int-snw-10188

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.950 4.38e-16 1.79e-03 3.17e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-10188 subnetwork

Genes (9)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
[ TNK2 ] 10188 10.3370.95048Yes-
EIF2S2 8894 271.0751.13881Yes-
RBX1 9978 971.1851.151139Yes-
CLTC 1213 350.8841.138247Yes-
ACTB 60 1671.1531.151587Yes-
ATP6V1B2 526 440.8811.076278--
BCAR1 9564 2-0.4540.95381-Yes
RPSA 3921 1561.3271.151152Yes-

Interactions (11)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ATP6V1B2 526 CLTC 1213 pp -- int.I2D: IntAct_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
ATP6V1B2 526 RPSA 3921 pp -- int.I2D: IntAct_Yeast
ACTB 60 ATP6V1B2 526 pp -- int.I2D: BioGrid_Yeast
ACTB 60 BCAR1 9564 pp -- int.I2D: MINT
CLTC 1213 TNK2 10188 pp -- int.I2D: BCI, MINT, BioGrid, HPRD;
int.Mint: MI:0915(physical association), MI:0407(direct interaction);
int.HPRD: in vitro, in vivo
BCAR1 9564 TNK2 10188 pp -- int.I2D: MINT;
int.Mint: MI:0915(physical association)
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 CLTC 1213 pp -- int.I2D: IntAct_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
CLTC 1213 EIF2S2 8894 pp -- int.I2D: YeastLow

Related GO terms (218)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005829cytosol1.20e-041.00e+002.16871322496
GO:0033572transferrin transport1.49e-041.00e+006.7392530
GO:0030136clathrin-coated vesicle2.94e-041.00e+006.2542442
GO:0019901protein kinase binding8.01e-041.00e+003.923321317
GO:0001726ruffle1.07e-031.00e+005.3242480
GO:0005925focal adhesion1.21e-031.00e+003.715319366
GO:0070436Grb2-EGFR complex1.25e-031.00e+009.646112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.25e-031.00e+009.646112
GO:0002176male germ cell proliferation1.25e-031.00e+009.646112
GO:0005055laminin receptor activity1.25e-031.00e+009.646112
GO:0006407rRNA export from nucleus1.25e-031.00e+009.646112
GO:0042470melanosome1.38e-031.00e+005.1382991
GO:0005850eukaryotic translation initiation factor 2 complex1.87e-031.00e+009.061113
GO:1900126negative regulation of hyaluronan biosynthetic process1.87e-031.00e+009.061123
GO:0071439clathrin complex1.87e-031.00e+009.061123
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.49e-031.00e+008.646114
GO:003068690S preribosome2.49e-031.00e+008.646114
GO:0032051clathrin light chain binding2.49e-031.00e+008.646114
GO:0031467Cul7-RING ubiquitin ligase complex2.49e-031.00e+008.646114
GO:0019788NEDD8 ligase activity2.49e-031.00e+008.646114
GO:1903077negative regulation of protein localization to plasma membrane2.49e-031.00e+008.646114
GO:0044267cellular protein metabolic process2.56e-031.00e+003.342329474
GO:0006413translational initiation2.83e-031.00e+004.613217131
GO:0031465Cul4B-RING E3 ubiquitin ligase complex3.12e-031.00e+008.324135
GO:0031461cullin-RING ubiquitin ligase complex3.12e-031.00e+008.324115
GO:0030891VCB complex3.12e-031.00e+008.324125
GO:0050851antigen receptor-mediated signaling pathway3.12e-031.00e+008.324115
GO:0000730DNA recombinase assembly3.12e-031.00e+008.324115
GO:2000001regulation of DNA damage checkpoint3.12e-031.00e+008.324115
GO:2000369regulation of clathrin-mediated endocytosis3.12e-031.00e+008.324115
GO:0008286insulin receptor signaling pathway3.31e-031.00e+004.49627142
GO:0061024membrane organization3.45e-031.00e+004.46627145
GO:0048012hepatocyte growth factor receptor signaling pathway3.74e-031.00e+008.061116
GO:0030130clathrin coat of trans-Golgi network vesicle3.74e-031.00e+008.061136
GO:0030957Tat protein binding3.74e-031.00e+008.061136
GO:0030118clathrin coat3.74e-031.00e+008.061126
GO:0031466Cul5-RING ubiquitin ligase complex3.74e-031.00e+008.061116
GO:0033180proton-transporting V-type ATPase, V1 domain4.36e-031.00e+007.839127
GO:0030132clathrin coat of coated pit4.36e-031.00e+007.839127
GO:0000028ribosomal small subunit assembly4.36e-031.00e+007.839117
GO:0035729cellular response to hepatocyte growth factor stimulus4.36e-031.00e+007.839117
GO:0031462Cul2-RING ubiquitin ligase complex4.36e-031.00e+007.839127
GO:0030424axon4.50e-031.00e+004.27124166
GO:0031464Cul4A-RING E3 ubiquitin ligase complex4.98e-031.00e+007.646128
GO:0070688MLL5-L complex4.98e-031.00e+007.646118
GO:0045116protein neddylation4.98e-031.00e+007.646128
GO:0031625ubiquitin protein ligase binding5.15e-031.00e+004.170214178
GO:0005515protein binding5.23e-031.00e+001.09081846024
GO:0010569regulation of double-strand break repair via homologous recombination6.22e-031.00e+007.3241110
GO:0031571mitotic G1 DNA damage checkpoint6.85e-031.00e+007.1871411
GO:0005662DNA replication factor A complex8.09e-031.00e+006.9461113
GO:0005095GTPase inhibitor activity8.09e-031.00e+006.9461113
GO:0006412translation8.47e-031.00e+003.801220230
GO:0035267NuA4 histone acetyltransferase complex8.70e-031.00e+006.8391414
GO:0046961proton-transporting ATPase activity, rotational mechanism9.32e-031.00e+006.7391315
GO:0046034ATP metabolic process9.32e-031.00e+006.7391115
GO:0050998nitric-oxide synthase binding9.94e-031.00e+006.6461116
GO:0006281DNA repair1.08e-021.00e+003.618218261
GO:0035861site of double-strand break1.12e-021.00e+006.4761118
GO:0015078hydrogen ion transmembrane transporter activity1.18e-021.00e+006.3981319
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.18e-021.00e+006.3981119
GO:0005886plasma membrane1.22e-021.00e+001.6345452582
GO:0048010vascular endothelial growth factor receptor signaling pathway1.24e-021.00e+006.3241120
GO:0006298mismatch repair1.24e-021.00e+006.3241320
GO:0032201telomere maintenance via semi-conservative replication1.30e-021.00e+006.2541521
GO:0050699WW domain binding1.30e-021.00e+006.2541121
GO:0000718nucleotide-excision repair, DNA damage removal1.30e-021.00e+006.2541421
GO:0006297nucleotide-excision repair, DNA gap filling1.36e-021.00e+006.1871322
GO:0030863cortical cytoskeleton1.36e-021.00e+006.1871122
GO:0036464cytoplasmic ribonucleoprotein granule1.36e-021.00e+006.1871422
GO:0043234protein complex1.37e-021.00e+003.442218295
GO:0043044ATP-dependent chromatin remodeling1.43e-021.00e+006.1231423
GO:0031463Cul3-RING ubiquitin ligase complex1.43e-021.00e+006.1231323
GO:0043236laminin binding1.43e-021.00e+006.1231123
GO:0016020membrane1.43e-021.00e+001.9314901681
GO:0006513protein monoubiquitination1.43e-021.00e+006.1231123
GO:0008135translation factor activity, nucleic acid binding1.49e-021.00e+006.0611724
GO:0000722telomere maintenance via recombination1.55e-021.00e+006.0021525
GO:0015991ATP hydrolysis coupled proton transport1.61e-021.00e+005.9461426
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.61e-021.00e+005.9461326
GO:0005154epidermal growth factor receptor binding1.61e-021.00e+005.9461126
GO:0048008platelet-derived growth factor receptor signaling pathway1.67e-021.00e+005.8911227
GO:0043022ribosome binding1.67e-021.00e+005.8911327
GO:0031492nucleosomal DNA binding1.67e-021.00e+005.8911427
GO:0030669clathrin-coated endocytic vesicle membrane1.73e-021.00e+005.8391428
GO:0019894kinesin binding1.73e-021.00e+005.8391128
GO:0019005SCF ubiquitin ligase complex1.80e-021.00e+005.7881129
GO:0050853B cell receptor signaling pathway1.80e-021.00e+005.7881129
GO:0004712protein serine/threonine/tyrosine kinase activity1.80e-021.00e+005.7881429
GO:0015992proton transport1.80e-021.00e+005.7881329
GO:0006271DNA strand elongation involved in DNA replication1.86e-021.00e+005.7391730
GO:0031623receptor internalization1.92e-021.00e+005.6921231
GO:0051701interaction with host1.98e-021.00e+005.6461432
GO:0007155cell adhesion2.09e-021.00e+003.11926369
GO:0032588trans-Golgi network membrane2.10e-021.00e+005.5591234
GO:0001895retina homeostasis2.10e-021.00e+005.5591134
GO:0005912adherens junction2.16e-021.00e+005.5171235
GO:0034332adherens junction organization2.22e-021.00e+005.4761136
GO:0090382phagosome maturation2.22e-021.00e+005.4761536
GO:0051084'de novo' posttranslational protein folding2.29e-021.00e+005.4371437
GO:0007015actin filament organization2.29e-021.00e+005.4371237
GO:0006284base-excision repair2.29e-021.00e+005.4371337
GO:0005902microvillus2.35e-021.00e+005.3981238
GO:0044822poly(A) RNA binding2.35e-021.00e+002.1873491056
GO:0070527platelet aggregation2.35e-021.00e+005.3981238
GO:0010595positive regulation of endothelial cell migration2.35e-021.00e+005.3981138
GO:0022627cytosolic small ribosomal subunit2.41e-021.00e+005.3611439
GO:0000781chromosome, telomeric region2.41e-021.00e+005.3611339
GO:0005654nucleoplasm2.51e-021.00e+002.1523761082
GO:0004715non-membrane spanning protein tyrosine kinase activity2.59e-021.00e+005.2541442
GO:0006892post-Golgi vesicle-mediated transport2.65e-021.00e+005.2201343
GO:0021762substantia nigra development2.71e-021.00e+005.1871244
GO:0006283transcription-coupled nucleotide-excision repair2.83e-021.00e+005.1231746
GO:0003743translation initiation factor activity3.02e-021.00e+005.0311849
GO:0003684damaged DNA binding3.02e-021.00e+005.0311749
GO:0060326cell chemotaxis3.08e-021.00e+005.0021250
GO:0005905coated pit3.08e-021.00e+005.0021350
GO:0007596blood coagulation3.09e-021.00e+002.816218455
GO:0006879cellular iron ion homeostasis3.14e-021.00e+004.9741451
GO:0003725double-stranded RNA binding3.20e-021.00e+004.9461552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3.26e-021.00e+004.9181553
GO:0045216cell-cell junction organization3.32e-021.00e+004.8911254
GO:0000724double-strand break repair via homologous recombination3.38e-021.00e+004.8651355
GO:0000723telomere maintenance3.44e-021.00e+004.8391656
GO:0012505endomembrane system3.44e-021.00e+004.8391256
GO:0001558regulation of cell growth3.74e-021.00e+004.7151261
GO:0019903protein phosphatase binding3.80e-021.00e+004.6921462
GO:0006302double-strand break repair3.80e-021.00e+004.6921462
GO:0005524ATP binding4.04e-021.00e+001.8893601298
GO:0016032viral process4.14e-021.00e+002.585255534
GO:0006289nucleotide-excision repair4.17e-021.00e+004.55911168
GO:0034329cell junction assembly4.17e-021.00e+004.5591168
GO:0003697single-stranded DNA binding4.17e-021.00e+004.5591568
GO:0043086negative regulation of catalytic activity4.41e-021.00e+004.4761272
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis4.53e-021.00e+004.4371674
GO:0008584male gonad development4.59e-021.00e+004.4171375
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation4.59e-021.00e+004.4171375
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process4.59e-021.00e+004.4171275
GO:0007229integrin-mediated signaling pathway4.76e-021.00e+004.3611278
GO:0070062extracellular vesicular exosome4.77e-021.00e+001.41741042400
GO:0051301cell division4.94e-021.00e+004.3061581
GO:0019083viral transcription4.94e-021.00e+004.30611081
GO:0004713protein tyrosine kinase activity5.00e-021.00e+004.2891582
GO:0006898receptor-mediated endocytosis5.12e-021.00e+004.2541384
GO:0050852T cell receptor signaling pathway5.18e-021.00e+004.2371485
GO:0047485protein N-terminus binding5.24e-021.00e+004.2201586
GO:0006415translational termination5.30e-021.00e+004.20311087
GO:0016605PML body5.36e-021.00e+004.1871388
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II5.48e-021.00e+004.1541790
GO:0016310phosphorylation5.48e-021.00e+004.1541490
GO:0006928cellular component movement5.54e-021.00e+004.1381791
GO:0005200structural constituent of cytoskeleton5.54e-021.00e+004.1381891
GO:0001649osteoblast differentiation5.60e-021.00e+004.1231692
GO:0071456cellular response to hypoxia5.60e-021.00e+004.1231692
GO:0006414translational elongation5.66e-021.00e+004.10711393
GO:0030426growth cone5.83e-021.00e+004.0611596
GO:0030659cytoplasmic vesicle membrane6.13e-021.00e+003.98812101
GO:0010467gene expression6.23e-021.00e+002.260259669
GO:0006614SRP-dependent cotranslational protein targeting to membrane6.31e-021.00e+003.946110104
GO:0014069postsynaptic density6.37e-021.00e+003.93213105
GO:0006897endocytosis6.43e-021.00e+003.91818106
GO:0072562blood microparticle6.72e-021.00e+003.85213111
GO:0030529ribonucleoprotein complex6.78e-021.00e+003.83918112
GO:0005819spindle6.78e-021.00e+003.83917112
GO:0017124SH3 domain binding6.84e-021.00e+003.82613113
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay6.89e-021.00e+003.813111114
GO:0019058viral life cycle6.95e-021.00e+003.801113115
GO:0006325chromatin organization7.13e-021.00e+003.76415118
GO:0007219Notch signaling pathway7.25e-021.00e+003.73915120
GO:0006260DNA replication7.30e-021.00e+003.72719121
GO:0030027lamellipodium7.54e-021.00e+003.68014125
GO:0030335positive regulation of cell migration7.65e-021.00e+003.65717127
GO:0016477cell migration7.71e-021.00e+003.64615128
GO:0000790nuclear chromatin7.77e-021.00e+003.63519129
GO:0031982vesicle7.89e-021.00e+003.61319131
GO:0018108peptidyl-tyrosine phosphorylation7.94e-021.00e+003.60217132
GO:0003735structural constituent of ribosome8.23e-021.00e+003.548110137
GO:0006457protein folding8.58e-021.00e+003.48617143
GO:0007166cell surface receptor signaling pathway8.81e-021.00e+003.44613147
GO:0000082G1/S transition of mitotic cell cycle8.92e-021.00e+003.427132149
GO:0005198structural molecule activity8.98e-021.00e+003.41715150
GO:0042981regulation of apoptotic process8.98e-021.00e+003.417124150
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding9.84e-021.00e+003.28017165
GO:0005768endosome1.01e-011.00e+003.24516169
GO:0006886intracellular protein transport1.02e-011.00e+003.22815171
GO:0032403protein complex binding1.09e-011.00e+003.130110183
GO:0007173epidermal growth factor receptor signaling pathway1.12e-011.00e+003.084112189
GO:0001701in utero embryonic development1.19e-011.00e+002.99518201
GO:0005765lysosomal membrane1.20e-011.00e+002.98115203
GO:0030168platelet activation1.21e-011.00e+002.967110205
GO:0004871signal transducer activity1.23e-011.00e+002.94614208
GO:0016071mRNA metabolic process1.31e-011.00e+002.845131223
GO:0007067mitotic nuclear division1.33e-011.00e+002.820114227
GO:0030425dendrite1.35e-011.00e+002.80113230
GO:0043025neuronal cell body1.43e-011.00e+002.71019245
GO:0016070RNA metabolic process1.44e-011.00e+002.698132247
GO:0004842ubiquitin-protein transferase activity1.48e-011.00e+002.65216255
GO:0048011neurotrophin TRK receptor signaling pathway1.56e-011.00e+002.575115269
GO:0019899enzyme binding1.60e-011.00e+002.532112277
GO:0007264small GTPase mediated signal transduction1.61e-011.00e+002.52214279
GO:0007186G-protein coupled receptor signaling pathway1.67e-011.00e+002.47117289
GO:0005856cytoskeleton1.68e-011.00e+002.461112291
GO:0016567protein ubiquitination1.70e-011.00e+002.44215295
GO:0004674protein serine/threonine kinase activity1.77e-011.00e+002.379112308
GO:0043231intracellular membrane-bounded organelle1.82e-011.00e+002.33319318
GO:0007411axon guidance1.82e-011.00e+002.329113319
GO:0005737cytoplasm1.87e-011.00e+000.76741103767
GO:0008283cell proliferation1.87e-011.00e+002.289114328
GO:0046872metal ion binding1.93e-011.00e+001.2942251307
GO:0003723RNA binding1.94e-011.00e+002.228120342
GO:0000278mitotic cell cycle2.19e-011.00e+002.035148391
GO:0055085transmembrane transport2.41e-011.00e+001.881110435
GO:0005730nucleolus2.73e-011.00e+000.9662691641
GO:0045087innate immune response3.16e-011.00e+001.427124596
GO:0005615extracellular space4.61e-011.00e+000.744117957
GO:0008270zinc ion binding4.75e-011.00e+000.685112997
GO:0005634nucleus5.79e-011.00e+000.07731364559
GO:0016021integral component of membrane7.36e-011.00e+00-0.3071271982