int-snw-4035

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.799	4.06e-15	7.44e-04	4.59e-03

chia-screen-data-Fav-int-snw-4035 subnetwork

Genes (7)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
MMP15	4324	1	-2.370	2.799	2	Yes	Yes
SRSF3	6428	73	-2.992	3.538	54	Yes	-
PXN	5829	19	-2.554	3.193	206	Yes	Yes
MVP	9961	16	-2.846	3.193	20	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
PLAT	5327	2	-1.976	2.904	30	-	-
[ LRP1 ]	4035	1	-1.703	2.799	72	-	-

Interactions (6)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PXN	5829	SRSF3	6428	pp	--	int.I2D: BIND
LRP1	4035	PXN	5829	pp	--	int.I2D: BIND
LRP1	4035	PLAT	5327	pp	--	int.I2D: BioGrid, HPRD, BCI; int.HPRD: in vitro, in vivo
LRP1	4035	MMP15	4324	pp	--	int.I2D: HPRD, BCI; int.HPRD: in vitro
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
PXN	5829	MVP	9961	pp	--	int.I2D: BIND

Related GO terms (159)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0060795	cell fate commitment involved in formation of primary germ layer	4.85e-04	1.00e+00	11.009	1	1	1
GO:0023057	negative regulation of signaling	4.85e-04	1.00e+00	11.009	1	1	1
GO:0097242	beta-amyloid clearance	4.85e-04	1.00e+00	11.009	1	1	1
GO:0072376	protein activation cascade	4.85e-04	1.00e+00	11.009	1	1	1
GO:0042954	lipoprotein transporter activity	4.85e-04	1.00e+00	11.009	1	1	1
GO:0051435	BH4 domain binding	4.85e-04	1.00e+00	11.009	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	4.85e-04	1.00e+00	11.009	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	4.85e-04	1.00e+00	11.009	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	4.85e-04	1.00e+00	11.009	1	1	1
GO:0032370	positive regulation of lipid transport	4.85e-04	1.00e+00	11.009	1	1	1
GO:0006464	cellular protein modification process	6.91e-04	1.00e+00	5.616	2	4	84
GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway	9.70e-04	1.00e+00	10.009	1	1	2
GO:0009786	regulation of asymmetric cell division	9.70e-04	1.00e+00	10.009	1	1	2
GO:0032429	regulation of phospholipase A2 activity	9.70e-04	1.00e+00	10.009	1	1	2
GO:0060279	positive regulation of ovulation	1.46e-03	1.00e+00	9.424	1	1	3
GO:0070325	lipoprotein particle receptor binding	1.46e-03	1.00e+00	9.424	1	1	3
GO:0060913	cardiac cell fate determination	1.46e-03	1.00e+00	9.424	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.46e-03	1.00e+00	9.424	1	1	3
GO:0038127	ERBB signaling pathway	1.94e-03	1.00e+00	9.009	1	1	4
GO:0032374	regulation of cholesterol transport	1.94e-03	1.00e+00	9.009	1	1	4
GO:0051222	positive regulation of protein transport	1.94e-03	1.00e+00	9.009	1	1	4
GO:0005515	protein binding	2.21e-03	1.00e+00	1.260	7	198	6024
GO:0031012	extracellular matrix	2.30e-03	1.00e+00	4.742	2	6	154
GO:0001714	endodermal cell fate specification	2.42e-03	1.00e+00	8.687	1	1	5
GO:0014909	smooth muscle cell migration	2.42e-03	1.00e+00	8.687	1	1	5
GO:0031639	plasminogen activation	2.91e-03	1.00e+00	8.424	1	1	6
GO:0061099	negative regulation of protein tyrosine kinase activity	3.39e-03	1.00e+00	8.201	1	1	7
GO:0007172	signal complex assembly	3.88e-03	1.00e+00	8.009	1	1	8
GO:0060396	growth hormone receptor signaling pathway	3.88e-03	1.00e+00	8.009	1	1	8
GO:0031953	negative regulation of protein autophosphorylation	4.36e-03	1.00e+00	7.839	1	1	9
GO:0035413	positive regulation of catenin import into nucleus	4.84e-03	1.00e+00	7.687	1	2	10
GO:0014912	negative regulation of smooth muscle cell migration	5.33e-03	1.00e+00	7.549	1	1	11
GO:0017166	vinculin binding	5.33e-03	1.00e+00	7.549	1	1	11
GO:0010875	positive regulation of cholesterol efflux	5.33e-03	1.00e+00	7.549	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	5.33e-03	1.00e+00	7.549	1	4	11
GO:0035909	aorta morphogenesis	5.81e-03	1.00e+00	7.424	1	1	12
GO:0035198	miRNA binding	5.81e-03	1.00e+00	7.424	1	1	12
GO:0042953	lipoprotein transport	5.81e-03	1.00e+00	7.424	1	2	12
GO:0042789	mRNA transcription from RNA polymerase II promoter	6.29e-03	1.00e+00	7.308	1	2	13
GO:0043277	apoptotic cell clearance	6.29e-03	1.00e+00	7.308	1	1	13
GO:0034614	cellular response to reactive oxygen species	6.78e-03	1.00e+00	7.201	1	2	14
GO:0034185	apolipoprotein binding	6.78e-03	1.00e+00	7.201	1	1	14
GO:0001824	blastocyst development	7.26e-03	1.00e+00	7.102	1	2	15
GO:0043274	phospholipase binding	7.74e-03	1.00e+00	7.009	1	1	16
GO:0042730	fibrinolysis	8.71e-03	1.00e+00	6.839	1	3	18
GO:0045861	negative regulation of proteolysis	8.71e-03	1.00e+00	6.839	1	4	18
GO:0019901	protein kinase binding	9.40e-03	1.00e+00	3.700	2	18	317
GO:0071549	cellular response to dexamethasone stimulus	9.67e-03	1.00e+00	6.687	1	3	20
GO:0008283	cell proliferation	1.00e-02	1.00e+00	3.651	2	14	328
GO:0048041	focal adhesion assembly	1.01e-02	1.00e+00	6.616	1	1	21
GO:0044822	poly(A) RNA binding	1.10e-02	1.00e+00	2.549	3	50	1056
GO:0005925	focal adhesion	1.24e-02	1.00e+00	3.493	2	9	366
GO:0035987	endodermal cell differentiation	1.26e-02	1.00e+00	6.308	1	1	26
GO:0048008	platelet-derived growth factor receptor signaling pathway	1.30e-02	1.00e+00	6.254	1	2	27
GO:0048754	branching morphogenesis of an epithelial tube	1.30e-02	1.00e+00	6.254	1	1	27
GO:0006508	proteolysis	1.32e-02	1.00e+00	3.446	2	6	378
GO:0005875	microtubule associated complex	1.35e-02	1.00e+00	6.201	1	1	28
GO:0030032	lamellipodium assembly	1.40e-02	1.00e+00	6.151	1	1	29
GO:0032956	regulation of actin cytoskeleton organization	1.45e-02	1.00e+00	6.102	1	1	30
GO:0048167	regulation of synaptic plasticity	1.45e-02	1.00e+00	6.102	1	2	30
GO:0035249	synaptic transmission, glutamatergic	1.54e-02	1.00e+00	6.009	1	3	32
GO:0005737	cytoplasm	1.56e-02	1.00e+00	1.451	5	124	3767
GO:0006366	transcription from RNA polymerase II promoter	1.60e-02	1.00e+00	3.298	2	30	419
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	1.69e-02	1.00e+00	5.879	1	2	35
GO:0030178	negative regulation of Wnt signaling pathway	1.69e-02	1.00e+00	5.879	1	4	35
GO:0042157	lipoprotein metabolic process	1.73e-02	1.00e+00	5.839	1	1	36
GO:0034446	substrate adhesion-dependent cell spreading	1.73e-02	1.00e+00	5.839	1	2	36
GO:0008047	enzyme activator activity	1.88e-02	1.00e+00	5.723	1	3	39
GO:0035019	somatic stem cell maintenance	1.93e-02	1.00e+00	5.687	1	6	40
GO:0030136	clathrin-coated vesicle	2.02e-02	1.00e+00	5.616	1	5	42
GO:0031124	mRNA 3'-end processing	2.02e-02	1.00e+00	5.616	1	2	42
GO:0051591	response to cAMP	2.16e-02	1.00e+00	5.517	1	4	45
GO:0043434	response to peptide hormone	2.16e-02	1.00e+00	5.517	1	5	45
GO:0006369	termination of RNA polymerase II transcription	2.16e-02	1.00e+00	5.517	1	2	45
GO:0001523	retinoid metabolic process	2.31e-02	1.00e+00	5.424	1	1	48
GO:0005905	coated pit	2.40e-02	1.00e+00	5.365	1	6	50
GO:0051028	mRNA transport	2.50e-02	1.00e+00	5.308	1	4	52
GO:0009611	response to wounding	2.50e-02	1.00e+00	5.308	1	5	52
GO:0005509	calcium ion binding	2.51e-02	1.00e+00	2.956	2	11	531
GO:0030666	endocytic vesicle membrane	2.54e-02	1.00e+00	5.281	1	1	53
GO:0001725	stress fiber	2.64e-02	1.00e+00	5.227	1	4	55
GO:0008203	cholesterol metabolic process	2.73e-02	1.00e+00	5.176	1	2	57
GO:0005643	nuclear pore	2.73e-02	1.00e+00	5.176	1	11	57
GO:0008013	beta-catenin binding	2.88e-02	1.00e+00	5.102	1	9	60
GO:0006406	mRNA export from nucleus	2.92e-02	1.00e+00	5.078	1	4	61
GO:0043085	positive regulation of catalytic activity	2.92e-02	1.00e+00	5.078	1	2	61
GO:0019903	protein phosphatase binding	2.97e-02	1.00e+00	5.055	1	2	62
GO:0030141	secretory granule	2.97e-02	1.00e+00	5.055	1	4	62
GO:0030574	collagen catabolic process	3.21e-02	1.00e+00	4.943	1	2	67
GO:0010468	regulation of gene expression	3.25e-02	1.00e+00	4.921	1	2	68
GO:0034329	cell junction assembly	3.25e-02	1.00e+00	4.921	1	3	68
GO:0032355	response to estradiol	3.40e-02	1.00e+00	4.859	1	3	71
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	3.54e-02	1.00e+00	4.799	1	4	74
GO:0002020	protease binding	3.54e-02	1.00e+00	4.799	1	6	74
GO:0004222	metalloendopeptidase activity	3.68e-02	1.00e+00	4.742	1	1	77
GO:0007603	phototransduction, visible light	3.73e-02	1.00e+00	4.723	1	1	78
GO:0007229	integrin-mediated signaling pathway	3.73e-02	1.00e+00	4.723	1	3	78
GO:0045177	apical part of cell	3.87e-02	1.00e+00	4.669	1	3	81
GO:0009653	anatomical structure morphogenesis	3.96e-02	1.00e+00	4.634	1	2	83
GO:0006898	receptor-mediated endocytosis	4.01e-02	1.00e+00	4.616	1	3	84
GO:0006936	muscle contraction	4.15e-02	1.00e+00	4.566	1	3	87
GO:0000187	activation of MAPK activity	4.29e-02	1.00e+00	4.517	1	3	90
GO:0007010	cytoskeleton organization	4.33e-02	1.00e+00	4.501	1	4	91
GO:0006928	cellular component movement	4.33e-02	1.00e+00	4.501	1	3	91
GO:0005178	integrin binding	4.57e-02	1.00e+00	4.424	1	4	96
GO:0043235	receptor complex	4.71e-02	1.00e+00	4.379	1	2	99
GO:0008360	regulation of cell shape	4.89e-02	1.00e+00	4.322	1	4	103
GO:0005938	cell cortex	4.94e-02	1.00e+00	4.308	1	5	104
GO:0004252	serine-type endopeptidase activity	5.03e-02	1.00e+00	4.281	1	3	106
GO:0022617	extracellular matrix disassembly	5.08e-02	1.00e+00	4.267	1	2	107
GO:0030529	ribonucleoprotein complex	5.31e-02	1.00e+00	4.201	1	5	112
GO:0043524	negative regulation of neuron apoptotic process	5.54e-02	1.00e+00	4.138	1	5	117
GO:0007568	aging	5.54e-02	1.00e+00	4.138	1	2	117
GO:0030027	lamellipodium	5.91e-02	1.00e+00	4.043	1	7	125
GO:0007179	transforming growth factor beta receptor signaling pathway	6.05e-02	1.00e+00	4.009	1	11	128
GO:0018108	peptidyl-tyrosine phosphorylation	6.23e-02	1.00e+00	3.964	1	4	132
GO:0045202	synapse	6.42e-02	1.00e+00	3.921	1	5	136
GO:0005887	integral component of plasma membrane	6.47e-02	1.00e+00	2.214	2	10	888
GO:0001666	response to hypoxia	7.01e-02	1.00e+00	3.790	1	7	149
GO:0000398	mRNA splicing, via spliceosome	7.69e-02	1.00e+00	3.651	1	15	164
GO:0044212	transcription regulatory region DNA binding	7.88e-02	1.00e+00	3.616	1	17	168
GO:0005768	endosome	7.92e-02	1.00e+00	3.608	1	3	169
GO:0008270	zinc ion binding	7.95e-02	1.00e+00	2.047	2	27	997
GO:0016607	nuclear speck	8.06e-02	1.00e+00	3.582	1	12	172
GO:0005667	transcription factor complex	8.19e-02	1.00e+00	3.558	1	17	175
GO:0031625	ubiquitin protein ligase binding	8.33e-02	1.00e+00	3.533	1	5	178
GO:0032403	protein complex binding	8.55e-02	1.00e+00	3.493	1	6	183
GO:0004872	receptor activity	8.82e-02	1.00e+00	3.446	1	8	189
GO:0007173	epidermal growth factor receptor signaling pathway	8.82e-02	1.00e+00	3.446	1	5	189
GO:0005654	nucleoplasm	9.17e-02	1.00e+00	1.929	2	64	1082
GO:0005765	lysosomal membrane	9.45e-02	1.00e+00	3.343	1	3	203
GO:0030425	dendrite	1.06e-01	1.00e+00	3.163	1	6	230
GO:0008380	RNA splicing	1.06e-01	1.00e+00	3.176	1	22	228
GO:0008134	transcription factor binding	1.12e-01	1.00e+00	3.090	1	18	242
GO:0043025	neuronal cell body	1.13e-01	1.00e+00	3.072	1	9	245
GO:0005886	plasma membrane	1.14e-01	1.00e+00	1.259	3	49	2582
GO:0000166	nucleotide binding	1.19e-01	1.00e+00	2.992	1	13	259
GO:0030198	extracellular matrix organization	1.30e-01	1.00e+00	2.864	1	6	283
GO:0005856	cytoskeleton	1.33e-01	1.00e+00	2.824	1	9	291
GO:0005634	nucleus	1.48e-01	1.00e+00	0.854	4	159	4559
GO:0015031	protein transport	1.54e-01	1.00e+00	2.595	1	11	341
GO:0003723	RNA binding	1.55e-01	1.00e+00	2.591	1	18	342
GO:0043565	sequence-specific DNA binding	1.56e-01	1.00e+00	2.574	1	11	346
GO:0007155	cell adhesion	1.66e-01	1.00e+00	2.481	1	5	369
GO:0009986	cell surface	1.80e-01	1.00e+00	2.358	1	9	402
GO:0007596	blood coagulation	2.01e-01	1.00e+00	2.179	1	11	455
GO:0048471	perinuclear region of cytoplasm	2.20e-01	1.00e+00	2.037	1	8	502
GO:0010467	gene expression	2.83e-01	1.00e+00	1.623	1	45	669
GO:0003700	sequence-specific DNA binding transcription factor activity	2.94e-01	1.00e+00	1.560	1	39	699
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	3.26e-01	1.00e+00	1.385	1	41	789
GO:0070062	extracellular vesicular exosome	3.29e-01	1.00e+00	0.780	2	57	2400
GO:0007165	signal transduction	3.65e-01	1.00e+00	1.184	1	13	907
GO:0005576	extracellular region	3.77e-01	1.00e+00	1.129	1	13	942
GO:0005615	extracellular space	3.82e-01	1.00e+00	1.106	1	20	957
GO:0006355	regulation of transcription, DNA-templated	3.94e-01	1.00e+00	1.047	1	43	997
GO:0003677	DNA binding	4.61e-01	1.00e+00	0.758	1	49	1218
GO:0005730	nucleolus	5.71e-01	1.00e+00	0.328	1	66	1641
GO:0016020	membrane	5.80e-01	1.00e+00	0.294	1	46	1681
GO:0005829	cytosol	7.36e-01	1.00e+00	-0.277	1	86	2496

chia-Fav

int-snw-4035

Statistics

Genes (7)

Interactions (6)

Related GO terms (159)