int-snw-23192

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.993 7.89e-18 6.58e-04 1.50e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-23192 subnetwork

Genes (13)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
RSL24D1 51187 361.3001.02059Yes-
EEF2 1938 270.8901.043301Yes-
RBX1 9978 971.1851.151139Yes-
CLTC 1213 350.8841.138247Yes-
RPL14 9045 421.2501.113143Yes-
TUBA1C 84790 30.9660.99391Yes-
ACTB 60 1671.1531.151587Yes-
[ ATG4B ] 23192 1-0.1100.993159-Yes
CFL1 1072 120.6741.020203Yes-
RPSA 3921 1561.3271.151152Yes-
RPL11 6135 90.7181.017200Yes-
PGD 5226 751.2011.106138Yes-

Interactions (17)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ATG4B 23192 TUBA1C 84790 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
EEF2 1938 PGD 5226 pp -- int.I2D: BioGrid_Yeast
CFL1 1072 ATG4B 23192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
ACTB 60 ATG4B 23192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
ACTB 60 CLTC 1213 pp -- int.I2D: IntAct_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
EEF2 1938 ATG4B 23192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
CLTC 1213 ATG4B 23192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
CFL1 1072 RSL24D1 51187 pp -- int.I2D: YeastLow
RPL11 6135 ATG4B 23192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
ACTB 60 CFL1 1072 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, MINT_Yeast, MIPS, BioGrid, BIND_Yeast, HPRD, IntAct, IntAct_Yeast, MINT, VidalHuman_core, YeastLow, Yu_GoldStd;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
RPL11 6135 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 EEF2 1938 pp -- int.I2D: YeastLow, IntAct_Yeast
CFL1 1072 PGD 5226 pp -- int.I2D: YeastLow
ACTB 60 RPL11 6135 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct

Related GO terms (209)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0006414translational elongation1.11e-061.60e-025.57641393
GO:0044267cellular protein metabolic process1.72e-062.48e-023.812629474
GO:0006412translation4.02e-055.80e-014.270420230
GO:0019083viral transcription4.69e-056.76e-015.36131081
GO:0006415translational termination5.80e-058.37e-015.25831087
GO:0042273ribosomal large subunit biogenesis5.82e-058.39e-017.4152413
GO:0006614SRP-dependent cotranslational protein targeting to membrane9.88e-051.00e+005.000310104
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.30e-041.00e+004.868311114
GO:0019058viral life cycle1.33e-041.00e+004.855313115
GO:0006413translational initiation1.96e-041.00e+004.667317131
GO:0031982vesicle1.96e-041.00e+004.66739131
GO:0003735structural constituent of ribosome2.24e-041.00e+004.603310137
GO:0016020membrane2.61e-041.00e+002.2087901681
GO:0070062extracellular vesicular exosome3.39e-041.00e+001.88781042400
GO:0005829cytosol4.48e-041.00e+001.83081322496
GO:0051084'de novo' posttranslational protein folding4.91e-041.00e+005.9062437
GO:0022625cytosolic large ribosomal subunit8.61e-041.00e+005.5012649
GO:0019521D-gluconate metabolic process9.01e-041.00e+0010.116111
GO:0016071mRNA metabolic process9.30e-041.00e+003.900331223
GO:0016032viral process1.02e-031.00e+003.055455534
GO:0016070RNA metabolic process1.25e-031.00e+003.752332247
GO:0044822poly(A) RNA binding1.63e-031.00e+002.3935491056
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.80e-031.00e+009.116112
GO:0019322pentose biosynthetic process1.80e-031.00e+009.116122
GO:0005055laminin receptor activity1.80e-031.00e+009.116112
GO:0006407rRNA export from nucleus1.80e-031.00e+009.116112
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis1.95e-031.00e+004.9062674
GO:0005515protein binding2.00e-031.00e+001.019111846024
GO:0010467gene expression2.34e-031.00e+002.730459669
GO:0019901protein kinase binding2.55e-031.00e+003.392321317
GO:0001842neural fold formation2.70e-031.00e+008.531113
GO:1900126negative regulation of hyaluronan biosynthetic process2.70e-031.00e+008.531123
GO:0009051pentose-phosphate shunt, oxidative branch2.70e-031.00e+008.531123
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.70e-031.00e+008.531113
GO:0071439clathrin complex2.70e-031.00e+008.531123
GO:0005200structural constituent of cytoskeleton2.94e-031.00e+004.6082891
GO:0006364rRNA processing3.13e-031.00e+004.5612694
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.60e-031.00e+008.116114
GO:003068690S preribosome3.60e-031.00e+008.116114
GO:0032051clathrin light chain binding3.60e-031.00e+008.116114
GO:0031467Cul7-RING ubiquitin ligase complex3.60e-031.00e+008.116114
GO:0019788NEDD8 ligase activity3.60e-031.00e+008.116114
GO:1903077negative regulation of protein localization to plasma membrane3.60e-031.00e+008.116114
GO:0005925focal adhesion3.84e-031.00e+003.185319366
GO:0030529ribonucleoprotein complex4.41e-031.00e+004.30828112
GO:0031465Cul4B-RING E3 ubiquitin ligase complex4.50e-031.00e+007.794135
GO:0031461cullin-RING ubiquitin ligase complex4.50e-031.00e+007.794115
GO:0030891VCB complex4.50e-031.00e+007.794125
GO:0000730DNA recombinase assembly4.50e-031.00e+007.794115
GO:2000001regulation of DNA damage checkpoint4.50e-031.00e+007.794115
GO:0030130clathrin coat of trans-Golgi network vesicle5.40e-031.00e+007.531136
GO:0030957Tat protein binding5.40e-031.00e+007.531136
GO:0030836positive regulation of actin filament depolymerization5.40e-031.00e+007.531126
GO:0030118clathrin coat5.40e-031.00e+007.531126
GO:0031466Cul5-RING ubiquitin ligase complex5.40e-031.00e+007.531116
GO:0030132clathrin coat of coated pit6.29e-031.00e+007.308127
GO:0000028ribosomal small subunit assembly6.29e-031.00e+007.308117
GO:0031462Cul2-RING ubiquitin ligase complex6.29e-031.00e+007.308127
GO:0006457protein folding7.09e-031.00e+003.95627143
GO:0031464Cul4A-RING E3 ubiquitin ligase complex7.19e-031.00e+007.116128
GO:0070688MLL5-L complex7.19e-031.00e+007.116118
GO:0030042actin filament depolymerization7.19e-031.00e+007.116128
GO:0045116protein neddylation7.19e-031.00e+007.116128
GO:0061024membrane organization7.28e-031.00e+003.93627145
GO:0005198structural molecule activity7.77e-031.00e+003.88725150
GO:0008494translation activator activity8.09e-031.00e+006.946119
GO:0006098pentose-phosphate shunt8.98e-031.00e+006.7941410
GO:0010569regulation of double-strand break repair via homologous recombination8.98e-031.00e+006.7941110
GO:0031571mitotic G1 DNA damage checkpoint9.87e-031.00e+006.6561411
GO:0061001regulation of dendritic spine morphogenesis9.87e-031.00e+006.6561211
GO:0031625ubiquitin protein ligase binding1.08e-021.00e+003.640214178
GO:0005662DNA replication factor A complex1.17e-021.00e+006.4151113
GO:0035267NuA4 histone acetyltransferase complex1.26e-021.00e+006.3081414
GO:0030705cytoskeleton-dependent intracellular transport1.26e-021.00e+006.3081114
GO:0003924GTPase activity1.31e-021.00e+003.494212197
GO:0050998nitric-oxide synthase binding1.43e-021.00e+006.1161116
GO:0031258lamellipodium membrane1.43e-021.00e+006.1161216
GO:0022604regulation of cell morphogenesis1.43e-021.00e+006.1161116
GO:0003746translation elongation factor activity1.52e-021.00e+006.0281317
GO:0006184GTP catabolic process1.53e-021.00e+003.374212214
GO:0035861site of double-strand break1.61e-021.00e+005.9461118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.70e-021.00e+005.8681119
GO:0006298mismatch repair1.79e-021.00e+005.7941320
GO:0032201telomere maintenance via semi-conservative replication1.88e-021.00e+005.7231521
GO:0030010establishment of cell polarity1.88e-021.00e+005.7231221
GO:0000281mitotic cytokinesis1.88e-021.00e+005.7231121
GO:0000718nucleotide-excision repair, DNA damage removal1.88e-021.00e+005.7231421
GO:0010508positive regulation of autophagy1.97e-021.00e+005.6561122
GO:0006297nucleotide-excision repair, DNA gap filling1.97e-021.00e+005.6561322
GO:0030863cortical cytoskeleton1.97e-021.00e+005.6561122
GO:0036464cytoplasmic ribonucleoprotein granule1.97e-021.00e+005.6561422
GO:0043044ATP-dependent chromatin remodeling2.05e-021.00e+005.5921423
GO:0005844polysome2.05e-021.00e+005.5921423
GO:0030864cortical actin cytoskeleton2.05e-021.00e+005.5921123
GO:0031463Cul3-RING ubiquitin ligase complex2.05e-021.00e+005.5921323
GO:0043236laminin binding2.05e-021.00e+005.5921123
GO:0043200response to amino acid2.05e-021.00e+005.5921123
GO:0006513protein monoubiquitination2.05e-021.00e+005.5921123
GO:0000722telomere maintenance via recombination2.23e-021.00e+005.4721525
GO:0006281DNA repair2.23e-021.00e+003.088218261
GO:0000045autophagic vacuole assembly2.32e-021.00e+005.4151126
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.32e-021.00e+005.4151326
GO:0007017microtubule-based process2.41e-021.00e+005.3611327
GO:0019843rRNA binding2.41e-021.00e+005.3611327
GO:0043022ribosome binding2.41e-021.00e+005.3611327
GO:0050661NADP binding2.41e-021.00e+005.3611227
GO:0051258protein polymerization2.41e-021.00e+005.3611227
GO:0031492nucleosomal DNA binding2.41e-021.00e+005.3611427
GO:0001755neural crest cell migration2.50e-021.00e+005.3081228
GO:0030669clathrin-coated endocytic vesicle membrane2.50e-021.00e+005.3081428
GO:0019894kinesin binding2.50e-021.00e+005.3081128
GO:0034504protein localization to nucleus2.50e-021.00e+005.3081228
GO:0019005SCF ubiquitin ligase complex2.58e-021.00e+005.2581129
GO:0042254ribosome biogenesis2.67e-021.00e+005.2091130
GO:0033572transferrin transport2.67e-021.00e+005.2091530
GO:0006271DNA strand elongation involved in DNA replication2.67e-021.00e+005.2091730
GO:0031623receptor internalization2.76e-021.00e+005.1611231
GO:0043234protein complex2.80e-021.00e+002.911218295
GO:0004175endopeptidase activity2.85e-021.00e+005.1161232
GO:0032588trans-Golgi network membrane3.02e-021.00e+005.0281234
GO:0001895retina homeostasis3.02e-021.00e+005.0281134
GO:0005525GTP binding3.07e-021.00e+002.840212310
GO:0006605protein targeting3.11e-021.00e+004.9861235
GO:0034332adherens junction organization3.20e-021.00e+004.9461136
GO:0007411axon guidance3.24e-021.00e+002.798213319
GO:0008234cysteine-type peptidase activity3.29e-021.00e+004.9061337
GO:0006284base-excision repair3.29e-021.00e+004.9061337
GO:0070527platelet aggregation3.37e-021.00e+004.8681238
GO:0022627cytosolic small ribosomal subunit3.46e-021.00e+004.8301439
GO:0000781chromosome, telomeric region3.46e-021.00e+004.8301339
GO:0005881cytoplasmic microtubule3.55e-021.00e+004.7941140
GO:0003723RNA binding3.68e-021.00e+002.698220342
GO:0030136clathrin-coated vesicle3.72e-021.00e+004.7231442
GO:0006892post-Golgi vesicle-mediated transport3.81e-021.00e+004.6891343
GO:0021762substantia nigra development3.90e-021.00e+004.6561244
GO:0045727positive regulation of translation3.90e-021.00e+004.6561344
GO:0006283transcription-coupled nucleotide-excision repair4.07e-021.00e+004.5921746
GO:0007266Rho protein signal transduction4.16e-021.00e+004.5611247
GO:0003684damaged DNA binding4.33e-021.00e+004.5011749
GO:0045732positive regulation of protein catabolic process4.42e-021.00e+004.4721350
GO:0003725double-stranded RNA binding4.59e-021.00e+004.4151552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.68e-021.00e+004.3881553
GO:0002244hematopoietic progenitor cell differentiation4.76e-021.00e+004.3611154
GO:0045216cell-cell junction organization4.76e-021.00e+004.3611254
GO:0000724double-strand break repair via homologous recombination4.85e-021.00e+004.3341355
GO:0000723telomere maintenance4.93e-021.00e+004.3081656
GO:0019903protein phosphatase binding5.45e-021.00e+004.1611462
GO:0006302double-strand break repair5.45e-021.00e+004.1611462
GO:0006289nucleotide-excision repair5.96e-021.00e+004.02811168
GO:0034329cell junction assembly5.96e-021.00e+004.0281168
GO:0003697single-stranded DNA binding5.96e-021.00e+004.0281568
GO:0032587ruffle membrane6.13e-021.00e+003.9861370
GO:0007596blood coagulation6.16e-021.00e+002.286218455
GO:0006914autophagy6.47e-021.00e+003.9061174
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.56e-021.00e+003.8871275
GO:0005654nucleoplasm6.83e-021.00e+001.6213761082
GO:0051301cell division7.06e-021.00e+003.7761581
GO:0002576platelet degranulation7.15e-021.00e+003.7581482
GO:0006898receptor-mediated endocytosis7.32e-021.00e+003.7231384
GO:0047485protein N-terminus binding7.48e-021.00e+003.6891586
GO:0016605PML body7.65e-021.00e+003.6561388
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II7.82e-021.00e+003.6241790
GO:0007010cytoskeleton organization7.90e-021.00e+003.6081191
GO:0042470melanosome7.90e-021.00e+003.6081991
GO:0016363nuclear matrix7.90e-021.00e+003.60811291
GO:0006928cellular component movement7.90e-021.00e+003.6081791
GO:0001649osteoblast differentiation7.99e-021.00e+003.5921692
GO:0071456cellular response to hypoxia7.99e-021.00e+003.5921692
GO:0014069postsynaptic density9.07e-021.00e+003.40113105
GO:0072562blood microparticle9.56e-021.00e+003.32113111
GO:0005819spindle9.64e-021.00e+003.30817112
GO:0045087innate immune response9.84e-021.00e+001.896224596
GO:0006325chromatin organization1.01e-011.00e+003.23315118
GO:0007219Notch signaling pathway1.03e-011.00e+003.20915120
GO:0006260DNA replication1.04e-011.00e+003.19719121
GO:0030036actin cytoskeleton organization1.05e-011.00e+003.17315123
GO:0009615response to virus1.08e-011.00e+003.13815126
GO:0000790nuclear chromatin1.10e-011.00e+003.10419129
GO:0005911cell-cell junction1.16e-011.00e+003.02814136
GO:0010628positive regulation of gene expression1.24e-011.00e+002.92615146
GO:0000082G1/S transition of mitotic cell cycle1.26e-011.00e+002.896132149
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.39e-011.00e+002.74917165
GO:0030424axon1.40e-011.00e+002.74114166
GO:0006886intracellular protein transport1.44e-011.00e+002.69815171
GO:0032403protein complex binding1.53e-011.00e+002.600110183
GO:0030168platelet activation1.70e-011.00e+002.436110205
GO:0005730nucleolus1.77e-011.00e+001.0203691641
GO:0007067mitotic nuclear division1.86e-011.00e+002.289114227
GO:0005634nucleus2.00e-011.00e+000.54661364559
GO:0005874microtubule2.03e-011.00e+002.15617249
GO:0005975carbohydrate metabolic process2.06e-011.00e+002.13319253
GO:0004842ubiquitin-protein transferase activity2.07e-011.00e+002.12116255
GO:0005615extracellular space2.12e-011.00e+001.213217957
GO:0003779actin binding2.15e-011.00e+002.060112266
GO:0019899enzyme binding2.23e-011.00e+002.002112277
GO:0005856cytoskeleton2.33e-011.00e+001.931112291
GO:0005737cytoplasm2.35e-011.00e+000.55851103767
GO:0016567protein ubiquitination2.36e-011.00e+001.91115295
GO:0015031protein transport2.67e-011.00e+001.70215341
GO:0007155cell adhesion2.86e-011.00e+001.58816369
GO:0006508proteolysis2.92e-011.00e+001.55319378
GO:0000278mitotic cell cycle3.01e-011.00e+001.505148391
GO:0055114oxidation-reduction process3.19e-011.00e+001.401112420
GO:0043066negative regulation of apoptotic process3.22e-011.00e+001.388131424
GO:0006468protein phosphorylation3.44e-011.00e+001.270118460
GO:0008270zinc ion binding6.06e-011.00e+000.154112997
GO:0044281small molecule metabolic process6.80e-011.00e+00-0.1261581211
GO:0005886plasma membrane7.05e-011.00e+00-0.2192452582
GO:0005524ATP binding7.07e-011.00e+00-0.2261601298