int-snw-4214

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.975	4.80e-17	8.20e-05	9.64e-04

chia-screen-data-Fav-int-snw-4214 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
TUBB4A	10382	7	-2.312	2.975	88	Yes	-
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
LARS	51520	14	-2.574	3.157	105	Yes	Yes
TCP1	6950	10	-2.383	3.119	241	Yes	-
GLUD1	2746	1	-2.295	2.975	49	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes
[ MAP3K1 ]	4214	3	-2.088	2.975	123	Yes	-

Interactions (9)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
MAP3K1	4214	TCP1	6950	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, MINT; int.Mint: MI:0915(physical association)
GLUD1	2746	LARS	51520	pp	--	int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast
GLUD1	2746	MAP3K1	4214	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, MINT; int.Mint: MI:0915(physical association)
DDIT3	1649	TCP1	6950	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
POU5F1	5460	TUBB4A	10382	pp	--	int.I2D: BioGrid
PSMD2	5708	TCP1	6950	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow
DDIT3	1649	TUBB4A	10382	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
PSMD2	5708	LARS	51520	pp	--	int.I2D: BioGrid_Yeast
MAP3K1	4214	TUBB4A	10382	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, MINT; int.Mint: MI:0915(physical association)

Related GO terms (165)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0042789	mRNA transcription from RNA polymerase II promoter	2.09e-05	3.02e-01	8.116	2	2	13
GO:0005829	cytosol	3.14e-05	4.52e-01	2.338	7	86	2496
GO:0051084	'de novo' posttranslational protein folding	1.78e-04	1.00e+00	6.607	2	5	37
GO:0060795	cell fate commitment involved in formation of primary germ layer	5.55e-04	1.00e+00	10.816	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	5.55e-04	1.00e+00	10.816	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	5.55e-04	1.00e+00	10.816	1	1	1
GO:0005515	protein binding	9.24e-04	1.00e+00	1.260	8	198	6024
GO:0006429	leucyl-tRNA aminoacylation	1.11e-03	1.00e+00	9.816	1	1	2
GO:0004352	glutamate dehydrogenase (NAD+) activity	1.11e-03	1.00e+00	9.816	1	1	2
GO:0009786	regulation of asymmetric cell division	1.11e-03	1.00e+00	9.816	1	1	2
GO:0004823	leucine-tRNA ligase activity	1.11e-03	1.00e+00	9.816	1	1	2
GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	1.11e-03	1.00e+00	9.816	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.11e-03	1.00e+00	9.816	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.11e-03	1.00e+00	9.816	1	1	2
GO:0072350	tricarboxylic acid metabolic process	1.66e-03	1.00e+00	9.231	1	1	3
GO:0008545	JUN kinase kinase activity	1.66e-03	1.00e+00	9.231	1	1	3
GO:0060913	cardiac cell fate determination	1.66e-03	1.00e+00	9.231	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.66e-03	1.00e+00	9.231	1	1	3
GO:0044267	cellular protein metabolic process	1.75e-03	1.00e+00	3.512	3	20	474
GO:0007021	tubulin complex assembly	2.22e-03	1.00e+00	8.816	1	1	4
GO:0070728	leucine binding	2.22e-03	1.00e+00	8.816	1	1	4
GO:0033269	internode region of axon	2.22e-03	1.00e+00	8.816	1	1	4
GO:0006538	glutamate catabolic process	2.22e-03	1.00e+00	8.816	1	1	4
GO:0006457	protein folding	2.63e-03	1.00e+00	4.656	2	7	143
GO:0001714	endodermal cell fate specification	2.77e-03	1.00e+00	8.494	1	1	5
GO:0006537	glutamate biosynthetic process	2.77e-03	1.00e+00	8.494	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	2.77e-03	1.00e+00	8.494	1	1	5
GO:0005524	ATP binding	3.40e-03	1.00e+00	2.474	4	31	1298
GO:0044212	transcription regulatory region DNA binding	3.61e-03	1.00e+00	4.424	2	17	168
GO:0034641	cellular nitrogen compound metabolic process	3.73e-03	1.00e+00	4.398	2	2	171
GO:0002161	aminoacyl-tRNA editing activity	3.88e-03	1.00e+00	8.009	1	2	7
GO:0001955	blood vessel maturation	4.43e-03	1.00e+00	7.816	1	1	8
GO:0006983	ER overload response	4.98e-03	1.00e+00	7.646	1	1	9
GO:0006450	regulation of translational fidelity	4.98e-03	1.00e+00	7.646	1	2	9
GO:0003382	epithelial cell morphogenesis	4.98e-03	1.00e+00	7.646	1	1	9
GO:0005832	chaperonin-containing T-complex	4.98e-03	1.00e+00	7.646	1	2	9
GO:0002199	zona pellucida receptor complex	5.53e-03	1.00e+00	7.494	1	2	10
GO:0035413	positive regulation of catenin import into nucleus	5.53e-03	1.00e+00	7.494	1	2	10
GO:0061029	eyelid development in camera-type eye	5.53e-03	1.00e+00	7.494	1	2	10
GO:0070403	NAD+ binding	6.09e-03	1.00e+00	7.357	1	1	11
GO:0045662	negative regulation of myoblast differentiation	6.09e-03	1.00e+00	7.357	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	6.09e-03	1.00e+00	7.357	1	4	11
GO:0005838	proteasome regulatory particle	6.64e-03	1.00e+00	7.231	1	1	12
GO:0035198	miRNA binding	6.64e-03	1.00e+00	7.231	1	1	12
GO:0030234	enzyme regulator activity	7.19e-03	1.00e+00	7.116	1	2	13
GO:0008134	transcription factor binding	7.34e-03	1.00e+00	3.897	2	18	242
GO:0000242	pericentriolar material	7.74e-03	1.00e+00	7.009	1	1	14
GO:0005874	microtubule	7.76e-03	1.00e+00	3.856	2	7	249
GO:0001824	blastocyst development	8.29e-03	1.00e+00	6.909	1	2	15
GO:0042176	regulation of protein catabolic process	8.84e-03	1.00e+00	6.816	1	2	16
GO:0043209	myelin sheath	8.84e-03	1.00e+00	6.816	1	1	16
GO:0006541	glutamine metabolic process	9.39e-03	1.00e+00	6.729	1	2	17
GO:0008652	cellular amino acid biosynthetic process	9.39e-03	1.00e+00	6.729	1	1	17
GO:0022624	proteasome accessory complex	9.39e-03	1.00e+00	6.729	1	1	17
GO:0004709	MAP kinase kinase kinase activity	9.94e-03	1.00e+00	6.646	1	2	18
GO:0032757	positive regulation of interleukin-8 production	1.10e-02	1.00e+00	6.494	1	1	20
GO:0008637	apoptotic mitochondrial changes	1.16e-02	1.00e+00	6.424	1	2	21
GO:0005525	GTP binding	1.18e-02	1.00e+00	3.540	2	12	310
GO:0005720	nuclear heterochromatin	1.21e-02	1.00e+00	6.357	1	2	22
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.27e-02	1.00e+00	6.293	1	1	23
GO:0007339	binding of sperm to zona pellucida	1.38e-02	1.00e+00	6.172	1	2	25
GO:0051209	release of sequestered calcium ion into cytosol	1.43e-02	1.00e+00	6.116	1	1	26
GO:0043565	sequence-specific DNA binding	1.46e-02	1.00e+00	3.381	2	11	346
GO:0007017	microtubule-based process	1.49e-02	1.00e+00	6.061	1	2	27
GO:0051258	protein polymerization	1.49e-02	1.00e+00	6.061	1	2	27
GO:0043531	ADP binding	1.54e-02	1.00e+00	6.009	1	3	28
GO:0042594	response to starvation	1.71e-02	1.00e+00	5.862	1	4	31
GO:0005654	nucleoplasm	1.77e-02	1.00e+00	2.322	3	64	1082
GO:0032024	positive regulation of insulin secretion	1.82e-02	1.00e+00	5.772	1	3	33
GO:0000278	mitotic cell cycle	1.84e-02	1.00e+00	3.205	2	15	391
GO:0030838	positive regulation of actin filament polymerization	1.87e-02	1.00e+00	5.729	1	1	34
GO:0007257	activation of JUN kinase activity	1.98e-02	1.00e+00	5.646	1	5	36
GO:0035019	somatic stem cell maintenance	2.20e-02	1.00e+00	5.494	1	6	40
GO:0006418	tRNA aminoacylation for protein translation	2.31e-02	1.00e+00	5.424	1	3	42
GO:0021762	substantia nigra development	2.42e-02	1.00e+00	5.357	1	4	44
GO:0043525	positive regulation of neuron apoptotic process	2.52e-02	1.00e+00	5.293	1	4	46
GO:0044297	cell body	2.52e-02	1.00e+00	5.293	1	2	46
GO:0001669	acrosomal vesicle	2.69e-02	1.00e+00	5.201	1	2	49
GO:0006521	regulation of cellular amino acid metabolic process	2.74e-02	1.00e+00	5.172	1	1	50
GO:0006986	response to unfolded protein	2.74e-02	1.00e+00	5.172	1	4	50
GO:0030334	regulation of cell migration	2.74e-02	1.00e+00	5.172	1	5	50
GO:0034976	response to endoplasmic reticulum stress	2.79e-02	1.00e+00	5.144	1	2	51
GO:0045454	cell redox homeostasis	2.79e-02	1.00e+00	5.144	1	1	51
GO:0009611	response to wounding	2.85e-02	1.00e+00	5.116	1	5	52
GO:0000186	activation of MAPKK activity	2.96e-02	1.00e+00	5.061	1	2	54
GO:0000502	proteasome complex	3.17e-02	1.00e+00	4.958	1	3	58
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	3.23e-02	1.00e+00	4.933	1	6	59
GO:0006987	activation of signaling protein activity involved in unfolded protein response	3.33e-02	1.00e+00	4.885	1	2	61
GO:0042060	wound healing	3.50e-02	1.00e+00	4.816	1	2	64
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	3.50e-02	1.00e+00	4.816	1	1	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.55e-02	1.00e+00	4.794	1	2	65
GO:0034146	toll-like receptor 5 signaling pathway	3.55e-02	1.00e+00	4.794	1	4	65
GO:0071260	cellular response to mechanical stimulus	3.55e-02	1.00e+00	4.794	1	4	65
GO:0034166	toll-like receptor 10 signaling pathway	3.55e-02	1.00e+00	4.794	1	4	65
GO:0010468	regulation of gene expression	3.71e-02	1.00e+00	4.729	1	2	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.82e-02	1.00e+00	4.687	1	2	70
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	3.87e-02	1.00e+00	4.666	1	4	71
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	3.87e-02	1.00e+00	4.666	1	4	71
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	3.93e-02	1.00e+00	4.646	1	1	72
GO:0034162	toll-like receptor 9 signaling pathway	3.93e-02	1.00e+00	4.646	1	4	72
GO:0034134	toll-like receptor 2 signaling pathway	3.98e-02	1.00e+00	4.626	1	4	73
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.03e-02	1.00e+00	4.607	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.03e-02	1.00e+00	4.607	1	2	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.09e-02	1.00e+00	4.587	1	1	75
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	4.09e-02	1.00e+00	4.587	1	1	75
GO:0005929	cilium	4.19e-02	1.00e+00	4.549	1	2	77
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	4.30e-02	1.00e+00	4.512	1	2	79
GO:0030968	endoplasmic reticulum unfolded protein response	4.30e-02	1.00e+00	4.512	1	2	79
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	4.35e-02	1.00e+00	4.494	1	5	80
GO:0009653	anatomical structure morphogenesis	4.51e-02	1.00e+00	4.441	1	2	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	4.67e-02	1.00e+00	4.390	1	8	86
GO:0005200	structural constituent of cytoskeleton	4.94e-02	1.00e+00	4.308	1	6	91
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	4.99e-02	1.00e+00	4.293	1	1	92
GO:0010467	gene expression	4.99e-02	1.00e+00	2.430	2	45	669
GO:0005770	late endosome	5.04e-02	1.00e+00	4.277	1	2	93
GO:0051082	unfolded protein binding	5.04e-02	1.00e+00	4.277	1	7	93
GO:0034142	toll-like receptor 4 signaling pathway	5.20e-02	1.00e+00	4.231	1	4	96
GO:0003700	sequence-specific DNA binding transcription factor activity	5.41e-02	1.00e+00	2.367	2	39	699
GO:0002224	toll-like receptor signaling pathway	5.89e-02	1.00e+00	4.048	1	4	109
GO:0000209	protein polyubiquitination	6.26e-02	1.00e+00	3.958	1	3	116
GO:0007050	cell cycle arrest	6.68e-02	1.00e+00	3.862	1	5	124
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	6.72e-02	1.00e+00	2.192	2	41	789
GO:0007179	transforming growth factor beta receptor signaling pathway	6.88e-02	1.00e+00	3.816	1	11	128
GO:0000086	G2/M transition of mitotic cell cycle	7.30e-02	1.00e+00	3.729	1	4	136
GO:0016055	Wnt signaling pathway	7.40e-02	1.00e+00	3.708	1	4	138
GO:0000082	G1/S transition of mitotic cell cycle	7.97e-02	1.00e+00	3.597	1	3	149
GO:0042981	regulation of apoptotic process	8.03e-02	1.00e+00	3.587	1	4	150
GO:0006974	cellular response to DNA damage stimulus	8.08e-02	1.00e+00	3.578	1	7	151
GO:0038095	Fc-epsilon receptor signaling pathway	8.95e-02	1.00e+00	3.424	1	5	168
GO:0005667	transcription factor complex	9.31e-02	1.00e+00	3.365	1	17	175
GO:0004672	protein kinase activity	9.41e-02	1.00e+00	3.348	1	3	177
GO:0031625	ubiquitin protein ligase binding	9.46e-02	1.00e+00	3.340	1	5	178
GO:0003714	transcription corepressor activity	9.46e-02	1.00e+00	3.340	1	11	178
GO:0006355	regulation of transcription, DNA-templated	1.01e-01	1.00e+00	1.855	2	43	997
GO:0003924	GTPase activity	1.04e-01	1.00e+00	3.194	1	7	197
GO:0044822	poly(A) RNA binding	1.12e-01	1.00e+00	1.772	2	50	1056
GO:0006184	GTP catabolic process	1.13e-01	1.00e+00	3.075	1	7	214
GO:0016071	mRNA metabolic process	1.17e-01	1.00e+00	3.015	1	8	223
GO:0005759	mitochondrial matrix	1.20e-01	1.00e+00	2.983	1	4	228
GO:0043025	neuronal cell body	1.28e-01	1.00e+00	2.879	1	9	245
GO:0016070	RNA metabolic process	1.29e-01	1.00e+00	2.868	1	8	247
GO:0070062	extracellular vesicular exosome	1.34e-01	1.00e+00	1.172	3	57	2400
GO:0044281	small molecule metabolic process	1.41e-01	1.00e+00	1.574	2	20	1211
GO:0003677	DNA binding	1.42e-01	1.00e+00	1.566	2	49	1218
GO:0019901	protein kinase binding	1.63e-01	1.00e+00	2.508	1	18	317
GO:0005813	centrosome	1.67e-01	1.00e+00	2.467	1	7	326
GO:0046982	protein heterodimerization activity	1.92e-01	1.00e+00	2.246	1	8	380
GO:0045892	negative regulation of transcription, DNA-templated	2.07e-01	1.00e+00	2.126	1	24	413
GO:0006366	transcription from RNA polymerase II promoter	2.10e-01	1.00e+00	2.105	1	30	419
GO:0055114	oxidation-reduction process	2.11e-01	1.00e+00	2.102	1	10	420
GO:0043066	negative regulation of apoptotic process	2.12e-01	1.00e+00	2.088	1	16	424
GO:0005634	nucleus	2.24e-01	1.00e+00	0.662	4	159	4559
GO:0006468	protein phosphorylation	2.28e-01	1.00e+00	1.971	1	10	460
GO:0045893	positive regulation of transcription, DNA-templated	2.36e-01	1.00e+00	1.915	1	24	478
GO:0042802	identical protein binding	2.39e-01	1.00e+00	1.897	1	19	484
GO:0016032	viral process	2.61e-01	1.00e+00	1.755	1	26	534
GO:0006915	apoptotic process	2.69e-01	1.00e+00	1.700	1	12	555
GO:0045087	innate immune response	2.87e-01	1.00e+00	1.597	1	15	596
GO:0005794	Golgi apparatus	2.92e-01	1.00e+00	1.563	1	9	610
GO:0005737	cytoplasm	3.49e-01	1.00e+00	0.522	3	124	3767
GO:0008270	zinc ion binding	4.36e-01	1.00e+00	0.855	1	27	997
GO:0005739	mitochondrion	4.37e-01	1.00e+00	0.853	1	23	998
GO:0016020	membrane	6.29e-01	1.00e+00	0.101	1	46	1681

chia-Fav

int-snw-4214

Statistics

Genes (8)

Interactions (9)

Related GO terms (165)