meta-reg-snw-3145

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
int-snw-10980 chia-screen-data-Fav 2.797 4.21e-15 7.56e-04 4.65e-03 12 8
reg-snw-3145 chia-screen-data-Fav 2.226 2.10e-07 3.98e-02 3.04e-02 23 17
int-snw-6334 chia-screen-data-Fav 2.813 2.82e-15 6.25e-04 4.06e-03 16 14
chia-screen-data-Fav-meta-reg-snw-3145 subnetwork

Genes (41)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
EP300 2033 2-2.2743.120415YesYes
ANAPC5 51433 6-1.2642.263239--
CNOT1 23019 7-2.3472.263124Yes-
PHB2 11331 6-2.2362.994151Yes-
SCN8A 6334 3-1.1732.8135--
PHB 5245 12-2.7432.689163YesYes
REXO4 57109 3-1.7432.28795--
ICT1 3396 3-2.2102.813208Yes-
MED13L 23389 8-2.5502.30750Yes-
APC 324 6-2.2933.004384Yes-
HMOX2 3163 2-2.1162.79736Yes-
POU5F1 5460 12-5.1483.538179YesYes
GSTP1 2950 3-2.2512.95559Yes-
MAPK14 1432 3-1.9022.955304--
KLHL8 57563 2-1.9932.79735--
PSMD2 5708 6-4.1723.157389YesYes
EIF2S2 8894 9-2.9992.459103YesYes
FBXL6 26233 5-2.2532.68922Yes-
SUV39H2 79723 7-2.3072.41021YesYes
COPS4 51138 2-3.1983.04362YesYes
COPS3 8533 5-1.8732.435118--
CLPP 8192 3-2.2002.29110Yes-
CCT7 10574 10-2.3352.459173Yes-
HNRNPU 3192 12-2.8692.644172Yes-
ZNRD1 30834 3-1.3752.226106--
TMEM14B 81853 3-2.8792.2266YesYes
NDUFA4L2 56901 10-2.4772.45921Yes-
CENPA 1058 5-2.1852.393205Yes-
COPS2 9318 2-2.5313.04346Yes-
YAP1 10413 12-4.2563.53853Yes-
SNAP23 8773 3-2.0732.43015Yes-
TADA2B 93624 4-3.0613.08219Yes-
POLR2E 5434 5-2.0372.644316Yes-
NOD2 64127 2-1.9212.79726--
EIF2B2 8892 4-2.4622.96895YesYes
HMBS 3145 3-1.1172.22622--
EIF2B3 8891 5-2.5462.43513YesYes
COPS6 10980 3-1.7652.393157--
GPS1 2873 10-3.6212.68962YesYes
DDIT3 1649 11-2.8253.504343YesYes
FUBP1 8880 6-2.4142.38941YesYes

Interactions (71)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CENPA 1058 ZNRD1 30834 pd <> reg.ITFP.txt: no annot
CCT7 10574 REXO4 57109 pd < reg.ITFP.txt: no annot
MAPK14 1432 DDIT3 1649 pp -- int.I2D: BCI, BioGrid, HPRD;
int.HPRD: in vitro
CCT7 10574 ZNRD1 30834 pd < reg.ITFP.txt: no annot
MAPK14 1432 GSTP1 2950 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, BCI
EP300 2033 COPS6 10980 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, HPRD, IntAct, StelzlMedium;
int.HPRD: yeast 2-hybrid
GPS1 2873 PHB 5245 pd > reg.ITFP.txt: no annot
APC 324 CCT7 10574 pp -- int.I2D: Jorgensen_EphR, SOURAV_MAPK_LOW, IntAct
EIF2B2 8892 TADA2B 93624 pp -- int.I2D: BioGrid_Fly, BIND_Fly, FlyLow, IntAct_Fly, MINT_Fly
APC 324 PHB 5245 pp -- int.I2D: Jorgensen_EphR
ICT1 3396 PHB 5245 pp -- int.I2D: BioGrid
POLR2E 5434 ANAPC5 51433 pd <> reg.ITFP.txt: no annot
COPS6 10980 KLHL8 57563 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, IntAct
HNRNPU 3192 ANAPC5 51433 pd < reg.ITFP.txt: no annot
COPS3 8533 COPS6 10980 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, BIND, HPRD, IntAct, BCI, INNATEDB, MGI;
int.HPRD: in vitro;
int.DIP: MI:0915(physical association)
COPS6 10980 COPS4 51138 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, BioGrid_Fly, BIND_Fly, FlyLow, HPRD, IntAct, IntAct_Fly, BIND, MGI, MINT_Fly;
int.HPRD: in vitro
PSMD2 5708 CNOT1 23019 pp -- int.I2D: YeastLow
CNOT1 23019 ANAPC5 51433 pd < reg.ITFP.txt: no annot
COPS3 8533 COPS2 9318 pp -- int.I2D: BioGrid, BCI, HPRD, INNATEDB, MGI;
int.HPRD: in vitro;
int.DIP: MI:0915(physical association)
HMOX2 3163 COPS6 10980 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, HPRD, MINT, StelzlMedium, IntAct;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
GPS1 2873 COPS6 10980 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, BioGrid, HPRD, MGI;
int.HPRD: in vitro
HMBS 3145 COPS3 8533 pd < reg.ITFP.txt: no annot
GPS1 2873 COPS4 51138 pp -- int.Intact: MI:0915(physical association);
int.I2D: BIND, IntAct, MGI
CENPA 1058 SUV39H2 79723 pd > reg.ITFP.txt: no annot
POLR2E 5434 SNAP23 8773 pd > reg.ITFP.txt: no annot
PHB 5245 PHB2 11331 pp -- int.I2D: BioGrid, BioGrid_Yeast, IntAct_Yeast
CENPA 1058 FBXL6 26233 pd > reg.ITFP.txt: no annot
HMBS 3145 REXO4 57109 pd < reg.ITFP.txt: no annot
HMBS 3145 ZNRD1 30834 pd < reg.ITFP.txt: no annot
DDIT3 1649 HNRNPU 3192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
CENPA 1058 HMBS 3145 pd > reg.ITFP.txt: no annot
HMBS 3145 ANAPC5 51433 pd < reg.ITFP.txt: no annot
PHB2 11331 ZNRD1 30834 pd < reg.ITFP.txt: no annot
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
GPS1 2873 COPS2 9318 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Worm, MGI, MINT_Worm, BioGrid_Worm, BIND, BIND_Worm, CORE_1, HPRD, IntAct, INNATEDB;
int.HPRD: in vitro, yeast 2-hybrid
GPS1 2873 CLPP 8192 pd > reg.ITFP.txt: no annot
MAPK14 1432 EIF2B2 8892 pp -- int.I2D: IntAct, SOURAV_MAPK_LOW
MAPK14 1432 ANAPC5 51433 pd < reg.ITFP.txt: no annot
DDIT3 1649 EP300 2033 pp -- int.Intact: MI:0915(physical association)
COPS2 9318 COPS4 51138 pp -- int.I2D: BIND, HPRD, MGI;
int.HPRD: in vitro, in vivo
COPS6 10980 NOD2 64127 pp -- int.I2D: INNATEDB
MAPK14 1432 FUBP1 8880 pp -- int.I2D: BioGrid
GPS1 2873 COPS3 8533 pp -- int.Intact: MI:0915(physical association);
int.I2D: HPRD, IntAct, INNATEDB, BioGrid, MGI;
int.HPRD: in vitro, yeast 2-hybrid
EIF2B3 8891 EIF2S2 8894 pp -- int.I2D: HPRD;
int.HPRD: in vitro
ZNRD1 30834 TMEM14B 81853 pd > reg.ITFP.txt: no annot
PHB 5245 ZNRD1 30834 pd < reg.ITFP.txt: no annot
PSMD2 5708 CCT7 10574 pp -- int.I2D: BioGrid_Yeast
COPS3 8533 EIF2B3 8891 pd > reg.ITFP.txt: no annot
HMBS 3145 COPS6 10980 pd < reg.ITFP.txt: no annot
MAPK14 1432 POLR2E 5434 pd < reg.ITFP.txt: no annot
EIF2B2 8892 EIF2S2 8894 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh
EP300 2033 YAP1 10413 pp -- int.I2D: BioGrid
MED13L 23389 ANAPC5 51433 pd < reg.ITFP.txt: no annot
CENPA 1058 NDUFA4L2 56901 pd > reg.ITFP.txt: no annot
PSMD2 5708 EIF2B2 8892 pp -- int.I2D: IntAct_Yeast
EP300 2033 HNRNPU 3192 pp -- int.I2D: BioGrid, HPRD, BCI;
int.HPRD: in vitro, in vivo
DDIT3 1649 GSTP1 2950 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
GPS1 2873 PHB2 11331 pd > reg.ITFP.txt: no annot
SNAP23 8773 ANAPC5 51433 pd < reg.ITFP.txt: no annot
EP300 2033 ANAPC5 51433 pp -- int.I2D: BioGrid
MAPK14 1432 NOD2 64127 pp -- int.I2D: INNATEDB
MAPK14 1432 SCN8A 6334 pp -- int.I2D: HPRD;
int.HPRD: in vivo
ICT1 3396 PHB2 11331 pp -- int.I2D: BioGrid
PHB 5245 SCN8A 6334 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
HNRNPU 3192 POLR2E 5434 pd < reg.ITFP.txt: no annot
COPS2 9318 COPS6 10980 pp -- int.Intact: MI:0915(physical association);
int.I2D: BCI, BIND, BioGrid, HPRD, IntAct, MGI;
int.HPRD: in vitro
FUBP1 8880 ANAPC5 51433 pd <> reg.ITFP.txt: no annot
CLPP 8192 COPS6 10980 pd < reg.ITFP.txt: no annot
COPS3 8533 COPS4 51138 pp -- int.I2D: BIND, HPRD, BioGrid, INNATEDB, MGI;
int.HPRD: in vitro, in vivo;
int.DIP: MI:0915(physical association)
PSMD2 5708 PHB2 11331 pp -- int.I2D: IntAct_Yeast

Related GO terms (626)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0010388cullin deneddylation9.72e-121.59e-077.789559
GO:0008180COP9 signalosome2.19e-103.57e-066.1346634
GO:0005515protein binding1.62e-052.65e-010.91429776127
GO:0010467gene expression3.34e-055.45e-012.421927669
GO:0051716cellular response to stimulus3.68e-056.01e-017.637224
GO:0005654nucleoplasm5.74e-059.37e-012.00011311095
GO:0005829cytosol6.91e-051.00e+001.40117382562
GO:0005851eukaryotic translation initiation factor 2B complex9.18e-051.00e+007.052236
GO:0032495response to muramyl dipeptide2.19e-041.00e+006.467229
GO:0003743translation initiation factor activity2.50e-041.00e+004.6073549
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway2.74e-041.00e+006.3152210
GO:0001054RNA polymerase I activity3.34e-041.00e+006.1772211
GO:0005736DNA-directed RNA polymerase I complex4.00e-041.00e+006.0522212
GO:0042789mRNA transcription from RNA polymerase II promoter4.72e-041.00e+005.9362213
GO:0043409negative regulation of MAPK cascade4.72e-041.00e+005.9362213
GO:0044212transcription regulatory region DNA binding8.71e-041.00e+003.21945171
GO:0006778porphyrin-containing compound metabolic process9.18e-041.00e+005.4672218
GO:0014003oligodendrocyte development1.14e-031.00e+005.3152320
GO:0090090negative regulation of canonical Wnt signaling pathway1.39e-031.00e+003.7623488
GO:0008135translation factor activity, nucleic acid binding1.64e-031.00e+005.0522224
GO:0032720negative regulation of tumor necrosis factor production2.08e-031.00e+004.8822227
GO:0030331estrogen receptor binding2.08e-031.00e+004.8822227
GO:0002367cytokine production involved in immune response2.51e-031.00e+008.637111
GO:0070126mitochondrial translational termination2.51e-031.00e+008.637111
GO:1901985positive regulation of protein acetylation2.51e-031.00e+008.637111
GO:2000016negative regulation of determination of dorsal identity2.51e-031.00e+008.637111
GO:0043969histone H2B acetylation2.51e-031.00e+008.637111
GO:0032500muramyl dipeptide binding2.51e-031.00e+008.637111
GO:0097057TRAF2-GSTP1 complex2.51e-031.00e+008.637111
GO:0042483negative regulation of odontogenesis2.51e-031.00e+008.637111
GO:0060795cell fate commitment involved in formation of primary germ layer2.51e-031.00e+008.637111
GO:0071608macrophage inflammatory protein-1 alpha production2.51e-031.00e+008.637111
GO:0016150translation release factor activity, codon nonspecific2.51e-031.00e+008.637111
GO:0051171regulation of nitrogen compound metabolic process2.51e-031.00e+008.637111
GO:0014835myoblast differentiation involved in skeletal muscle regeneration2.51e-031.00e+008.637111
GO:0004418hydroxymethylbilane synthase activity2.51e-031.00e+008.637111
GO:0046645positive regulation of gamma-delta T cell activation2.51e-031.00e+008.637111
GO:0070664negative regulation of leukocyte proliferation2.51e-031.00e+008.637111
GO:0035732nitric oxide storage2.51e-031.00e+008.637111
GO:0032498detection of muramyl dipeptide2.51e-031.00e+008.637111
GO:0090308regulation of methylation-dependent chromatin silencing2.51e-031.00e+008.637111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway2.51e-031.00e+008.637111
GO:0002710negative regulation of T cell mediated immunity2.51e-031.00e+008.637111
GO:0070026nitric oxide binding2.51e-031.00e+008.637111
GO:0060177regulation of angiotensin metabolic process2.51e-031.00e+008.637111
GO:0035731dinitrosyl-iron complex binding2.51e-031.00e+008.637111
GO:0018160peptidyl-pyrromethane cofactor linkage2.51e-031.00e+008.637111
GO:0038066p38MAPK cascade2.51e-031.00e+008.637111
GO:0002732positive regulation of dendritic cell cytokine production2.51e-031.00e+008.637111
GO:0035730S-nitrosoglutathione binding2.51e-031.00e+008.637111
GO:2000629negative regulation of miRNA metabolic process2.51e-031.00e+008.637111
GO:2000363positive regulation of prostaglandin-E synthase activity2.51e-031.00e+008.637111
GO:0032701negative regulation of interleukin-18 production2.51e-031.00e+008.637111
GO:0007094mitotic spindle assembly checkpoint2.73e-031.00e+004.6832331
GO:0005634nucleus2.93e-031.00e+000.79221554828
GO:0042552myelination3.67e-031.00e+004.4672236
GO:0006366transcription from RNA polymerase II promoter4.05e-031.00e+002.227514425
GO:0006413translational initiation4.31e-031.00e+003.18834131
GO:0009408response to heat4.52e-031.00e+004.3152240
GO:0035019somatic stem cell maintenance4.52e-031.00e+004.3152240
GO:0007519skeletal muscle tissue development4.75e-031.00e+004.2792241
GO:0060242contact inhibition5.02e-031.00e+007.637112
GO:0035419activation of MAPK activity involved in innate immune response5.02e-031.00e+007.637112
GO:0000939condensed chromosome inner kinetochore5.02e-031.00e+007.637112
GO:0090043regulation of tubulin deacetylation5.02e-031.00e+007.637112
GO:0060965negative regulation of gene silencing by miRNA5.02e-031.00e+007.637112
GO:0035984cellular response to trichostatin A5.02e-031.00e+007.637112
GO:0004392heme oxygenase (decyclizing) activity5.02e-031.00e+007.637112
GO:0044324regulation of transcription involved in anterior/posterior axis specification5.02e-031.00e+007.637112
GO:0009368endopeptidase Clp complex5.02e-031.00e+007.637112
GO:0009890negative regulation of biosynthetic process5.02e-031.00e+007.637112
GO:0044337canonical Wnt signaling pathway involved in positive regulation of apoptotic process5.02e-031.00e+007.637112
GO:0002176male germ cell proliferation5.02e-031.00e+007.637112
GO:0009786regulation of asymmetric cell division5.02e-031.00e+007.637112
GO:0019207kinase regulator activity5.02e-031.00e+007.637112
GO:0071389cellular response to mineralocorticoid stimulus5.02e-031.00e+007.637112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress5.02e-031.00e+007.637112
GO:0006788heme oxidation5.02e-031.00e+007.637112
GO:0014737positive regulation of muscle atrophy5.02e-031.00e+007.637112
GO:0006965positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria5.02e-031.00e+007.637112
GO:0009798axis specification5.02e-031.00e+007.637112
GO:0043434response to peptide hormone5.94e-031.00e+004.1132246
GO:0006974cellular response to DNA damage stimulus7.25e-031.00e+002.91834158
GO:0007254JNK cascade7.26e-031.00e+003.9642251
GO:0071638negative regulation of monocyte chemotactic protein-1 production7.52e-031.00e+007.052113
GO:0018076N-terminal peptidyl-lysine acetylation7.52e-031.00e+007.052113
GO:0071459protein localization to chromosome, centromeric region7.52e-031.00e+007.052113
GO:0010560positive regulation of glycoprotein biosynthetic process7.52e-031.00e+007.052113
GO:0009595detection of biotic stimulus7.52e-031.00e+007.052113
GO:0034136negative regulation of toll-like receptor 2 signaling pathway7.52e-031.00e+007.052113
GO:0004045aminoacyl-tRNA hydrolase activity7.52e-031.00e+007.052113
GO:0036123histone H3-K9 dimethylation7.52e-031.00e+007.052113
GO:0090022regulation of neutrophil chemotaxis7.52e-031.00e+007.052113
GO:0000338protein deneddylation7.52e-031.00e+007.052113
GO:0035726common myeloid progenitor cell proliferation7.52e-031.00e+007.052113
GO:0071225cellular response to muramyl dipeptide7.52e-031.00e+007.052113
GO:0005850eukaryotic translation initiation factor 2 complex7.52e-031.00e+007.052123
GO:0090400stress-induced premature senescence7.52e-031.00e+007.052113
GO:0003130BMP signaling pathway involved in heart induction7.52e-031.00e+007.052113
GO:0060585positive regulation of prostaglandin-endoperoxide synthase activity7.52e-031.00e+007.052113
GO:0000775chromosome, centromeric region7.54e-031.00e+003.9362352
GO:0044267cellular protein metabolic process7.66e-031.00e+002.00857495
GO:0051403stress-activated MAPK cascade8.11e-031.00e+003.8822254
GO:0003682chromatin binding9.61e-031.00e+002.25347334
GO:0008013beta-catenin binding9.94e-031.00e+003.7302460
GO:0000778condensed nuclear chromosome kinetochore1.00e-021.00e+006.637114
GO:0097157pre-mRNA intronic binding1.00e-021.00e+006.637114
GO:0060913cardiac cell fate determination1.00e-021.00e+006.637114
GO:0051771negative regulation of nitric-oxide synthase biosynthetic process1.00e-021.00e+006.637114
GO:0046523S-methyl-5-thioribose-1-phosphate isomerase activity1.00e-021.00e+006.637114
GO:0019887protein kinase regulator activity1.00e-021.00e+006.637114
GO:0018393internal peptidyl-lysine acetylation1.00e-021.00e+006.637114
GO:2000110negative regulation of macrophage apoptotic process1.00e-021.00e+006.637114
GO:0071224cellular response to peptidoglycan1.00e-021.00e+006.637114
GO:0050871positive regulation of B cell activation1.00e-021.00e+006.637114
GO:0003714transcription corepressor activity1.02e-021.00e+002.73835179
GO:0032481positive regulation of type I interferon production1.03e-021.00e+003.7062261
GO:0016032viral process1.09e-021.00e+001.882516540
GO:0009749response to glucose1.12e-021.00e+003.6372264
GO:0034146toll-like receptor 5 signaling pathway1.16e-021.00e+003.6152265
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.16e-021.00e+003.6152365
GO:0034166toll-like receptor 10 signaling pathway1.16e-021.00e+003.6152265
GO:0070461SAGA-type complex1.25e-021.00e+006.315125
GO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic process1.25e-021.00e+006.315115
GO:0004468lysine N-acetyltransferase activity, acting on acetyl phosphate as donor1.25e-021.00e+006.315115
GO:0070934CRD-mediated mRNA stabilization1.25e-021.00e+006.315125
GO:0065004protein-DNA complex assembly1.25e-021.00e+006.315115
GO:0070431nucleotide-binding oligomerization domain containing 2 signaling pathway1.25e-021.00e+006.315115
GO:0060298positive regulation of sarcomere organization1.25e-021.00e+006.315115
GO:0001714endodermal cell fate specification1.25e-021.00e+006.315115
GO:0043620regulation of DNA-templated transcription in response to stress1.25e-021.00e+006.315115
GO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulin1.25e-021.00e+006.315115
GO:0010606positive regulation of cytoplasmic mRNA processing body assembly1.25e-021.00e+006.315115
GO:0051525NFAT protein binding1.25e-021.00e+006.315115
GO:0033600negative regulation of mammary gland epithelial cell proliferation1.25e-021.00e+006.315115
GO:1901741positive regulation of myoblast fusion1.25e-021.00e+006.315115
GO:0032057negative regulation of translational initiation in response to stress1.25e-021.00e+006.315115
GO:0036124histone H3-K9 trimethylation1.25e-021.00e+006.315115
GO:0002830positive regulation of type 2 immune response1.25e-021.00e+006.315115
GO:0032025response to cobalt ion1.25e-021.00e+006.315115
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.33e-021.00e+003.5082470
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway1.37e-021.00e+003.4872271
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway1.37e-021.00e+003.4872271
GO:0034162toll-like receptor 9 signaling pathway1.41e-021.00e+003.4672272
GO:0005739mitochondrion1.44e-021.00e+001.4147161046
GO:0034134toll-like receptor 2 signaling pathway1.45e-021.00e+003.4472273
GO:0000785chromatin1.45e-021.00e+003.4472273
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.48e-021.00e+003.4272474
GO:0005085guanyl-nucleotide exchange factor activity1.48e-021.00e+003.4272274
GO:0030858positive regulation of epithelial cell differentiation1.50e-021.00e+006.052116
GO:0050847progesterone receptor signaling pathway1.50e-021.00e+006.052116
GO:0002381immunoglobulin production involved in immunoglobulin mediated immune response1.50e-021.00e+006.052116
GO:0046974histone methyltransferase activity (H3-K9 specific)1.50e-021.00e+006.052116
GO:0032873negative regulation of stress-activated MAPK cascade1.50e-021.00e+006.052116
GO:0045944positive regulation of transcription from RNA polymerase II promoter1.50e-021.00e+001.558613811
GO:0032691negative regulation of interleukin-1 beta production1.50e-021.00e+006.052116
GO:0006333chromatin assembly or disassembly1.50e-021.00e+006.052116
GO:0060762regulation of branching involved in mammary gland duct morphogenesis1.50e-021.00e+006.052116
GO:0060744mammary gland branching involved in thelarche1.50e-021.00e+006.052116
GO:2000323negative regulation of glucocorticoid receptor signaling pathway1.50e-021.00e+006.052116
GO:0070937CRD-mediated mRNA stability complex1.50e-021.00e+006.052126
GO:0008432JUN kinase binding1.50e-021.00e+006.052116
GO:0042167heme catabolic process1.50e-021.00e+006.052116
GO:0002862negative regulation of inflammatory response to antigenic stimulus1.50e-021.00e+006.052116
GO:0000122negative regulation of transcription from RNA polymerase II promoter1.54e-021.00e+001.757510589
GO:0035666TRIF-dependent toll-like receptor signaling pathway1.56e-021.00e+003.3892276
GO:0002756MyD88-independent toll-like receptor signaling pathway1.64e-021.00e+003.3512278
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.68e-021.00e+003.3332479
GO:0002755MyD88-dependent toll-like receptor signaling pathway1.72e-021.00e+003.3152380
GO:0034138toll-like receptor 3 signaling pathway1.72e-021.00e+003.3152280
GO:0000278mitotic cell cycle1.73e-021.00e+002.000412398
GO:0051353positive regulation of oxidoreductase activity1.75e-021.00e+005.830117
GO:0032930positive regulation of superoxide anion generation1.75e-021.00e+005.830117
GO:0002606positive regulation of dendritic cell antigen processing and presentation1.75e-021.00e+005.830117
GO:0002674negative regulation of acute inflammatory response1.75e-021.00e+005.830117
GO:0006475internal protein amino acid acetylation1.75e-021.00e+005.830117
GO:0007091metaphase/anaphase transition of mitotic cell cycle1.75e-021.00e+005.830117
GO:0060770negative regulation of epithelial cell proliferation involved in prostate gland development1.75e-021.00e+005.830117
GO:0051988regulation of attachment of spindle microtubules to kinetochore1.75e-021.00e+005.830117
GO:0032731positive regulation of interleukin-1 beta production1.75e-021.00e+005.830117
GO:0071222cellular response to lipopolysaccharide1.76e-021.00e+003.2972281
GO:0016071mRNA metabolic process1.83e-021.00e+002.42138223
GO:0006355regulation of transcription, DNA-templated1.89e-021.00e+001.3367131104
GO:0032872regulation of stress-activated MAPK cascade1.99e-021.00e+005.637118
GO:0042582azurophil granule1.99e-021.00e+005.637118
GO:0045670regulation of osteoclast differentiation1.99e-021.00e+005.637118
GO:0042754negative regulation of circadian rhythm1.99e-021.00e+005.637118
GO:0001955blood vessel maturation1.99e-021.00e+005.637118
GO:0006903vesicle targeting1.99e-021.00e+005.637118
GO:0000780condensed nuclear chromosome, centromeric region1.99e-021.00e+005.637118
GO:0001055RNA polymerase II activity1.99e-021.00e+005.637118
GO:0050700CARD domain binding1.99e-021.00e+005.637118
GO:0010831positive regulation of myotube differentiation1.99e-021.00e+005.637118
GO:0016779nucleotidyltransferase activity1.99e-021.00e+005.637118
GO:0006412translation2.10e-021.00e+002.34535235
GO:0045892negative regulation of transcription, DNA-templated2.13e-021.00e+001.90947424
GO:0000187activation of MAPK activity2.15e-021.00e+003.1452290
GO:0010804negative regulation of tumor necrosis factor-mediated signaling pathway2.24e-021.00e+005.467119
GO:0035259glucocorticoid receptor binding2.24e-021.00e+005.467119
GO:0000302response to reactive oxygen species2.24e-021.00e+005.467119
GO:0019509L-methionine biosynthetic process from methylthioadenosine2.24e-021.00e+005.467119
GO:0006983ER overload response2.24e-021.00e+005.467119
GO:0042834peptidoglycan binding2.24e-021.00e+005.467119
GO:0071354cellular response to interleukin-62.24e-021.00e+005.467119
GO:0045793positive regulation of cell size2.24e-021.00e+005.467119
GO:0006782protoporphyrinogen IX biosynthetic process2.24e-021.00e+005.467119
GO:0060765regulation of androgen receptor signaling pathway2.24e-021.00e+005.467119
GO:0005832chaperonin-containing T-complex2.24e-021.00e+005.467119
GO:0008134transcription factor binding2.37e-021.00e+002.27936246
GO:0001649osteoblast differentiation2.37e-021.00e+003.0672395
GO:0016070RNA metabolic process2.39e-021.00e+002.27338247
GO:0034142toll-like receptor 4 signaling pathway2.42e-021.00e+003.0522296
GO:0002199zona pellucida receptor complex2.48e-021.00e+005.3151110
GO:0045667regulation of osteoblast differentiation2.48e-021.00e+005.3151110
GO:0001518voltage-gated sodium channel complex2.48e-021.00e+005.3151110
GO:0032703negative regulation of interleukin-2 production2.48e-021.00e+005.3151110
GO:0016407acetyltransferase activity2.48e-021.00e+005.3151110
GO:0043194axon initial segment2.48e-021.00e+005.3151110
GO:0031274positive regulation of pseudopodium assembly2.48e-021.00e+005.3151110
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay2.48e-021.00e+005.3151110
GO:0051382kinetochore assembly2.48e-021.00e+005.3151110
GO:0010944negative regulation of transcription by competitive promoter binding2.48e-021.00e+005.3151110
GO:0030877beta-catenin destruction complex2.48e-021.00e+005.3151110
GO:0071456cellular response to hypoxia2.51e-021.00e+003.0222298
GO:0005737cytoplasm2.64e-021.00e+000.68016433976
GO:0007417central nervous system development2.66e-021.00e+002.97922101
GO:0048387negative regulation of retinoic acid receptor signaling pathway2.73e-021.00e+005.1771111
GO:0030277maintenance of gastrointestinal epithelium2.73e-021.00e+005.1771111
GO:0031116positive regulation of microtubule polymerization2.73e-021.00e+005.1771111
GO:0032740positive regulation of interleukin-17 production2.73e-021.00e+005.1771111
GO:0004535poly(A)-specific ribonuclease activity2.73e-021.00e+005.1771111
GO:0033160positive regulation of protein import into nucleus, translocation2.73e-021.00e+005.1771111
GO:2000036regulation of stem cell maintenance2.73e-021.00e+005.1771111
GO:0042975peroxisome proliferator activated receptor binding2.73e-021.00e+005.1771111
GO:0060391positive regulation of SMAD protein import into nucleus2.73e-021.00e+005.1771111
GO:0045663positive regulation of myoblast differentiation2.73e-021.00e+005.1771111
GO:0051010microtubule plus-end binding2.73e-021.00e+005.1771211
GO:0045662negative regulation of myoblast differentiation2.73e-021.00e+005.1771111
GO:0019395fatty acid oxidation2.73e-021.00e+005.1771111
GO:0004707MAP kinase activity2.73e-021.00e+005.1771111
GO:0060213positive regulation of nuclear-transcribed mRNA poly(A) tail shortening2.73e-021.00e+005.1771111
GO:0043923positive regulation by host of viral transcription2.73e-021.00e+005.1771111
GO:0035413positive regulation of catenin import into nucleus2.73e-021.00e+005.1771111
GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway2.73e-021.00e+005.1771111
GO:0042770signal transduction in response to DNA damage2.73e-021.00e+005.1771111
GO:0032874positive regulation of stress-activated MAPK cascade2.97e-021.00e+005.0521112
GO:00709353'-UTR-mediated mRNA stabilization2.97e-021.00e+005.0521112
GO:0051146striated muscle cell differentiation2.97e-021.00e+005.0521112
GO:0045295gamma-catenin binding2.97e-021.00e+005.0521112
GO:0032695negative regulation of interleukin-12 production2.97e-021.00e+005.0521112
GO:0005838proteasome regulatory particle2.97e-021.00e+005.0521112
GO:0042581specific granule2.97e-021.00e+005.0521112
GO:0032886regulation of microtubule-based process2.97e-021.00e+005.0521112
GO:0002224toll-like receptor signaling pathway3.06e-021.00e+002.86922109
GO:0007140male meiosis3.22e-021.00e+004.9361113
GO:0043508negative regulation of JUN kinase activity3.22e-021.00e+004.9361113
GO:0009416response to light stimulus3.22e-021.00e+004.9361113
GO:0051019mitogen-activated protein kinase binding3.22e-021.00e+004.9361213
GO:0030914STAGA complex3.22e-021.00e+004.9361113
GO:0042974retinoic acid receptor binding3.22e-021.00e+004.9361113
GO:0004708MAP kinase kinase activity3.22e-021.00e+004.9361113
GO:0060766negative regulation of androgen receptor signaling pathway3.22e-021.00e+004.9361113
GO:0044295axonal growth cone3.22e-021.00e+004.9361113
GO:0030234enzyme regulator activity3.22e-021.00e+004.9361113
GO:0035198miRNA binding3.22e-021.00e+004.9361113
GO:0035371microtubule plus-end3.46e-021.00e+004.8301114
GO:0016045detection of bacterium3.46e-021.00e+004.8301114
GO:0070542response to fatty acid3.46e-021.00e+004.8301114
GO:0050905neuromuscular process3.46e-021.00e+004.8301114
GO:0051770positive regulation of nitric-oxide synthase biosynthetic process3.46e-021.00e+004.8301114
GO:0071480cellular response to gamma radiation3.46e-021.00e+004.8301114
GO:0004527exonuclease activity3.46e-021.00e+004.8301114
GO:0005095GTPase inhibitor activity3.46e-021.00e+004.8301114
GO:0032993protein-DNA complex3.46e-021.00e+004.8301114
GO:0001824blastocyst development3.70e-021.00e+004.7301115
GO:0030014CCR4-NOT complex3.70e-021.00e+004.7301115
GO:0060749mammary gland alveolus development3.70e-021.00e+004.7301115
GO:0042307positive regulation of protein import into nucleus3.70e-021.00e+004.7301215
GO:0005762mitochondrial large ribosomal subunit3.70e-021.00e+004.7301115
GO:1990090cellular response to nerve growth factor stimulus3.70e-021.00e+004.7301115
GO:0006325chromatin organization3.82e-021.00e+002.69423123
GO:0003700sequence-specific DNA binding transcription factor activity3.83e-021.00e+001.412510748
GO:0007026negative regulation of microtubule depolymerization3.95e-021.00e+004.6371216
GO:0033268node of Ranvier3.95e-021.00e+004.6371116
GO:0000132establishment of mitotic spindle orientation3.95e-021.00e+004.6371116
GO:0001056RNA polymerase III activity3.95e-021.00e+004.6371116
GO:0042176regulation of protein catabolic process3.95e-021.00e+004.6371116
GO:0005665DNA-directed RNA polymerase II, core complex3.95e-021.00e+004.6371116
GO:0016746transferase activity, transferring acyl groups3.95e-021.00e+004.6371216
GO:0051603proteolysis involved in cellular protein catabolic process3.95e-021.00e+004.6371116
GO:0046716muscle cell cellular homeostasis3.95e-021.00e+004.6371116
GO:0051276chromosome organization3.95e-021.00e+004.6371216
GO:0005248voltage-gated sodium channel activity3.95e-021.00e+004.6371116
GO:0007050cell cycle arrest3.99e-021.00e+002.66023126
GO:0043536positive regulation of blood vessel endothelial cell migration4.19e-021.00e+004.5491117
GO:0022624proteasome accessory complex4.19e-021.00e+004.5491117
GO:0001829trophectodermal cell differentiation4.19e-021.00e+004.5491217
GO:0005666DNA-directed RNA polymerase III complex4.19e-021.00e+004.5491117
GO:0070372regulation of ERK1 and ERK2 cascade4.19e-021.00e+004.5491117
GO:0044130negative regulation of growth of symbiont in host4.19e-021.00e+004.5491117
GO:0031122cytoplasmic microtubule organization4.43e-021.00e+004.4671118
GO:0045773positive regulation of axon extension4.43e-021.00e+004.4671118
GO:0033613activating transcription factor binding4.43e-021.00e+004.4671118
GO:0006386termination of RNA polymerase III transcription4.43e-021.00e+004.4671118
GO:0019228neuronal action potential4.43e-021.00e+004.4671118
GO:0050718positive regulation of interleukin-1 beta secretion4.43e-021.00e+004.4671118
GO:0006385transcription elongation from RNA polymerase III promoter4.43e-021.00e+004.4671118
GO:0031982vesicle4.45e-021.00e+002.57122134
GO:0032733positive regulation of interleukin-10 production4.67e-021.00e+004.3891219
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity4.67e-021.00e+004.3891219
GO:0035257nuclear hormone receptor binding4.67e-021.00e+004.3891119
GO:0071549cellular response to dexamethasone stimulus4.91e-021.00e+004.3151120
GO:0002227innate immune response in mucosa4.91e-021.00e+004.3151120
GO:0051090regulation of sequence-specific DNA binding transcription factor activity4.91e-021.00e+004.3151120
GO:0006783heme biosynthetic process4.91e-021.00e+004.3151120
GO:0010942positive regulation of cell death4.91e-021.00e+004.3151120
GO:0001502cartilage condensation4.91e-021.00e+004.3151120
GO:0035924cellular response to vascular endothelial growth factor stimulus4.91e-021.00e+004.3151120
GO:0005680anaphase-promoting complex4.91e-021.00e+004.3151120
GO:0003677DNA binding4.92e-021.00e+001.0447161351
GO:0044822poly(A) RNA binding5.08e-021.00e+001.1486271078
GO:0048010vascular endothelial growth factor receptor signaling pathway5.15e-021.00e+004.2451121
GO:0045648positive regulation of erythrocyte differentiation5.15e-021.00e+004.2451121
GO:0032967positive regulation of collagen biosynthetic process5.15e-021.00e+004.2451121
GO:0045862positive regulation of proteolysis5.15e-021.00e+004.2451221
GO:0000123histone acetyltransferase complex5.15e-021.00e+004.2451221
GO:0004364glutathione transferase activity5.15e-021.00e+004.2451121
GO:0016575histone deacetylation5.15e-021.00e+004.2451121
GO:0032757positive regulation of interleukin-8 production5.15e-021.00e+004.2451121
GO:0009954proximal/distal pattern formation5.15e-021.00e+004.2451121
GO:0000281mitotic cytokinesis5.15e-021.00e+004.2451121
GO:0030316osteoclast differentiation5.39e-021.00e+004.1771122
GO:0005720nuclear heterochromatin5.39e-021.00e+004.1771122
GO:0036464cytoplasmic ribonucleoprotein granule5.39e-021.00e+004.1771122
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription5.39e-021.00e+004.1771222
GO:0006915apoptotic process5.42e-021.00e+001.48048571
GO:0001666response to hypoxia5.45e-021.00e+002.40823150
GO:0042981regulation of apoptotic process5.51e-021.00e+002.39823151
GO:0005730nucleolus5.53e-021.00e+000.9198281684
GO:0031463Cul3-RING ubiquitin ligase complex5.62e-021.00e+004.1131123
GO:0045747positive regulation of Notch signaling pathway5.62e-021.00e+004.1131123
GO:1901687glutathione derivative biosynthetic process5.62e-021.00e+004.1131123
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress5.86e-021.00e+004.0521124
GO:0048147negative regulation of fibroblast proliferation5.86e-021.00e+004.0521124
GO:0050766positive regulation of phagocytosis5.86e-021.00e+004.0521124
GO:0032689negative regulation of interferon-gamma production5.86e-021.00e+004.0521124
GO:0043388positive regulation of DNA binding5.86e-021.00e+004.0521124
GO:0006363termination of RNA polymerase I transcription5.86e-021.00e+004.0521124
GO:0043425bHLH transcription factor binding5.86e-021.00e+004.0521124
GO:2000379positive regulation of reactive oxygen species metabolic process5.86e-021.00e+004.0521124
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening6.10e-021.00e+003.9931125
GO:0051059NF-kappaB binding6.10e-021.00e+003.9931225
GO:0071479cellular response to ionizing radiation6.10e-021.00e+003.9931125
GO:0086010membrane depolarization during action potential6.10e-021.00e+003.9931125
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway6.10e-021.00e+003.9931125
GO:0003899DNA-directed RNA polymerase activity6.10e-021.00e+003.9931125
GO:0045296cadherin binding6.10e-021.00e+003.9931125
GO:0032735positive regulation of interleukin-12 production6.10e-021.00e+003.9931225
GO:0031047gene silencing by RNA6.34e-021.00e+003.9361226
GO:0070979protein K11-linked ubiquitination6.34e-021.00e+003.9361126
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia6.34e-021.00e+003.9361126
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolytic6.34e-021.00e+003.9361126
GO:0035329hippo signaling6.34e-021.00e+003.9361126
GO:0061025membrane fusion6.34e-021.00e+003.9361126
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity6.34e-021.00e+003.9361126
GO:0051209release of sequestered calcium ion into cytosol6.34e-021.00e+003.9361226
GO:0000398mRNA splicing, via spliceosome6.45e-021.00e+002.27129165
GO:0051149positive regulation of muscle cell differentiation6.57e-021.00e+003.8821127
GO:0007422peripheral nervous system development6.57e-021.00e+003.8821127
GO:0000188inactivation of MAPK activity6.57e-021.00e+003.8821127
GO:0034080CENP-A containing nucleosome assembly6.57e-021.00e+003.8821227
GO:0048565digestive tract development6.57e-021.00e+003.8821127
GO:0007339binding of sperm to zona pellucida6.57e-021.00e+003.8821127
GO:0045087innate immune response6.78e-021.00e+001.37044616
GO:0000077DNA damage checkpoint6.81e-021.00e+003.8301128
GO:0000976transcription regulatory region sequence-specific DNA binding6.81e-021.00e+003.8301128
GO:0043967histone H4 acetylation6.81e-021.00e+003.8301128
GO:0003823antigen binding6.81e-021.00e+003.8301128
GO:0034612response to tumor necrosis factor6.81e-021.00e+003.8301128
GO:0007628adult walking behavior7.04e-021.00e+003.7791129
GO:0050714positive regulation of protein secretion7.04e-021.00e+003.7791129
GO:0071897DNA biosynthetic process7.04e-021.00e+003.7791129
GO:0005913cell-cell adherens junction7.04e-021.00e+003.7791129
GO:0006749glutathione metabolic process7.04e-021.00e+003.7791129
GO:0031663lipopolysaccharide-mediated signaling pathway7.04e-021.00e+003.7791129
GO:0006360transcription from RNA polymerase I promoter7.27e-021.00e+003.7301130
GO:0043330response to exogenous dsRNA7.27e-021.00e+003.7301130
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling7.27e-021.00e+003.7301130
GO:00063707-methylguanosine mRNA capping7.27e-021.00e+003.7301230
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator7.27e-021.00e+003.7301130
GO:0005667transcription factor complex7.35e-021.00e+002.16123178
GO:0070373negative regulation of ERK1 and ERK2 cascade7.51e-021.00e+003.6831131
GO:0006139nucleobase-containing compound metabolic process7.74e-021.00e+003.6371132
GO:0042594response to starvation7.74e-021.00e+003.6371332
GO:0043491protein kinase B signaling7.74e-021.00e+003.6371132
GO:0002062chondrocyte differentiation7.74e-021.00e+003.6371232
GO:1903507negative regulation of nucleic acid-templated transcription7.74e-021.00e+003.6371132
GO:0009953dorsal/ventral pattern formation7.74e-021.00e+003.6371132
GO:0006367transcription initiation from RNA polymerase II promoter7.79e-021.00e+002.11325184
GO:0070830tight junction assembly7.97e-021.00e+003.5921133
GO:0033077T cell differentiation in thymus7.97e-021.00e+003.5921133
GO:0001104RNA polymerase II transcription cofactor activity7.97e-021.00e+003.5921333
GO:0043407negative regulation of MAP kinase activity8.20e-021.00e+003.5491134
GO:0042692muscle cell differentiation8.20e-021.00e+003.5491134
GO:0043547positive regulation of GTPase activity8.23e-021.00e+002.06722190
GO:0071333cellular response to glucose stimulus8.44e-021.00e+003.5081135
GO:2001237negative regulation of extrinsic apoptotic signaling pathway8.44e-021.00e+003.5081135
GO:0016592mediator complex8.44e-021.00e+003.5081535
GO:0001942hair follicle development8.44e-021.00e+003.5081135
GO:0048538thymus development8.67e-021.00e+003.4671136
GO:0032755positive regulation of interleukin-6 production8.67e-021.00e+003.4671236
GO:0006446regulation of translational initiation8.67e-021.00e+003.4671236
GO:0001102RNA polymerase II activating transcription factor binding8.90e-021.00e+003.4271137
GO:0051084'de novo' posttranslational protein folding8.90e-021.00e+003.4271137
GO:0032760positive regulation of tumor necrosis factor production8.90e-021.00e+003.4271137
GO:0001541ovarian follicle development8.90e-021.00e+003.4271137
GO:0001756somitogenesis9.13e-021.00e+003.3891138
GO:0050681androgen receptor binding9.13e-021.00e+003.3891138
GO:0051781positive regulation of cell division9.35e-021.00e+003.3511139
GO:0032092positive regulation of protein binding9.35e-021.00e+003.3511139
GO:0006383transcription from RNA polymerase III promoter9.35e-021.00e+003.3511339
GO:0031490chromatin DNA binding9.35e-021.00e+003.3511139
GO:0071407cellular response to organic cyclic compound9.35e-021.00e+003.3511339
GO:0046332SMAD binding9.58e-021.00e+003.3151140
GO:0001701in utero embryonic development9.75e-021.00e+001.92322210
GO:0005881cytoplasmic microtubule9.81e-021.00e+003.2791241
GO:0070301cellular response to hydrogen peroxide9.81e-021.00e+003.2791141
GO:0045785positive regulation of cell adhesion9.81e-021.00e+003.2791141
GO:0051259protein oligomerization9.81e-021.00e+003.2791141
GO:0071320cellular response to cAMP1.00e-011.00e+003.2451142
GO:0035914skeletal muscle cell differentiation1.00e-011.00e+003.2451142
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway1.03e-011.00e+003.2111143
GO:0004402histone acetyltransferase activity1.03e-011.00e+003.2111143
GO:0006892post-Golgi vesicle-mediated transport1.05e-011.00e+003.1771144
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding1.05e-011.00e+003.1771144
GO:0050434positive regulation of viral transcription1.05e-011.00e+003.1771244
GO:0043966histone H3 acetylation1.07e-011.00e+003.1451145
GO:0016328lateral plasma membrane1.09e-011.00e+003.1131146
GO:0044297cell body1.09e-011.00e+003.1131146
GO:0043525positive regulation of neuron apoptotic process1.09e-011.00e+003.1131246
GO:0006283transcription-coupled nucleotide-excision repair1.09e-011.00e+003.1131146
GO:0045727positive regulation of translation1.09e-011.00e+003.1131246
GO:0001047core promoter binding1.09e-011.00e+003.1131246
GO:0050727regulation of inflammatory response1.12e-011.00e+003.0821147
GO:0006921cellular component disassembly involved in execution phase of apoptosis1.12e-011.00e+003.0821147
GO:0048511rhythmic process1.12e-011.00e+003.0821247
GO:0008380RNA splicing1.15e-011.00e+001.779214232
GO:0050830defense response to Gram-positive bacterium1.16e-011.00e+003.0221149
GO:0006521regulation of cellular amino acid metabolic process1.18e-011.00e+002.9931250
GO:0035690cellular response to drug1.18e-011.00e+002.9931250
GO:0005778peroxisomal membrane1.18e-011.00e+002.9931250
GO:0005524ATP binding1.20e-011.00e+000.8196131354
GO:0006986response to unfolded protein1.21e-011.00e+002.9641251
GO:0003713transcription coactivator activity1.21e-011.00e+001.73627239
GO:0000902cell morphogenesis1.21e-011.00e+002.9641151
GO:0045732positive regulation of protein catabolic process1.21e-011.00e+002.9641151
GO:0045454cell redox homeostasis1.23e-011.00e+002.9361152
GO:0031398positive regulation of protein ubiquitination1.23e-011.00e+002.9361152
GO:0034976response to endoplasmic reticulum stress1.23e-011.00e+002.9361152
GO:0009611response to wounding1.25e-011.00e+002.9091153
GO:0006952defense response1.25e-011.00e+002.9091153
GO:0060041retina development in camera-type eye1.25e-011.00e+002.9091153
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay1.25e-011.00e+002.9091253
GO:0007399nervous system development1.26e-011.00e+001.70023245
GO:0090305nucleic acid phosphodiester bond hydrolysis1.27e-011.00e+002.8821154
GO:0007623circadian rhythm1.27e-011.00e+002.8821254
GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process1.27e-011.00e+002.8821154
GO:0050679positive regulation of epithelial cell proliferation1.27e-011.00e+002.8821154
GO:0002039p53 binding1.29e-011.00e+002.8561355
GO:0008233peptidase activity1.29e-011.00e+002.8561155
GO:0051592response to calcium ion1.29e-011.00e+002.8561155
GO:0006814sodium ion transport1.29e-011.00e+002.8561155
GO:0046330positive regulation of JNK cascade1.29e-011.00e+002.8561155
GO:0000932cytoplasmic mRNA processing body1.32e-011.00e+002.8301256
GO:0071300cellular response to retinoic acid1.32e-011.00e+002.8301156
GO:0043627response to estrogen1.34e-011.00e+002.8041157
GO:0006879cellular iron ion homeostasis1.34e-011.00e+002.8041157
GO:0000502proteasome complex1.36e-011.00e+002.7791258
GO:0035725sodium ion transmembrane transport1.36e-011.00e+002.7791158
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity1.38e-011.00e+002.7541259
GO:0006396RNA processing1.40e-011.00e+002.7301460
GO:0006987activation of signaling protein activity involved in unfolded protein response1.45e-011.00e+002.6831262
GO:0000776kinetochore1.47e-011.00e+002.6601463
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process1.47e-011.00e+002.6601163
GO:0006417regulation of translation1.47e-011.00e+002.6601163
GO:0019903protein phosphatase binding1.47e-011.00e+002.6601163
GO:0032088negative regulation of NF-kappaB transcription factor activity1.49e-011.00e+002.6371264
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.51e-011.00e+002.6151365
GO:0006469negative regulation of protein kinase activity1.51e-011.00e+002.6151265
GO:0006357regulation of transcription from RNA polymerase II promoter1.52e-011.00e+001.53424275
GO:0009636response to toxic substance1.53e-011.00e+002.5921166
GO:0007409axonogenesis1.53e-011.00e+002.5921166
GO:0006368transcription elongation from RNA polymerase II promoter1.55e-011.00e+002.5711367
GO:0006338chromatin remodeling1.58e-011.00e+002.5491168
GO:0003697single-stranded DNA binding1.60e-011.00e+002.5281269
GO:0018105peptidyl-serine phosphorylation1.60e-011.00e+002.5281169
GO:0006289nucleotide-excision repair1.60e-011.00e+002.5281169
GO:0006887exocytosis1.60e-011.00e+002.5281169
GO:0000786nucleosome1.62e-011.00e+002.5081170
GO:0042742defense response to bacterium1.62e-011.00e+002.5081170
GO:0019899enzyme binding1.63e-011.00e+001.46723288
GO:0032587ruffle membrane1.66e-011.00e+002.4671172
GO:0010468regulation of gene expression1.66e-011.00e+002.4671172
GO:0007584response to nutrient1.66e-011.00e+002.4671172
GO:0008021synaptic vesicle1.68e-011.00e+002.4471273
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent1.68e-011.00e+002.4471273
GO:0042826histone deacetylase binding1.70e-011.00e+002.4271274
GO:0070062extracellular vesicular exosome1.71e-011.00e+000.5109152516
GO:0007265Ras protein signal transduction1.72e-011.00e+002.4081275
GO:0060070canonical Wnt signaling pathway1.72e-011.00e+002.4081275
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation1.72e-011.00e+002.4081175
GO:0016567protein ubiquitination1.73e-011.00e+001.41325299
GO:0005743mitochondrial inner membrane1.74e-011.00e+001.40823300
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process1.74e-011.00e+002.3891276
GO:0043234protein complex1.74e-011.00e+001.40824300
GO:0030324lung development1.74e-011.00e+002.3891176
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I1.76e-011.00e+002.3701277
GO:0008584male gonad development1.76e-011.00e+002.3701177
GO:0030182neuron differentiation1.76e-011.00e+002.3701177
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity1.76e-011.00e+002.3701277
GO:0001822kidney development1.81e-011.00e+002.3331279
GO:0006334nucleosome assembly1.81e-011.00e+002.3331379
GO:0071013catalytic step 2 spliceosome1.81e-011.00e+002.3331379
GO:0030968endoplasmic reticulum unfolded protein response1.85e-011.00e+002.2971281
GO:0001889liver development1.87e-011.00e+002.2791282
GO:0035556intracellular signal transduction1.89e-011.00e+001.32922317
GO:0007517muscle organ development1.89e-011.00e+002.2621183
GO:0009952anterior/posterior pattern specification1.91e-011.00e+002.2451284
GO:0019901protein kinase binding1.92e-011.00e+001.31524320
GO:0009653anatomical structure morphogenesis1.97e-011.00e+002.1941187
GO:0045471response to ethanol1.99e-011.00e+002.1771188
GO:0009887organ morphogenesis2.01e-011.00e+002.1611189
GO:0008283cell proliferation2.02e-011.00e+001.26623331
GO:0006351transcription, DNA-templated2.03e-011.00e+000.5926171585
GO:0000922spindle pole2.05e-011.00e+002.1291191
GO:0006928cellular component movement2.07e-011.00e+002.1131192
GO:0016363nuclear matrix2.07e-011.00e+002.1131592
GO:0005923tight junction2.07e-011.00e+002.1131192
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity2.09e-011.00e+002.0981293
GO:0002474antigen processing and presentation of peptide antigen via MHC class I2.11e-011.00e+002.0821294
GO:0005770late endosome2.11e-011.00e+002.0821194
GO:0051082unfolded protein binding2.13e-011.00e+002.0671395
GO:0007165signal transduction2.14e-011.00e+000.74548950
GO:0030018Z disc2.19e-011.00e+002.0221298
GO:0003723RNA binding2.24e-011.00e+001.165215355
GO:0051726regulation of cell cycle2.27e-011.00e+001.96414102
GO:0043565sequence-specific DNA binding2.33e-011.00e+001.12523365
GO:0008285negative regulation of cell proliferation2.35e-011.00e+001.11724367
GO:0016023cytoplasmic membrane-bounded vesicle2.37e-011.00e+001.89511107
GO:0001934positive regulation of protein phosphorylation2.39e-011.00e+001.88211108
GO:0006935chemotaxis2.39e-011.00e+001.88211108
GO:0070374positive regulation of ERK1 and ERK2 cascade2.42e-011.00e+001.85611110
GO:0006461protein complex assembly2.44e-011.00e+001.84212111
GO:0007605sensory perception of sound2.44e-011.00e+001.84211111
GO:0034765regulation of ion transmembrane transport2.48e-011.00e+001.81711113
GO:0030308negative regulation of cell growth2.48e-011.00e+001.81712113
GO:0030529ribonucleoprotein complex2.50e-011.00e+001.80416114
GO:0000209protein polyubiquitination2.54e-011.00e+001.77915116
GO:0004252serine-type endopeptidase activity2.59e-011.00e+001.74211119
GO:0006006glucose metabolic process2.59e-011.00e+001.74211119
GO:0032496response to lipopolysaccharide2.65e-011.00e+001.70611122
GO:0003676nucleic acid binding2.65e-011.00e+001.70612122
GO:0046982protein heterodimerization activity2.65e-011.00e+000.99723399
GO:0051092positive regulation of NF-kappaB transcription factor activity2.71e-011.00e+001.67111125
GO:0007219Notch signaling pathway2.71e-011.00e+001.67112125
GO:0006805xenobiotic metabolic process2.78e-011.00e+001.62611129
GO:0008270zinc ion binding2.79e-011.00e+000.5784111067
GO:0030027lamellipodium2.80e-011.00e+001.61511130
GO:0030335positive regulation of cell migration2.80e-011.00e+001.61512130
GO:0016477cell migration2.82e-011.00e+001.60312131
GO:0009986cell surface2.87e-011.00e+000.91624422
GO:0000086G2/M transition of mitotic cell cycle2.93e-011.00e+001.53913137
GO:0043066negative regulation of apoptotic process2.97e-011.00e+000.87925433
GO:0045202synapse2.98e-011.00e+001.50811140
GO:0007507heart development3.00e-011.00e+001.49712141
GO:0016055Wnt signaling pathway3.00e-011.00e+001.49713141
GO:0061024membrane organization3.08e-011.00e+001.44711146
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling3.12e-011.00e+001.42711148
GO:0010628positive regulation of gene expression3.14e-011.00e+001.41812149
GO:0006457protein folding3.14e-011.00e+001.41811149
GO:0007166cell surface receptor signaling pathway3.14e-011.00e+001.41811149
GO:0008017microtubule binding3.15e-011.00e+001.40814150
GO:0051260protein homooligomerization3.15e-011.00e+001.40811150
GO:0000082G1/S transition of mitotic cell cycle3.15e-011.00e+001.40814150
GO:0043005neuron projection3.34e-011.00e+001.30614161
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding3.46e-011.00e+001.24513168
GO:0045893positive regulation of transcription, DNA-templated3.47e-011.00e+000.70926487
GO:0042802identical protein binding3.51e-011.00e+000.69726491
GO:0034641cellular nitrogen compound metabolic process3.61e-011.00e+001.16913177
GO:0007049cell cycle3.61e-011.00e+001.16914177
GO:0031625ubiquitin protein ligase binding3.66e-011.00e+001.14512180
GO:0032403protein complex binding3.74e-011.00e+001.10612185
GO:0001525angiogenesis3.97e-011.00e+000.99311200
GO:0030168platelet activation4.05e-011.00e+000.95711205
GO:0044281small molecule metabolic process4.12e-011.00e+000.2984121295
GO:0004871signal transducer activity4.21e-011.00e+000.88211216
GO:0005622intracellular4.36e-011.00e+000.81712226
GO:0007067mitotic nuclear division4.43e-011.00e+000.78514231
GO:0005759mitochondrial matrix4.46e-011.00e+000.77314233
GO:0016020membrane4.50e-011.00e+000.1895271746
GO:0030425dendrite4.56e-011.00e+000.73011240
GO:0043025neuronal cell body4.75e-011.00e+000.64813254
GO:0004842ubiquitin-protein transferase activity4.77e-011.00e+000.63715256
GO:0005874microtubule4.80e-011.00e+000.62613258
GO:0006281DNA repair4.88e-011.00e+000.59214264
GO:0048011neurotrophin TRK receptor signaling pathway5.00e-011.00e+000.54412273
GO:0043065positive regulation of apoptotic process5.01e-011.00e+000.53913274
GO:0005856cytoskeleton5.46e-011.00e+000.35612311
GO:0004674protein serine/threonine kinase activity5.47e-011.00e+000.35112312
GO:0030154cell differentiation5.62e-011.00e+000.29312325
GO:0007411axon guidance5.64e-011.00e+000.28412327
GO:0005525GTP binding5.65e-011.00e+000.27915328
GO:0005813centrosome5.78e-011.00e+000.23214339
GO:0030054cell junction5.96e-011.00e+000.16113356
GO:0015031protein transport5.97e-011.00e+000.15712357
GO:0005925focal adhesion6.10e-011.00e+000.10612370
GO:0007155cell adhesion6.24e-011.00e+000.05212384
GO:0006508proteolysis6.48e-011.00e+00-0.04312410
GO:0007596blood coagulation6.94e-011.00e+00-0.22111464
GO:0005615extracellular space7.30e-011.00e+00-0.343241010
GO:0055085transmembrane transport7.31e-011.00e+00-0.36915514
GO:0005886plasma membrane7.40e-011.00e+00-0.2476142834
GO:0005789endoplasmic reticulum membrane8.04e-011.00e+00-0.67612636
GO:0046872metal ion binding8.94e-011.00e+00-0.880261465
GO:0005887integral component of plasma membrane9.17e-011.00e+00-1.27211961
GO:0016021integral component of membrane9.90e-011.00e+00-1.641272483