int-snw-10309

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.866	7.78e-16	3.34e-04	2.61e-03

chia-screen-data-Fav-int-snw-10309 subnetwork

Genes (5)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
APLF	200558	2	-2.206	2.866	10	Yes	-
XRCC1	7515	3	-2.092	3.043	34	Yes	Yes
[ CCNO ]	10309	1	-1.753	2.866	6	-	-

Interactions (4)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
POU5F1	5460	XRCC1	7515	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
XRCC1	7515	APLF	200558	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, HPRD; int.HPRD: in vitro, in vivo, yeast 2-hybrid
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
XRCC1	7515	CCNO	10309	pp	--	int.I2D: MINT; int.Mint: MI:0915(physical association)

Related GO terms (68)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0000012	single strand break repair	2.02e-06	2.91e-02	9.687	2	3	7
GO:0006281	DNA repair	5.70e-05	8.23e-01	5.051	3	14	261
GO:0006284	base-excision repair	6.37e-05	9.19e-01	7.285	2	3	37
GO:0060795	cell fate commitment involved in formation of primary germ layer	3.47e-04	1.00e+00	11.494	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	3.47e-04	1.00e+00	11.494	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	3.47e-04	1.00e+00	11.494	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	3.47e-04	1.00e+00	11.494	1	1	1
GO:0009786	regulation of asymmetric cell division	6.93e-04	1.00e+00	10.494	1	1	2
GO:0060913	cardiac cell fate determination	1.04e-03	1.00e+00	9.909	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.04e-03	1.00e+00	9.909	1	1	3
GO:0051106	positive regulation of DNA ligation	1.04e-03	1.00e+00	9.909	1	1	3
GO:0045191	regulation of isotype switching	1.39e-03	1.00e+00	9.494	1	1	4
GO:0004844	uracil DNA N-glycosylase activity	1.39e-03	1.00e+00	9.494	1	1	4
GO:1903251	multi-ciliated epithelial cell differentiation	1.39e-03	1.00e+00	9.494	1	1	4
GO:0001714	endodermal cell fate specification	1.73e-03	1.00e+00	9.172	1	1	5
GO:0045008	depyrimidination	1.73e-03	1.00e+00	9.172	1	1	5
GO:0004520	endodeoxyribonuclease activity	2.08e-03	1.00e+00	8.909	1	1	6
GO:0006285	base-excision repair, AP site formation	2.77e-03	1.00e+00	8.494	1	1	8
GO:0035413	positive regulation of catenin import into nucleus	3.46e-03	1.00e+00	8.172	1	2	10
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	3.46e-03	1.00e+00	8.172	1	2	10
GO:0042493	response to drug	3.71e-03	1.00e+00	4.344	2	6	284
GO:0005654	nucleoplasm	3.75e-03	1.00e+00	3.000	3	64	1082
GO:0060391	positive regulation of SMAD protein import into nucleus	3.81e-03	1.00e+00	8.035	1	4	11
GO:0035198	miRNA binding	4.15e-03	1.00e+00	7.909	1	1	12
GO:0042789	mRNA transcription from RNA polymerase II promoter	4.50e-03	1.00e+00	7.794	1	2	13
GO:0031011	Ino80 complex	4.84e-03	1.00e+00	7.687	1	6	14
GO:0001824	blastocyst development	5.19e-03	1.00e+00	7.587	1	2	15
GO:0008408	3'-5' exonuclease activity	5.54e-03	1.00e+00	7.494	1	1	16
GO:0035861	site of double-strand break	6.23e-03	1.00e+00	7.324	1	1	18
GO:0006366	transcription from RNA polymerase II promoter	7.94e-03	1.00e+00	3.783	2	30	419
GO:0010033	response to organic substance	9.33e-03	1.00e+00	6.739	1	1	27
GO:0000737	DNA catabolic process, endonucleolytic	1.21e-02	1.00e+00	6.365	1	2	35
GO:0021766	hippocampus development	1.31e-02	1.00e+00	6.246	1	1	38
GO:0035019	somatic stem cell maintenance	1.38e-02	1.00e+00	6.172	1	6	40
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	1.55e-02	1.00e+00	6.002	1	2	45
GO:0003684	damaged DNA binding	1.69e-02	1.00e+00	5.879	1	2	49
GO:0009611	response to wounding	1.79e-02	1.00e+00	5.794	1	5	52
GO:0090305	nucleic acid phosphodiester bond hydrolysis	1.82e-02	1.00e+00	5.766	1	3	53
GO:0006302	double-strand break repair	2.13e-02	1.00e+00	5.540	1	3	62
GO:0006310	DNA recombination	2.23e-02	1.00e+00	5.472	1	7	65
GO:0010468	regulation of gene expression	2.34e-02	1.00e+00	5.407	1	2	68
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	2.54e-02	1.00e+00	5.285	1	4	74
GO:0002020	protease binding	2.54e-02	1.00e+00	5.285	1	6	74
GO:0051301	cell division	2.78e-02	1.00e+00	5.154	1	2	81
GO:0009653	anatomical structure morphogenesis	2.84e-02	1.00e+00	5.119	1	2	83
GO:0042384	cilium assembly	2.95e-02	1.00e+00	5.068	1	1	86
GO:0005634	nucleus	3.73e-02	1.00e+00	1.340	4	159	4559
GO:0006355	regulation of transcription, DNA-templated	4.15e-02	1.00e+00	2.533	2	43	997
GO:0001666	response to hypoxia	5.06e-02	1.00e+00	4.275	1	7	149
GO:0006974	cellular response to DNA damage stimulus	5.13e-02	1.00e+00	4.256	1	7	151
GO:0044212	transcription regulatory region DNA binding	5.69e-02	1.00e+00	4.102	1	17	168
GO:0007049	cell cycle	5.89e-02	1.00e+00	4.051	1	6	174
GO:0005667	transcription factor complex	5.92e-02	1.00e+00	4.043	1	17	175
GO:0003677	DNA binding	6.00e-02	1.00e+00	2.244	2	49	1218
GO:0031625	ubiquitin protein ligase binding	6.02e-02	1.00e+00	4.018	1	5	178
GO:0008134	transcription factor binding	8.11e-02	1.00e+00	3.575	1	18	242
GO:0000166	nucleotide binding	8.66e-02	1.00e+00	3.477	1	13	259
GO:0006954	inflammatory response	9.24e-02	1.00e+00	3.380	1	6	277
GO:0005515	protein binding	1.01e-01	1.00e+00	0.938	4	198	6024
GO:0005730	nucleolus	1.02e-01	1.00e+00	1.814	2	66	1641
GO:0019901	protein kinase binding	1.05e-01	1.00e+00	3.186	1	18	317
GO:0043565	sequence-specific DNA binding	1.14e-01	1.00e+00	3.060	1	11	346
GO:0005829	cytosol	2.09e-01	1.00e+00	1.209	2	86	2496
GO:0003700	sequence-specific DNA binding transcription factor activity	2.20e-01	1.00e+00	2.045	1	39	699
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	2.45e-01	1.00e+00	1.870	1	41	789
GO:0044822	poly(A) RNA binding	3.16e-01	1.00e+00	1.450	1	50	1056
GO:0046872	metal ion binding	3.78e-01	1.00e+00	1.142	1	29	1307
GO:0005737	cytoplasm	3.91e-01	1.00e+00	0.615	2	124	3767

chia-Fav

int-snw-10309

Statistics

Genes (5)

Interactions (4)

Related GO terms (68)