int-snw-1643

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.951	3.86e-16	1.74e-03	3.10e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-1643 subnetwork

Genes (7)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
[ DDB2 ]	1643	1	0.132	0.951	21	-	-
RBX1	9978	97	1.185	1.151	139	Yes	-
DDB1	1642	1	0.515	0.951	26	-	-
RPSA	3921	156	1.327	1.151	152	Yes	-

Interactions (7)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
DDB2	1643	RBX1	9978	pp	--	int.I2D: BioGrid
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
DDB1	1642	DDB2	1643	pp	--	int.Transfac: -; int.Ravasi: -; int.HPRD: in vitro, in vivo; int.DIP: MI:0407(direct interaction), MI:0915(physical association)
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct

Related GO terms (154)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	7.00e-10	1.01e-05	10.272	3	3	5
GO:0000718	nucleotide-excision repair, DNA damage removal	9.28e-08	1.34e-03	8.201	3	4	21
GO:0005654	nucleoplasm	1.15e-06	1.66e-02	3.514	6	76	1082
GO:0003684	damaged DNA binding	1.28e-06	1.84e-02	6.979	3	7	49
GO:0006289	nucleotide-excision repair	3.46e-06	4.99e-02	6.506	3	11	68
GO:0006281	DNA repair	3.51e-06	5.07e-02	4.981	4	18	261
GO:0070914	UV-damage excision repair	4.24e-06	6.11e-02	9.201	2	2	7
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	5.65e-06	8.14e-02	9.009	2	2	8
GO:0035518	histone H2A monoubiquitination	1.11e-05	1.60e-01	8.549	2	3	11
GO:0016032	viral process	5.95e-05	8.58e-01	3.948	4	55	534
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.51e-04	1.00e+00	5.780	2	2	75
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9.70e-04	1.00e+00	10.009	1	1	2
GO:0005055	laminin receptor activity	9.70e-04	1.00e+00	10.009	1	1	2
GO:0006407	rRNA export from nucleus	9.70e-04	1.00e+00	10.009	1	1	2
GO:0000209	protein polyubiquitination	1.31e-03	1.00e+00	5.151	2	20	116
GO:1901990	regulation of mitotic cell cycle phase transition	1.94e-03	1.00e+00	9.009	1	1	4
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.94e-03	1.00e+00	9.009	1	1	4
GO:0030686	90S preribosome	1.94e-03	1.00e+00	9.009	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	1.94e-03	1.00e+00	9.009	1	1	4
GO:0006290	pyrimidine dimer repair	1.94e-03	1.00e+00	9.009	1	1	4
GO:0019788	NEDD8 ligase activity	1.94e-03	1.00e+00	9.009	1	1	4
GO:0000082	G1/S transition of mitotic cell cycle	2.15e-03	1.00e+00	4.790	2	32	149
GO:0005515	protein binding	2.21e-03	1.00e+00	1.260	7	184	6024
GO:0031461	cullin-RING ubiquitin ligase complex	2.42e-03	1.00e+00	8.687	1	1	5
GO:0043248	proteasome assembly	2.42e-03	1.00e+00	8.687	1	1	5
GO:0030891	VCB complex	2.42e-03	1.00e+00	8.687	1	2	5
GO:0000730	DNA recombinase assembly	2.42e-03	1.00e+00	8.687	1	1	5
GO:2000001	regulation of DNA damage checkpoint	2.42e-03	1.00e+00	8.687	1	1	5
GO:0030957	Tat protein binding	2.91e-03	1.00e+00	8.424	1	3	6
GO:0031466	Cul5-RING ubiquitin ligase complex	2.91e-03	1.00e+00	8.424	1	1	6
GO:0031625	ubiquitin protein ligase binding	3.05e-03	1.00e+00	4.533	2	14	178
GO:0000028	ribosomal small subunit assembly	3.39e-03	1.00e+00	8.201	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	3.39e-03	1.00e+00	8.201	1	2	7
GO:0070688	MLL5-L complex	3.88e-03	1.00e+00	8.009	1	1	8
GO:0045116	protein neddylation	3.88e-03	1.00e+00	8.009	1	2	8
GO:0016071	mRNA metabolic process	4.75e-03	1.00e+00	4.208	2	31	223
GO:0010569	regulation of double-strand break repair via homologous recombination	4.84e-03	1.00e+00	7.687	1	1	10
GO:0031571	mitotic G1 DNA damage checkpoint	5.33e-03	1.00e+00	7.549	1	4	11
GO:0016070	RNA metabolic process	5.80e-03	1.00e+00	4.060	2	32	247
GO:0005838	proteasome regulatory particle	5.81e-03	1.00e+00	7.424	1	7	12
GO:0004842	ubiquitin-protein transferase activity	6.17e-03	1.00e+00	4.014	2	6	255
GO:0005662	DNA replication factor A complex	6.29e-03	1.00e+00	7.308	1	1	13
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	6.78e-03	1.00e+00	7.201	1	1	14
GO:0035267	NuA4 histone acetyltransferase complex	6.78e-03	1.00e+00	7.201	1	4	14
GO:0050998	nitric-oxide synthase binding	7.74e-03	1.00e+00	7.009	1	1	16
GO:0043234	protein complex	8.18e-03	1.00e+00	3.804	2	18	295
GO:0022624	proteasome accessory complex	8.22e-03	1.00e+00	6.921	1	8	17
GO:0035861	site of double-strand break	8.71e-03	1.00e+00	6.839	1	1	18
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	9.19e-03	1.00e+00	6.761	1	1	19
GO:0048863	stem cell differentiation	9.19e-03	1.00e+00	6.761	1	1	19
GO:0006298	mismatch repair	9.67e-03	1.00e+00	6.687	1	3	20
GO:0032201	telomere maintenance via semi-conservative replication	1.01e-02	1.00e+00	6.616	1	5	21
GO:0006297	nucleotide-excision repair, DNA gap filling	1.06e-02	1.00e+00	6.549	1	3	22
GO:0030863	cortical cytoskeleton	1.06e-02	1.00e+00	6.549	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.06e-02	1.00e+00	6.549	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.11e-02	1.00e+00	6.485	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.11e-02	1.00e+00	6.485	1	3	23
GO:0043236	laminin binding	1.11e-02	1.00e+00	6.485	1	1	23
GO:0006513	protein monoubiquitination	1.11e-02	1.00e+00	6.485	1	1	23
GO:0000722	telomere maintenance via recombination	1.21e-02	1.00e+00	6.365	1	5	25
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.26e-02	1.00e+00	6.308	1	3	26
GO:0043022	ribosome binding	1.30e-02	1.00e+00	6.254	1	3	27
GO:0031492	nucleosomal DNA binding	1.30e-02	1.00e+00	6.254	1	4	27
GO:0019894	kinesin binding	1.35e-02	1.00e+00	6.201	1	1	28
GO:0019005	SCF ubiquitin ligase complex	1.40e-02	1.00e+00	6.151	1	1	29
GO:0000278	mitotic cell cycle	1.41e-02	1.00e+00	3.398	2	48	391
GO:0006271	DNA strand elongation involved in DNA replication	1.45e-02	1.00e+00	6.102	1	7	30
GO:0001895	retina homeostasis	1.64e-02	1.00e+00	5.921	1	1	34
GO:0043066	negative regulation of apoptotic process	1.64e-02	1.00e+00	3.281	2	31	424
GO:0034332	adherens junction organization	1.73e-02	1.00e+00	5.839	1	1	36
GO:0070062	extracellular vesicular exosome	1.75e-02	1.00e+00	1.780	4	104	2400
GO:0051084	'de novo' posttranslational protein folding	1.78e-02	1.00e+00	5.799	1	4	37
GO:0006284	base-excision repair	1.78e-02	1.00e+00	5.799	1	3	37
GO:0070527	platelet aggregation	1.83e-02	1.00e+00	5.761	1	2	38
GO:0022627	cytosolic small ribosomal subunit	1.88e-02	1.00e+00	5.723	1	4	39
GO:0000781	chromosome, telomeric region	1.88e-02	1.00e+00	5.723	1	3	39
GO:0051865	protein autoubiquitination	1.97e-02	1.00e+00	5.651	1	1	41
GO:0005829	cytosol	2.01e-02	1.00e+00	1.723	4	132	2496
GO:0044267	cellular protein metabolic process	2.03e-02	1.00e+00	3.120	2	29	474
GO:0021762	substantia nigra development	2.12e-02	1.00e+00	5.549	1	2	44
GO:0009411	response to UV	2.12e-02	1.00e+00	5.549	1	1	44
GO:0006283	transcription-coupled nucleotide-excision repair	2.21e-02	1.00e+00	5.485	1	7	46
GO:0006521	regulation of cellular amino acid metabolic process	2.40e-02	1.00e+00	5.365	1	17	50
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.54e-02	1.00e+00	5.281	1	5	53
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	2.59e-02	1.00e+00	5.254	1	1	54
GO:0045216	cell-cell junction organization	2.59e-02	1.00e+00	5.254	1	2	54
GO:0000724	double-strand break repair via homologous recombination	2.64e-02	1.00e+00	5.227	1	3	55
GO:0000723	telomere maintenance	2.69e-02	1.00e+00	5.201	1	6	56
GO:0000502	proteasome complex	2.78e-02	1.00e+00	5.151	1	17	58
GO:0019903	protein phosphatase binding	2.97e-02	1.00e+00	5.055	1	4	62
GO:0006302	double-strand break repair	2.97e-02	1.00e+00	5.055	1	4	62
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	3.07e-02	1.00e+00	5.009	1	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.11e-02	1.00e+00	4.986	1	22	65
GO:0034329	cell junction assembly	3.25e-02	1.00e+00	4.921	1	1	68
GO:0003697	single-stranded DNA binding	3.25e-02	1.00e+00	4.921	1	5	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.35e-02	1.00e+00	4.879	1	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	3.44e-02	1.00e+00	4.839	1	20	72
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	3.54e-02	1.00e+00	4.799	1	6	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.54e-02	1.00e+00	4.799	1	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	3.58e-02	1.00e+00	4.780	1	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	3.77e-02	1.00e+00	4.705	1	23	79
GO:0016020	membrane	3.85e-02	1.00e+00	1.879	3	90	1681
GO:0010467	gene expression	3.86e-02	1.00e+00	2.623	2	59	669
GO:0019083	viral transcription	3.87e-02	1.00e+00	4.669	1	10	81
GO:0047485	protein N-terminus binding	4.10e-02	1.00e+00	4.582	1	5	86
GO:0006415	translational termination	4.15e-02	1.00e+00	4.566	1	10	87
GO:0016605	PML body	4.19e-02	1.00e+00	4.549	1	3	88
GO:0006928	cellular component movement	4.33e-02	1.00e+00	4.501	1	7	91
GO:0005200	structural constituent of cytoskeleton	4.33e-02	1.00e+00	4.501	1	8	91
GO:0071456	cellular response to hypoxia	4.38e-02	1.00e+00	4.485	1	6	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	4.38e-02	1.00e+00	4.485	1	21	92
GO:0006414	translational elongation	4.43e-02	1.00e+00	4.470	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	4.94e-02	1.00e+00	4.308	1	10	104
GO:0014069	postsynaptic density	4.99e-02	1.00e+00	4.294	1	3	105
GO:0072562	blood microparticle	5.27e-02	1.00e+00	4.214	1	3	111
GO:0030529	ribonucleoprotein complex	5.31e-02	1.00e+00	4.201	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	5.40e-02	1.00e+00	4.176	1	11	114
GO:0019058	viral life cycle	5.45e-02	1.00e+00	4.163	1	13	115
GO:0006325	chromatin organization	5.59e-02	1.00e+00	4.126	1	5	118
GO:0007219	Notch signaling pathway	5.68e-02	1.00e+00	4.102	1	5	120
GO:0006260	DNA replication	5.73e-02	1.00e+00	4.090	1	9	121
GO:0006511	ubiquitin-dependent protein catabolic process	5.96e-02	1.00e+00	4.031	1	5	126
GO:0000790	nuclear chromatin	6.10e-02	1.00e+00	3.998	1	9	129
GO:0006413	translational initiation	6.19e-02	1.00e+00	3.975	1	17	131
GO:0003735	structural constituent of ribosome	6.46e-02	1.00e+00	3.911	1	10	137
GO:0016055	Wnt signaling pathway	6.51e-02	1.00e+00	3.900	1	7	138
GO:0006457	protein folding	6.74e-02	1.00e+00	3.849	1	7	143
GO:0061024	membrane organization	6.83e-02	1.00e+00	3.829	1	7	145
GO:0042981	regulation of apoptotic process	7.06e-02	1.00e+00	3.780	1	24	150
GO:0005615	extracellular space	7.39e-02	1.00e+00	2.106	2	17	957
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	7.74e-02	1.00e+00	3.642	1	7	165
GO:0030424	axon	7.79e-02	1.00e+00	3.634	1	4	166
GO:0034641	cellular nitrogen compound metabolic process	8.01e-02	1.00e+00	3.591	1	20	171
GO:0032403	protein complex binding	8.55e-02	1.00e+00	3.493	1	10	183
GO:0006412	translation	1.06e-01	1.00e+00	3.163	1	20	230
GO:0003677	DNA binding	1.13e-01	1.00e+00	1.758	2	28	1218
GO:0019899	enzyme binding	1.27e-01	1.00e+00	2.895	1	12	277
GO:0005856	cytoskeleton	1.33e-01	1.00e+00	2.824	1	12	291
GO:0016567	protein ubiquitination	1.35e-01	1.00e+00	2.804	1	5	295
GO:0019901	protein kinase binding	1.44e-01	1.00e+00	2.700	1	21	317
GO:0007411	axon guidance	1.45e-01	1.00e+00	2.691	1	13	319
GO:0005634	nucleus	1.48e-01	1.00e+00	0.854	4	136	4559
GO:0005925	focal adhesion	1.65e-01	1.00e+00	2.493	1	19	366
GO:0007155	cell adhesion	1.66e-01	1.00e+00	2.481	1	6	369
GO:0007596	blood coagulation	2.01e-01	1.00e+00	2.179	1	18	455
GO:0006915	apoptotic process	2.40e-01	1.00e+00	1.892	1	33	555
GO:0045087	innate immune response	2.56e-01	1.00e+00	1.790	1	24	596
GO:0005737	cytoplasm	2.67e-01	1.00e+00	0.714	3	110	3767
GO:0008270	zinc ion binding	3.94e-01	1.00e+00	1.047	1	12	997
GO:0044822	poly(A) RNA binding	4.13e-01	1.00e+00	0.964	1	49	1056
GO:0044281	small molecule metabolic process	4.59e-01	1.00e+00	0.767	1	58	1211
GO:0005524	ATP binding	4.83e-01	1.00e+00	0.667	1	60	1298
GO:0005730	nucleolus	5.71e-01	1.00e+00	0.328	1	69	1641
GO:0005886	plasma membrane	7.49e-01	1.00e+00	-0.326	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-1643

Statistics

Genes (7)

Interactions (7)

Related GO terms (154)