteasome complex | 1.64e-07 | 2.36e-03 | 6.258 | 4 | 17 | 58 | 
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 2.45e-07 | 3.53e-03 | 6.116 | 4 | 19 | 64 | 
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 3.94e-07 | 5.69e-03 | 5.946 | 4 | 20 | 72 | 
| GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 4.65e-07 | 6.71e-03 | 5.887 | 4 | 20 | 75 | 
| GO:0016071 | mRNA metabolic process | 9.83e-07 | 1.42e-02 | 4.637 | 5 | 31 | 223 | 
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 1.06e-06 | 1.53e-02 | 5.592 | 4 | 21 | 92 | 
| GO:0016070 | RNA metabolic process | 1.63e-06 | 2.35e-02 | 4.489 | 5 | 32 | 247 | 
| GO:0000209 | protein polyubiquitination | 2.69e-06 | 3.87e-02 | 5.258 | 4 | 20 | 116 | 
| GO:0016032 | viral process | 3.44e-06 | 4.96e-02 | 3.640 | 6 | 55 | 534 | 
| GO:0042981 | regulation of apoptotic process | 7.47e-06 | 1.08e-01 | 4.887 | 4 | 24 | 150 | 
| GO:0034641 | cellular nitrogen compound metabolic process | 1.25e-05 | 1.81e-01 | 4.698 | 4 | 20 | 171 | 
| GO:0010467 | gene expression | 1.26e-05 | 1.82e-01 | 3.315 | 6 | 59 | 669 | 
| GO:0016020 | membrane | 2.51e-05 | 3.62e-01 | 2.401 | 8 | 90 | 1681 | 
| GO:0005838 | proteasome regulatory particle | 4.92e-05 | 7.10e-01 | 7.531 | 2 | 7 | 12 | 
| GO:0005829 | cytosol | 5.02e-05 | 7.24e-01 | 2.000 | 9 | 132 | 2496 | 
| GO:0022624 | proteasome accessory complex | 1.01e-04 | 1.00e+00 | 7.028 | 2 | 8 | 17 | 
| GO:0005839 | proteasome core complex | 1.14e-04 | 1.00e+00 | 6.946 | 2 | 8 | 18 | 
| GO:0004298 | threonine-type endopeptidase activity | 1.27e-04 | 1.00e+00 | 6.868 | 2 | 8 | 19 | 
| GO:0043066 | negative regulation of apoptotic process | 4.26e-04 | 1.00e+00 | 3.388 | 4 | 31 | 424 | 
| GO:0010970 | microtubule-based transport | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 | 
| GO:0006915 | apoptotic process | 1.17e-03 | 1.00e+00 | 2.999 | 4 | 33 | 555 | 
| GO:0003697 | single-stranded DNA binding | 1.65e-03 | 1.00e+00 | 5.028 | 2 | 5 | 68 | 
| GO:0000461 | endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 | 
| GO:0000961 | negative regulation of mitochondrial RNA catabolic process | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 | 
| GO:0005055 | laminin receptor activity | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 | 
| GO:0006407 | rRNA export from nucleus | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 | 
| GO:0005515 | protein binding | 2.00e-03 | 1.00e+00 | 1.019 | 11 | 184 | 6024 | 
| GO:0070062 | extracellular vesicular exosome | 2.36e-03 | 1.00e+00 | 1.694 | 7 | 104 | 2400 | 
| GO:0070129 | regulation of mitochondrial translation | 2.70e-03 | 1.00e+00 | 8.531 | 1 | 1 | 3 | 
| GO:0005813 | centrosome | 2.77e-03 | 1.00e+00 | 3.352 | 3 | 14 | 326 | 
| GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 | 
| GO:0030686 | 90S preribosome | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 | 
| GO:0031467 | Cul7-RING ubiquitin ligase complex | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 | 
| GO:0019788 | NEDD8 ligase activity | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 | 
| GO:0030529 | ribonucleoprotein complex | 4.41e-03 | 1.00e+00 | 4.308 | 2 | 8 | 112 | 
| GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 3 | 5 | 
| GO:0031461 | cullin-RING ubiquitin ligase complex | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:0043248 | proteasome assembly | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:0030891 | VCB complex | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 2 | 5 | 
| GO:0000730 | DNA recombinase assembly | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:2000001 | regulation of DNA damage checkpoint | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:0030957 | Tat protein binding | 5.40e-03 | 1.00e+00 | 7.531 | 1 | 3 | 6 | 
| GO:0031466 | Cul5-RING ubiquitin ligase complex | 5.40e-03 | 1.00e+00 | 7.531 | 1 | 1 | 6 | 
| GO:0000028 | ribosomal small subunit assembly | 6.29e-03 | 1.00e+00 | 7.308 | 1 | 1 | 7 | 
| GO:0031462 | Cul2-RING ubiquitin ligase complex | 6.29e-03 | 1.00e+00 | 7.308 | 1 | 2 | 7 | 
| GO:0019773 | proteasome core complex, alpha-subunit complex | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 4 | 8 | 
| GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 2 | 8 | 
| GO:0070688 | MLL5-L complex | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 1 | 8 | 
| GO:0005869 | dynactin complex | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 1 | 8 | 
| GO:0045116 | protein neddylation | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 2 | 8 | 
| GO:0044267 | cellular protein metabolic process | 7.89e-03 | 1.00e+00 | 2.812 | 3 | 29 | 474 | 
| GO:0047497 | mitochondrion transport along microtubule | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 3 | 9 | 
| GO:0010569 | regulation of double-strand break repair via homologous recombination | 8.98e-03 | 1.00e+00 | 6.794 | 1 | 1 | 10 | 
| GO:0045502 | dynein binding | 9.87e-03 | 1.00e+00 | 6.656 | 1 | 2 | 11 | 
| GO:0030286 | dynein complex | 9.87e-03 | 1.00e+00 | 6.656 | 1 | 1 | 11 | 
| GO:0031571 | mitotic G1 DNA damage checkpoint | 9.87e-03 | 1.00e+00 | 6.656 | 1 | 4 | 11 | 
| GO:0031625 | ubiquitin protein ligase binding | 1.08e-02 | 1.00e+00 | 3.640 | 2 | 14 | 178 | 
| GO:0005730 | nucleolus | 1.11e-02 | 1.00e+00 | 1.757 | 5 | 69 | 1641 | 
| GO:0005662 | DNA replication factor A complex | 1.17e-02 | 1.00e+00 | 6.415 | 1 | 1 | 13 | 
| GO:0004602 | glutathione peroxidase activity | 1.17e-02 | 1.00e+00 | 6.415 | 1 | 1 | 13 | 
| GO:0030234 | enzyme regulator activity | 1.17e-02 | 1.00e+00 | 6.415 | 1 | 3 | 13 | 
| GO:0035267 | NuA4 histone acetyltransferase complex | 1.26e-02 | 1.00e+00 | 6.308 | 1 | 4 | 14 | 
| GO:0030904 | retromer complex | 1.34e-02 | 1.00e+00 | 6.209 | 1 | 2 | 15 | 
| GO:0050998 | nitric-oxide synthase binding | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 1 | 16 | 
| GO:0042176 | regulation of protein catabolic process | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 3 | 16 | 
| GO:0007088 | regulation of mitosis | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 1 | 18 | 
| GO:0035861 | site of double-strand break | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 1 | 18 | 
| GO:0004364 | glutathione transferase activity | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 1 | 18 | 
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 1.70e-02 | 1.00e+00 | 5.868 | 1 | 1 | 19 | 
| GO:0048863 | stem cell differentiation | 1.70e-02 | 1.00e+00 | 5.868 | 1 | 1 | 19 | 
| GO:0007067 | mitotic nuclear division | 1.72e-02 | 1.00e+00 | 3.289 | 2 | 14 | 227 | 
| GO:0005680 | anaphase-promoting complex | 1.79e-02 | 1.00e+00 | 5.794 | 1 | 4 | 20 | 
| GO:0006298 | mismatch repair | 1.79e-02 | 1.00e+00 | 5.794 | 1 | 3 | 20 | 
| GO:0032402 | melanosome transport | 1.79e-02 | 1.00e+00 | 5.794 | 1 | 1 | 20 | 
| GO:0032201 | telomere maintenance via semi-conservative replication | 1.88e-02 | 1.00e+00 | 5.723 | 1 | 5 | 21 | 
| GO:0015035 | protein disulfide oxidoreductase activity | 1.88e-02 | 1.00e+00 | 5.723 | 1 | 1 | 21 | 
| GO:0000718 | nucleotide-excision repair, DNA damage removal | 1.88e-02 | 1.00e+00 | 5.723 | 1 | 4 | 21 | 
| GO:0044281 | small molecule metabolic process | 1.91e-02 | 1.00e+00 | 1.874 | 4 | 58 | 1211 | 
| GO:0005640 | nuclear outer membrane | 1.97e-02 | 1.00e+00 | 5.656 | 1 | 1 | 22 | 
| GO:0006297 | nucleotide-excision repair, DNA gap filling | 1.97e-02 | 1.00e+00 | 5.656 | 1 | 3 | 22 | 
| GO:0030863 | cortical cytoskeleton | 1.97e-02 | 1.00e+00 | 5.656 | 1 | 1 | 22 | 
| GO:0036464 | cytoplasmic ribonucleoprotein granule | 1.97e-02 | 1.00e+00 | 5.656 | 1 | 4 | 22 | 
| GO:0005874 | microtubule | 2.04e-02 | 1.00e+00 | 3.156 | 2 | 7 | 249 | 
| GO:0043044 | ATP-dependent chromatin remodeling | 2.05e-02 | 1.00e+00 | 5.592 | 1 | 4 | 23 | 
| GO:0005844 | polysome | 2.05e-02 | 1.00e+00 | 5.592 | 1 | 4 | 23 | 
| GO:0031463 | Cul3-RING ubiquitin ligase complex | 2.05e-02 | 1.00e+00 | 5.592 | 1 | 3 | 23 | 
| GO:0043236 | laminin binding | 2.05e-02 | 1.00e+00 | 5.592 | 1 | 1 | 23 | 
| GO:0006513 | protein monoubiquitination | 2.05e-02 | 1.00e+00 | 5.592 | 1 | 1 | 23 | 
| GO:0000794 | condensed nuclear chromosome | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 2 | 24 | 
| GO:0005637 | nuclear inner membrane | 2.23e-02 | 1.00e+00 | 5.472 | 1 | 2 | 25 | 
| GO:0000722 | telomere maintenance via recombination | 2.23e-02 | 1.00e+00 | 5.472 | 1 | 5 | 25 | 
| GO:0006281 | DNA repair | 2.23e-02 | 1.00e+00 | 3.088 | 2 | 18 | 261 | 
| GO:0070979 | protein K11-linked ubiquitination | 2.32e-02 | 1.00e+00 | 5.415 | 1 | 6 | 26 | 
| GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 2.32e-02 | 1.00e+00 | 5.415 | 1 | 3 | 26 | 
| GO:0043022 | ribosome binding | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 3 | 27 | 
| GO:0006749 | glutathione metabolic process | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 2 | 27 | 
| GO:0031492 | nucleosomal DNA binding | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 4 | 27 | 
| GO:0031252 | cell leading edge | 2.50e-02 | 1.00e+00 | 5.308 | 1 | 4 | 28 | 
| GO:0019894 | kinesin binding | 2.50e-02 | 1.00e+00 | 5.308 | 1 | 1 | 28 | 
| GO:0005634 | nucleus | 2.51e-02 | 1.00e+00 | 0.961 | 8 | 136 | 4559 | 
| GO:0019005 | SCF ubiquitin ligase complex | 2.58e-02 | 1.00e+00 | 5.258 | 1 | 1 | 29 | 
| GO:0048487 | beta-tubulin binding | 2.67e-02 | 1.00e+00 | 5.209 | 1 | 2 | 30 | 
| GO:0006271 | DNA strand elongation involved in DNA replication | 2.67e-02 | 1.00e+00 | 5.209 | 1 | 7 | 30 | 
| GO:0005856 | cytoskeleton | 2.73e-02 | 1.00e+00 | 2.931 | 2 | 12 | 291 | 
| GO:0007094 | mitotic spindle assembly checkpoint | 2.76e-02 | 1.00e+00 | 5.161 | 1 | 4 | 31 | 
| GO:0001895 | retina homeostasis | 3.02e-02 | 1.00e+00 | 5.028 | 1 | 1 | 34 | 
| GO:0005876 | spindle microtubule | 3.02e-02 | 1.00e+00 | 5.028 | 1 | 2 | 34 | 
| GO:0034332 | adherens junction organization | 3.20e-02 | 1.00e+00 | 4.946 | 1 | 1 | 36 | 
| GO:0042645 | mitochondrial nucleoid | 3.29e-02 | 1.00e+00 | 4.906 | 1 | 1 | 37 | 
| GO:0051084 | 'de novo' posttranslational protein folding | 3.29e-02 | 1.00e+00 | 4.906 | 1 | 4 | 37 | 
| GO:0006284 | base-excision repair | 3.29e-02 | 1.00e+00 | 4.906 | 1 | 3 | 37 | 
| GO:0070527 | platelet aggregation | 3.37e-02 | 1.00e+00 | 4.868 | 1 | 2 | 38 | 
| GO:0022627 | cytosolic small ribosomal subunit | 3.46e-02 | 1.00e+00 | 4.830 | 1 | 4 | 39 | 
| GO:0000781 | chromosome, telomeric region | 3.46e-02 | 1.00e+00 | 4.830 | 1 | 3 | 39 | 
| GO:0042147 | retrograde transport, endosome to Golgi | 3.63e-02 | 1.00e+00 | 4.758 | 1 | 3 | 41 | 
| GO:0003723 | RNA binding | 3.68e-02 | 1.00e+00 | 2.698 | 2 | 20 | 342 | 
| GO:0003774 | motor activity | 3.81e-02 | 1.00e+00 | 4.689 | 1 | 2 | 43 | 
| GO:0021762 | substantia nigra development | 3.90e-02 | 1.00e+00 | 4.656 | 1 | 2 | 44 | 
| GO:0015030 | Cajal body | 3.90e-02 | 1.00e+00 | 4.656 | 1 | 3 | 44 | 
| GO:0006283 | transcription-coupled nucleotide-excision repair | 4.07e-02 | 1.00e+00 | 4.592 | 1 | 7 | 46 | 
| GO:0003684 | damaged DNA binding | 4.33e-02 | 1.00e+00 | 4.501 | 1 | 7 | 49 | 
| GO:0051028 | mRNA transport | 4.59e-02 | 1.00e+00 | 4.415 | 1 | 2 | 52 | 
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 4.68e-02 | 1.00e+00 | 4.388 | 1 | 5 | 53 | 
| GO:0045216 | cell-cell junction organization | 4.76e-02 | 1.00e+00 | 4.361 | 1 | 2 | 54 | 
| GO:0000724 | double-strand break repair via homologous recombination | 4.85e-02 | 1.00e+00 | 4.334 | 1 | 3 | 55 | 
| GO:0000723 | telomere maintenance | 4.93e-02 | 1.00e+00 | 4.308 | 1 | 6 | 56 | 
| GO:0030855 | epithelial cell differentiation | 5.36e-02 | 1.00e+00 | 4.185 | 1 | 4 | 61 | 
| GO:0006987 | activation of signaling protein activity involved in unfolded protein response | 5.36e-02 | 1.00e+00 | 4.185 | 1 | 3 | 61 | 
| GO:0019903 | protein phosphatase binding | 5.45e-02 | 1.00e+00 | 4.161 | 1 | 4 | 62 | 
| GO:0006302 | double-strand break repair | 5.45e-02 | 1.00e+00 | 4.161 | 1 | 4 | 62 | 
| GO:0000776 | kinetochore | 5.53e-02 | 1.00e+00 | 4.138 | 1 | 4 | 63 | 
| GO:0006289 | nucleotide-excision repair | 5.96e-02 | 1.00e+00 | 4.028 | 1 | 11 | 68 | 
| GO:0034329 | cell junction assembly | 5.96e-02 | 1.00e+00 | 4.028 | 1 | 1 | 68 | 
| GO:0044822 | poly(A) RNA binding | 6.44e-02 | 1.00e+00 | 1.656 | 3 | 49 | 1056 | 
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 6.47e-02 | 1.00e+00 | 3.906 | 1 | 6 | 74 | 
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 6.56e-02 | 1.00e+00 | 3.887 | 1 | 2 | 75 | 
| GO:0071013 | catalytic step 2 spliceosome | 6.81e-02 | 1.00e+00 | 3.830 | 1 | 4 | 78 | 
| GO:0030968 | endoplasmic reticulum unfolded protein response | 6.89e-02 | 1.00e+00 | 3.812 | 1 | 4 | 79 | 
| GO:0019083 | viral transcription | 7.06e-02 | 1.00e+00 | 3.776 | 1 | 10 | 81 | 
| GO:0005681 | spliceosomal complex | 7.23e-02 | 1.00e+00 | 3.741 | 1 | 4 | 83 | 
| GO:0005777 | peroxisome | 7.32e-02 | 1.00e+00 | 3.723 | 1 | 4 | 84 | 
| GO:0047485 | protein N-terminus binding | 7.48e-02 | 1.00e+00 | 3.689 | 1 | 5 | 86 | 
| GO:0000922 | spindle pole | 7.57e-02 | 1.00e+00 | 3.673 | 1 | 2 | 87 | 
| GO:0006415 | translational termination | 7.57e-02 | 1.00e+00 | 3.673 | 1 | 10 | 87 | 
| GO:0016605 | PML body | 7.65e-02 | 1.00e+00 | 3.656 | 1 | 3 | 88 | 
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | 7.82e-02 | 1.00e+00 | 3.624 | 1 | 7 | 90 | 
| GO:0006928 | cellular component movement | 7.90e-02 | 1.00e+00 | 3.608 | 1 | 7 | 91 | 
| GO:0005200 | structural constituent of cytoskeleton | 7.90e-02 | 1.00e+00 | 3.608 | 1 | 8 | 91 | 
| GO:0051015 | actin filament binding | 7.99e-02 | 1.00e+00 | 3.592 | 1 | 2 | 92 | 
| GO:0071456 | cellular response to hypoxia | 7.99e-02 | 1.00e+00 | 3.592 | 1 | 6 | 92 | 
| GO:0006414 | translational elongation | 8.07e-02 | 1.00e+00 | 3.576 | 1 | 13 | 93 | 
| GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 8.98e-02 | 1.00e+00 | 3.415 | 1 | 10 | 104 | 
| GO:0014069 | postsynaptic density | 9.07e-02 | 1.00e+00 | 3.401 | 1 | 3 | 105 | 
| GO:0015630 | microtubule cytoskeleton | 9.48e-02 | 1.00e+00 | 3.334 | 1 | 4 | 110 | 
| GO:0072562 | blood microparticle | 9.56e-02 | 1.00e+00 | 3.321 | 1 | 3 | 111 | 
| GO:0005737 | cytoplasm | 9.60e-02 | 1.00e+00 | 0.821 | 6 | 110 | 3767 | 
| GO:0005819 | spindle | 9.64e-02 | 1.00e+00 | 3.308 | 1 | 7 | 112 | 
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 9.81e-02 | 1.00e+00 | 3.283 | 1 | 11 | 114 | 
| GO:0019058 | viral life cycle | 9.89e-02 | 1.00e+00 | 3.270 | 1 | 13 | 115 | 
| GO:0006325 | chromatin organization | 1.01e-01 | 1.00e+00 | 3.233 | 1 | 5 | 118 | 
| GO:0007219 | Notch signaling pathway | 1.03e-01 | 1.00e+00 | 3.209 | 1 | 5 | 120 | 
| GO:0006260 | DNA replication | 1.04e-01 | 1.00e+00 | 3.197 | 1 | 9 | 121 | 
| GO:0006511 | ubiquitin-dependent protein catabolic process | 1.08e-01 | 1.00e+00 | 3.138 | 1 | 5 | 126 | 
| GO:0000790 | nuclear chromatin | 1.10e-01 | 1.00e+00 | 3.104 | 1 | 9 | 129 | 
| GO:0006413 | translational initiation | 1.12e-01 | 1.00e+00 | 3.082 | 1 | 17 | 131 | 
| GO:0000086 | G2/M transition of mitotic cell cycle | 1.16e-01 | 1.00e+00 | 3.028 | 1 | 9 | 136 | 
| GO:0003735 | structural constituent of ribosome | 1.17e-01 | 1.00e+00 | 3.018 | 1 | 10 | 137 | 
| GO:0006457 | protein folding | 1.22e-01 | 1.00e+00 | 2.956 | 1 | 7 | 143 | 
| GO:0061024 | membrane organization | 1.23e-01 | 1.00e+00 | 2.936 | 1 | 7 | 145 | 
| GO:0008017 | microtubule binding | 1.25e-01 | 1.00e+00 | 2.916 | 1 | 6 | 147 | 
| GO:0006397 | mRNA processing | 1.35e-01 | 1.00e+00 | 2.794 | 1 | 2 | 160 | 
| GO:0000398 | mRNA splicing, via spliceosome | 1.38e-01 | 1.00e+00 | 2.758 | 1 | 8 | 164 | 
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 1.39e-01 | 1.00e+00 | 2.749 | 1 | 7 | 165 | 
| GO:0030424 | axon | 1.40e-01 | 1.00e+00 | 2.741 | 1 | 4 | 166 | 
| GO:0016607 | nuclear speck | 1.44e-01 | 1.00e+00 | 2.689 | 1 | 3 | 172 | 
| GO:0032403 | protein complex binding | 1.53e-01 | 1.00e+00 | 2.600 | 1 | 10 | 183 | 
| GO:0003924 | GTPase activity | 1.64e-01 | 1.00e+00 | 2.494 | 1 | 12 | 197 | 
| GO:0005622 | intracellular | 1.71e-01 | 1.00e+00 | 2.422 | 1 | 6 | 207 | 
| GO:0006184 | GTP catabolic process | 1.77e-01 | 1.00e+00 | 2.374 | 1 | 12 | 214 | 
| GO:0008380 | RNA splicing | 1.87e-01 | 1.00e+00 | 2.283 | 1 | 11 | 228 | 
| GO:0005759 | mitochondrial matrix | 1.87e-01 | 1.00e+00 | 2.283 | 1 | 14 | 228 | 
| GO:0007399 | nervous system development | 1.89e-01 | 1.00e+00 | 2.264 | 1 | 5 | 231 | 
| GO:0006412 | translation | 1.89e-01 | 1.00e+00 | 2.270 | 1 | 20 | 230 | 
| GO:0004842 | ubiquitin-protein transferase activity | 2.07e-01 | 1.00e+00 | 2.121 | 1 | 6 | 255 | 
| GO:0005102 | receptor binding | 2.11e-01 | 1.00e+00 | 2.093 | 1 | 6 | 260 | 
| GO:0005743 | mitochondrial inner membrane | 2.23e-01 | 1.00e+00 | 2.002 | 1 | 8 | 277 | 
| GO:0019899 | enzyme binding | 2.23e-01 | 1.00e+00 | 2.002 | 1 | 12 | 277 | 
| GO:0043234 | protein complex | 2.36e-01 | 1.00e+00 | 1.911 | 1 | 18 | 295 | 
| GO:0016567 | protein ubiquitination | 2.36e-01 | 1.00e+00 | 1.911 | 1 | 5 | 295 | 
| GO:0005525 | GTP binding | 2.46e-01 | 1.00e+00 | 1.840 | 1 | 12 | 310 | 
| GO:0019901 | protein kinase binding | 2.51e-01 | 1.00e+00 | 1.807 | 1 | 21 | 317 | 
| GO:0007411 | axon guidance | 2.52e-01 | 1.00e+00 | 1.798 | 1 | 13 | 319 | 
| GO:0008283 | cell proliferation | 2.59e-01 | 1.00e+00 | 1.758 | 1 | 14 | 328 | 
| GO:0005925 | focal adhesion | 2.84e-01 | 1.00e+00 | 1.600 | 1 | 19 | 366 | 
| GO:0007155 | cell adhesion | 2.86e-01 | 1.00e+00 | 1.588 | 1 | 6 | 369 | 
| GO:0055114 | oxidation-reduction process | 3.19e-01 | 1.00e+00 | 1.401 | 1 | 12 | 420 | 
| GO:0007596 | blood coagulation | 3.41e-01 | 1.00e+00 | 1.286 | 1 | 18 | 455 | 
| GO:0048471 | perinuclear region of cytoplasm | 3.69e-01 | 1.00e+00 | 1.144 | 1 | 13 | 502 | 
| GO:0045087 | innate immune response | 4.22e-01 | 1.00e+00 | 0.896 | 1 | 24 | 596 | 
| GO:0005615 | extracellular space | 5.91e-01 | 1.00e+00 | 0.213 | 1 | 17 | 957 | 
| GO:0005739 | mitochondrion | 6.06e-01 | 1.00e+00 | 0.153 | 1 | 28 | 998 | 
| GO:0006355 | regulation of transcription, DNA-templated | 6.06e-01 | 1.00e+00 | 0.154 | 1 | 18 | 997 | 
| GO:0008270 | zinc ion binding | 6.06e-01 | 1.00e+00 | 0.154 | 1 | 12 | 997 | 
| GO:0005524 | ATP binding | 7.07e-01 | 1.00e+00 | -0.226 | 1 | 60 | 1298 | 
| GO:0006351 | transcription, DNA-templated | 7.47e-01 | 1.00e+00 | -0.382 | 1 | 31 | 1446 | 
| GO:0005886 | plasma membrane | 9.23e-01 | 1.00e+00 | -1.219 | 1 | 45 | 2582 |