int-snw-2771

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	1.057	1.36e-20	1.28e-04	4.17e-03

wolf-screen-ratio-mammosphere-adherent-int-snw-2771 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
PSMD1	5707	12	0.836	1.057	113	Yes	-
RBX1	9978	97	1.185	1.151	139	Yes	-
[ GNAI2 ]	2771	3	-0.516	1.057	98	-	Yes
PSMA2	5683	60	1.093	1.106	89	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-

Interactions (10)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMD1	5707	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast
PSMA2	5683	PSMD1	5707	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
ACTB	60	GNAI2	2771	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
GNAI2	2771	PSMD1	5707	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (181)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0000082	G1/S transition of mitotic cell cycle	7.42e-07	1.07e-02	5.597	4	32	149
GO:0006521	regulation of cellular amino acid metabolic process	2.17e-06	3.13e-02	6.757	3	17	50
GO:0000502	proteasome complex	3.41e-06	4.91e-02	6.543	3	17	58
GO:0016032	viral process	3.49e-06	5.03e-02	4.077	5	55	534
GO:0016071	mRNA metabolic process	3.71e-06	5.35e-02	5.015	4	31	223
GO:0005654	nucleoplasm	4.32e-06	6.23e-02	3.322	6	76	1082
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.59e-06	6.62e-02	6.401	3	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.81e-06	6.94e-02	6.379	3	22	65
GO:0016070	RNA metabolic process	5.57e-06	8.03e-02	4.868	4	32	247
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	6.03e-06	8.69e-02	6.272	3	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	6.56e-06	9.46e-02	6.231	3	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	7.13e-06	1.03e-01	6.192	3	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	7.42e-06	1.07e-01	6.172	3	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	8.68e-06	1.25e-01	6.097	3	23	79
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	1.37e-05	1.98e-01	5.877	3	21	92
GO:0005838	proteasome regulatory particle	1.77e-05	2.56e-01	8.231	2	7	12
GO:0000209	protein polyubiquitination	2.76e-05	3.98e-01	5.543	3	20	116
GO:0005829	cytosol	3.14e-05	4.52e-01	2.338	7	132	2496
GO:0000278	mitotic cell cycle	3.42e-05	4.93e-01	4.205	4	48	391
GO:0022624	proteasome accessory complex	3.65e-05	5.26e-01	7.729	2	8	17
GO:0042981	regulation of apoptotic process	5.94e-05	8.57e-01	5.172	3	24	150
GO:0034641	cellular nitrogen compound metabolic process	8.78e-05	1.00e+00	4.983	3	20	171
GO:0010467	gene expression	2.77e-04	1.00e+00	3.430	4	59	669
GO:0070062	extracellular vesicular exosome	4.35e-04	1.00e+00	2.172	6	104	2400
GO:0016020	membrane	8.83e-04	1.00e+00	2.423	5	90	1681
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.11e-03	1.00e+00	9.816	1	1	2
GO:0005055	laminin receptor activity	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006407	rRNA export from nucleus	1.11e-03	1.00e+00	9.816	1	1	2
GO:0043066	negative regulation of apoptotic process	1.27e-03	1.00e+00	3.673	3	31	424
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.22e-03	1.00e+00	8.816	1	1	4
GO:0030686	90S preribosome	2.22e-03	1.00e+00	8.816	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	2.22e-03	1.00e+00	8.816	1	1	4
GO:0019788	NEDD8 ligase activity	2.22e-03	1.00e+00	8.816	1	1	4
GO:0050805	negative regulation of synaptic transmission	2.22e-03	1.00e+00	8.816	1	1	4
GO:0006915	apoptotic process	2.75e-03	1.00e+00	3.285	3	33	555
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	2.77e-03	1.00e+00	8.494	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	2.77e-03	1.00e+00	8.494	1	1	5
GO:0043248	proteasome assembly	2.77e-03	1.00e+00	8.494	1	1	5
GO:0030891	VCB complex	2.77e-03	1.00e+00	8.494	1	2	5
GO:0000730	DNA recombinase assembly	2.77e-03	1.00e+00	8.494	1	1	5
GO:2000001	regulation of DNA damage checkpoint	2.77e-03	1.00e+00	8.494	1	1	5
GO:0030957	Tat protein binding	3.32e-03	1.00e+00	8.231	1	3	6
GO:0031466	Cul5-RING ubiquitin ligase complex	3.32e-03	1.00e+00	8.231	1	1	6
GO:0000028	ribosomal small subunit assembly	3.88e-03	1.00e+00	8.009	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	3.88e-03	1.00e+00	8.009	1	2	7
GO:0031625	ubiquitin protein ligase binding	4.04e-03	1.00e+00	4.340	2	14	178
GO:0019773	proteasome core complex, alpha-subunit complex	4.43e-03	1.00e+00	7.816	1	4	8
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	4.43e-03	1.00e+00	7.816	1	2	8
GO:0070688	MLL5-L complex	4.43e-03	1.00e+00	7.816	1	1	8
GO:0045116	protein neddylation	4.43e-03	1.00e+00	7.816	1	2	8
GO:0001973	adenosine receptor signaling pathway	4.98e-03	1.00e+00	7.646	1	1	9
GO:0010569	regulation of double-strand break repair via homologous recombination	5.53e-03	1.00e+00	7.494	1	1	10
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway	6.09e-03	1.00e+00	7.357	1	1	11
GO:0031571	mitotic G1 DNA damage checkpoint	6.09e-03	1.00e+00	7.357	1	4	11
GO:0005662	DNA replication factor A complex	7.19e-03	1.00e+00	7.116	1	1	13
GO:0030234	enzyme regulator activity	7.19e-03	1.00e+00	7.116	1	3	13
GO:0035267	NuA4 histone acetyltransferase complex	7.74e-03	1.00e+00	7.009	1	4	14
GO:0006281	DNA repair	8.50e-03	1.00e+00	3.788	2	18	261
GO:0050998	nitric-oxide synthase binding	8.84e-03	1.00e+00	6.816	1	1	16
GO:0042176	regulation of protein catabolic process	8.84e-03	1.00e+00	6.816	1	3	16
GO:0035861	site of double-strand break	9.94e-03	1.00e+00	6.646	1	1	18
GO:0005839	proteasome core complex	9.94e-03	1.00e+00	6.646	1	8	18
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.05e-02	1.00e+00	6.568	1	1	19
GO:0048863	stem cell differentiation	1.05e-02	1.00e+00	6.568	1	1	19
GO:0007214	gamma-aminobutyric acid signaling pathway	1.05e-02	1.00e+00	6.568	1	1	19
GO:0004298	threonine-type endopeptidase activity	1.05e-02	1.00e+00	6.568	1	8	19
GO:0006298	mismatch repair	1.10e-02	1.00e+00	6.494	1	3	20
GO:0005515	protein binding	1.12e-02	1.00e+00	1.067	7	184	6024
GO:0007194	negative regulation of adenylate cyclase activity	1.16e-02	1.00e+00	6.424	1	1	21
GO:0031683	G-protein beta/gamma-subunit complex binding	1.16e-02	1.00e+00	6.424	1	1	21
GO:0032201	telomere maintenance via semi-conservative replication	1.16e-02	1.00e+00	6.424	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.16e-02	1.00e+00	6.424	1	4	21
GO:0006297	nucleotide-excision repair, DNA gap filling	1.21e-02	1.00e+00	6.357	1	3	22
GO:0051924	regulation of calcium ion transport	1.21e-02	1.00e+00	6.357	1	1	22
GO:0030863	cortical cytoskeleton	1.21e-02	1.00e+00	6.357	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.21e-02	1.00e+00	6.357	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.27e-02	1.00e+00	6.293	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.27e-02	1.00e+00	6.293	1	3	23
GO:0043236	laminin binding	1.27e-02	1.00e+00	6.293	1	1	23
GO:0006513	protein monoubiquitination	1.27e-02	1.00e+00	6.293	1	1	23
GO:0000722	telomere maintenance via recombination	1.38e-02	1.00e+00	6.172	1	5	25
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.43e-02	1.00e+00	6.116	1	3	26
GO:0043022	ribosome binding	1.49e-02	1.00e+00	6.061	1	3	27
GO:0031492	nucleosomal DNA binding	1.49e-02	1.00e+00	6.061	1	4	27
GO:0019894	kinesin binding	1.54e-02	1.00e+00	6.009	1	1	28
GO:0019005	SCF ubiquitin ligase complex	1.60e-02	1.00e+00	5.958	1	1	29
GO:0006271	DNA strand elongation involved in DNA replication	1.65e-02	1.00e+00	5.909	1	7	30
GO:0001895	retina homeostasis	1.87e-02	1.00e+00	5.729	1	1	34
GO:0005834	heterotrimeric G-protein complex	1.87e-02	1.00e+00	5.729	1	1	34
GO:0034332	adherens junction organization	1.98e-02	1.00e+00	5.646	1	1	36
GO:0051084	'de novo' posttranslational protein folding	2.03e-02	1.00e+00	5.607	1	4	37
GO:0006284	base-excision repair	2.03e-02	1.00e+00	5.607	1	3	37
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	2.09e-02	1.00e+00	5.568	1	1	38
GO:0070527	platelet aggregation	2.09e-02	1.00e+00	5.568	1	2	38
GO:0001664	G-protein coupled receptor binding	2.09e-02	1.00e+00	5.568	1	1	38
GO:0022627	cytosolic small ribosomal subunit	2.14e-02	1.00e+00	5.531	1	4	39
GO:0000781	chromosome, telomeric region	2.14e-02	1.00e+00	5.531	1	3	39
GO:0044281	small molecule metabolic process	2.40e-02	1.00e+00	2.159	3	58	1211
GO:0021762	substantia nigra development	2.42e-02	1.00e+00	5.357	1	2	44
GO:0007596	blood coagulation	2.45e-02	1.00e+00	2.986	2	18	455
GO:0006283	transcription-coupled nucleotide-excision repair	2.52e-02	1.00e+00	5.293	1	7	46
GO:0044267	cellular protein metabolic process	2.65e-02	1.00e+00	2.927	2	29	474
GO:0003684	damaged DNA binding	2.69e-02	1.00e+00	5.201	1	7	49
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.90e-02	1.00e+00	5.088	1	5	53
GO:0045216	cell-cell junction organization	2.96e-02	1.00e+00	5.061	1	2	54
GO:0000186	activation of MAPKK activity	2.96e-02	1.00e+00	5.061	1	1	54
GO:0000932	cytoplasmic mRNA processing body	2.96e-02	1.00e+00	5.061	1	3	54
GO:0000724	double-strand break repair via homologous recombination	3.01e-02	1.00e+00	5.035	1	3	55
GO:0000723	telomere maintenance	3.06e-02	1.00e+00	5.009	1	6	56
GO:0019903	protein phosphatase binding	3.39e-02	1.00e+00	4.862	1	4	62
GO:0006302	double-strand break repair	3.39e-02	1.00e+00	4.862	1	4	62
GO:0006289	nucleotide-excision repair	3.71e-02	1.00e+00	4.729	1	11	68
GO:0034329	cell junction assembly	3.71e-02	1.00e+00	4.729	1	1	68
GO:0003697	single-stranded DNA binding	3.71e-02	1.00e+00	4.729	1	5	68
GO:0007584	response to nutrient	3.87e-02	1.00e+00	4.666	1	4	71
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.03e-02	1.00e+00	4.607	1	6	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.09e-02	1.00e+00	4.587	1	2	75
GO:0051301	cell division	4.41e-02	1.00e+00	4.476	1	5	81
GO:0019083	viral transcription	4.41e-02	1.00e+00	4.476	1	10	81
GO:0047485	protein N-terminus binding	4.67e-02	1.00e+00	4.390	1	5	86
GO:0006415	translational termination	4.73e-02	1.00e+00	4.373	1	10	87
GO:0016605	PML body	4.78e-02	1.00e+00	4.357	1	3	88
GO:0006928	cellular component movement	4.94e-02	1.00e+00	4.308	1	7	91
GO:0005200	structural constituent of cytoskeleton	4.94e-02	1.00e+00	4.308	1	8	91
GO:0071456	cellular response to hypoxia	4.99e-02	1.00e+00	4.293	1	6	92
GO:0006414	translational elongation	5.04e-02	1.00e+00	4.277	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	5.63e-02	1.00e+00	4.116	1	10	104
GO:0014069	postsynaptic density	5.68e-02	1.00e+00	4.102	1	3	105
GO:0030496	midbody	5.84e-02	1.00e+00	4.061	1	5	108
GO:0072562	blood microparticle	5.99e-02	1.00e+00	4.022	1	3	111
GO:0030529	ribonucleoprotein complex	6.05e-02	1.00e+00	4.009	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6.15e-02	1.00e+00	3.983	1	11	114
GO:0019058	viral life cycle	6.20e-02	1.00e+00	3.971	1	13	115
GO:0006325	chromatin organization	6.36e-02	1.00e+00	3.933	1	5	118
GO:0007219	Notch signaling pathway	6.47e-02	1.00e+00	3.909	1	5	120
GO:0006260	DNA replication	6.52e-02	1.00e+00	3.897	1	9	121
GO:0006511	ubiquitin-dependent protein catabolic process	6.78e-02	1.00e+00	3.839	1	5	126
GO:0009615	response to virus	6.78e-02	1.00e+00	3.839	1	5	126
GO:0000790	nuclear chromatin	6.94e-02	1.00e+00	3.805	1	9	129
GO:0006413	translational initiation	7.04e-02	1.00e+00	3.783	1	17	131
GO:0031982	vesicle	7.04e-02	1.00e+00	3.783	1	9	131
GO:0005634	nucleus	7.14e-02	1.00e+00	0.984	5	136	4559
GO:0003735	structural constituent of ribosome	7.35e-02	1.00e+00	3.718	1	10	137
GO:0006457	protein folding	7.66e-02	1.00e+00	3.656	1	7	143
GO:0061024	membrane organization	7.77e-02	1.00e+00	3.636	1	7	145
GO:0045121	membrane raft	8.33e-02	1.00e+00	3.531	1	8	156
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	8.80e-02	1.00e+00	3.450	1	7	165
GO:0030424	axon	8.85e-02	1.00e+00	3.441	1	4	166
GO:0007049	cell cycle	9.26e-02	1.00e+00	3.373	1	2	174
GO:0032403	protein complex binding	9.71e-02	1.00e+00	3.300	1	10	183
GO:0003924	GTPase activity	1.04e-01	1.00e+00	3.194	1	12	197
GO:0030168	platelet activation	1.08e-01	1.00e+00	3.137	1	10	205
GO:0004871	signal transducer activity	1.10e-01	1.00e+00	3.116	1	4	208
GO:0006184	GTP catabolic process	1.13e-01	1.00e+00	3.075	1	12	214
GO:0006412	translation	1.21e-01	1.00e+00	2.971	1	20	230
GO:0004842	ubiquitin-protein transferase activity	1.33e-01	1.00e+00	2.822	1	6	255
GO:0019899	enzyme binding	1.44e-01	1.00e+00	2.702	1	12	277
GO:0005856	cytoskeleton	1.50e-01	1.00e+00	2.631	1	12	291
GO:0007186	G-protein coupled receptor signaling pathway	1.50e-01	1.00e+00	2.641	1	7	289
GO:0043234	protein complex	1.52e-01	1.00e+00	2.612	1	18	295
GO:0016567	protein ubiquitination	1.52e-01	1.00e+00	2.612	1	5	295
GO:0035556	intracellular signal transduction	1.56e-01	1.00e+00	2.573	1	9	303
GO:0005525	GTP binding	1.60e-01	1.00e+00	2.540	1	12	310
GO:0019901	protein kinase binding	1.63e-01	1.00e+00	2.508	1	21	317
GO:0007411	axon guidance	1.64e-01	1.00e+00	2.499	1	13	319
GO:0005813	centrosome	1.67e-01	1.00e+00	2.467	1	14	326
GO:0008283	cell proliferation	1.68e-01	1.00e+00	2.459	1	14	328
GO:0007268	synaptic transmission	1.70e-01	1.00e+00	2.441	1	6	332
GO:0005925	focal adhesion	1.86e-01	1.00e+00	2.300	1	19	366
GO:0007155	cell adhesion	1.87e-01	1.00e+00	2.289	1	6	369
GO:0008284	positive regulation of cell proliferation	1.93e-01	1.00e+00	2.239	1	8	382
GO:0005730	nucleolus	2.29e-01	1.00e+00	1.136	2	69	1641
GO:0045087	innate immune response	2.87e-01	1.00e+00	1.597	1	24	596
GO:0005737	cytoplasm	3.49e-01	1.00e+00	0.522	3	110	3767
GO:0007165	signal transduction	4.05e-01	1.00e+00	0.991	1	24	907
GO:0005615	extracellular space	4.23e-01	1.00e+00	0.914	1	17	957
GO:0005886	plasma membrane	4.34e-01	1.00e+00	0.482	2	45	2582
GO:0008270	zinc ion binding	4.36e-01	1.00e+00	0.855	1	12	997
GO:0044822	poly(A) RNA binding	4.56e-01	1.00e+00	0.772	1	49	1056
GO:0005524	ATP binding	5.30e-01	1.00e+00	0.474	1	60	1298
GO:0046872	metal ion binding	5.32e-01	1.00e+00	0.464	1	25	1307

Wolf-ratios-Mammosphere-Adherent

int-snw-2771

Statistics

Genes (8)

Interactions (10)

Related GO terms (181)