int-snw-27343

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.950	4.14e-16	1.77e-03	3.14e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-27343 subnetwork

Genes (12)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
ACO2	50	50	1.000	1.076	191	Yes	-
PSMD13	5719	16	0.848	1.029	104	Yes	-
RBX1	9978	97	1.185	1.151	139	Yes	-
PSMA2	5683	60	1.093	1.106	89	Yes	-
[ POLL ]	27343	1	0.025	0.950	31	Yes	-
PSMD7	5713	5	0.640	0.958	133	Yes	-
PSMA1	5682	61	0.996	1.052	123	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
PSMC1	5700	14	0.840	1.018	137	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (33)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ACO2	50	PSMD7	5713	pp	--	int.I2D: YeastLow
PSMA2	5683	PSMD7	5713	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMD11	5717	POLL	27343	pp	--	int.I2D: Krogan_NonCore
PSMD7	5713	RBX1	9978	pp	--	int.I2D: YeastLow, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast
PSMD11	5717	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastHigh, BioGrid, INTEROLOG
ACO2	50	PSMC1	5700	pp	--	int.I2D: YeastLow
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
PSMA1	5682	PSMC1	5700	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct_Fly, YeastMedium, IntAct
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMA1	5682	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
PSMC1	5700	PSMD7	5713	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid, IntAct, MINT_Yeast, YeastHigh, BCI, BioGrid_Yeast, HPRD, Krogan_Core; int.HPRD: in vitro
PSMA2	5683	PSMC1	5700	pp	--	int.I2D: BioGrid_Yeast, IntAct_Fly, YeastLow
PSMD7	5713	PSMD11	5717	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastHigh, BioGrid, IntAct
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
PSMA1	5682	PSMD7	5713	pp	--	int.I2D: BioGrid_Yeast, YeastMedium, IntAct_Yeast, MINT_Yeast
PSMC1	5700	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
PSMA2	5683	PSMD13	5719	pp	--	int.I2D: YeastLow
PSMD7	5713	POLL	27343	pp	--	int.I2D: Krogan_NonCore
ACTB	60	PSMC1	5700	pp	--	int.I2D: BioGrid_Yeast
PSMC1	5700	POLL	27343	pp	--	int.I2D: BioGrid_Yeast
PSMD13	5719	POLL	27343	pp	--	int.I2D: BioGrid_Yeast, Krogan_NonCore
PSMC1	5700	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct, MINT_Yeast, YeastHigh, BioGrid, IntAct_Yeast, Krogan_Core
PSMA1	5682	PSMA2	5683	pp	--	int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh; int.HPRD: yeast 2-hybrid
PSMD7	5713	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid, BioGrid_Yeast, IntAct, IntAct_Yeast, MINT_Yeast, YeastHigh, IntAct_Fly, Krogan_Core, Tarassov_PCA
ACTB	60	PSMA1	5682	pp	--	int.I2D: BioGrid_Yeast
ACO2	50	PSMD11	5717	pp	--	int.I2D: YeastLow
ACTB	60	PSMD7	5713	pp	--	int.I2D: BioGrid_Yeast
ACO2	50	PGD	5226	pp	--	int.I2D: YeastLow
PSMA1	5682	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct, YeastMedium, BioGrid, BioGrid_Yeast, IntAct_Yeast
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD13	5719	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (158)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006521	regulation of cellular amino acid metabolic process	1.16e-12	1.67e-08	7.172	6	17	50
GO:0000502	proteasome complex	2.94e-12	4.24e-08	6.958	6	17	58
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	5.43e-12	7.84e-08	6.816	6	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.98e-12	8.63e-08	6.794	6	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	9.48e-12	1.37e-07	6.687	6	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	1.13e-11	1.63e-07	6.646	6	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.34e-11	1.93e-07	6.607	6	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	1.45e-11	2.10e-07	6.587	6	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	2.00e-11	2.89e-07	6.512	6	23	79
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	5.12e-11	7.38e-07	6.293	6	21	92
GO:0005838	proteasome regulatory particle	1.35e-10	1.95e-06	8.646	4	7	12
GO:0016071	mRNA metabolic process	1.43e-10	2.06e-06	5.238	7	31	223
GO:0000209	protein polyubiquitination	2.11e-10	3.04e-06	5.958	6	20	116
GO:0016070	RNA metabolic process	2.92e-10	4.21e-06	5.090	7	32	247
GO:0000082	G1/S transition of mitotic cell cycle	9.65e-10	1.39e-05	5.597	6	32	149
GO:0042981	regulation of apoptotic process	1.00e-09	1.45e-05	5.587	6	24	150
GO:0016032	viral process	1.46e-09	2.10e-05	4.170	8	55	534
GO:0034641	cellular nitrogen compound metabolic process	2.22e-09	3.20e-05	5.398	6	20	171
GO:0010467	gene expression	2.89e-07	4.17e-03	3.653	7	59	669
GO:0022624	proteasome accessory complex	2.97e-07	4.29e-03	7.729	3	8	17
GO:0000278	mitotic cell cycle	3.07e-07	4.44e-03	4.205	6	48	391
GO:0005654	nucleoplasm	3.69e-07	5.32e-03	3.152	8	76	1082
GO:0043066	negative regulation of apoptotic process	4.96e-07	7.15e-03	4.088	6	31	424
GO:0044281	small molecule metabolic process	8.80e-07	1.27e-02	2.989	8	58	1211
GO:0005829	cytosol	1.11e-06	1.61e-02	2.268	10	132	2496
GO:0006915	apoptotic process	2.40e-06	3.46e-02	3.700	6	33	555
GO:0019773	proteasome core complex, alpha-subunit complex	1.77e-05	2.56e-01	8.231	2	4	8
GO:0005839	proteasome core complex	9.64e-05	1.00e+00	7.061	2	8	18
GO:0004298	threonine-type endopeptidase activity	1.08e-04	1.00e+00	6.983	2	8	19
GO:0070062	extracellular vesicular exosome	1.53e-04	1.00e+00	2.002	8	104	2400
GO:0005634	nucleus	3.32e-04	1.00e+00	1.399	10	136	4559
GO:0019521	D-gluconate metabolic process	8.32e-04	1.00e+00	10.231	1	1	1
GO:0016020	membrane	1.23e-03	1.00e+00	2.101	6	90	1681
GO:0051538	3 iron, 4 sulfur cluster binding	1.66e-03	1.00e+00	9.231	1	1	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.66e-03	1.00e+00	9.231	1	1	2
GO:0019322	pentose biosynthetic process	1.66e-03	1.00e+00	9.231	1	2	2
GO:0003994	aconitate hydratase activity	1.66e-03	1.00e+00	9.231	1	1	2
GO:0005055	laminin receptor activity	1.66e-03	1.00e+00	9.231	1	1	2
GO:0006407	rRNA export from nucleus	1.66e-03	1.00e+00	9.231	1	1	2
GO:0007127	meiosis I	1.66e-03	1.00e+00	9.231	1	1	2
GO:0009051	pentose-phosphate shunt, oxidative branch	2.49e-03	1.00e+00	8.646	1	2	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	2.49e-03	1.00e+00	8.646	1	1	3
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3.32e-03	1.00e+00	8.231	1	1	4
GO:0030686	90S preribosome	3.32e-03	1.00e+00	8.231	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	3.32e-03	1.00e+00	8.231	1	1	4
GO:0019788	NEDD8 ligase activity	3.32e-03	1.00e+00	8.231	1	1	4
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	4.15e-03	1.00e+00	7.909	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	4.15e-03	1.00e+00	7.909	1	1	5
GO:0043248	proteasome assembly	4.15e-03	1.00e+00	7.909	1	1	5
GO:0006102	isocitrate metabolic process	4.15e-03	1.00e+00	7.909	1	1	5
GO:0030891	VCB complex	4.15e-03	1.00e+00	7.909	1	2	5
GO:0030957	Tat protein binding	4.98e-03	1.00e+00	7.646	1	3	6
GO:0006101	citrate metabolic process	4.98e-03	1.00e+00	7.646	1	1	6
GO:0031466	Cul5-RING ubiquitin ligase complex	4.98e-03	1.00e+00	7.646	1	1	6
GO:0000028	ribosomal small subunit assembly	5.81e-03	1.00e+00	7.424	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	5.81e-03	1.00e+00	7.424	1	2	7
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	6.64e-03	1.00e+00	7.231	1	2	8
GO:0070688	MLL5-L complex	6.64e-03	1.00e+00	7.231	1	1	8
GO:0045116	protein neddylation	6.64e-03	1.00e+00	7.231	1	2	8
GO:0016446	somatic hypermutation of immunoglobulin genes	7.47e-03	1.00e+00	7.061	1	1	9
GO:0006098	pentose-phosphate shunt	8.29e-03	1.00e+00	6.909	1	4	10
GO:0016829	lyase activity	1.08e-02	1.00e+00	6.531	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	1.16e-02	1.00e+00	6.424	1	4	14
GO:0050998	nitric-oxide synthase binding	1.32e-02	1.00e+00	6.231	1	1	16
GO:0017025	TBP-class protein binding	1.41e-02	1.00e+00	6.144	1	3	17
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.57e-02	1.00e+00	5.983	1	1	19
GO:0048863	stem cell differentiation	1.57e-02	1.00e+00	5.983	1	1	19
GO:0030863	cortical cytoskeleton	1.82e-02	1.00e+00	5.772	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.82e-02	1.00e+00	5.772	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.90e-02	1.00e+00	5.708	1	4	23
GO:0005844	polysome	1.90e-02	1.00e+00	5.708	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.90e-02	1.00e+00	5.708	1	3	23
GO:0043236	laminin binding	1.90e-02	1.00e+00	5.708	1	1	23
GO:0006513	protein monoubiquitination	1.90e-02	1.00e+00	5.708	1	1	23
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	2.14e-02	1.00e+00	5.531	1	3	26
GO:0043022	ribosome binding	2.22e-02	1.00e+00	5.476	1	3	27
GO:0050661	NADP binding	2.22e-02	1.00e+00	5.476	1	2	27
GO:0031492	nucleosomal DNA binding	2.22e-02	1.00e+00	5.476	1	4	27
GO:0006099	tricarboxylic acid cycle	2.31e-02	1.00e+00	5.424	1	4	28
GO:0003887	DNA-directed DNA polymerase activity	2.31e-02	1.00e+00	5.424	1	3	28
GO:0071897	DNA biosynthetic process	2.31e-02	1.00e+00	5.424	1	2	28
GO:0019894	kinesin binding	2.31e-02	1.00e+00	5.424	1	1	28
GO:0019005	SCF ubiquitin ligase complex	2.39e-02	1.00e+00	5.373	1	1	29
GO:0001895	retina homeostasis	2.79e-02	1.00e+00	5.144	1	1	34
GO:0051539	4 iron, 4 sulfur cluster binding	2.87e-02	1.00e+00	5.102	1	3	35
GO:0034332	adherens junction organization	2.96e-02	1.00e+00	5.061	1	1	36
GO:0051084	'de novo' posttranslational protein folding	3.04e-02	1.00e+00	5.022	1	4	37
GO:0070527	platelet aggregation	3.12e-02	1.00e+00	4.983	1	2	38
GO:0022627	cytosolic small ribosomal subunit	3.20e-02	1.00e+00	4.946	1	4	39
GO:0021762	substantia nigra development	3.60e-02	1.00e+00	4.772	1	2	44
GO:0006091	generation of precursor metabolites and energy	4.08e-02	1.00e+00	4.587	1	3	50
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	4.32e-02	1.00e+00	4.503	1	5	53
GO:0045216	cell-cell junction organization	4.40e-02	1.00e+00	4.476	1	2	54
GO:0000932	cytoplasmic mRNA processing body	4.40e-02	1.00e+00	4.476	1	3	54
GO:0006289	nucleotide-excision repair	5.52e-02	1.00e+00	4.144	1	11	68
GO:0034329	cell junction assembly	5.52e-02	1.00e+00	4.144	1	1	68
GO:0044267	cellular protein metabolic process	5.72e-02	1.00e+00	2.342	2	29	474
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.99e-02	1.00e+00	4.022	1	6	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6.07e-02	1.00e+00	4.002	1	2	75
GO:0019083	viral transcription	6.54e-02	1.00e+00	3.891	1	10	81
GO:0006415	translational termination	7.01e-02	1.00e+00	3.788	1	10	87
GO:0006928	cellular component movement	7.32e-02	1.00e+00	3.723	1	7	91
GO:0005200	structural constituent of cytoskeleton	7.32e-02	1.00e+00	3.723	1	8	91
GO:0005515	protein binding	7.35e-02	1.00e+00	0.675	8	184	6024
GO:0071456	cellular response to hypoxia	7.39e-02	1.00e+00	3.708	1	6	92
GO:0006414	translational elongation	7.47e-02	1.00e+00	3.692	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	8.32e-02	1.00e+00	3.531	1	10	104
GO:0014069	postsynaptic density	8.40e-02	1.00e+00	3.517	1	3	105
GO:0005506	iron ion binding	8.40e-02	1.00e+00	3.517	1	4	105
GO:0072562	blood microparticle	8.86e-02	1.00e+00	3.437	1	3	111
GO:0030529	ribonucleoprotein complex	8.93e-02	1.00e+00	3.424	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	9.09e-02	1.00e+00	3.398	1	11	114
GO:0019058	viral life cycle	9.16e-02	1.00e+00	3.386	1	13	115
GO:0044237	cellular metabolic process	9.32e-02	1.00e+00	3.361	1	5	117
GO:0006325	chromatin organization	9.39e-02	1.00e+00	3.348	1	5	118
GO:0007219	Notch signaling pathway	9.54e-02	1.00e+00	3.324	1	5	120
GO:0006260	DNA replication	9.62e-02	1.00e+00	3.312	1	9	121
GO:0006511	ubiquitin-dependent protein catabolic process	1.00e-01	1.00e+00	3.254	1	5	126
GO:0009615	response to virus	1.00e-01	1.00e+00	3.254	1	5	126
GO:0000790	nuclear chromatin	1.02e-01	1.00e+00	3.220	1	9	129
GO:0006413	translational initiation	1.04e-01	1.00e+00	3.198	1	17	131
GO:0003735	structural constituent of ribosome	1.08e-01	1.00e+00	3.133	1	10	137
GO:0016887	ATPase activity	1.10e-01	1.00e+00	3.102	1	7	140
GO:0006457	protein folding	1.13e-01	1.00e+00	3.071	1	7	143
GO:0061024	membrane organization	1.14e-01	1.00e+00	3.051	1	7	145
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.29e-01	1.00e+00	2.865	1	7	165
GO:0030424	axon	1.30e-01	1.00e+00	2.856	1	4	166
GO:0031625	ubiquitin protein ligase binding	1.38e-01	1.00e+00	2.755	1	14	178
GO:0032403	protein complex binding	1.42e-01	1.00e+00	2.715	1	10	183
GO:0005730	nucleolus	1.48e-01	1.00e+00	1.136	3	69	1641
GO:0005759	mitochondrial matrix	1.74e-01	1.00e+00	2.398	1	14	228
GO:0006412	translation	1.75e-01	1.00e+00	2.386	1	20	230
GO:0005975	carbohydrate metabolic process	1.91e-01	1.00e+00	2.248	1	9	253
GO:0004842	ubiquitin-protein transferase activity	1.93e-01	1.00e+00	2.237	1	6	255
GO:0006281	DNA repair	1.97e-01	1.00e+00	2.203	1	18	261
GO:0005856	cytoskeleton	2.17e-01	1.00e+00	2.046	1	12	291
GO:0044822	poly(A) RNA binding	2.18e-01	1.00e+00	1.187	2	49	1056
GO:0006200	ATP catabolic process	2.18e-01	1.00e+00	2.041	1	15	292
GO:0043234	protein complex	2.20e-01	1.00e+00	2.027	1	18	295
GO:0016567	protein ubiquitination	2.20e-01	1.00e+00	2.027	1	5	295
GO:0019901	protein kinase binding	2.34e-01	1.00e+00	1.923	1	21	317
GO:0007411	axon guidance	2.35e-01	1.00e+00	1.914	1	13	319
GO:0005813	centrosome	2.40e-01	1.00e+00	1.882	1	14	326
GO:0003723	RNA binding	2.50e-01	1.00e+00	1.813	1	20	342
GO:0005925	focal adhesion	2.65e-01	1.00e+00	1.715	1	19	366
GO:0007155	cell adhesion	2.67e-01	1.00e+00	1.704	1	6	369
GO:0005524	ATP binding	2.95e-01	1.00e+00	0.889	2	60	1298
GO:0055114	oxidation-reduction process	2.99e-01	1.00e+00	1.517	1	12	420
GO:0007596	blood coagulation	3.19e-01	1.00e+00	1.401	1	18	455
GO:0042803	protein homodimerization activity	3.97e-01	1.00e+00	1.014	1	12	595
GO:0045087	innate immune response	3.97e-01	1.00e+00	1.012	1	24	596
GO:0005615	extracellular space	5.61e-01	1.00e+00	0.329	1	17	957
GO:0005739	mitochondrion	5.77e-01	1.00e+00	0.268	1	28	998
GO:0008270	zinc ion binding	5.77e-01	1.00e+00	0.270	1	12	997
GO:0005737	cytoplasm	6.43e-01	1.00e+00	-0.063	3	110	3767
GO:0003677	DNA binding	6.53e-01	1.00e+00	-0.019	1	28	1218
GO:0046872	metal ion binding	6.80e-01	1.00e+00	-0.121	1	25	1307
GO:0005886	plasma membrane	9.06e-01	1.00e+00	-1.103	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-27343

Statistics

Genes (12)

Interactions (33)

Related GO terms (158)