int-snw-145226

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.992	8.41e-18	6.69e-04	1.52e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-145226 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
ACO2	50	50	1.000	1.076	191	Yes	-
RBX1	9978	97	1.185	1.151	139	Yes	-
PIGK	10026	5	0.718	0.992	68	Yes	-
PSMA2	5683	60	1.093	1.106	89	Yes	-
PSMA1	5682	61	0.996	1.052	123	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
[ RDH12 ]	145226	1	-0.258	0.992	30	-	-
PSMC1	5700	14	0.840	1.018	137	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-

Interactions (18)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMA1	5682	PSMC1	5700	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct_Fly, YeastMedium, IntAct
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMA1	5682	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	PSMC1	5700	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
PSMA2	5683	PSMC1	5700	pp	--	int.I2D: BioGrid_Yeast, IntAct_Fly, YeastLow
PSMA1	5682	PSMA2	5683	pp	--	int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh; int.HPRD: yeast 2-hybrid
PIGK	10026	RDH12	145226	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RDH12	145226	pp	--	int.I2D: BioGrid_Yeast
PSMC1	5700	RDH12	145226	pp	--	int.I2D: BioGrid_Yeast
ACO2	50	PSMC1	5700	pp	--	int.I2D: YeastLow
PSMC1	5700	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
ACTB	60	PSMA1	5682	pp	--	int.I2D: BioGrid_Yeast
ACO2	50	PSMD11	5717	pp	--	int.I2D: YeastLow

Related GO terms (186)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006521	regulation of cellular amino acid metabolic process	4.14e-08	5.97e-04	6.713	4	17	50
GO:0000082	G1/S transition of mitotic cell cycle	4.83e-08	6.97e-04	5.459	5	32	149
GO:0000502	proteasome complex	7.61e-08	1.10e-03	6.499	4	17	58
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	1.14e-07	1.64e-03	6.357	4	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.21e-07	1.75e-03	6.334	4	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.64e-07	2.36e-03	6.227	4	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	1.83e-07	2.65e-03	6.187	4	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.05e-07	2.96e-03	6.147	4	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	2.16e-07	3.12e-03	6.128	4	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	2.67e-07	3.85e-03	6.053	4	23	79
GO:0016071	mRNA metabolic process	3.62e-07	5.22e-03	4.878	5	31	223
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	4.94e-07	7.13e-03	5.833	4	21	92
GO:0016070	RNA metabolic process	6.01e-07	8.67e-03	4.730	5	32	247
GO:0016032	viral process	9.88e-07	1.42e-02	3.881	6	55	534
GO:0000209	protein polyubiquitination	1.26e-06	1.81e-02	5.499	4	20	116
GO:0005654	nucleoplasm	3.31e-06	4.77e-02	3.085	7	76	1082
GO:0042981	regulation of apoptotic process	3.50e-06	5.05e-02	5.128	4	24	150
GO:0000278	mitotic cell cycle	5.76e-06	8.31e-02	4.068	5	48	391
GO:0034641	cellular nitrogen compound metabolic process	5.90e-06	8.51e-02	4.939	4	20	171
GO:0019773	proteasome core complex, alpha-subunit complex	1.48e-05	2.13e-01	8.357	2	4	8
GO:0005838	proteasome regulatory particle	3.48e-05	5.01e-01	7.772	2	7	12
GO:0022624	proteasome accessory complex	7.15e-05	1.00e+00	7.269	2	8	17
GO:0010467	gene expression	7.74e-05	1.00e+00	3.293	5	59	669
GO:0005839	proteasome core complex	8.04e-05	1.00e+00	7.187	2	8	18
GO:0004298	threonine-type endopeptidase activity	8.98e-05	1.00e+00	7.109	2	8	19
GO:0043066	negative regulation of apoptotic process	2.06e-04	1.00e+00	3.629	4	31	424
GO:0006915	apoptotic process	5.77e-04	1.00e+00	3.240	4	33	555
GO:0005829	cytosol	7.94e-04	1.00e+00	1.879	7	132	2496
GO:0005515	protein binding	1.10e-03	1.00e+00	1.122	10	184	6024
GO:0044281	small molecule metabolic process	1.24e-03	1.00e+00	2.437	5	58	1211
GO:0051538	3 iron, 4 sulfur cluster binding	1.52e-03	1.00e+00	9.357	1	1	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.52e-03	1.00e+00	9.357	1	1	2
GO:0060342	photoreceptor inner segment membrane	1.52e-03	1.00e+00	9.357	1	1	2
GO:0003994	aconitate hydratase activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0005055	laminin receptor activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0006407	rRNA export from nucleus	1.52e-03	1.00e+00	9.357	1	1	2
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3.05e-03	1.00e+00	8.357	1	1	4
GO:0030686	90S preribosome	3.05e-03	1.00e+00	8.357	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	3.05e-03	1.00e+00	8.357	1	1	4
GO:0019788	NEDD8 ligase activity	3.05e-03	1.00e+00	8.357	1	1	4
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	3.81e-03	1.00e+00	8.035	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	3.81e-03	1.00e+00	8.035	1	1	5
GO:0043248	proteasome assembly	3.81e-03	1.00e+00	8.035	1	1	5
GO:0006102	isocitrate metabolic process	3.81e-03	1.00e+00	8.035	1	1	5
GO:0030891	VCB complex	3.81e-03	1.00e+00	8.035	1	2	5
GO:0003923	GPI-anchor transamidase activity	3.81e-03	1.00e+00	8.035	1	1	5
GO:0000730	DNA recombinase assembly	3.81e-03	1.00e+00	8.035	1	1	5
GO:2000001	regulation of DNA damage checkpoint	3.81e-03	1.00e+00	8.035	1	1	5
GO:0042765	GPI-anchor transamidase complex	3.81e-03	1.00e+00	8.035	1	1	5
GO:0030957	Tat protein binding	4.57e-03	1.00e+00	7.772	1	3	6
GO:0006101	citrate metabolic process	4.57e-03	1.00e+00	7.772	1	1	6
GO:0031466	Cul5-RING ubiquitin ligase complex	4.57e-03	1.00e+00	7.772	1	1	6
GO:0044267	cellular protein metabolic process	4.78e-03	1.00e+00	3.053	3	29	474
GO:0006457	protein folding	5.06e-03	1.00e+00	4.197	2	7	143
GO:0016255	attachment of GPI anchor to protein	5.33e-03	1.00e+00	7.549	1	1	7
GO:0000028	ribosomal small subunit assembly	5.33e-03	1.00e+00	7.549	1	1	7
GO:0004745	retinol dehydrogenase activity	5.33e-03	1.00e+00	7.549	1	1	7
GO:0034235	GPI anchor binding	5.33e-03	1.00e+00	7.549	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	5.33e-03	1.00e+00	7.549	1	2	7
GO:0016020	membrane	5.39e-03	1.00e+00	1.963	5	90	1681
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	6.09e-03	1.00e+00	7.357	1	2	8
GO:0070688	MLL5-L complex	6.09e-03	1.00e+00	7.357	1	1	8
GO:0045116	protein neddylation	6.09e-03	1.00e+00	7.357	1	2	8
GO:0010569	regulation of double-strand break repair via homologous recombination	7.60e-03	1.00e+00	7.035	1	1	10
GO:0031625	ubiquitin protein ligase binding	7.74e-03	1.00e+00	3.881	2	14	178
GO:0031571	mitotic G1 DNA damage checkpoint	8.36e-03	1.00e+00	6.897	1	4	11
GO:0005662	DNA replication factor A complex	9.87e-03	1.00e+00	6.656	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	1.06e-02	1.00e+00	6.549	1	4	14
GO:0042572	retinol metabolic process	1.06e-02	1.00e+00	6.549	1	1	14
GO:0050998	nitric-oxide synthase binding	1.21e-02	1.00e+00	6.357	1	1	16
GO:0017025	TBP-class protein binding	1.29e-02	1.00e+00	6.269	1	3	17
GO:0035861	site of double-strand break	1.36e-02	1.00e+00	6.187	1	1	18
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.44e-02	1.00e+00	6.109	1	1	19
GO:0048863	stem cell differentiation	1.44e-02	1.00e+00	6.109	1	1	19
GO:0006298	mismatch repair	1.52e-02	1.00e+00	6.035	1	3	20
GO:0032201	telomere maintenance via semi-conservative replication	1.59e-02	1.00e+00	5.964	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.59e-02	1.00e+00	5.964	1	4	21
GO:0006281	DNA repair	1.61e-02	1.00e+00	3.329	2	18	261
GO:0003756	protein disulfide isomerase activity	1.67e-02	1.00e+00	5.897	1	1	22
GO:0006297	nucleotide-excision repair, DNA gap filling	1.67e-02	1.00e+00	5.897	1	3	22
GO:0030863	cortical cytoskeleton	1.67e-02	1.00e+00	5.897	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.67e-02	1.00e+00	5.897	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.74e-02	1.00e+00	5.833	1	4	23
GO:0005844	polysome	1.74e-02	1.00e+00	5.833	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.74e-02	1.00e+00	5.833	1	3	23
GO:0043236	laminin binding	1.74e-02	1.00e+00	5.833	1	1	23
GO:0006513	protein monoubiquitination	1.74e-02	1.00e+00	5.833	1	1	23
GO:0045494	photoreceptor cell maintenance	1.82e-02	1.00e+00	5.772	1	1	24
GO:0000722	telomere maintenance via recombination	1.89e-02	1.00e+00	5.713	1	5	25
GO:0006501	C-terminal protein lipidation	1.97e-02	1.00e+00	5.656	1	2	26
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.97e-02	1.00e+00	5.656	1	3	26
GO:0043022	ribosome binding	2.04e-02	1.00e+00	5.602	1	3	27
GO:0031492	nucleosomal DNA binding	2.04e-02	1.00e+00	5.602	1	4	27
GO:0006099	tricarboxylic acid cycle	2.12e-02	1.00e+00	5.549	1	4	28
GO:0019894	kinesin binding	2.12e-02	1.00e+00	5.549	1	1	28
GO:0019005	SCF ubiquitin ligase complex	2.19e-02	1.00e+00	5.499	1	1	29
GO:0006271	DNA strand elongation involved in DNA replication	2.27e-02	1.00e+00	5.450	1	7	30
GO:0070062	extracellular vesicular exosome	2.43e-02	1.00e+00	1.450	5	104	2400
GO:0001895	retina homeostasis	2.56e-02	1.00e+00	5.269	1	1	34
GO:0051539	4 iron, 4 sulfur cluster binding	2.64e-02	1.00e+00	5.227	1	3	35
GO:0034332	adherens junction organization	2.71e-02	1.00e+00	5.187	1	1	36
GO:0051084	'de novo' posttranslational protein folding	2.79e-02	1.00e+00	5.147	1	4	37
GO:0006284	base-excision repair	2.79e-02	1.00e+00	5.147	1	3	37
GO:0070527	platelet aggregation	2.86e-02	1.00e+00	5.109	1	2	38
GO:0005634	nucleus	2.89e-02	1.00e+00	1.010	7	136	4559
GO:0022627	cytosolic small ribosomal subunit	2.94e-02	1.00e+00	5.071	1	4	39
GO:0000781	chromosome, telomeric region	2.94e-02	1.00e+00	5.071	1	3	39
GO:0021762	substantia nigra development	3.31e-02	1.00e+00	4.897	1	2	44
GO:0006283	transcription-coupled nucleotide-excision repair	3.45e-02	1.00e+00	4.833	1	7	46
GO:0001523	retinoid metabolic process	3.60e-02	1.00e+00	4.772	1	2	48
GO:0003684	damaged DNA binding	3.68e-02	1.00e+00	4.742	1	7	49
GO:0006091	generation of precursor metabolites and energy	3.75e-02	1.00e+00	4.713	1	3	50
GO:0004197	cysteine-type endopeptidase activity	3.75e-02	1.00e+00	4.713	1	3	50
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.97e-02	1.00e+00	4.629	1	5	53
GO:0030176	integral component of endoplasmic reticulum membrane	3.97e-02	1.00e+00	4.629	1	2	53
GO:0045216	cell-cell junction organization	4.04e-02	1.00e+00	4.602	1	2	54
GO:0000932	cytoplasmic mRNA processing body	4.04e-02	1.00e+00	4.602	1	3	54
GO:0000724	double-strand break repair via homologous recombination	4.12e-02	1.00e+00	4.575	1	3	55
GO:0000723	telomere maintenance	4.19e-02	1.00e+00	4.549	1	6	56
GO:0019903	protein phosphatase binding	4.63e-02	1.00e+00	4.402	1	4	62
GO:0006302	double-strand break repair	4.63e-02	1.00e+00	4.402	1	4	62
GO:0006289	nucleotide-excision repair	5.07e-02	1.00e+00	4.269	1	11	68
GO:0034329	cell junction assembly	5.07e-02	1.00e+00	4.269	1	1	68
GO:0003697	single-stranded DNA binding	5.07e-02	1.00e+00	4.269	1	5	68
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.50e-02	1.00e+00	4.147	1	6	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.58e-02	1.00e+00	4.128	1	2	75
GO:0007603	phototransduction, visible light	5.79e-02	1.00e+00	4.071	1	1	78
GO:0019083	viral transcription	6.01e-02	1.00e+00	4.017	1	10	81
GO:0047485	protein N-terminus binding	6.37e-02	1.00e+00	3.930	1	5	86
GO:0006415	translational termination	6.44e-02	1.00e+00	3.914	1	10	87
GO:0016605	PML body	6.51e-02	1.00e+00	3.897	1	3	88
GO:0006928	cellular component movement	6.73e-02	1.00e+00	3.849	1	7	91
GO:0005200	structural constituent of cytoskeleton	6.73e-02	1.00e+00	3.849	1	8	91
GO:0071456	cellular response to hypoxia	6.80e-02	1.00e+00	3.833	1	6	92
GO:0006414	translational elongation	6.87e-02	1.00e+00	3.817	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7.65e-02	1.00e+00	3.656	1	10	104
GO:0014069	postsynaptic density	7.73e-02	1.00e+00	3.642	1	3	105
GO:0005506	iron ion binding	7.73e-02	1.00e+00	3.642	1	4	105
GO:0072562	blood microparticle	8.15e-02	1.00e+00	3.562	1	3	111
GO:0030529	ribonucleoprotein complex	8.22e-02	1.00e+00	3.549	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	8.36e-02	1.00e+00	3.524	1	11	114
GO:0019058	viral life cycle	8.43e-02	1.00e+00	3.511	1	13	115
GO:0044237	cellular metabolic process	8.57e-02	1.00e+00	3.486	1	5	117
GO:0006325	chromatin organization	8.64e-02	1.00e+00	3.474	1	5	118
GO:0007219	Notch signaling pathway	8.78e-02	1.00e+00	3.450	1	5	120
GO:0006260	DNA replication	8.85e-02	1.00e+00	3.438	1	9	121
GO:0006511	ubiquitin-dependent protein catabolic process	9.20e-02	1.00e+00	3.379	1	5	126
GO:0009615	response to virus	9.20e-02	1.00e+00	3.379	1	5	126
GO:0000790	nuclear chromatin	9.41e-02	1.00e+00	3.345	1	9	129
GO:0006413	translational initiation	9.55e-02	1.00e+00	3.323	1	17	131
GO:0003735	structural constituent of ribosome	9.97e-02	1.00e+00	3.259	1	10	137
GO:0016887	ATPase activity	1.02e-01	1.00e+00	3.227	1	7	140
GO:0061024	membrane organization	1.05e-01	1.00e+00	3.177	1	7	145
GO:0007601	visual perception	1.13e-01	1.00e+00	3.062	1	1	157
GO:0043687	post-translational protein modification	1.17e-01	1.00e+00	3.017	1	5	162
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.19e-01	1.00e+00	2.990	1	7	165
GO:0030424	axon	1.20e-01	1.00e+00	2.982	1	4	166
GO:0005730	nucleolus	1.21e-01	1.00e+00	1.261	3	69	1641
GO:0032403	protein complex binding	1.31e-01	1.00e+00	2.841	1	10	183
GO:0005622	intracellular	1.47e-01	1.00e+00	2.663	1	6	207
GO:0005759	mitochondrial matrix	1.61e-01	1.00e+00	2.524	1	14	228
GO:0006412	translation	1.62e-01	1.00e+00	2.511	1	20	230
GO:0004842	ubiquitin-protein transferase activity	1.78e-01	1.00e+00	2.362	1	6	255
GO:0044822	poly(A) RNA binding	1.90e-01	1.00e+00	1.312	2	49	1056
GO:0019899	enzyme binding	1.92e-01	1.00e+00	2.243	1	12	277
GO:0005856	cytoskeleton	2.01e-01	1.00e+00	2.172	1	12	291
GO:0006200	ATP catabolic process	2.02e-01	1.00e+00	2.167	1	15	292
GO:0043234	protein complex	2.03e-01	1.00e+00	2.152	1	18	295
GO:0016567	protein ubiquitination	2.03e-01	1.00e+00	2.152	1	5	295
GO:0019901	protein kinase binding	2.17e-01	1.00e+00	2.048	1	21	317
GO:0007411	axon guidance	2.18e-01	1.00e+00	2.039	1	13	319
GO:0005813	centrosome	2.22e-01	1.00e+00	2.008	1	14	326
GO:0003723	RNA binding	2.32e-01	1.00e+00	1.939	1	20	342
GO:0005925	focal adhesion	2.46e-01	1.00e+00	1.841	1	19	366
GO:0007155	cell adhesion	2.48e-01	1.00e+00	1.829	1	6	369
GO:0006508	proteolysis	2.53e-01	1.00e+00	1.794	1	9	378
GO:0005524	ATP binding	2.60e-01	1.00e+00	1.015	2	60	1298
GO:0055114	oxidation-reduction process	2.78e-01	1.00e+00	1.642	1	12	420
GO:0007596	blood coagulation	2.97e-01	1.00e+00	1.527	1	18	455
GO:0005789	endoplasmic reticulum membrane	3.58e-01	1.00e+00	1.202	1	16	570
GO:0045087	innate immune response	3.71e-01	1.00e+00	1.137	1	24	596
GO:0005615	extracellular space	5.30e-01	1.00e+00	0.454	1	17	957
GO:0008270	zinc ion binding	5.45e-01	1.00e+00	0.395	1	12	997
GO:0005739	mitochondrion	5.46e-01	1.00e+00	0.394	1	28	998
GO:0005737	cytoplasm	5.79e-01	1.00e+00	0.062	3	110	3767
GO:0005886	plasma membrane	8.86e-01	1.00e+00	-0.978	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-145226

Statistics

Genes (11)

Interactions (18)

Related GO terms (186)