int-snw-2549

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.911	2.45e-16	1.88e-04	1.74e-03

chia-screen-data-Fav-int-snw-2549 subnetwork

Genes (6)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
APC	324	13	-2.293	3.004	353	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
PXN	5829	19	-2.554	3.193	206	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
MVP	9961	16	-2.846	3.193	20	Yes	Yes
[ GAB1 ]	2549	1	-1.635	2.911	41	-	-

Interactions (5)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PXN	5829	MVP	9961	pp	--	int.I2D: BIND
APC	324	PXN	5829	pp	--	int.I2D: MINT, MINT_Mouse; int.Mint: MI:0914(association)
PXN	5829	SRSF3	6428	pp	--	int.I2D: BIND
GAB1	2549	PXN	5829	pp	--	int.I2D: MINT; int.Mint: MI:0915(physical association)
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid

Related GO terms (168)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0035019	somatic stem cell maintenance	1.12e-04	1.00e+00	6.909	2	6	40
GO:0019901	protein kinase binding	2.00e-04	1.00e+00	4.508	3	18	317
GO:0008013	beta-catenin binding	2.53e-04	1.00e+00	6.324	2	9	60
GO:0060795	cell fate commitment involved in formation of primary germ layer	4.16e-04	1.00e+00	11.231	1	1	1
GO:0023057	negative regulation of signaling	4.16e-04	1.00e+00	11.231	1	1	1
GO:0051171	regulation of nitrogen compound metabolic process	4.16e-04	1.00e+00	11.231	1	1	1
GO:0072376	protein activation cascade	4.16e-04	1.00e+00	11.231	1	1	1
GO:0051435	BH4 domain binding	4.16e-04	1.00e+00	11.231	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	4.16e-04	1.00e+00	11.231	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	4.16e-04	1.00e+00	11.231	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	4.16e-04	1.00e+00	11.231	1	1	1
GO:0042483	negative regulation of odontogenesis	4.16e-04	1.00e+00	11.231	1	1	1
GO:0044337	canonical Wnt signaling pathway involved in positive regulation of apoptotic process	8.32e-04	1.00e+00	10.231	1	1	2
GO:0009786	regulation of asymmetric cell division	8.32e-04	1.00e+00	10.231	1	1	2
GO:0009798	axis specification	8.32e-04	1.00e+00	10.231	1	1	2
GO:0030027	lamellipodium	1.09e-03	1.00e+00	5.265	2	7	125
GO:0060913	cardiac cell fate determination	1.25e-03	1.00e+00	9.646	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.25e-03	1.00e+00	9.646	1	1	3
GO:0038127	ERBB signaling pathway	1.66e-03	1.00e+00	9.231	1	1	4
GO:0019887	protein kinase regulator activity	1.66e-03	1.00e+00	9.231	1	1	4
GO:0001714	endodermal cell fate specification	2.08e-03	1.00e+00	8.909	1	1	5
GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process	2.08e-03	1.00e+00	8.909	1	2	5
GO:0007173	epidermal growth factor receptor signaling pathway	2.47e-03	1.00e+00	4.669	2	5	189
GO:0030858	positive regulation of epithelial cell differentiation	2.49e-03	1.00e+00	8.646	1	1	6
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	2.91e-03	1.00e+00	8.424	1	2	7
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	2.91e-03	1.00e+00	8.424	1	1	7
GO:0051988	regulation of attachment of spindle microtubules to kinetochore	2.91e-03	1.00e+00	8.424	1	2	7
GO:0070102	interleukin-6-mediated signaling pathway	2.91e-03	1.00e+00	8.424	1	1	7
GO:0061099	negative regulation of protein tyrosine kinase activity	2.91e-03	1.00e+00	8.424	1	1	7
GO:0045670	regulation of osteoclast differentiation	3.32e-03	1.00e+00	8.231	1	2	8
GO:0007172	signal complex assembly	3.32e-03	1.00e+00	8.231	1	1	8
GO:0060396	growth hormone receptor signaling pathway	3.32e-03	1.00e+00	8.231	1	1	8
GO:0045667	regulation of osteoblast differentiation	3.74e-03	1.00e+00	8.061	1	1	9
GO:0031953	negative regulation of protein autophosphorylation	3.74e-03	1.00e+00	8.061	1	1	9
GO:0060711	labyrinthine layer development	3.74e-03	1.00e+00	8.061	1	3	9
GO:0035413	positive regulation of catenin import into nucleus	4.15e-03	1.00e+00	7.909	1	2	10
GO:0031274	positive regulation of pseudopodium assembly	4.15e-03	1.00e+00	7.909	1	2	10
GO:0030877	beta-catenin destruction complex	4.15e-03	1.00e+00	7.909	1	2	10
GO:0031116	positive regulation of microtubule polymerization	4.57e-03	1.00e+00	7.772	1	1	11
GO:0051010	microtubule plus-end binding	4.57e-03	1.00e+00	7.772	1	1	11
GO:0017166	vinculin binding	4.57e-03	1.00e+00	7.772	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	4.57e-03	1.00e+00	7.772	1	4	11
GO:0045295	gamma-catenin binding	4.98e-03	1.00e+00	7.646	1	1	12
GO:0032886	regulation of microtubule-based process	4.98e-03	1.00e+00	7.646	1	1	12
GO:0035198	miRNA binding	4.98e-03	1.00e+00	7.646	1	1	12
GO:0005515	protein binding	5.30e-03	1.00e+00	1.260	6	198	6024
GO:0044295	axonal growth cone	5.40e-03	1.00e+00	7.531	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	5.40e-03	1.00e+00	7.531	1	2	13
GO:0043409	negative regulation of MAPK cascade	5.40e-03	1.00e+00	7.531	1	2	13
GO:0005737	cytoplasm	5.70e-03	1.00e+00	1.674	5	124	3767
GO:0035371	microtubule plus-end	5.81e-03	1.00e+00	7.424	1	1	14
GO:0034614	cellular response to reactive oxygen species	5.81e-03	1.00e+00	7.424	1	2	14
GO:0001824	blastocyst development	6.22e-03	1.00e+00	7.324	1	2	15
GO:0007026	negative regulation of microtubule depolymerization	6.64e-03	1.00e+00	7.231	1	1	16
GO:0046716	muscle cell cellular homeostasis	6.64e-03	1.00e+00	7.231	1	1	16
GO:0043274	phospholipase binding	6.64e-03	1.00e+00	7.231	1	1	16
GO:0051276	chromosome organization	6.64e-03	1.00e+00	7.231	1	2	16
GO:0008283	cell proliferation	7.28e-03	1.00e+00	3.874	2	14	328
GO:0031122	cytoplasmic microtubule organization	7.47e-03	1.00e+00	7.061	1	1	18
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	7.88e-03	1.00e+00	6.983	1	2	19
GO:0048041	focal adhesion assembly	8.71e-03	1.00e+00	6.839	1	1	21
GO:0009954	proximal/distal pattern formation	8.71e-03	1.00e+00	6.839	1	1	21
GO:0000281	mitotic cytokinesis	8.71e-03	1.00e+00	6.839	1	2	21
GO:0007155	cell adhesion	9.15e-03	1.00e+00	3.704	2	5	369
GO:0045296	cadherin binding	9.94e-03	1.00e+00	6.646	1	3	24
GO:0048008	platelet-derived growth factor receptor signaling pathway	1.12e-02	1.00e+00	6.476	1	2	27
GO:0048754	branching morphogenesis of an epithelial tube	1.12e-02	1.00e+00	6.476	1	1	27
GO:0005875	microtubule associated complex	1.16e-02	1.00e+00	6.424	1	1	28
GO:0070830	tight junction assembly	1.16e-02	1.00e+00	6.424	1	1	28
GO:0006366	transcription from RNA polymerase II promoter	1.17e-02	1.00e+00	3.520	2	30	419
GO:0030032	lamellipodium assembly	1.20e-02	1.00e+00	6.373	1	1	29
GO:0005913	cell-cell adherens junction	1.20e-02	1.00e+00	6.373	1	3	29
GO:0009953	dorsal/ventral pattern formation	1.28e-02	1.00e+00	6.277	1	2	31
GO:0007094	mitotic spindle assembly checkpoint	1.28e-02	1.00e+00	6.277	1	3	31
GO:0033077	T cell differentiation in thymus	1.37e-02	1.00e+00	6.187	1	1	33
GO:0001942	hair follicle development	1.45e-02	1.00e+00	6.102	1	2	35
GO:0034446	substrate adhesion-dependent cell spreading	1.49e-02	1.00e+00	6.061	1	2	36
GO:0048538	thymus development	1.49e-02	1.00e+00	6.061	1	2	36
GO:0007257	activation of JUN kinase activity	1.49e-02	1.00e+00	6.061	1	5	36
GO:0051781	positive regulation of cell division	1.61e-02	1.00e+00	5.946	1	1	39
GO:0005881	cytoplasmic microtubule	1.65e-02	1.00e+00	5.909	1	1	40
GO:0045785	positive regulation of cell adhesion	1.65e-02	1.00e+00	5.909	1	2	40
GO:0031124	mRNA 3'-end processing	1.73e-02	1.00e+00	5.839	1	2	42
GO:0006369	termination of RNA polymerase II transcription	1.86e-02	1.00e+00	5.739	1	2	45
GO:0016328	lateral plasma membrane	1.90e-02	1.00e+00	5.708	1	3	46
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	1.94e-02	1.00e+00	5.677	1	2	47
GO:0005070	SH3/SH2 adaptor activity	1.98e-02	1.00e+00	5.646	1	2	48
GO:0030334	regulation of cell migration	2.06e-02	1.00e+00	5.587	1	5	50
GO:0045732	positive regulation of protein catabolic process	2.06e-02	1.00e+00	5.587	1	1	50
GO:0060041	retina development in camera-type eye	2.10e-02	1.00e+00	5.559	1	2	51
GO:0051028	mRNA transport	2.14e-02	1.00e+00	5.531	1	4	52
GO:0009611	response to wounding	2.14e-02	1.00e+00	5.531	1	5	52
GO:0001725	stress fiber	2.27e-02	1.00e+00	5.450	1	4	55
GO:0005643	nuclear pore	2.35e-02	1.00e+00	5.398	1	11	57
GO:0006406	mRNA export from nucleus	2.51e-02	1.00e+00	5.300	1	4	61
GO:0019903	protein phosphatase binding	2.55e-02	1.00e+00	5.277	1	2	62
GO:0000776	kinetochore	2.59e-02	1.00e+00	5.254	1	5	63
GO:0007409	axonogenesis	2.67e-02	1.00e+00	5.209	1	2	65
GO:0010468	regulation of gene expression	2.80e-02	1.00e+00	5.144	1	2	68
GO:0034329	cell junction assembly	2.80e-02	1.00e+00	5.144	1	3	68
GO:0008544	epidermis development	2.84e-02	1.00e+00	5.123	1	1	69
GO:0032587	ruffle membrane	2.88e-02	1.00e+00	5.102	1	3	70
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	3.04e-02	1.00e+00	5.022	1	4	74
GO:0060070	canonical Wnt signaling pathway	3.08e-02	1.00e+00	5.002	1	4	75
GO:0001822	kidney development	3.20e-02	1.00e+00	4.946	1	3	78
GO:0007229	integrin-mediated signaling pathway	3.20e-02	1.00e+00	4.946	1	3	78
GO:0009653	anatomical structure morphogenesis	3.40e-02	1.00e+00	4.856	1	2	83
GO:0009952	anterior/posterior pattern specification	3.40e-02	1.00e+00	4.856	1	4	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	3.53e-02	1.00e+00	4.805	1	8	86
GO:0005923	tight junction	3.53e-02	1.00e+00	4.805	1	2	86
GO:0006979	response to oxidative stress	3.57e-02	1.00e+00	4.788	1	6	87
GO:0006936	muscle contraction	3.57e-02	1.00e+00	4.788	1	3	87
GO:0000187	activation of MAPK activity	3.69e-02	1.00e+00	4.739	1	3	90
GO:0007010	cytoskeleton organization	3.73e-02	1.00e+00	4.723	1	4	91
GO:0006928	cellular component movement	3.73e-02	1.00e+00	4.723	1	3	91
GO:0005178	integrin binding	3.93e-02	1.00e+00	4.646	1	4	96
GO:0008360	regulation of cell shape	4.21e-02	1.00e+00	4.545	1	4	103
GO:0005938	cell cortex	4.25e-02	1.00e+00	4.531	1	5	104
GO:0006461	protein complex assembly	4.53e-02	1.00e+00	4.437	1	4	111
GO:0030529	ribonucleoprotein complex	4.57e-02	1.00e+00	4.424	1	5	112
GO:0048015	phosphatidylinositol-mediated signaling	4.65e-02	1.00e+00	4.398	1	2	114
GO:0007050	cell cycle arrest	5.05e-02	1.00e+00	4.277	1	5	124
GO:0030335	positive regulation of cell migration	5.17e-02	1.00e+00	4.242	1	5	127
GO:0007179	transforming growth factor beta receptor signaling pathway	5.21e-02	1.00e+00	4.231	1	11	128
GO:0016477	cell migration	5.21e-02	1.00e+00	4.231	1	4	128
GO:0018108	peptidyl-tyrosine phosphorylation	5.37e-02	1.00e+00	4.187	1	4	132
GO:0007507	heart development	5.65e-02	1.00e+00	4.112	1	7	139
GO:0008286	insulin receptor signaling pathway	5.76e-02	1.00e+00	4.081	1	1	142
GO:0008017	microtubule binding	5.96e-02	1.00e+00	4.031	1	2	147
GO:0006974	cellular response to DNA damage stimulus	6.12e-02	1.00e+00	3.993	1	7	151
GO:0008543	fibroblast growth factor receptor signaling pathway	6.32e-02	1.00e+00	3.946	1	1	156
GO:0044822	poly(A) RNA binding	6.59e-02	1.00e+00	2.187	2	50	1056
GO:0000398	mRNA splicing, via spliceosome	6.63e-02	1.00e+00	3.874	1	15	164
GO:0044212	transcription regulatory region DNA binding	6.79e-02	1.00e+00	3.839	1	17	168
GO:0038095	Fc-epsilon receptor signaling pathway	6.79e-02	1.00e+00	3.839	1	5	168
GO:0005829	cytosol	6.86e-02	1.00e+00	1.531	3	86	2496
GO:0005654	nucleoplasm	6.89e-02	1.00e+00	2.152	2	64	1082
GO:0016607	nuclear speck	6.95e-02	1.00e+00	3.805	1	12	172
GO:0005667	transcription factor complex	7.06e-02	1.00e+00	3.780	1	17	175
GO:0031625	ubiquitin protein ligase binding	7.18e-02	1.00e+00	3.755	1	5	178
GO:0004871	signal transducer activity	8.35e-02	1.00e+00	3.531	1	4	208
GO:0005634	nucleus	8.39e-02	1.00e+00	1.077	4	159	4559
GO:0008380	RNA splicing	9.12e-02	1.00e+00	3.398	1	22	228
GO:0008134	transcription factor binding	9.66e-02	1.00e+00	3.312	1	18	242
GO:0000166	nucleotide binding	1.03e-01	1.00e+00	3.214	1	13	259
GO:0043065	positive regulation of apoptotic process	1.06e-01	1.00e+00	3.165	1	7	268
GO:0048011	neurotrophin TRK receptor signaling pathway	1.07e-01	1.00e+00	3.160	1	7	269
GO:0005856	cytoskeleton	1.15e-01	1.00e+00	3.046	1	9	291
GO:0005813	centrosome	1.28e-01	1.00e+00	2.882	1	7	326
GO:0015031	protein transport	1.34e-01	1.00e+00	2.817	1	11	341
GO:0003723	RNA binding	1.34e-01	1.00e+00	2.813	1	18	342
GO:0043565	sequence-specific DNA binding	1.36e-01	1.00e+00	2.796	1	11	346
GO:0008285	negative regulation of cell proliferation	1.38e-01	1.00e+00	2.768	1	10	353
GO:0005925	focal adhesion	1.43e-01	1.00e+00	2.715	1	9	366
GO:0048471	perinuclear region of cytoplasm	1.92e-01	1.00e+00	2.260	1	8	502
GO:0006915	apoptotic process	2.10e-01	1.00e+00	2.115	1	12	555
GO:0045087	innate immune response	2.24e-01	1.00e+00	2.012	1	15	596
GO:0010467	gene expression	2.48e-01	1.00e+00	1.845	1	45	669
GO:0003700	sequence-specific DNA binding transcription factor activity	2.58e-01	1.00e+00	1.782	1	39	699
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	2.87e-01	1.00e+00	1.607	1	41	789
GO:0005886	plasma membrane	2.93e-01	1.00e+00	0.897	2	49	2582
GO:0007165	signal transduction	3.23e-01	1.00e+00	1.406	1	13	907
GO:0006355	regulation of transcription, DNA-templated	3.49e-01	1.00e+00	1.270	1	43	997
GO:0008270	zinc ion binding	3.49e-01	1.00e+00	1.270	1	27	997
GO:0003677	DNA binding	4.11e-01	1.00e+00	0.981	1	49	1218
GO:0005730	nucleolus	5.16e-01	1.00e+00	0.551	1	66	1641
GO:0016020	membrane	5.25e-01	1.00e+00	0.516	1	46	1681
GO:0070062	extracellular vesicular exosome	6.65e-01	1.00e+00	0.002	1	57	2400

chia-Fav

int-snw-2549

Statistics

Genes (6)

Interactions (5)

Related GO terms (168)