int-snw-1292

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.925	1.73e-16	1.58e-04	1.53e-03

chia-screen-data-Fav-int-snw-1292 subnetwork

Genes (6)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
PXN	5829	19	-2.554	3.193	206	Yes	Yes
SRSF3	6428	73	-2.992	3.538	54	Yes	-
[ COL6A2 ]	1292	1	-1.868	2.925	7	-	-
MVP	9961	16	-2.846	3.193	20	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
COX6A2	1339	1	-2.142	2.925	4	Yes	-

Interactions (5)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
COL6A2	1292	COX6A2	1339	pp	--	int.Intact: MI:0915(physical association)
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
COL6A2	1292	PXN	5829	pp	--	int.I2D: BIND
PXN	5829	SRSF3	6428	pp	--	int.I2D: BIND
PXN	5829	MVP	9961	pp	--	int.I2D: BIND

Related GO terms (110)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0051435	BH4 domain binding	4.16e-04	1.00e+00	11.231	1	1	1
GO:0060795	cell fate commitment involved in formation of primary germ layer	4.16e-04	1.00e+00	11.231	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	4.16e-04	1.00e+00	11.231	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	4.16e-04	1.00e+00	11.231	1	1	1
GO:0023057	negative regulation of signaling	4.16e-04	1.00e+00	11.231	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	4.16e-04	1.00e+00	11.231	1	1	1
GO:0072376	protein activation cascade	4.16e-04	1.00e+00	11.231	1	1	1
GO:0009786	regulation of asymmetric cell division	8.32e-04	1.00e+00	10.231	1	1	2
GO:0060913	cardiac cell fate determination	1.25e-03	1.00e+00	9.646	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.25e-03	1.00e+00	9.646	1	1	3
GO:0038127	ERBB signaling pathway	1.66e-03	1.00e+00	9.231	1	1	4
GO:0005751	mitochondrial respiratory chain complex IV	1.66e-03	1.00e+00	9.231	1	1	4
GO:0001714	endodermal cell fate specification	2.08e-03	1.00e+00	8.909	1	1	5
GO:0061099	negative regulation of protein tyrosine kinase activity	2.91e-03	1.00e+00	8.424	1	1	7
GO:0007172	signal complex assembly	3.32e-03	1.00e+00	8.231	1	1	8
GO:0060396	growth hormone receptor signaling pathway	3.32e-03	1.00e+00	8.231	1	1	8
GO:0070208	protein heterotrimerization	3.74e-03	1.00e+00	8.061	1	1	9
GO:0031953	negative regulation of protein autophosphorylation	3.74e-03	1.00e+00	8.061	1	1	9
GO:0035413	positive regulation of catenin import into nucleus	4.15e-03	1.00e+00	7.909	1	2	10
GO:0017166	vinculin binding	4.57e-03	1.00e+00	7.772	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	4.57e-03	1.00e+00	7.772	1	4	11
GO:0035198	miRNA binding	4.98e-03	1.00e+00	7.646	1	1	12
GO:0042789	mRNA transcription from RNA polymerase II promoter	5.40e-03	1.00e+00	7.531	1	2	13
GO:0034614	cellular response to reactive oxygen species	5.81e-03	1.00e+00	7.424	1	2	14
GO:0001824	blastocyst development	6.22e-03	1.00e+00	7.324	1	2	15
GO:0043274	phospholipase binding	6.64e-03	1.00e+00	7.231	1	1	16
GO:0019901	protein kinase binding	6.81e-03	1.00e+00	3.923	2	18	317
GO:0004129	cytochrome-c oxidase activity	8.29e-03	1.00e+00	6.909	1	1	20
GO:0048041	focal adhesion assembly	8.71e-03	1.00e+00	6.839	1	1	21
GO:0007155	cell adhesion	9.15e-03	1.00e+00	3.704	2	5	369
GO:0048754	branching morphogenesis of an epithelial tube	1.12e-02	1.00e+00	6.476	1	1	27
GO:0005875	microtubule associated complex	1.16e-02	1.00e+00	6.424	1	1	28
GO:0006366	transcription from RNA polymerase II promoter	1.17e-02	1.00e+00	3.520	2	30	419
GO:0030032	lamellipodium assembly	1.20e-02	1.00e+00	6.373	1	1	29
GO:0034446	substrate adhesion-dependent cell spreading	1.49e-02	1.00e+00	6.061	1	2	36
GO:0005581	collagen trimer	1.57e-02	1.00e+00	5.983	1	1	38
GO:0035019	somatic stem cell maintenance	1.65e-02	1.00e+00	5.909	1	6	40
GO:0031124	mRNA 3'-end processing	1.73e-02	1.00e+00	5.839	1	2	42
GO:1902600	hydrogen ion transmembrane transport	1.78e-02	1.00e+00	5.805	1	2	43
GO:0006369	termination of RNA polymerase II transcription	1.86e-02	1.00e+00	5.739	1	2	45
GO:0006091	generation of precursor metabolites and energy	2.06e-02	1.00e+00	5.587	1	1	50
GO:0009611	response to wounding	2.14e-02	1.00e+00	5.531	1	5	52
GO:0051028	mRNA transport	2.14e-02	1.00e+00	5.531	1	4	52
GO:0001725	stress fiber	2.27e-02	1.00e+00	5.450	1	4	55
GO:0005643	nuclear pore	2.35e-02	1.00e+00	5.398	1	11	57
GO:0008013	beta-catenin binding	2.47e-02	1.00e+00	5.324	1	9	60
GO:0006406	mRNA export from nucleus	2.51e-02	1.00e+00	5.300	1	4	61
GO:0019903	protein phosphatase binding	2.55e-02	1.00e+00	5.277	1	2	62
GO:0009749	response to glucose	2.63e-02	1.00e+00	5.231	1	7	64
GO:0030574	collagen catabolic process	2.76e-02	1.00e+00	5.165	1	2	67
GO:0010468	regulation of gene expression	2.80e-02	1.00e+00	5.144	1	2	68
GO:0034329	cell junction assembly	2.80e-02	1.00e+00	5.144	1	3	68
GO:0042383	sarcolemma	2.92e-02	1.00e+00	5.081	1	1	71
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	3.04e-02	1.00e+00	5.022	1	4	74
GO:0007229	integrin-mediated signaling pathway	3.20e-02	1.00e+00	4.946	1	3	78
GO:0009653	anatomical structure morphogenesis	3.40e-02	1.00e+00	4.856	1	2	83
GO:0006936	muscle contraction	3.57e-02	1.00e+00	4.788	1	3	87
GO:0000187	activation of MAPK activity	3.69e-02	1.00e+00	4.739	1	3	90
GO:0007010	cytoskeleton organization	3.73e-02	1.00e+00	4.723	1	4	91
GO:0006928	cellular component movement	3.73e-02	1.00e+00	4.723	1	3	91
GO:0005178	integrin binding	3.93e-02	1.00e+00	4.646	1	4	96
GO:0008360	regulation of cell shape	4.21e-02	1.00e+00	4.545	1	4	103
GO:0005938	cell cortex	4.25e-02	1.00e+00	4.531	1	5	104
GO:0022617	extracellular matrix disassembly	4.37e-02	1.00e+00	4.490	1	2	107
GO:0005737	cytoplasm	4.38e-02	1.00e+00	1.352	4	124	3767
GO:0030529	ribonucleoprotein complex	4.57e-02	1.00e+00	4.424	1	5	112
GO:0005515	protein binding	4.97e-02	1.00e+00	0.997	5	198	6024
GO:0030027	lamellipodium	5.09e-02	1.00e+00	4.265	1	7	125
GO:0007179	transforming growth factor beta receptor signaling pathway	5.21e-02	1.00e+00	4.231	1	11	128
GO:0031982	vesicle	5.33e-02	1.00e+00	4.198	1	3	131
GO:0018108	peptidyl-tyrosine phosphorylation	5.37e-02	1.00e+00	4.187	1	4	132
GO:0005788	endoplasmic reticulum lumen	5.88e-02	1.00e+00	4.051	1	5	145
GO:0031012	extracellular matrix	6.24e-02	1.00e+00	3.964	1	6	154
GO:0005578	proteinaceous extracellular matrix	6.48e-02	1.00e+00	3.909	1	4	160
GO:0044822	poly(A) RNA binding	6.59e-02	1.00e+00	2.187	2	50	1056
GO:0000398	mRNA splicing, via spliceosome	6.63e-02	1.00e+00	3.874	1	15	164
GO:0044212	transcription regulatory region DNA binding	6.79e-02	1.00e+00	3.839	1	17	168
GO:0005654	nucleoplasm	6.89e-02	1.00e+00	2.152	2	64	1082
GO:0016607	nuclear speck	6.95e-02	1.00e+00	3.805	1	12	172
GO:0005667	transcription factor complex	7.06e-02	1.00e+00	3.780	1	17	175
GO:0031625	ubiquitin protein ligase binding	7.18e-02	1.00e+00	3.755	1	5	178
GO:0007173	epidermal growth factor receptor signaling pathway	7.61e-02	1.00e+00	3.669	1	5	189
GO:0008380	RNA splicing	9.12e-02	1.00e+00	3.398	1	22	228
GO:0008134	transcription factor binding	9.66e-02	1.00e+00	3.312	1	18	242
GO:0000166	nucleotide binding	1.03e-01	1.00e+00	3.214	1	13	259
GO:0030198	extracellular matrix organization	1.12e-01	1.00e+00	3.086	1	6	283
GO:0005856	cytoskeleton	1.15e-01	1.00e+00	3.046	1	9	291
GO:0043234	protein complex	1.17e-01	1.00e+00	3.027	1	11	295
GO:0007411	axon guidance	1.26e-01	1.00e+00	2.914	1	5	319
GO:0008283	cell proliferation	1.29e-01	1.00e+00	2.874	1	14	328
GO:0015031	protein transport	1.34e-01	1.00e+00	2.817	1	11	341
GO:0003723	RNA binding	1.34e-01	1.00e+00	2.813	1	18	342
GO:0043565	sequence-specific DNA binding	1.36e-01	1.00e+00	2.796	1	11	346
GO:0005925	focal adhesion	1.43e-01	1.00e+00	2.715	1	9	366
GO:0048471	perinuclear region of cytoplasm	1.92e-01	1.00e+00	2.260	1	8	502
GO:0010467	gene expression	2.48e-01	1.00e+00	1.845	1	45	669
GO:0003700	sequence-specific DNA binding transcription factor activity	2.58e-01	1.00e+00	1.782	1	39	699
GO:0070062	extracellular vesicular exosome	2.63e-01	1.00e+00	1.002	2	57	2400
GO:0005634	nucleus	2.86e-01	1.00e+00	0.662	3	159	4559
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	2.87e-01	1.00e+00	1.607	1	41	789
GO:0007165	signal transduction	3.23e-01	1.00e+00	1.406	1	13	907
GO:0005576	extracellular region	3.33e-01	1.00e+00	1.352	1	13	942
GO:0005615	extracellular space	3.38e-01	1.00e+00	1.329	1	20	957
GO:0006355	regulation of transcription, DNA-templated	3.49e-01	1.00e+00	1.270	1	43	997
GO:0008270	zinc ion binding	3.49e-01	1.00e+00	1.270	1	27	997
GO:0003677	DNA binding	4.11e-01	1.00e+00	0.981	1	49	1218
GO:0005730	nucleolus	5.16e-01	1.00e+00	0.551	1	66	1641
GO:0016020	membrane	5.25e-01	1.00e+00	0.516	1	46	1681
GO:0005829	cytosol	6.80e-01	1.00e+00	-0.054	1	86	2496
GO:0005886	plasma membrane	6.94e-01	1.00e+00	-0.103	1	49	2582

chia-Fav

int-snw-1292

Statistics

Genes (6)

Interactions (5)

Related GO terms (110)