int-snw-2539

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	1.022	4.59e-19	3.19e-04	8.59e-03

wolf-screen-ratio-mammosphere-adherent-int-snw-2539 subnetwork

Genes (6)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
ACTB	60	167	1.153	1.151	587	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
RBX1	9978	97	1.185	1.151	139	Yes	-
[ G6PD ]	2539	1	-0.172	1.022	27	-	-
RPSA	3921	156	1.327	1.151	152	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (7)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
G6PD	2539	PGD	5226	pp	--	int.I2D: YeastMedium
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
G6PD	2539	RBX1	9978	pp	--	int.I2D: IntAct_Yeast
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (144)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0019322	pentose biosynthetic process	1.44e-07	2.08e-03	11.231	2	2	2
GO:0009051	pentose-phosphate shunt, oxidative branch	4.33e-07	6.24e-03	10.646	2	2	3
GO:0006098	pentose-phosphate shunt	6.48e-06	9.35e-02	8.909	2	4	10
GO:0005829	cytosol	2.67e-05	3.86e-01	2.531	6	132	2496
GO:0050661	NADP binding	5.04e-05	7.27e-01	7.476	2	2	27
GO:0021762	substantia nigra development	1.35e-04	1.00e+00	6.772	2	2	44
GO:0046390	ribose phosphate biosynthetic process	4.16e-04	1.00e+00	11.231	1	1	1
GO:0004345	glucose-6-phosphate dehydrogenase activity	4.16e-04	1.00e+00	11.231	1	1	1
GO:0010734	negative regulation of protein glutathionylation	4.16e-04	1.00e+00	11.231	1	1	1
GO:0019521	D-gluconate metabolic process	4.16e-04	1.00e+00	11.231	1	1	1
GO:0070062	extracellular vesicular exosome	6.57e-04	1.00e+00	2.324	5	104	2400
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	8.32e-04	1.00e+00	10.231	1	1	2
GO:0005055	laminin receptor activity	8.32e-04	1.00e+00	10.231	1	1	2
GO:0006740	NADPH regeneration	8.32e-04	1.00e+00	10.231	1	1	2
GO:0006407	rRNA export from nucleus	8.32e-04	1.00e+00	10.231	1	1	2
GO:0016032	viral process	9.28e-04	1.00e+00	3.755	3	55	534
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	1.25e-03	1.00e+00	9.646	1	1	3
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.66e-03	1.00e+00	9.231	1	1	4
GO:0030686	90S preribosome	1.66e-03	1.00e+00	9.231	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	1.66e-03	1.00e+00	9.231	1	1	4
GO:0019788	NEDD8 ligase activity	1.66e-03	1.00e+00	9.231	1	1	4
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	2.08e-03	1.00e+00	8.909	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	2.08e-03	1.00e+00	8.909	1	1	5
GO:0043248	proteasome assembly	2.08e-03	1.00e+00	8.909	1	1	5
GO:0030891	VCB complex	2.08e-03	1.00e+00	8.909	1	2	5
GO:0016020	membrane	2.27e-03	1.00e+00	2.516	4	90	1681
GO:0030957	Tat protein binding	2.49e-03	1.00e+00	8.646	1	3	6
GO:0006739	NADP metabolic process	2.49e-03	1.00e+00	8.646	1	1	6
GO:0031466	Cul5-RING ubiquitin ligase complex	2.49e-03	1.00e+00	8.646	1	1	6
GO:0051156	glucose 6-phosphate metabolic process	2.91e-03	1.00e+00	8.424	1	1	7
GO:0000028	ribosomal small subunit assembly	2.91e-03	1.00e+00	8.424	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	2.91e-03	1.00e+00	8.424	1	2	7
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	3.32e-03	1.00e+00	8.231	1	2	8
GO:0005536	glucose binding	3.32e-03	1.00e+00	8.231	1	1	8
GO:0070688	MLL5-L complex	3.32e-03	1.00e+00	8.231	1	1	8
GO:0045116	protein neddylation	3.32e-03	1.00e+00	8.231	1	2	8
GO:0016071	mRNA metabolic process	3.43e-03	1.00e+00	4.430	2	31	223
GO:0016070	RNA metabolic process	4.19e-03	1.00e+00	4.283	2	32	247
GO:0005975	carbohydrate metabolic process	4.39e-03	1.00e+00	4.248	2	9	253
GO:0043249	erythrocyte maturation	4.57e-03	1.00e+00	7.772	1	1	11
GO:0005838	proteasome regulatory particle	4.98e-03	1.00e+00	7.646	1	7	12
GO:0035267	NuA4 histone acetyltransferase complex	5.81e-03	1.00e+00	7.424	1	4	14
GO:0032094	response to food	6.22e-03	1.00e+00	7.324	1	1	15
GO:0050998	nitric-oxide synthase binding	6.64e-03	1.00e+00	7.231	1	1	16
GO:0022624	proteasome accessory complex	7.05e-03	1.00e+00	7.144	1	8	17
GO:0005654	nucleoplasm	7.09e-03	1.00e+00	2.737	3	76	1082
GO:0043523	regulation of neuron apoptotic process	7.47e-03	1.00e+00	7.061	1	1	18
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7.88e-03	1.00e+00	6.983	1	1	19
GO:0048863	stem cell differentiation	7.88e-03	1.00e+00	6.983	1	1	19
GO:0030863	cortical cytoskeleton	9.12e-03	1.00e+00	6.772	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	9.12e-03	1.00e+00	6.772	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	9.53e-03	1.00e+00	6.708	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	9.53e-03	1.00e+00	6.708	1	3	23
GO:0043236	laminin binding	9.53e-03	1.00e+00	6.708	1	1	23
GO:0006513	protein monoubiquitination	9.53e-03	1.00e+00	6.708	1	1	23
GO:0044281	small molecule metabolic process	9.73e-03	1.00e+00	2.574	3	58	1211
GO:0001816	cytokine production	1.04e-02	1.00e+00	6.587	1	3	25
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.08e-02	1.00e+00	6.531	1	3	26
GO:0043022	ribosome binding	1.12e-02	1.00e+00	6.476	1	3	27
GO:0006749	glutathione metabolic process	1.12e-02	1.00e+00	6.476	1	2	27
GO:0031492	nucleosomal DNA binding	1.12e-02	1.00e+00	6.476	1	4	27
GO:0019894	kinesin binding	1.16e-02	1.00e+00	6.424	1	1	28
GO:0055114	oxidation-reduction process	1.17e-02	1.00e+00	3.517	2	12	420
GO:0019005	SCF ubiquitin ligase complex	1.20e-02	1.00e+00	6.373	1	1	29
GO:0034599	cellular response to oxidative stress	1.37e-02	1.00e+00	6.187	1	2	33
GO:0001895	retina homeostasis	1.41e-02	1.00e+00	6.144	1	1	34
GO:0006695	cholesterol biosynthetic process	1.41e-02	1.00e+00	6.144	1	4	34
GO:0044267	cellular protein metabolic process	1.48e-02	1.00e+00	3.342	2	29	474
GO:0034332	adherens junction organization	1.49e-02	1.00e+00	6.061	1	1	36
GO:0051084	'de novo' posttranslational protein folding	1.53e-02	1.00e+00	6.022	1	4	37
GO:0070527	platelet aggregation	1.57e-02	1.00e+00	5.983	1	2	38
GO:0022627	cytosolic small ribosomal subunit	1.61e-02	1.00e+00	5.946	1	4	39
GO:0009898	cytoplasmic side of plasma membrane	1.69e-02	1.00e+00	5.874	1	1	41
GO:0014070	response to organic cyclic compound	1.78e-02	1.00e+00	5.805	1	4	43
GO:0006521	regulation of cellular amino acid metabolic process	2.06e-02	1.00e+00	5.587	1	17	50
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.19e-02	1.00e+00	5.503	1	5	53
GO:0045216	cell-cell junction organization	2.23e-02	1.00e+00	5.476	1	2	54
GO:0000502	proteasome complex	2.39e-02	1.00e+00	5.373	1	17	58
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	2.63e-02	1.00e+00	5.231	1	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.67e-02	1.00e+00	5.209	1	22	65
GO:0034329	cell junction assembly	2.80e-02	1.00e+00	5.144	1	1	68
GO:0010467	gene expression	2.85e-02	1.00e+00	2.845	2	59	669
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.88e-02	1.00e+00	5.102	1	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	2.96e-02	1.00e+00	5.061	1	20	72
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	3.04e-02	1.00e+00	5.022	1	6	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.04e-02	1.00e+00	5.022	1	22	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	3.08e-02	1.00e+00	5.002	1	2	75
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	3.08e-02	1.00e+00	5.002	1	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	3.24e-02	1.00e+00	4.927	1	23	79
GO:0019083	viral transcription	3.32e-02	1.00e+00	4.891	1	10	81
GO:0045471	response to ethanol	3.53e-02	1.00e+00	4.805	1	3	86
GO:0006415	translational termination	3.57e-02	1.00e+00	4.788	1	10	87
GO:0006629	lipid metabolic process	3.69e-02	1.00e+00	4.739	1	5	90
GO:0006928	cellular component movement	3.73e-02	1.00e+00	4.723	1	7	91
GO:0005200	structural constituent of cytoskeleton	3.73e-02	1.00e+00	4.723	1	8	91
GO:0071456	cellular response to hypoxia	3.77e-02	1.00e+00	4.708	1	6	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	3.77e-02	1.00e+00	4.708	1	21	92
GO:0006414	translational elongation	3.81e-02	1.00e+00	4.692	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	4.25e-02	1.00e+00	4.531	1	10	104
GO:0014069	postsynaptic density	4.29e-02	1.00e+00	4.517	1	3	105
GO:0072562	blood microparticle	4.53e-02	1.00e+00	4.437	1	3	111
GO:0030529	ribonucleoprotein complex	4.57e-02	1.00e+00	4.424	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	4.65e-02	1.00e+00	4.398	1	11	114
GO:0019058	viral life cycle	4.69e-02	1.00e+00	4.386	1	13	115
GO:0000209	protein polyubiquitination	4.73e-02	1.00e+00	4.373	1	20	116
GO:0006325	chromatin organization	4.81e-02	1.00e+00	4.348	1	5	118
GO:0007219	Notch signaling pathway	4.89e-02	1.00e+00	4.324	1	5	120
GO:0005515	protein binding	4.97e-02	1.00e+00	0.997	5	184	6024
GO:0006511	ubiquitin-dependent protein catabolic process	5.13e-02	1.00e+00	4.254	1	5	126
GO:0000790	nuclear chromatin	5.25e-02	1.00e+00	4.220	1	9	129
GO:0006413	translational initiation	5.33e-02	1.00e+00	4.198	1	17	131
GO:0003735	structural constituent of ribosome	5.57e-02	1.00e+00	4.133	1	10	137
GO:0006457	protein folding	5.80e-02	1.00e+00	4.071	1	7	143
GO:0061024	membrane organization	5.88e-02	1.00e+00	4.051	1	7	145
GO:0000082	G1/S transition of mitotic cell cycle	6.04e-02	1.00e+00	4.012	1	32	149
GO:0042981	regulation of apoptotic process	6.08e-02	1.00e+00	4.002	1	24	150
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	6.67e-02	1.00e+00	3.865	1	7	165
GO:0030424	axon	6.71e-02	1.00e+00	3.856	1	4	166
GO:0034641	cellular nitrogen compound metabolic process	6.91e-02	1.00e+00	3.813	1	20	171
GO:0031625	ubiquitin protein ligase binding	7.18e-02	1.00e+00	3.755	1	14	178
GO:0032403	protein complex binding	7.38e-02	1.00e+00	3.715	1	10	183
GO:0005634	nucleus	8.39e-02	1.00e+00	1.077	4	136	4559
GO:0006412	translation	9.20e-02	1.00e+00	3.386	1	20	230
GO:0004842	ubiquitin-protein transferase activity	1.02e-01	1.00e+00	3.237	1	6	255
GO:0006281	DNA repair	1.04e-01	1.00e+00	3.203	1	18	261
GO:0005856	cytoskeleton	1.15e-01	1.00e+00	3.046	1	12	291
GO:0043234	protein complex	1.17e-01	1.00e+00	3.027	1	18	295
GO:0016567	protein ubiquitination	1.17e-01	1.00e+00	3.027	1	5	295
GO:0019901	protein kinase binding	1.25e-01	1.00e+00	2.923	1	21	317
GO:0007411	axon guidance	1.26e-01	1.00e+00	2.914	1	13	319
GO:0005925	focal adhesion	1.43e-01	1.00e+00	2.715	1	19	366
GO:0007155	cell adhesion	1.44e-01	1.00e+00	2.704	1	6	369
GO:0000278	mitotic cell cycle	1.52e-01	1.00e+00	2.620	1	48	391
GO:0043066	negative regulation of apoptotic process	1.64e-01	1.00e+00	2.503	1	31	424
GO:0007596	blood coagulation	1.75e-01	1.00e+00	2.401	1	18	455
GO:0005737	cytoplasm	1.87e-01	1.00e+00	0.937	3	110	3767
GO:0006915	apoptotic process	2.10e-01	1.00e+00	2.115	1	33	555
GO:0042803	protein homodimerization activity	2.23e-01	1.00e+00	2.014	1	12	595
GO:0045087	innate immune response	2.24e-01	1.00e+00	2.012	1	24	596
GO:0005615	extracellular space	3.38e-01	1.00e+00	1.329	1	17	957
GO:0008270	zinc ion binding	3.49e-01	1.00e+00	1.270	1	12	997
GO:0044822	poly(A) RNA binding	3.66e-01	1.00e+00	1.187	1	49	1056
GO:0005524	ATP binding	4.32e-01	1.00e+00	0.889	1	60	1298
GO:0005886	plasma membrane	6.94e-01	1.00e+00	-0.103	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-2539

Statistics

Genes (6)

Interactions (7)

Related GO terms (144)