int-snw-2357

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.979 2.87e-17 9.10e-04 1.92e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-2357 subnetwork

Genes (12)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
PSMD1 5707 120.8361.057113Yes-
RBX1 9978 971.1851.151139Yes-
PSMA2 5683 601.0931.10689Yes-
PSMD3 5709 570.9861.106146Yes-
[ FPR1 ] 2357 1-0.3320.9797-Yes
PSMB7 5695 480.9821.05257Yes-
PSMA1 5682 610.9961.052123Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
GNAI2 2771 3-0.5161.05798-Yes
RPSA 3921 1561.3271.151152Yes-

Interactions (26)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PSMD1 5707 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, Krogan_Core
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
GNAI2 2771 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
FPR1 2357 GNAI2 2771 pp -- int.I2D: HPRD;
int.HPRD: in vivo
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMA2 5683 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
PSMD1 5707 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast
ACTB 60 GNAI2 2771 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
PSMA1 5682 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD1 5707 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct

Related GO terms (194)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0006521regulation of cellular amino acid metabolic process1.16e-121.67e-087.17261750
GO:0000502proteasome complex2.94e-124.24e-086.95861758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest5.43e-127.84e-086.81661964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.98e-128.63e-086.79462265
GO:0000082G1/S transition of mitotic cell cycle8.27e-121.19e-075.819732149
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle9.48e-121.37e-076.68762270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent1.13e-111.63e-076.64662072
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.34e-111.93e-076.60762274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I1.45e-112.10e-076.58762075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process2.00e-112.89e-076.51262379
GO:0002474antigen processing and presentation of peptide antigen via MHC class I5.12e-117.38e-076.29362192
GO:0016071mRNA metabolic process1.43e-102.06e-065.238731223
GO:0000209protein polyubiquitination2.11e-103.04e-065.958620116
GO:0016070RNA metabolic process2.92e-104.21e-065.090732247
GO:0042981regulation of apoptotic process1.00e-091.45e-055.587624150
GO:0016032viral process1.46e-092.10e-054.170855534
GO:0034641cellular nitrogen compound metabolic process2.22e-093.20e-055.398620171
GO:0000278mitotic cell cycle7.19e-091.04e-044.427748391
GO:0005654nucleoplasm1.30e-081.88e-043.3229761082
GO:0005838proteasome regulatory particle9.64e-081.39e-038.2313712
GO:0010467gene expression2.89e-074.17e-033.653759669
GO:0022624proteasome accessory complex2.97e-074.29e-037.7293817
GO:0005839proteasome core complex3.57e-075.14e-037.6463818
GO:0004298threonine-type endopeptidase activity4.23e-076.10e-037.5683819
GO:0043066negative regulation of apoptotic process4.96e-077.15e-034.088631424
GO:0005829cytosol1.11e-061.61e-022.268101322496
GO:0006915apoptotic process2.40e-063.46e-023.700633555
GO:0070062extracellular vesicular exosome1.31e-051.89e-012.17291042400
GO:0019773proteasome core complex, alpha-subunit complex1.77e-052.56e-018.231248
GO:0030234enzyme regulator activity4.92e-057.10e-017.5312313
GO:0042176regulation of protein catabolic process7.57e-051.00e+007.2312316
GO:0044281small molecule metabolic process2.05e-041.00e+002.5746581211
GO:0016020membrane1.23e-031.00e+002.1016901681
GO:0004982N-formyl peptide receptor activity1.66e-031.00e+009.231112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.66e-031.00e+009.231112
GO:0005055laminin receptor activity1.66e-031.00e+009.231112
GO:0006407rRNA export from nucleus1.66e-031.00e+009.231112
GO:0006928cellular component movement2.49e-031.00e+004.7232791
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.32e-031.00e+008.231114
GO:003068690S preribosome3.32e-031.00e+008.231114
GO:0031467Cul7-RING ubiquitin ligase complex3.32e-031.00e+008.231114
GO:0019788NEDD8 ligase activity3.32e-031.00e+008.231114
GO:0050805negative regulation of synaptic transmission3.32e-031.00e+008.231114
GO:0005515protein binding4.10e-031.00e+000.997101846024
GO:0031465Cul4B-RING E3 ubiquitin ligase complex4.15e-031.00e+007.909135
GO:0031461cullin-RING ubiquitin ligase complex4.15e-031.00e+007.909115
GO:0043248proteasome assembly4.15e-031.00e+007.909115
GO:0030891VCB complex4.15e-031.00e+007.909125
GO:0000730DNA recombinase assembly4.15e-031.00e+007.909115
GO:2000001regulation of DNA damage checkpoint4.15e-031.00e+007.909115
GO:0030957Tat protein binding4.98e-031.00e+007.646136
GO:0031466Cul5-RING ubiquitin ligase complex4.98e-031.00e+007.646116
GO:0000028ribosomal small subunit assembly5.81e-031.00e+007.424117
GO:0031462Cul2-RING ubiquitin ligase complex5.81e-031.00e+007.424127
GO:0031464Cul4A-RING E3 ubiquitin ligase complex6.64e-031.00e+007.231128
GO:0070688MLL5-L complex6.64e-031.00e+007.231118
GO:0045116protein neddylation6.64e-031.00e+007.231128
GO:0001973adenosine receptor signaling pathway7.47e-031.00e+007.061119
GO:0005730nucleolus7.54e-031.00e+001.8735691641
GO:0010569regulation of double-strand break repair via homologous recombination8.29e-031.00e+006.9091110
GO:0007213G-protein coupled acetylcholine receptor signaling pathway9.12e-031.00e+006.7721111
GO:0031571mitotic G1 DNA damage checkpoint9.12e-031.00e+006.7721411
GO:0050786RAGE receptor binding9.12e-031.00e+006.7721111
GO:0031625ubiquitin protein ligase binding9.22e-031.00e+003.755214178
GO:0005662DNA replication factor A complex1.08e-021.00e+006.5311113
GO:0035267NuA4 histone acetyltransferase complex1.16e-021.00e+006.4241414
GO:0050998nitric-oxide synthase binding1.32e-021.00e+006.2311116
GO:0005634nucleus1.33e-021.00e+001.07781364559
GO:0007263nitric oxide mediated signal transduction1.41e-021.00e+006.1441117
GO:0035861site of double-strand break1.49e-021.00e+006.0611118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.57e-021.00e+005.9831119
GO:0048863stem cell differentiation1.57e-021.00e+005.9831119
GO:0007214gamma-aminobutyric acid signaling pathway1.57e-021.00e+005.9831119
GO:0006298mismatch repair1.65e-021.00e+005.9091320
GO:0007194negative regulation of adenylate cyclase activity1.73e-021.00e+005.8391121
GO:0031683G-protein beta/gamma-subunit complex binding1.73e-021.00e+005.8391121
GO:0032201telomere maintenance via semi-conservative replication1.73e-021.00e+005.8391521
GO:0000718nucleotide-excision repair, DNA damage removal1.73e-021.00e+005.8391421
GO:0006297nucleotide-excision repair, DNA gap filling1.82e-021.00e+005.7721322
GO:0051924regulation of calcium ion transport1.82e-021.00e+005.7721122
GO:0030863cortical cytoskeleton1.82e-021.00e+005.7721122
GO:0036464cytoplasmic ribonucleoprotein granule1.82e-021.00e+005.7721422
GO:0043044ATP-dependent chromatin remodeling1.90e-021.00e+005.7081423
GO:0005844polysome1.90e-021.00e+005.7081423
GO:0031463Cul3-RING ubiquitin ligase complex1.90e-021.00e+005.7081323
GO:0043236laminin binding1.90e-021.00e+005.7081123
GO:0006513protein monoubiquitination1.90e-021.00e+005.7081123
GO:0006281DNA repair1.91e-021.00e+003.203218261
GO:0000722telomere maintenance via recombination2.06e-021.00e+005.5871525
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.14e-021.00e+005.5311326
GO:0043022ribosome binding2.22e-021.00e+005.4761327
GO:0031492nucleosomal DNA binding2.22e-021.00e+005.4761427
GO:0007186G-protein coupled receptor signaling pathway2.31e-021.00e+003.05627289
GO:0019894kinesin binding2.31e-021.00e+005.4241128
GO:0019005SCF ubiquitin ligase complex2.39e-021.00e+005.3731129
GO:0006271DNA strand elongation involved in DNA replication2.47e-021.00e+005.3241730
GO:0001895retina homeostasis2.79e-021.00e+005.1441134
GO:0005834heterotrimeric G-protein complex2.79e-021.00e+005.1441134
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway2.79e-021.00e+005.1441134
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway2.87e-021.00e+005.1021135
GO:0005813centrosome2.89e-021.00e+002.882214326
GO:0034332adherens junction organization2.96e-021.00e+005.0611136
GO:0051084'de novo' posttranslational protein folding3.04e-021.00e+005.0221437
GO:0006284base-excision repair3.04e-021.00e+005.0221337
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway3.12e-021.00e+004.9831138
GO:0070527platelet aggregation3.12e-021.00e+004.9831238
GO:0001664G-protein coupled receptor binding3.12e-021.00e+004.9831138
GO:0022627cytosolic small ribosomal subunit3.20e-021.00e+004.9461439
GO:0000781chromosome, telomeric region3.20e-021.00e+004.9461339
GO:0021762substantia nigra development3.60e-021.00e+004.7721244
GO:0006283transcription-coupled nucleotide-excision repair3.76e-021.00e+004.7081746
GO:0003684damaged DNA binding4.00e-021.00e+004.6161749
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.32e-021.00e+004.5031553
GO:0045216cell-cell junction organization4.40e-021.00e+004.4761254
GO:0000186activation of MAPKK activity4.40e-021.00e+004.4761154
GO:0000932cytoplasmic mRNA processing body4.40e-021.00e+004.4761354
GO:0000724double-strand break repair via homologous recombination4.48e-021.00e+004.4501355
GO:0000723telomere maintenance4.56e-021.00e+004.4241656
GO:0019903protein phosphatase binding5.04e-021.00e+004.2771462
GO:0006302double-strand break repair5.04e-021.00e+004.2771462
GO:0007596blood coagulation5.32e-021.00e+002.401218455
GO:0006289nucleotide-excision repair5.52e-021.00e+004.14411168
GO:0034329cell junction assembly5.52e-021.00e+004.1441168
GO:0003697single-stranded DNA binding5.52e-021.00e+004.1441568
GO:0044267cellular protein metabolic process5.72e-021.00e+002.342229474
GO:0007584response to nutrient5.75e-021.00e+004.0811471
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis5.99e-021.00e+004.0221674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.07e-021.00e+004.0021275
GO:0051301cell division6.54e-021.00e+003.8911581
GO:0019083viral transcription6.54e-021.00e+003.89111081
GO:0047485protein N-terminus binding6.93e-021.00e+003.8051586
GO:0006415translational termination7.01e-021.00e+003.78811087
GO:0016605PML body7.08e-021.00e+003.7721388
GO:0000187activation of MAPK activity7.24e-021.00e+003.7391590
GO:0005200structural constituent of cytoskeleton7.32e-021.00e+003.7231891
GO:0071456cellular response to hypoxia7.39e-021.00e+003.7081692
GO:0006414translational elongation7.47e-021.00e+003.69211393
GO:0006614SRP-dependent cotranslational protein targeting to membrane8.32e-021.00e+003.531110104
GO:0014069postsynaptic density8.40e-021.00e+003.51713105
GO:0006935chemotaxis8.40e-021.00e+003.51713105
GO:0030496midbody8.63e-021.00e+003.47615108
GO:0015630microtubule cytoskeleton8.78e-021.00e+003.45014110
GO:0072562blood microparticle8.86e-021.00e+003.43713111
GO:0030529ribonucleoprotein complex8.93e-021.00e+003.42418112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay9.09e-021.00e+003.398111114
GO:0019058viral life cycle9.16e-021.00e+003.386113115
GO:0006325chromatin organization9.39e-021.00e+003.34815118
GO:0007219Notch signaling pathway9.54e-021.00e+003.32415120
GO:0006260DNA replication9.62e-021.00e+003.31219121
GO:0006511ubiquitin-dependent protein catabolic process1.00e-011.00e+003.25415126
GO:0009615response to virus1.00e-011.00e+003.25415126
GO:0000790nuclear chromatin1.02e-011.00e+003.22019129
GO:0006413translational initiation1.04e-011.00e+003.198117131
GO:0031982vesicle1.04e-011.00e+003.19819131
GO:0003735structural constituent of ribosome1.08e-011.00e+003.133110137
GO:0006457protein folding1.13e-011.00e+003.07117143
GO:0061024membrane organization1.14e-011.00e+003.05117145
GO:0045121membrane raft1.22e-011.00e+002.94618156
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.29e-011.00e+002.86517165
GO:0030424axon1.30e-011.00e+002.85614166
GO:0005768endosome1.32e-011.00e+002.83016169
GO:0007049cell cycle1.36e-011.00e+002.78812174
GO:0032403protein complex binding1.42e-011.00e+002.715110183
GO:0004872receptor activity1.46e-011.00e+002.66912189
GO:0003924GTPase activity1.52e-011.00e+002.609112197
GO:0030168platelet activation1.58e-011.00e+002.552110205
GO:0004871signal transducer activity1.60e-011.00e+002.53114208
GO:0006184GTP catabolic process1.64e-011.00e+002.490112214
GO:0007165signal transduction1.72e-011.00e+001.406224907
GO:0006412translation1.75e-011.00e+002.386120230
GO:0004842ubiquitin-protein transferase activity1.93e-011.00e+002.23716255
GO:0019899enzyme binding2.08e-011.00e+002.117112277
GO:0005856cytoskeleton2.17e-011.00e+002.046112291
GO:0043234protein complex2.20e-011.00e+002.027118295
GO:0016567protein ubiquitination2.20e-011.00e+002.02715295
GO:0035556intracellular signal transduction2.25e-011.00e+001.98819303
GO:0005525GTP binding2.30e-011.00e+001.955112310
GO:0019901protein kinase binding2.34e-011.00e+001.923121317
GO:0007411axon guidance2.35e-011.00e+001.914113319
GO:0008283cell proliferation2.41e-011.00e+001.874114328
GO:0007268synaptic transmission2.44e-011.00e+001.85616332
GO:0003723RNA binding2.50e-011.00e+001.813120342
GO:0005925focal adhesion2.65e-011.00e+001.715119366
GO:0007155cell adhesion2.67e-011.00e+001.70416369
GO:0008284positive regulation of cell proliferation2.75e-011.00e+001.65418382
GO:0005886plasma membrane3.67e-011.00e+000.4823452582
GO:0005737cytoplasm3.86e-011.00e+000.35241103767
GO:0045087innate immune response3.97e-011.00e+001.012124596
GO:0005615extracellular space5.61e-011.00e+000.329117957
GO:0008270zinc ion binding5.77e-011.00e+000.270112997
GO:0044822poly(A) RNA binding5.99e-011.00e+000.1871491056
GO:0005524ATP binding6.78e-011.00e+00-0.1111601298
GO:0046872metal ion binding6.80e-011.00e+00-0.1211251307
GO:0016021integral component of membrane8.30e-011.00e+00-0.7221271982