int-snw-373156

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.921 5.46e-15 3.31e-03 4.93e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-373156 subnetwork

Genes (13)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
[ GSTK1 ] 373156 1-0.1850.92197--
CDC16 8881 250.9501.02080Yes-
RBX1 9978 971.1851.151139Yes-
PSMD3 5709 570.9861.106146Yes-
EFTUD2 9343 70.8830.96978Yes-
PSMB7 5695 480.9821.05257Yes-
LRPPRC 10128 3-0.5581.09561-Yes
PSMA1 5682 610.9961.052123Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
RPSA 3921 1561.3271.151152Yes-
DCTN1 1639 20.4230.93386Yes-

Interactions (19)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
LRPPRC 10128 GSTK1 373156 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, BioGrid
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
EFTUD2 9343 GSTK1 373156 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, BioGrid
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
ACTB 60 LRPPRC 10128 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
ACTB 60 CDC16 8881 pp -- int.I2D: YeastLow
DCTN1 1639 GSTK1 373156 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, BioGrid
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct

Related GO terms (214)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005654nucleoplasm1.26e-091.82e-053.35810761082
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.99e-092.87e-056.41552265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.91e-094.19e-056.30852270
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.86e-095.57e-056.22852274
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process5.39e-097.78e-056.13452379
GO:0000278mitotic cell cycle1.52e-082.19e-044.312748391
GO:0006521regulation of cellular amino acid metabolic process8.93e-081.29e-036.47241750
GO:0000082G1/S transition of mitotic cell cycle1.32e-071.91e-035.218532149
GO:0000502proteasome complex1.64e-072.36e-036.25841758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest2.45e-073.53e-036.11641964
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent3.94e-075.69e-035.94642072
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I4.65e-076.71e-035.88742075
GO:0016071mRNA metabolic process9.83e-071.42e-024.637531223
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.06e-061.53e-025.59242192
GO:0016070RNA metabolic process1.63e-062.35e-024.489532247
GO:0000209protein polyubiquitination2.69e-063.87e-025.258420116
GO:0016032viral process3.44e-064.96e-023.640655534
GO:0042981regulation of apoptotic process7.47e-061.08e-014.887424150
GO:0034641cellular nitrogen compound metabolic process1.25e-051.81e-014.698420171
GO:0010467gene expression1.26e-051.82e-013.315659669
GO:0016020membrane2.51e-053.62e-012.4018901681
GO:0005838proteasome regulatory particle4.92e-057.10e-017.5312712
GO:0005829cytosol5.02e-057.24e-012.00091322496
GO:0022624proteasome accessory complex1.01e-041.00e+007.0282817
GO:0005839proteasome core complex1.14e-041.00e+006.9462818
GO:0004298threonine-type endopeptidase activity1.27e-041.00e+006.8682819
GO:0043066negative regulation of apoptotic process4.26e-041.00e+003.388431424
GO:0010970microtubule-based transport9.01e-041.00e+0010.116111
GO:0006915apoptotic process1.17e-031.00e+002.999433555
GO:0003697single-stranded DNA binding1.65e-031.00e+005.0282568
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.80e-031.00e+009.116112
GO:0000961negative regulation of mitochondrial RNA catabolic process1.80e-031.00e+009.116112
GO:0005055laminin receptor activity1.80e-031.00e+009.116112
GO:0006407rRNA export from nucleus1.80e-031.00e+009.116112
GO:0005515protein binding2.00e-031.00e+001.019111846024
GO:0070062extracellular vesicular exosome2.36e-031.00e+001.69471042400
GO:0070129regulation of mitochondrial translation2.70e-031.00e+008.531113
GO:0005813centrosome2.77e-031.00e+003.352314326
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.60e-031.00e+008.116114
GO:003068690S preribosome3.60e-031.00e+008.116114
GO:0031467Cul7-RING ubiquitin ligase complex3.60e-031.00e+008.116114
GO:0019788NEDD8 ligase activity3.60e-031.00e+008.116114
GO:0030529ribonucleoprotein complex4.41e-031.00e+004.30828112
GO:0031465Cul4B-RING E3 ubiquitin ligase complex4.50e-031.00e+007.794135
GO:0031461cullin-RING ubiquitin ligase complex4.50e-031.00e+007.794115
GO:0043248proteasome assembly4.50e-031.00e+007.794115
GO:0030891VCB complex4.50e-031.00e+007.794125
GO:0000730DNA recombinase assembly4.50e-031.00e+007.794115
GO:2000001regulation of DNA damage checkpoint4.50e-031.00e+007.794115
GO:0030957Tat protein binding5.40e-031.00e+007.531136
GO:0031466Cul5-RING ubiquitin ligase complex5.40e-031.00e+007.531116
GO:0000028ribosomal small subunit assembly6.29e-031.00e+007.308117
GO:0031462Cul2-RING ubiquitin ligase complex6.29e-031.00e+007.308127
GO:0019773proteasome core complex, alpha-subunit complex7.19e-031.00e+007.116148
GO:0031464Cul4A-RING E3 ubiquitin ligase complex7.19e-031.00e+007.116128
GO:0070688MLL5-L complex7.19e-031.00e+007.116118
GO:0005869dynactin complex7.19e-031.00e+007.116118
GO:0045116protein neddylation7.19e-031.00e+007.116128
GO:0044267cellular protein metabolic process7.89e-031.00e+002.812329474
GO:0047497mitochondrion transport along microtubule8.09e-031.00e+006.946139
GO:0010569regulation of double-strand break repair via homologous recombination8.98e-031.00e+006.7941110
GO:0045502dynein binding9.87e-031.00e+006.6561211
GO:0030286dynein complex9.87e-031.00e+006.6561111
GO:0031571mitotic G1 DNA damage checkpoint9.87e-031.00e+006.6561411
GO:0031625ubiquitin protein ligase binding1.08e-021.00e+003.640214178
GO:0005730nucleolus1.11e-021.00e+001.7575691641
GO:0005662DNA replication factor A complex1.17e-021.00e+006.4151113
GO:0004602glutathione peroxidase activity1.17e-021.00e+006.4151113
GO:0030234enzyme regulator activity1.17e-021.00e+006.4151313
GO:0035267NuA4 histone acetyltransferase complex1.26e-021.00e+006.3081414
GO:0030904retromer complex1.34e-021.00e+006.2091215
GO:0050998nitric-oxide synthase binding1.43e-021.00e+006.1161116
GO:0042176regulation of protein catabolic process1.43e-021.00e+006.1161316
GO:0007088regulation of mitosis1.61e-021.00e+005.9461118
GO:0035861site of double-strand break1.61e-021.00e+005.9461118
GO:0004364glutathione transferase activity1.61e-021.00e+005.9461118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.70e-021.00e+005.8681119
GO:0048863stem cell differentiation1.70e-021.00e+005.8681119
GO:0007067mitotic nuclear division1.72e-021.00e+003.289214227
GO:0005680anaphase-promoting complex1.79e-021.00e+005.7941420
GO:0006298mismatch repair1.79e-021.00e+005.7941320
GO:0032402melanosome transport1.79e-021.00e+005.7941120
GO:0032201telomere maintenance via semi-conservative replication1.88e-021.00e+005.7231521
GO:0015035protein disulfide oxidoreductase activity1.88e-021.00e+005.7231121
GO:0000718nucleotide-excision repair, DNA damage removal1.88e-021.00e+005.7231421
GO:0044281small molecule metabolic process1.91e-021.00e+001.8744581211
GO:0005640nuclear outer membrane1.97e-021.00e+005.6561122
GO:0006297nucleotide-excision repair, DNA gap filling1.97e-021.00e+005.6561322
GO:0030863cortical cytoskeleton1.97e-021.00e+005.6561122
GO:0036464cytoplasmic ribonucleoprotein granule1.97e-021.00e+005.6561422
GO:0005874microtubule2.04e-021.00e+003.15627249
GO:0043044ATP-dependent chromatin remodeling2.05e-021.00e+005.5921423
GO:0005844polysome2.05e-021.00e+005.5921423
GO:0031463Cul3-RING ubiquitin ligase complex2.05e-021.00e+005.5921323
GO:0043236laminin binding2.05e-021.00e+005.5921123
GO:0006513protein monoubiquitination2.05e-021.00e+005.5921123
GO:0000794condensed nuclear chromosome2.14e-021.00e+005.5311224
GO:0005637nuclear inner membrane2.23e-021.00e+005.4721225
GO:0000722telomere maintenance via recombination2.23e-021.00e+005.4721525
GO:0006281DNA repair2.23e-021.00e+003.088218261
GO:0070979protein K11-linked ubiquitination2.32e-021.00e+005.4151626
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.32e-021.00e+005.4151326
GO:0043022ribosome binding2.41e-021.00e+005.3611327
GO:0006749glutathione metabolic process2.41e-021.00e+005.3611227
GO:0031492nucleosomal DNA binding2.41e-021.00e+005.3611427
GO:0031252cell leading edge2.50e-021.00e+005.3081428
GO:0019894kinesin binding2.50e-021.00e+005.3081128
GO:0005634nucleus2.51e-021.00e+000.96181364559
GO:0019005SCF ubiquitin ligase complex2.58e-021.00e+005.2581129
GO:0048487beta-tubulin binding2.67e-021.00e+005.2091230
GO:0006271DNA strand elongation involved in DNA replication2.67e-021.00e+005.2091730
GO:0005856cytoskeleton2.73e-021.00e+002.931212291
GO:0007094mitotic spindle assembly checkpoint2.76e-021.00e+005.1611431
GO:0001895retina homeostasis3.02e-021.00e+005.0281134
GO:0005876spindle microtubule3.02e-021.00e+005.0281234
GO:0034332adherens junction organization3.20e-021.00e+004.9461136
GO:0042645mitochondrial nucleoid3.29e-021.00e+004.9061137
GO:0051084'de novo' posttranslational protein folding3.29e-021.00e+004.9061437
GO:0006284base-excision repair3.29e-021.00e+004.9061337
GO:0070527platelet aggregation3.37e-021.00e+004.8681238
GO:0022627cytosolic small ribosomal subunit3.46e-021.00e+004.8301439
GO:0000781chromosome, telomeric region3.46e-021.00e+004.8301339
GO:0042147retrograde transport, endosome to Golgi3.63e-021.00e+004.7581341
GO:0003723RNA binding3.68e-021.00e+002.698220342
GO:0003774motor activity3.81e-021.00e+004.6891243
GO:0021762substantia nigra development3.90e-021.00e+004.6561244
GO:0015030Cajal body3.90e-021.00e+004.6561344
GO:0006283transcription-coupled nucleotide-excision repair4.07e-021.00e+004.5921746
GO:0003684damaged DNA binding4.33e-021.00e+004.5011749
GO:0051028mRNA transport4.59e-021.00e+004.4151252
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.68e-021.00e+004.3881553
GO:0045216cell-cell junction organization4.76e-021.00e+004.3611254
GO:0000724double-strand break repair via homologous recombination4.85e-021.00e+004.3341355
GO:0000723telomere maintenance4.93e-021.00e+004.3081656
GO:0030855epithelial cell differentiation5.36e-021.00e+004.1851461
GO:0006987activation of signaling protein activity involved in unfolded protein response5.36e-021.00e+004.1851361
GO:0019903protein phosphatase binding5.45e-021.00e+004.1611462
GO:0006302double-strand break repair5.45e-021.00e+004.1611462
GO:0000776kinetochore5.53e-021.00e+004.1381463
GO:0006289nucleotide-excision repair5.96e-021.00e+004.02811168
GO:0034329cell junction assembly5.96e-021.00e+004.0281168
GO:0044822poly(A) RNA binding6.44e-021.00e+001.6563491056
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis6.47e-021.00e+003.9061674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.56e-021.00e+003.8871275
GO:0071013catalytic step 2 spliceosome6.81e-021.00e+003.8301478
GO:0030968endoplasmic reticulum unfolded protein response6.89e-021.00e+003.8121479
GO:0019083viral transcription7.06e-021.00e+003.77611081
GO:0005681spliceosomal complex7.23e-021.00e+003.7411483
GO:0005777peroxisome7.32e-021.00e+003.7231484
GO:0047485protein N-terminus binding7.48e-021.00e+003.6891586
GO:0000922spindle pole7.57e-021.00e+003.6731287
GO:0006415translational termination7.57e-021.00e+003.67311087
GO:0016605PML body7.65e-021.00e+003.6561388
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II7.82e-021.00e+003.6241790
GO:0006928cellular component movement7.90e-021.00e+003.6081791
GO:0005200structural constituent of cytoskeleton7.90e-021.00e+003.6081891
GO:0051015actin filament binding7.99e-021.00e+003.5921292
GO:0071456cellular response to hypoxia7.99e-021.00e+003.5921692
GO:0006414translational elongation8.07e-021.00e+003.57611393
GO:0006614SRP-dependent cotranslational protein targeting to membrane8.98e-021.00e+003.415110104
GO:0014069postsynaptic density9.07e-021.00e+003.40113105
GO:0015630microtubule cytoskeleton9.48e-021.00e+003.33414110
GO:0072562blood microparticle9.56e-021.00e+003.32113111
GO:0005737cytoplasm9.60e-021.00e+000.82161103767
GO:0005819spindle9.64e-021.00e+003.30817112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay9.81e-021.00e+003.283111114
GO:0019058viral life cycle9.89e-021.00e+003.270113115
GO:0006325chromatin organization1.01e-011.00e+003.23315118
GO:0007219Notch signaling pathway1.03e-011.00e+003.20915120
GO:0006260DNA replication1.04e-011.00e+003.19719121
GO:0006511ubiquitin-dependent protein catabolic process1.08e-011.00e+003.13815126
GO:0000790nuclear chromatin1.10e-011.00e+003.10419129
GO:0006413translational initiation1.12e-011.00e+003.082117131
GO:0000086G2/M transition of mitotic cell cycle1.16e-011.00e+003.02819136
GO:0003735structural constituent of ribosome1.17e-011.00e+003.018110137
GO:0006457protein folding1.22e-011.00e+002.95617143
GO:0061024membrane organization1.23e-011.00e+002.93617145
GO:0008017microtubule binding1.25e-011.00e+002.91616147
GO:0006397mRNA processing1.35e-011.00e+002.79412160
GO:0000398mRNA splicing, via spliceosome1.38e-011.00e+002.75818164
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.39e-011.00e+002.74917165
GO:0030424axon1.40e-011.00e+002.74114166
GO:0016607nuclear speck1.44e-011.00e+002.68913172
GO:0032403protein complex binding1.53e-011.00e+002.600110183
GO:0003924GTPase activity1.64e-011.00e+002.494112197
GO:0005622intracellular1.71e-011.00e+002.42216207
GO:0006184GTP catabolic process1.77e-011.00e+002.374112214
GO:0008380RNA splicing1.87e-011.00e+002.283111228
GO:0005759mitochondrial matrix1.87e-011.00e+002.283114228
GO:0007399nervous system development1.89e-011.00e+002.26415231
GO:0006412translation1.89e-011.00e+002.270120230
GO:0004842ubiquitin-protein transferase activity2.07e-011.00e+002.12116255
GO:0005102receptor binding2.11e-011.00e+002.09316260
GO:0005743mitochondrial inner membrane2.23e-011.00e+002.00218277
GO:0019899enzyme binding2.23e-011.00e+002.002112277
GO:0043234protein complex2.36e-011.00e+001.911118295
GO:0016567protein ubiquitination2.36e-011.00e+001.91115295
GO:0005525GTP binding2.46e-011.00e+001.840112310
GO:0019901protein kinase binding2.51e-011.00e+001.807121317
GO:0007411axon guidance2.52e-011.00e+001.798113319
GO:0008283cell proliferation2.59e-011.00e+001.758114328
GO:0005925focal adhesion2.84e-011.00e+001.600119366
GO:0007155cell adhesion2.86e-011.00e+001.58816369
GO:0055114oxidation-reduction process3.19e-011.00e+001.401112420
GO:0007596blood coagulation3.41e-011.00e+001.286118455
GO:0048471perinuclear region of cytoplasm3.69e-011.00e+001.144113502
GO:0045087innate immune response4.22e-011.00e+000.896124596
GO:0005615extracellular space5.91e-011.00e+000.213117957
GO:0005739mitochondrion6.06e-011.00e+000.153128998
GO:0006355regulation of transcription, DNA-templated6.06e-011.00e+000.154118997
GO:0008270zinc ion binding6.06e-011.00e+000.154112997
GO:0005524ATP binding7.07e-011.00e+00-0.2261601298
GO:0006351transcription, DNA-templated7.47e-011.00e+00-0.3821311446
GO:0005886plasma membrane9.23e-011.00e+00-1.2191452582