meta-reg-snw-2547

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
int-snw-9527 wolf-screen-ratio-mammosphere-adherent 0.934 1.77e-15 2.52e-03 4.06e-02 10 9
reg-snw-2547 wolf-screen-ratio-mammosphere-adherent 0.862 2.49e-07 1.43e-03 2.94e-03 5 4
wolf-screen-ratio-mammosphere-adherent-meta-reg-snw-2547 subnetwork

Genes (12)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree Transcription factor wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
XRCC6 2547 20.0310.86263TF--
CLTC 1213 560.8841.138247-Yes-
RPL8 6132 240.7780.874234TFYes-
HNRNPC 3183 1081.8120.973181-Yes-
RPL6 6128 370.8441.113164-Yes-
RPL14 9045 491.2501.113166-Yes-
TUBA1C 84790 50.9660.99391-Yes-
POLR2H 5437 20.7750.86214-Yes-
ACTB 60 1341.1531.151610-Yes-
HSPD1 3329 700.9131.035325-Yes-
GOSR1 9527 3-0.0220.934176---
RPL11 6135 210.7181.017200-Yes-

Interactions (24)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ACTB 60 RPL11 6135 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 CLTC 1213 pp -- int.I2D: IntAct_Yeast
ACTB 60 HSPD1 3329 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, YeastLow
RPL14 9045 GOSR1 9527 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
ACTB 60 GOSR1 9527 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
XRCC6 2547 RPL8 6132 pd <> reg.ITFP.txt: no annot
RPL8 6132 GOSR1 9527 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
RPL6 6128 GOSR1 9527 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
XRCC6 2547 HSPD1 3329 pd > reg.ITFP.txt: no annot
RPL11 6135 GOSR1 9527 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPC 3183 GOSR1 9527 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
RPL8 6132 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
RPL8 6132 RPL11 6135 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium, IntAct_Yeast
RPL11 6135 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
CLTC 1213 GOSR1 9527 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
XRCC6 2547 POLR2H 5437 pd > reg.ITFP.txt: no annot
XRCC6 2547 HNRNPC 3183 pd > reg.ITFP.txt: no annot
RPL6 6128 RPL8 6132 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB 60 RPL6 6128 pp -- int.I2D: BioGrid_Yeast
CLTC 1213 XRCC6 2547 pp -- int.Intact: MI:0915(physical association);
int.I2D: HPRD, IntAct, BIND, MINT;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
RPL6 6128 RPL11 6135 pp -- int.I2D: BioGrid_Yeast
GOSR1 9527 TUBA1C 84790 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
HSPD1 3329 GOSR1 9527 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
RPL6 6128 RPL14 9045 pp -- int.I2D: BioGrid_Yeast

Related GO terms (212)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0016020membrane1.03e-081.69e-042.96210801746
GO:0016032viral process2.86e-084.67e-044.140755540
GO:0022625cytosolic large ribosomal subunit3.49e-085.69e-046.7954549
GO:0044822poly(A) RNA binding1.38e-072.25e-033.3358501078
GO:0019083viral transcription2.70e-074.41e-036.0704881
GO:0006415translational termination3.61e-075.89e-035.9674887
GO:0005829cytosol4.35e-077.10e-032.408101252562
GO:0006414translational elongation4.72e-077.71e-035.87041193
GO:0044267cellular protein metabolic process5.97e-079.75e-034.043624495
GO:0006614SRP-dependent cotranslational protein targeting to membrane7.40e-071.21e-025.70948104
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.07e-061.75e-025.577410114
GO:0019058viral life cycle1.11e-061.81e-025.564410115
GO:0006413translational initiation1.87e-063.05e-025.376412131
GO:0003735structural constituent of ribosome2.50e-064.09e-025.27048141
GO:0003723RNA binding3.31e-065.40e-024.260519355
GO:0010467gene expression3.47e-065.66e-023.609658669
GO:0016071mRNA metabolic process1.54e-052.52e-014.609434223
GO:0006412translation1.89e-053.09e-014.533415235
GO:0016070RNA metabolic process2.30e-053.76e-014.461434247
GO:0042273ribosomal large subunit biogenesis3.85e-056.28e-017.7092413
GO:0043234protein complex4.93e-058.05e-014.181417300
GO:0005925focal adhesion1.11e-041.00e+003.878418370
GO:0036464cytoplasmic ribonucleoprotein granule1.14e-041.00e+006.9502422
GO:0043044ATP-dependent chromatin remodeling1.24e-041.00e+006.8862423
GO:0019843rRNA binding1.72e-041.00e+006.6552327
GO:0031492nucleosomal DNA binding1.85e-041.00e+006.6022428
GO:0051084'de novo' posttranslational protein folding3.25e-041.00e+006.2002437
GO:0003725double-stranded RNA binding6.94e-041.00e+005.6552654
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding6.94e-041.00e+005.6552554
GO:0002842positive regulation of T cell mediated immune response to tumor cell7.35e-041.00e+0010.409111
GO:0048291isotype switching to IgG isotypes7.35e-041.00e+0010.409111
GO:0002368B cell cytokine production7.35e-041.00e+0010.409111
GO:0032481positive regulation of type I interferon production8.85e-041.00e+005.4792661
GO:0043564Ku70:Ku80 complex1.47e-031.00e+009.409112
GO:0071475cellular hyperosmotic salinity response1.47e-031.00e+009.409112
GO:0005200structural constituent of cytoskeleton2.04e-031.00e+004.8702793
GO:0001649osteoblast differentiation2.13e-031.00e+004.8402695
GO:0006364rRNA processing2.17e-031.00e+004.8252596
GO:1900126negative regulation of hyaluronan biosynthetic process2.20e-031.00e+008.825113
GO:0006458'de novo' protein folding2.20e-031.00e+008.825113
GO:0030135coated vesicle2.20e-031.00e+008.825113
GO:0071439clathrin complex2.20e-031.00e+008.825113
GO:0032051clathrin light chain binding2.94e-031.00e+008.409114
GO:00515755'-deoxyribose-5-phosphate lyase activity2.94e-031.00e+008.409124
GO:1903077negative regulation of protein localization to plasma membrane2.94e-031.00e+008.409114
GO:0006266DNA ligation3.67e-031.00e+008.088115
GO:0003691double-stranded telomeric DNA binding3.67e-031.00e+008.088115
GO:0071481cellular response to X-ray3.67e-031.00e+008.088115
GO:0046696lipopolysaccharide receptor complex3.67e-031.00e+008.088115
GO:0000790nuclear chromatin4.12e-031.00e+004.35427133
GO:0031982vesicle4.18e-031.00e+004.343210134
GO:0070419nonhomologous end joining complex4.40e-031.00e+007.825116
GO:0003688DNA replication origin binding4.40e-031.00e+007.825116
GO:0030130clathrin coat of trans-Golgi network vesicle4.40e-031.00e+007.825116
GO:0030957Tat protein binding4.40e-031.00e+007.825146
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex4.40e-031.00e+007.825116
GO:0030118clathrin coat4.40e-031.00e+007.825116
GO:0061024membrane organization4.95e-031.00e+004.22025146
GO:0030132clathrin coat of coated pit5.14e-031.00e+007.602117
GO:0006457protein folding5.15e-031.00e+004.19028149
GO:0070062extracellular vesicular exosome5.32e-031.00e+001.6986982516
GO:0005198structural molecule activity5.84e-031.00e+004.09724159
GO:0001055RNA polymerase II activity5.87e-031.00e+007.409138
GO:0075713establishment of integrated proviral latency5.87e-031.00e+007.409128
GO:0070688MLL5-L complex5.87e-031.00e+007.409118
GO:0000398mRNA splicing, via spliceosome6.27e-031.00e+004.043212165
GO:0005654nucleoplasm6.45e-031.00e+002.3134831095
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding6.50e-031.00e+004.01725168
GO:0000783nuclear telomere cap complex6.60e-031.00e+007.240119
GO:0033151V(D)J recombination6.60e-031.00e+007.240119
GO:0043032positive regulation of macrophage activation7.33e-031.00e+007.0881110
GO:0051604protein maturation7.33e-031.00e+007.0881110
GO:0032727positive regulation of interferon-alpha production8.06e-031.00e+006.9501111
GO:0001054RNA polymerase I activity8.06e-031.00e+006.9501311
GO:0045120pronucleus8.06e-031.00e+006.9501111
GO:0005736DNA-directed RNA polymerase I complex8.79e-031.00e+006.8251312
GO:00709353'-UTR-mediated mRNA stabilization8.79e-031.00e+006.8251212
GO:0045087innate immune response9.12e-031.00e+002.728320616
GO:0001530lipopolysaccharide binding9.52e-031.00e+006.7091213
GO:0008266poly(U) RNA binding9.52e-031.00e+006.7091113
GO:0051131chaperone-mediated protein complex assembly9.52e-031.00e+006.7091113
GO:0035267NuA4 histone acetyltransferase complex1.02e-021.00e+006.6021414
GO:0030705cytoskeleton-dependent intracellular transport1.02e-021.00e+006.6021114
GO:0042026protein refolding1.10e-021.00e+006.5031215
GO:0050998nitric-oxide synthase binding1.17e-021.00e+006.4091116
GO:0005665DNA-directed RNA polymerase II, core complex1.17e-021.00e+006.4091416
GO:0001056RNA polymerase III activity1.17e-021.00e+006.4091316
GO:0008380RNA splicing1.21e-021.00e+003.551213232
GO:0005666DNA-directed RNA polymerase III complex1.24e-021.00e+006.3221317
GO:0050870positive regulation of T cell activation1.24e-021.00e+006.3221117
GO:0006891intra-Golgi vesicle-mediated transport1.24e-021.00e+006.3221117
GO:0006386termination of RNA polymerase III transcription1.32e-021.00e+006.2401318
GO:0006385transcription elongation from RNA polymerase III promoter1.32e-021.00e+006.2401318
GO:0006303double-strand break repair via nonhomologous end joining1.32e-021.00e+006.2401318
GO:0032733positive regulation of interleukin-10 production1.39e-021.00e+006.1621119
GO:0050769positive regulation of neurogenesis1.39e-021.00e+006.1621119
GO:0006281DNA repair1.55e-021.00e+003.365222264
GO:0030863cortical cytoskeleton1.61e-021.00e+005.9501122
GO:0006362transcription elongation from RNA polymerase I promoter1.68e-021.00e+005.8861323
GO:0006363termination of RNA polymerase I transcription1.75e-021.00e+005.8251324
GO:0005484SNAP receptor activity1.75e-021.00e+005.8251224
GO:0042100B cell proliferation1.82e-021.00e+005.7661125
GO:0042113B cell activation1.82e-021.00e+005.7661225
GO:0032735positive regulation of interleukin-12 production1.82e-021.00e+005.7661125
GO:0006361transcription initiation from RNA polymerase I promoter1.90e-021.00e+005.7091326
GO:0004003ATP-dependent DNA helicase activity1.97e-021.00e+005.6551327
GO:0051258protein polymerization1.97e-021.00e+005.6551227
GO:0007017microtubule-based process2.04e-021.00e+005.6021328
GO:0019894kinesin binding2.04e-021.00e+005.6021128
GO:0003730mRNA 3'-UTR binding2.11e-021.00e+005.5511229
GO:0030669clathrin-coated endocytic vesicle membrane2.11e-021.00e+005.5511129
GO:0006360transcription from RNA polymerase I promoter2.18e-021.00e+005.5031430
GO:00063707-methylguanosine mRNA capping2.18e-021.00e+005.5031430
GO:0034504protein localization to nucleus2.18e-021.00e+005.5031230
GO:0019901protein kinase binding2.22e-021.00e+003.088221320
GO:0031201SNARE complex2.26e-021.00e+005.4551231
GO:0031623receptor internalization2.26e-021.00e+005.4551131
GO:0033572transferrin transport2.33e-021.00e+005.4091632
GO:0005801cis-Golgi network2.54e-021.00e+005.2801135
GO:0032588trans-Golgi network membrane2.62e-021.00e+005.2401136
GO:0034332adherens junction organization2.62e-021.00e+005.2401136
GO:0001895retina homeostasis2.62e-021.00e+005.2401136
GO:0006605protein targeting2.62e-021.00e+005.2401236
GO:0032755positive regulation of interleukin-6 production2.62e-021.00e+005.2401236
GO:0070527platelet aggregation2.76e-021.00e+005.1621238
GO:0032729positive regulation of interferon-gamma production2.83e-021.00e+005.1241239
GO:0006383transcription from RNA polymerase III promoter2.83e-021.00e+005.1241339
GO:0005881cytoplasmic microtubule2.97e-021.00e+005.0521241
GO:0042147retrograde transport, endosome to Golgi3.05e-021.00e+005.0171342
GO:0032508DNA duplex unwinding3.05e-021.00e+005.0171442
GO:0042110T cell activation3.12e-021.00e+004.9831343
GO:0050434positive regulation of viral transcription3.19e-021.00e+004.9501544
GO:0006892post-Golgi vesicle-mediated transport3.19e-021.00e+004.9501244
GO:0021762substantia nigra development3.33e-021.00e+004.8861146
GO:0030136clathrin-coated vesicle3.33e-021.00e+004.8861146
GO:0006283transcription-coupled nucleotide-excision repair3.33e-021.00e+004.8861846
GO:0006986response to unfolded protein3.69e-021.00e+004.7371251
GO:0005905coated pit3.69e-021.00e+004.7371251
GO:0003684damaged DNA binding3.69e-021.00e+004.73711151
GO:0005515protein binding3.92e-021.00e+000.82981726127
GO:0002039p53 binding3.97e-021.00e+004.6281755
GO:0006888ER to Golgi vesicle-mediated transport3.97e-021.00e+004.6281255
GO:0051087chaperone binding4.25e-021.00e+004.5271659
GO:0000723telomere maintenance4.25e-021.00e+004.5271859
GO:0045216cell-cell junction organization4.25e-021.00e+004.5271259
GO:0006302double-strand break repair4.47e-021.00e+004.4551862
GO:0006368transcription elongation from RNA polymerase II promoter4.82e-021.00e+004.3431667
GO:0030141secretory granule4.82e-021.00e+004.3431267
GO:0006289nucleotide-excision repair4.96e-021.00e+004.30111269
GO:0003697single-stranded DNA binding4.96e-021.00e+004.3011969
GO:0034329cell junction assembly5.10e-021.00e+004.2601171
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process5.52e-021.00e+004.1431677
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis5.52e-021.00e+004.1431577
GO:0071013catalytic step 2 spliceosome5.66e-021.00e+004.1061779
GO:0002755MyD88-dependent toll-like receptor signaling pathway5.73e-021.00e+004.0881280
GO:0051301cell division5.80e-021.00e+004.0701681
GO:0005681spliceosomal complex5.94e-021.00e+004.0341383
GO:0006898receptor-mediated endocytosis6.15e-021.00e+003.9831286
GO:0003690double-stranded DNA binding6.49e-021.00e+003.9021491
GO:0050821protein stabilization6.49e-021.00e+003.9021291
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II6.56e-021.00e+003.8861492
GO:0042470melanosome6.56e-021.00e+003.88611092
GO:0006928cellular component movement6.56e-021.00e+003.8861792
GO:0051082unfolded protein binding6.77e-021.00e+003.8401695
GO:0003677DNA binding7.08e-021.00e+001.5953261351
GO:0005524ATP binding7.12e-021.00e+001.5913461354
GO:0014069postsynaptic density7.52e-021.00e+003.68211106
GO:0030529ribonucleoprotein complex8.07e-021.00e+003.57718114
GO:0005819spindle8.07e-021.00e+003.57717114
GO:0072562blood microparticle8.21e-021.00e+003.55114116
GO:0006325chromatin organization8.68e-021.00e+003.46714123
GO:0016887ATPase activity1.01e-011.00e+003.24017144
GO:0005769early endosome1.10e-011.00e+003.10612158
GO:0008022protein C-terminus binding1.12e-011.00e+003.07914161
GO:0007420brain development1.19e-011.00e+002.98311172
GO:0005730nucleolus1.19e-011.00e+001.2773701684
GO:0030424axon1.19e-011.00e+002.98313172
GO:0044212transcription regulatory region DNA binding1.19e-011.00e+002.99216171
GO:0006886intracellular protein transport1.20e-011.00e+002.97514173
GO:0005667transcription factor complex1.23e-011.00e+002.93416178
GO:0006367transcription initiation from RNA polymerase II promoter1.27e-011.00e+002.88618184
GO:0003924GTPase activity1.40e-011.00e+002.74419203
GO:0006184GTP catabolic process1.50e-011.00e+002.62819220
GO:0007067mitotic nuclear division1.57e-011.00e+002.558113231
GO:0005759mitochondrial matrix1.59e-011.00e+002.545112233
GO:0005615extracellular space1.68e-011.00e+001.4292171010
GO:0005874microtubule1.74e-011.00e+002.39816258
GO:0000166nucleotide binding1.83e-011.00e+002.32216272
GO:0043065positive regulation of apoptotic process1.84e-011.00e+002.31118274
GO:0005743mitochondrial inner membrane2.00e-011.00e+002.18115300
GO:0006200ATP catabolic process2.01e-011.00e+002.166114303
GO:0005856cytoskeleton2.06e-011.00e+002.12918311
GO:0007411axon guidance2.16e-011.00e+002.05619327
GO:0005525GTP binding2.16e-011.00e+002.052111328
GO:0015031protein transport2.33e-011.00e+001.93014357
GO:0000139Golgi membrane2.62e-011.00e+001.73712408
GO:0005634nucleus2.65e-011.00e+000.49451314828
GO:0009986cell surface2.70e-011.00e+001.68819422
GO:0045892negative regulation of transcription, DNA-templated2.71e-011.00e+001.682114424
GO:0006366transcription from RNA polymerase II promoter2.71e-011.00e+001.678112425
GO:0043066negative regulation of apoptotic process2.76e-011.00e+001.651130433
GO:0007596blood coagulation2.93e-011.00e+001.551114464
GO:0045893positive regulation of transcription, DNA-templated3.05e-011.00e+001.482117487
GO:0042802identical protein binding3.07e-011.00e+001.470118491
GO:0005794Golgi apparatus3.86e-011.00e+001.065114650
GO:0045944positive regulation of transcription from RNA polymerase II promoter4.58e-011.00e+000.746119811
GO:0005739mitochondrion5.48e-011.00e+000.3791241046
GO:0006355regulation of transcription, DNA-templated5.69e-011.00e+000.3011171104
GO:0005737cytoplasm5.89e-011.00e+000.0373983976
GO:0005886plasma membrane6.43e-011.00e+00-0.0592382834
GO:0006351transcription, DNA-templated7.07e-011.00e+00-0.2211251585
GO:0016021integral component of membrane8.62e-011.00e+00-0.8681152483