int-snw-9527

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.934	1.77e-15	2.52e-03	4.06e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-9527 subnetwork

Genes (10)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
CLTC	1213	35	0.884	1.138	247	Yes	-
HNRNPC	3183	20	1.812	1.026	119	Yes	-
RPL8	6132	9	0.778	0.967	218	Yes	-
RPL6	6128	11	0.844	1.113	164	Yes	-
RPL14	9045	42	1.250	1.113	143	Yes	-
TUBA1C	84790	3	0.966	0.993	91	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
HSPD1	3329	35	0.913	1.035	286	Yes	-
[ GOSR1 ]	9527	1	-0.022	0.934	176	-	-
RPL11	6135	9	0.718	1.017	200	Yes	-

Interactions (19)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ACTB	60	GOSR1	9527	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
RPL11	6135	GOSR1	9527	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
RPL14	9045	GOSR1	9527	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
HSPD1	3329	GOSR1	9527	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
CLTC	1213	GOSR1	9527	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
RPL6	6128	RPL11	6135	pp	--	int.I2D: BioGrid_Yeast
RPL11	6135	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RPL6	6128	pp	--	int.I2D: BioGrid_Yeast
RPL6	6128	RPL8	6132	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
RPL8	6132	GOSR1	9527	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
ACTB	60	CLTC	1213	pp	--	int.I2D: IntAct_Yeast
RPL6	6128	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
RPL6	6128	GOSR1	9527	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
GOSR1	9527	TUBA1C	84790	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPC	3183	GOSR1	9527	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
RPL8	6132	RPL11	6135	pp	--	int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium, IntAct_Yeast
RPL8	6132	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RPL11	6135	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
ACTB	60	HSPD1	3329	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, YeastLow

Related GO terms (164)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0022625	cytosolic large ribosomal subunit	2.43e-08	3.51e-04	6.879	4	6	49
GO:0016020	membrane	3.49e-08	5.03e-04	2.949	9	90	1681
GO:0019083	viral transcription	1.89e-07	2.73e-03	6.154	4	10	81
GO:0044267	cellular protein metabolic process	2.29e-07	3.31e-03	4.190	6	29	474
GO:0006415	translational termination	2.52e-07	3.64e-03	6.051	4	10	87
GO:0006414	translational elongation	3.30e-07	4.76e-03	5.955	4	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	5.18e-07	7.47e-03	5.794	4	10	104
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	7.49e-07	1.08e-02	5.661	4	11	114
GO:0019058	viral life cycle	7.76e-07	1.12e-02	5.649	4	13	115
GO:0044822	poly(A) RNA binding	1.09e-06	1.57e-02	3.257	7	49	1056
GO:0006413	translational initiation	1.31e-06	1.89e-02	5.461	4	17	131
GO:0003735	structural constituent of ribosome	1.57e-06	2.26e-02	5.396	4	10	137
GO:0003723	RNA binding	1.66e-06	2.40e-02	4.398	5	20	342
GO:0016071	mRNA metabolic process	1.09e-05	1.57e-01	4.693	4	31	223
GO:0006412	translation	1.23e-05	1.77e-01	4.649	4	20	230
GO:0016032	viral process	1.47e-05	2.13e-01	3.755	5	55	534
GO:0016070	RNA metabolic process	1.63e-05	2.34e-01	4.546	4	32	247
GO:0005829	cytosol	2.57e-05	3.71e-01	2.209	8	132	2496
GO:0043234	protein complex	3.27e-05	4.71e-01	4.290	4	18	295
GO:0042273	ribosomal large subunit biogenesis	3.36e-05	4.85e-01	7.794	2	4	13
GO:0010467	gene expression	4.39e-05	6.33e-01	3.430	5	59	669
GO:0005925	focal adhesion	7.59e-05	1.00e+00	3.978	4	19	366
GO:0036464	cytoplasmic ribonucleoprotein granule	9.92e-05	1.00e+00	7.035	2	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.09e-04	1.00e+00	6.971	2	4	23
GO:0019843	rRNA binding	1.50e-04	1.00e+00	6.739	2	3	27
GO:0031492	nucleosomal DNA binding	1.50e-04	1.00e+00	6.739	2	4	27
GO:0051084	'de novo' posttranslational protein folding	2.84e-04	1.00e+00	6.285	2	4	37
GO:0003725	double-stranded RNA binding	5.63e-04	1.00e+00	5.794	2	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	5.85e-04	1.00e+00	5.766	2	5	53
GO:0002842	positive regulation of T cell mediated immune response to tumor cell	6.93e-04	1.00e+00	10.494	1	1	1
GO:0048291	isotype switching to IgG isotypes	6.93e-04	1.00e+00	10.494	1	1	1
GO:0002368	B cell cytokine production	6.93e-04	1.00e+00	10.494	1	1	1
GO:0005200	structural constituent of cytoskeleton	1.71e-03	1.00e+00	4.986	2	8	91
GO:0001649	osteoblast differentiation	1.75e-03	1.00e+00	4.971	2	6	92
GO:0006364	rRNA processing	1.83e-03	1.00e+00	4.940	2	6	94
GO:1900126	negative regulation of hyaluronan biosynthetic process	2.08e-03	1.00e+00	8.909	1	2	3
GO:0006458	'de novo' protein folding	2.08e-03	1.00e+00	8.909	1	1	3
GO:0030135	coated vesicle	2.08e-03	1.00e+00	8.909	1	1	3
GO:0071439	clathrin complex	2.08e-03	1.00e+00	8.909	1	2	3
GO:0070062	extracellular vesicular exosome	2.41e-03	1.00e+00	1.850	6	104	2400
GO:0032051	clathrin light chain binding	2.77e-03	1.00e+00	8.494	1	1	4
GO:1903077	negative regulation of protein localization to plasma membrane	2.77e-03	1.00e+00	8.494	1	1	4
GO:0000790	nuclear chromatin	3.41e-03	1.00e+00	4.483	2	9	129
GO:0046696	lipopolysaccharide receptor complex	3.46e-03	1.00e+00	8.172	1	1	5
GO:0031982	vesicle	3.51e-03	1.00e+00	4.461	2	9	131
GO:0003688	DNA replication origin binding	4.15e-03	1.00e+00	7.909	1	2	6
GO:0030130	clathrin coat of trans-Golgi network vesicle	4.15e-03	1.00e+00	7.909	1	3	6
GO:0030957	Tat protein binding	4.15e-03	1.00e+00	7.909	1	3	6
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	4.15e-03	1.00e+00	7.909	1	1	6
GO:0030118	clathrin coat	4.15e-03	1.00e+00	7.909	1	2	6
GO:0006457	protein folding	4.17e-03	1.00e+00	4.334	2	7	143
GO:0061024	membrane organization	4.28e-03	1.00e+00	4.314	2	7	145
GO:0005198	structural molecule activity	4.58e-03	1.00e+00	4.265	2	5	150
GO:0030132	clathrin coat of coated pit	4.84e-03	1.00e+00	7.687	1	2	7
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	5.51e-03	1.00e+00	4.128	2	7	165
GO:0070688	MLL5-L complex	5.53e-03	1.00e+00	7.494	1	1	8
GO:0051604	protein maturation	5.53e-03	1.00e+00	7.494	1	1	8
GO:0043032	positive regulation of macrophage activation	6.91e-03	1.00e+00	7.172	1	1	10
GO:0032727	positive regulation of interferon-alpha production	7.60e-03	1.00e+00	7.035	1	1	11
GO:0045120	pronucleus	7.60e-03	1.00e+00	7.035	1	2	11
GO:0070935	3'-UTR-mediated mRNA stabilization	8.29e-03	1.00e+00	6.909	1	2	12
GO:0001530	lipopolysaccharide binding	8.98e-03	1.00e+00	6.794	1	3	13
GO:0008266	poly(U) RNA binding	8.98e-03	1.00e+00	6.794	1	1	13
GO:0051131	chaperone-mediated protein complex assembly	8.98e-03	1.00e+00	6.794	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	9.67e-03	1.00e+00	6.687	1	4	14
GO:0030705	cytoskeleton-dependent intracellular transport	9.67e-03	1.00e+00	6.687	1	1	14
GO:0042026	protein refolding	1.04e-02	1.00e+00	6.587	1	2	15
GO:0050998	nitric-oxide synthase binding	1.10e-02	1.00e+00	6.494	1	1	16
GO:0050870	positive regulation of T cell activation	1.17e-02	1.00e+00	6.407	1	1	17
GO:0006891	intra-Golgi vesicle-mediated transport	1.17e-02	1.00e+00	6.407	1	1	17
GO:0032733	positive regulation of interleukin-10 production	1.31e-02	1.00e+00	6.246	1	1	19
GO:0042100	B cell proliferation	1.45e-02	1.00e+00	6.102	1	1	21
GO:0030863	cortical cytoskeleton	1.52e-02	1.00e+00	6.035	1	1	22
GO:0005484	SNAP receptor activity	1.65e-02	1.00e+00	5.909	1	2	24
GO:0042113	B cell activation	1.72e-02	1.00e+00	5.850	1	2	25
GO:0032735	positive regulation of interleukin-12 production	1.72e-02	1.00e+00	5.850	1	1	25
GO:0003730	mRNA 3'-UTR binding	1.79e-02	1.00e+00	5.794	1	2	26
GO:0007017	microtubule-based process	1.86e-02	1.00e+00	5.739	1	3	27
GO:0051258	protein polymerization	1.86e-02	1.00e+00	5.739	1	2	27
GO:0019901	protein kinase binding	1.93e-02	1.00e+00	3.186	2	21	317
GO:0030669	clathrin-coated endocytic vesicle membrane	1.93e-02	1.00e+00	5.687	1	4	28
GO:0019894	kinesin binding	1.93e-02	1.00e+00	5.687	1	1	28
GO:0034504	protein localization to nucleus	1.93e-02	1.00e+00	5.687	1	2	28
GO:0033572	transferrin transport	2.06e-02	1.00e+00	5.587	1	5	30
GO:0031201	SNARE complex	2.13e-02	1.00e+00	5.540	1	2	31
GO:0031623	receptor internalization	2.13e-02	1.00e+00	5.540	1	2	31
GO:0005801	cis-Golgi network	2.27e-02	1.00e+00	5.450	1	1	33
GO:0032588	trans-Golgi network membrane	2.33e-02	1.00e+00	5.407	1	2	34
GO:0001895	retina homeostasis	2.33e-02	1.00e+00	5.407	1	1	34
GO:0006605	protein targeting	2.40e-02	1.00e+00	5.365	1	2	35
GO:0034332	adherens junction organization	2.47e-02	1.00e+00	5.324	1	1	36
GO:0032755	positive regulation of interleukin-6 production	2.47e-02	1.00e+00	5.324	1	2	36
GO:0070527	platelet aggregation	2.60e-02	1.00e+00	5.246	1	2	38
GO:0032729	positive regulation of interferon-gamma production	2.67e-02	1.00e+00	5.209	1	2	39
GO:0005881	cytoplasmic microtubule	2.74e-02	1.00e+00	5.172	1	1	40
GO:0042147	retrograde transport, endosome to Golgi	2.81e-02	1.00e+00	5.137	1	3	41
GO:0042110	T cell activation	2.88e-02	1.00e+00	5.102	1	3	42
GO:0030136	clathrin-coated vesicle	2.88e-02	1.00e+00	5.102	1	4	42
GO:0006892	post-Golgi vesicle-mediated transport	2.94e-02	1.00e+00	5.068	1	3	43
GO:0021762	substantia nigra development	3.01e-02	1.00e+00	5.035	1	2	44
GO:0006986	response to unfolded protein	3.41e-02	1.00e+00	4.850	1	2	50
GO:0005905	coated pit	3.41e-02	1.00e+00	4.850	1	3	50
GO:0006888	ER to Golgi vesicle-mediated transport	3.62e-02	1.00e+00	4.766	1	2	53
GO:0045216	cell-cell junction organization	3.68e-02	1.00e+00	4.739	1	2	54
GO:0002039	p53 binding	3.75e-02	1.00e+00	4.713	1	7	55
GO:0051087	chaperone binding	4.02e-02	1.00e+00	4.612	1	6	59
GO:0030141	secretory granule	4.22e-02	1.00e+00	4.540	1	2	62
GO:0034329	cell junction assembly	4.62e-02	1.00e+00	4.407	1	1	68
GO:0003697	single-stranded DNA binding	4.62e-02	1.00e+00	4.407	1	5	68
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.02e-02	1.00e+00	4.285	1	6	74
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	5.21e-02	1.00e+00	4.227	1	7	77
GO:0071013	catalytic step 2 spliceosome	5.28e-02	1.00e+00	4.209	1	4	78
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	5.41e-02	1.00e+00	4.172	1	3	80
GO:0051301	cell division	5.48e-02	1.00e+00	4.154	1	5	81
GO:0005681	spliceosomal complex	5.61e-02	1.00e+00	4.119	1	4	83
GO:0006898	receptor-mediated endocytosis	5.68e-02	1.00e+00	4.102	1	3	84
GO:0050821	protein stabilization	5.94e-02	1.00e+00	4.035	1	2	88
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	6.07e-02	1.00e+00	4.002	1	7	90
GO:0042470	melanosome	6.14e-02	1.00e+00	3.986	1	9	91
GO:0006928	cellular component movement	6.14e-02	1.00e+00	3.986	1	7	91
GO:0051082	unfolded protein binding	6.27e-02	1.00e+00	3.955	1	5	93
GO:0005515	protein binding	6.90e-02	1.00e+00	0.745	7	184	6024
GO:0014069	postsynaptic density	7.05e-02	1.00e+00	3.780	1	3	105
GO:0072562	blood microparticle	7.44e-02	1.00e+00	3.700	1	3	111
GO:0030529	ribonucleoprotein complex	7.50e-02	1.00e+00	3.687	1	8	112
GO:0005819	spindle	7.50e-02	1.00e+00	3.687	1	7	112
GO:0006325	chromatin organization	7.89e-02	1.00e+00	3.612	1	5	118
GO:0016887	ATPase activity	9.30e-02	1.00e+00	3.365	1	7	140
GO:0005769	early endosome	1.01e-01	1.00e+00	3.246	1	2	152
GO:0000398	mRNA splicing, via spliceosome	1.08e-01	1.00e+00	3.137	1	8	164
GO:0030424	axon	1.09e-01	1.00e+00	3.119	1	4	166
GO:0006886	intracellular protein transport	1.12e-01	1.00e+00	3.076	1	5	171
GO:0003924	GTPase activity	1.29e-01	1.00e+00	2.872	1	12	197
GO:0006184	GTP catabolic process	1.39e-01	1.00e+00	2.753	1	12	214
GO:0005615	extracellular space	1.39e-01	1.00e+00	1.592	2	17	957
GO:0008380	RNA splicing	1.47e-01	1.00e+00	2.661	1	11	228
GO:0007067	mitotic nuclear division	1.47e-01	1.00e+00	2.668	1	14	227
GO:0005759	mitochondrial matrix	1.47e-01	1.00e+00	2.661	1	14	228
GO:0005874	microtubule	1.60e-01	1.00e+00	2.534	1	7	249
GO:0000166	nucleotide binding	1.66e-01	1.00e+00	2.477	1	5	259
GO:0005654	nucleoplasm	1.70e-01	1.00e+00	1.415	2	76	1082
GO:0043065	positive regulation of apoptotic process	1.71e-01	1.00e+00	2.428	1	10	268
GO:0005743	mitochondrial inner membrane	1.76e-01	1.00e+00	2.380	1	8	277
GO:0005856	cytoskeleton	1.84e-01	1.00e+00	2.309	1	12	291
GO:0006200	ATP catabolic process	1.85e-01	1.00e+00	2.304	1	15	292
GO:0005525	GTP binding	1.95e-01	1.00e+00	2.218	1	12	310
GO:0007411	axon guidance	2.00e-01	1.00e+00	2.177	1	13	319
GO:0015031	protein transport	2.13e-01	1.00e+00	2.081	1	5	341
GO:0000139	Golgi membrane	2.24e-01	1.00e+00	1.998	1	3	361
GO:0005524	ATP binding	2.25e-01	1.00e+00	1.152	2	60	1298
GO:0009986	cell surface	2.46e-01	1.00e+00	1.843	1	11	402
GO:0043066	negative regulation of apoptotic process	2.58e-01	1.00e+00	1.766	1	31	424
GO:0007596	blood coagulation	2.74e-01	1.00e+00	1.664	1	18	455
GO:0042802	identical protein binding	2.89e-01	1.00e+00	1.575	1	20	484
GO:0005730	nucleolus	3.18e-01	1.00e+00	0.814	2	69	1641
GO:0045087	innate immune response	3.44e-01	1.00e+00	1.275	1	24	596
GO:0005794	Golgi apparatus	3.51e-01	1.00e+00	1.241	1	15	610
GO:0005737	cytoplasm	5.08e-01	1.00e+00	0.200	3	110	3767
GO:0005739	mitochondrion	5.12e-01	1.00e+00	0.531	1	28	998
GO:0006355	regulation of transcription, DNA-templated	5.12e-01	1.00e+00	0.533	1	18	997
GO:0005886	plasma membrane	5.58e-01	1.00e+00	0.160	2	45	2582
GO:0003677	DNA binding	5.86e-01	1.00e+00	0.244	1	28	1218
GO:0005634	nucleus	6.59e-01	1.00e+00	-0.075	3	136	4559
GO:0016021	integral component of membrane	7.72e-01	1.00e+00	-0.459	1	27	1982

Wolf-ratios-Mammosphere-Adherent

int-snw-9527

Statistics

Genes (10)

Interactions (19)

Related GO terms (164)