meta-int-snw-9948

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
reg-snw-11277 wolf-screen-ratio-mammosphere-adherent 0.882 1.09e-07 9.11e-04 1.96e-03 10 9
int-snw-9948 wolf-screen-ratio-mammosphere-adherent 1.003 2.99e-18 5.14e-04 1.24e-02 11 11
reg-snw-5925 wolf-screen-ratio-mammosphere-adherent 0.802 2.42e-06 4.82e-03 8.69e-03 8 5
wolf-screen-ratio-mammosphere-adherent-meta-int-snw-9948 subnetwork

Genes (23)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
PSMB1 5689 610.6880.901113Yes-
PPCS 79717 31-0.5690.8022-Yes
RBX1 9978 1151.1850.934148Yes-
WDR1 9948 30.4341.00338Yes-
PPIE 10450 310.5670.80241--
PSMB7 5695 1180.9820.93490Yes-
HNRNPC 3183 1081.8120.973181Yes-
TREX1 11277 51-0.0510.88291Yes-
OGDH 4967 720.8470.802126Yes-
TFRC 7037 310.7300.80217--
RPSA 3921 1201.3271.151152Yes-
PGD 5226 891.2011.106152Yes-
RPA2 6118 961.2501.15176Yes-
CAD 790 910.8070.973400--
RB1 5925 31-0.1020.802351--
RSL24D1 51187 381.3001.02059Yes-
RUVBL1 8607 950.7200.973469Yes-
PSMB2 5690 1160.8770.956169Yes-
PSMD11 5717 1241.0951.106218Yes-
ACTB 60 1341.1531.151610Yes-
RAN 5901 890.6320.899258Yes-
RUVBL2 10856 950.6930.956532Yes-
CFL1 1072 180.6741.020203Yes-

Interactions (64)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RUVBL1 8607 WDR1 9948 pp -- int.I2D: BioGrid_Mouse
PSMD11 5717 RUVBL1 8607 pp -- int.I2D: YeastLow
RB1 5925 PPCS 79717 pd > reg.pazar.txt: no annot
PSMB2 5690 TREX1 11277 pd < reg.ITFP.txt: no annot
RB1 5925 RPA2 6118 pd > reg.pazar.txt: no annot
ACTB 60 RUVBL1 8607 pp -- int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
PGD 5226 RAN 5901 pp -- int.I2D: YeastLow
CAD 790 TREX1 11277 pd < reg.ITFP.txt: no annot
PSMB1 5689 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
RAN 5901 RUVBL1 8607 pd < reg.ITFP.txt: no annot
CAD 790 RUVBL1 8607 pd < reg.ITFP.txt: no annot
CAD 790 RUVBL1 8607 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
PGD 5226 RB1 5925 pd < reg.pazar.txt: no annot
OGDH 4967 RUVBL1 8607 pp -- int.I2D: YeastLow
ACTB 60 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast
PSMB1 5689 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast, MINT, YeastHigh, IntAct_Yeast, INTEROLOG, Krogan_Core, MINT_Yeast;
int.Mint: MI:0915(physical association)
RBX1 9978 PPIE 10450 pd <> reg.ITFP.txt: no annot
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 RAN 5901 pp -- int.I2D: IntAct_Worm, BioGrid_Worm, BIND_Worm, CORE_2, MINT_Worm
WDR1 9948 RUVBL2 10856 pp -- int.I2D: BioGrid_Mouse
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
RUVBL1 8607 RUVBL2 10856 pd <> reg.ITFP.txt: no annot
RUVBL1 8607 RUVBL2 10856 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid, BioGrid_Mouse, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct, IntAct_Fly, IntAct_Worm, IntAct_Yeast, INTEROLOG, MINT_Worm, MINT_Yeast, BCI, BioGrid_Fly, BIND_Fly, BIND_Worm, FlyHigh, INNATEDB, Krogan_Core, MIPS, YeastHigh, Yu_GoldStd;
int.Ravasi: -;
int.HPRD: in vitro, in vivo, yeast 2-hybrid;
int.DIP: MI:0915(physical association)
OGDH 4967 RB1 5925 pd < reg.ITFP.txt: no annot
ACTB 60 CFL1 1072 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, MINT_Yeast, MIPS, BioGrid, BIND_Yeast, HPRD, IntAct, IntAct_Yeast, MINT, VidalHuman_core, YeastLow, Yu_GoldStd;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
ACTB 60 CAD 790 pp -- int.I2D: IntAct_Yeast
OGDH 4967 PGD 5226 pp -- int.I2D: YeastLow
PSMB7 5695 RBX1 9978 pd < reg.ITFP.txt: no annot
CAD 790 RUVBL2 10856 pd < reg.ITFP.txt: no annot
CAD 790 RUVBL2 10856 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
HNRNPC 3183 RUVBL1 8607 pd < reg.ITFP.txt: no annot
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RB1 5925 pd < reg.ITFP.txt: no annot
HNRNPC 3183 RUVBL2 10856 pd < reg.ITFP.txt: no annot
PSMB1 5689 PSMB7 5695 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BCI, BioGrid_Yeast, BIND_Yeast, HPRD, MINT, YeastLow, IntAct, Krogan_Core, MINT_Yeast, Yu_GoldStd;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB2 5690 RUVBL2 10856 pd < reg.ITFP.txt: no annot
CFL1 1072 WDR1 9948 pp -- int.I2D: BioGrid_Yeast, HPRD, YeastLow, BCI, IntAct_Yeast, MINT_Yeast;
int.HPRD: in vitro, yeast 2-hybrid
ACTB 60 WDR1 9948 pd < reg.ITFP.txt: no annot
ACTB 60 WDR1 9948 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MIPS
CFL1 1072 PGD 5226 pp -- int.I2D: YeastLow
PSMB2 5690 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct
ACTB 60 RAN 5901 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, NON_CORE
RB1 5925 WDR1 9948 pd <> reg.ITFP.txt: no annot
CAD 790 RAN 5901 pp -- int.I2D: IntAct_Yeast
PSMB7 5695 TREX1 11277 pd < reg.ITFP.txt: no annot
RPSA 3921 RUVBL2 10856 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
CAD 790 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast
PSMD11 5717 RUVBL2 10856 pp -- int.I2D: YeastLow
OGDH 4967 PSMD11 5717 pp -- int.I2D: YeastLow
CFL1 1072 OGDH 4967 pp -- int.I2D: YeastLow
PSMB7 5695 PPIE 10450 pd < reg.ITFP.txt: no annot
PSMB1 5689 RUVBL2 10856 pd < reg.ITFP.txt: no annot
PSMB1 5689 TREX1 11277 pd < reg.ITFP.txt: no annot
RB1 5925 TFRC 7037 pd > reg.ITFP.txt: no annot
CFL1 1072 RSL24D1 51187 pp -- int.I2D: YeastLow
OGDH 4967 RAN 5901 pp -- int.I2D: YeastLow
PSMB2 5690 PSMD11 5717 pd < reg.ITFP.txt: no annot
PSMB2 5690 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
RB1 5925 PPIE 10450 pd > reg.pazar.txt: no annot
RAN 5901 TREX1 11277 pd < reg.ITFP.txt: no annot
RUVBL2 10856 TREX1 11277 pd <> reg.ITFP.txt: no annot
CFL1 1072 RUVBL1 8607 pp -- int.I2D: YeastLow
ACTB 60 RUVBL2 10856 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow, BioGrid
CAD 790 RPSA 3921 pp -- int.I2D: IntAct_Yeast

Related GO terms (401)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005654nucleoplasm5.31e-098.66e-052.95912831095
GO:0070062extracellular vesicular exosome8.06e-091.32e-042.17416982516
GO:0016032viral process2.40e-083.92e-043.564955540
GO:0000082G1/S transition of mitotic cell cycle4.84e-087.89e-044.827633150
GO:0006521regulation of cellular amino acid metabolic process6.61e-071.08e-025.82742150
GO:0035267NuA4 histone acetyltransferase complex8.81e-071.44e-027.2483414
GO:0005829cytosol1.06e-061.74e-021.955141252562
GO:0000502proteasome complex1.21e-061.97e-025.61342258
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.92e-063.13e-025.44942465
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.92e-063.13e-025.44942265
GO:0005839proteasome core complex1.97e-063.21e-026.88631118
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.58e-064.22e-025.34242470
GO:0004298threonine-type endopeptidase activity2.74e-064.48e-026.73431120
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent3.06e-064.99e-025.28142373
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.23e-065.27e-025.26142474
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I3.79e-066.18e-025.20442377
GO:0034641cellular nitrogen compound metabolic process4.07e-066.65e-024.325525177
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process4.20e-066.85e-025.16742579
GO:0016363nuclear matrix7.71e-061.26e-014.94741192
GO:0016020membrane8.10e-061.32e-012.16011801746
GO:0002474antigen processing and presentation of peptide antigen via MHC class I8.40e-061.37e-014.91642394
GO:0016071mRNA metabolic process1.25e-052.05e-013.992534223
GO:0000278mitotic cell cycle1.44e-052.35e-013.419652398
GO:0000209protein polyubiquitination1.93e-053.15e-014.613421116
GO:0016070RNA metabolic process2.05e-053.35e-013.844534247
GO:0010467gene expression2.60e-054.24e-012.892758669
GO:0006281DNA repair2.83e-054.61e-013.748522264
GO:0044281small molecule metabolic process3.56e-055.81e-012.3029571295
GO:0000812Swr1 complex5.29e-058.64e-017.471238
GO:0042981regulation of apoptotic process5.44e-058.87e-014.232426151
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding5.79e-059.44e-015.3013554
GO:0005634nucleus8.58e-051.00e+001.234161314828
GO:0006310DNA recombination1.10e-041.00e+004.9903467
GO:0043968histone H2A acetylation1.24e-041.00e+006.8862312
GO:0031011Ino80 complex1.71e-041.00e+006.6642314
GO:0043066negative regulation of apoptotic process2.91e-041.00e+003.035530433
GO:0006259DNA metabolic process3.20e-041.00e+006.2232319
GO:0003678DNA helicase activity3.20e-041.00e+006.2232319
GO:0006298mismatch repair3.55e-041.00e+006.1492620
GO:0043044ATP-dependent chromatin remodeling4.72e-041.00e+005.9472423
GO:0042802identical protein binding5.18e-041.00e+002.853518491
GO:0030529ribonucleoprotein complex5.31e-041.00e+004.22338114
GO:0071339MLL1 complex6.53e-041.00e+005.7162327
GO:0006325chromatin organization6.63e-041.00e+004.11334123
GO:0043967histone H4 acetylation7.02e-041.00e+005.6642328
GO:0031492nucleosomal DNA binding7.02e-041.00e+005.6642428
GO:0006457protein folding1.15e-031.00e+003.83738149
GO:0050681androgen receptor binding1.29e-031.00e+005.2232438
GO:0004088carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity1.41e-031.00e+009.471111
GO:0034602oxoglutarate dehydrogenase (NAD+) activity1.41e-031.00e+009.471111
GO:0070335aspartate binding1.41e-031.00e+009.471111
GO:0032558adenyl deoxyribonucleotide binding1.41e-031.00e+009.471111
GO:0090230regulation of centromere complex assembly1.41e-031.00e+009.471111
GO:0004151dihydroorotase activity1.41e-031.00e+009.471111
GO:0004632phosphopantothenate--cysteine ligase activity1.41e-031.00e+009.471111
GO:0019521D-gluconate metabolic process1.41e-031.00e+009.471111
GO:0004070aspartate carbamoyltransferase activity1.41e-031.00e+009.471111
GO:0005730nucleolus1.50e-031.00e+001.7538701684
GO:0030521androgen receptor signaling pathway1.51e-031.00e+005.1132241
GO:0032508DNA duplex unwinding1.58e-031.00e+005.0792442
GO:0005515protein binding1.84e-031.00e+000.890161726127
GO:0031625ubiquitin protein ligase binding1.99e-031.00e+003.564313180
GO:0040008regulation of growth2.32e-031.00e+004.7982351
GO:0003684damaged DNA binding2.32e-031.00e+004.79821151
GO:0045252oxoglutarate dehydrogenase complex2.82e-031.00e+008.471122
GO:0097286iron ion import2.82e-031.00e+008.471112
GO:0006407rRNA export from nucleus2.82e-031.00e+008.471112
GO:0061034olfactory bulb mitral cell layer development2.82e-031.00e+008.471112
GO:00082963'-5'-exodeoxyribonuclease activity2.82e-031.00e+008.471112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.82e-031.00e+008.471112
GO:0004998transferrin receptor activity2.82e-031.00e+008.471112
GO:0019322pentose biosynthetic process2.82e-031.00e+008.471112
GO:0031134sister chromatid biorientation2.82e-031.00e+008.471112
GO:0005055laminin receptor activity2.82e-031.00e+008.471112
GO:0007070negative regulation of transcription from RNA polymerase II promoter during mitosis2.82e-031.00e+008.471122
GO:0070409carbamoyl phosphate biosynthetic process2.82e-031.00e+008.471112
GO:0042995cell projection3.52e-031.00e+004.4942663
GO:0006338chromatin remodeling4.09e-031.00e+004.3832468
GO:0003697single-stranded DNA binding4.21e-031.00e+004.3622969
GO:0004591oxoglutarate dehydrogenase (succinyl-transferring) activity4.22e-031.00e+007.886113
GO:0022028tangential migration from the subventricular zone to the olfactory bulb4.22e-031.00e+007.886113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity4.22e-031.00e+007.886113
GO:0071459protein localization to chromosome, centromeric region4.22e-031.00e+007.886113
GO:0071899negative regulation of estrogen receptor binding4.22e-031.00e+007.886113
GO:0071733transcriptional activation by promoter-enhancer looping4.22e-031.00e+007.886113
GO:0000056ribosomal small subunit export from nucleus4.22e-031.00e+007.886113
GO:0009051pentose-phosphate shunt, oxidative branch4.22e-031.00e+007.886113
GO:0044205'de novo' UMP biosynthetic process4.22e-031.00e+007.886113
GO:0071930negative regulation of transcription involved in G1/S transition of mitotic cell cycle4.22e-031.00e+007.886113
GO:0006207'de novo' pyrimidine nucleobase biosynthetic process4.22e-031.00e+007.886113
GO:0000785chromatin4.70e-031.00e+004.2812573
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis5.21e-031.00e+004.2042577
GO:0071013catalytic step 2 spliceosome5.48e-031.00e+004.1672779
GO:0048713regulation of oligodendrocyte differentiation5.63e-031.00e+007.471114
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)5.63e-031.00e+007.471114
GO:003068690S preribosome5.63e-031.00e+007.471114
GO:0071922regulation of cohesin localization to chromatin5.63e-031.00e+007.471114
GO:0019788NEDD8 ligase activity5.63e-031.00e+007.471114
GO:0001842neural fold formation5.63e-031.00e+007.471114
GO:0043141ATP-dependent 5'-3' DNA helicase activity5.63e-031.00e+007.471114
GO:0006104succinyl-CoA metabolic process5.63e-031.00e+007.471114
GO:0006543glutamine catabolic process5.63e-031.00e+007.471114
GO:0031467Cul7-RING ubiquitin ligase complex5.63e-031.00e+007.471114
GO:0043550regulation of lipid kinase activity5.63e-031.00e+007.471114
GO:0000055ribosomal large subunit export from nucleus5.63e-031.00e+007.471114
GO:0035189Rb-E2F complex5.63e-031.00e+007.471114
GO:0034349glial cell apoptotic process5.63e-031.00e+007.471114
GO:0034088maintenance of mitotic sister chromatid cohesion5.63e-031.00e+007.471114
GO:0008853exodeoxyribonuclease III activity5.63e-031.00e+007.471114
GO:0002576platelet degranulation5.89e-031.00e+004.1132482
GO:0051414response to cortisol7.03e-031.00e+007.149115
GO:0031465Cul4B-RING E3 ubiquitin ligase complex7.03e-031.00e+007.149125
GO:0032407MutSalpha complex binding7.03e-031.00e+007.149115
GO:2000001regulation of DNA damage checkpoint7.03e-031.00e+007.149115
GO:0031461cullin-RING ubiquitin ligase complex7.03e-031.00e+007.149115
GO:0071169establishment of protein localization to chromatin7.03e-031.00e+007.149115
GO:0043248proteasome assembly7.03e-031.00e+007.149115
GO:0048667cell morphogenesis involved in neuron differentiation7.03e-031.00e+007.149115
GO:0030891VCB complex7.03e-031.00e+007.149125
GO:0000730DNA recombinase assembly7.03e-031.00e+007.149135
GO:0006734NADH metabolic process7.03e-031.00e+007.149115
GO:0030976thiamine pyrophosphate binding7.03e-031.00e+007.149115
GO:0016605PML body7.36e-031.00e+003.9472592
GO:0042470melanosome7.36e-031.00e+003.94721092
GO:0006915apoptotic process7.73e-031.00e+002.314434571
GO:0043234protein complex8.29e-031.00e+002.827317300
GO:0043353enucleate erythrocyte differentiation8.43e-031.00e+006.886116
GO:0009108coenzyme biosynthetic process8.43e-031.00e+006.886116
GO:0045842positive regulation of mitotic metaphase/anaphase transition8.43e-031.00e+006.886116
GO:0021860pyramidal neuron development8.43e-031.00e+006.886116
GO:0031466Cul5-RING ubiquitin ligase complex8.43e-031.00e+006.886116
GO:0021695cerebellar cortex development8.43e-031.00e+006.886116
GO:0030957Tat protein binding8.43e-031.00e+006.886146
GO:0046134pyrimidine nucleoside biosynthetic process8.43e-031.00e+006.886116
GO:0032405MutLalpha complex binding8.43e-031.00e+006.886126
GO:0000028ribosomal small subunit assembly9.82e-031.00e+006.664117
GO:0031462Cul2-RING ubiquitin ligase complex9.82e-031.00e+006.664127
GO:0030836positive regulation of actin filament depolymerization9.82e-031.00e+006.664127
GO:0016018cyclosporin A binding9.82e-031.00e+006.664117
GO:0031464Cul4A-RING E3 ubiquitin ligase complex1.12e-021.00e+006.471128
GO:0070688MLL5-L complex1.12e-021.00e+006.471118
GO:0006554lysine catabolic process1.12e-021.00e+006.471128
GO:0045116protein neddylation1.12e-021.00e+006.471128
GO:0030042actin filament depolymerization1.12e-021.00e+006.471128
GO:0019058viral life cycle1.13e-021.00e+003.625210115
GO:0072562blood microparticle1.15e-021.00e+003.61324116
GO:0014075response to amine1.26e-021.00e+006.301119
GO:0015937coenzyme A biosynthetic process1.26e-021.00e+006.301119
GO:0097284hepatocyte apoptotic process1.26e-021.00e+006.301129
GO:0006228UTP biosynthetic process1.26e-021.00e+006.301119
GO:0000075cell cycle checkpoint1.26e-021.00e+006.301129
GO:0031000response to caffeine1.26e-021.00e+006.301129
GO:0006260DNA replication1.33e-021.00e+003.505212125
GO:0015939pantothenate metabolic process1.40e-021.00e+006.1491110
GO:0021756striatum development1.40e-021.00e+006.1491110
GO:0000790nuclear chromatin1.49e-021.00e+003.41627133
GO:0031982vesicle1.51e-021.00e+003.405210134
GO:0006098pentose-phosphate shunt1.54e-021.00e+006.0111311
GO:0010569regulation of double-strand break repair via homologous recombination1.54e-021.00e+006.0111111
GO:0031571mitotic G1 DNA damage checkpoint1.54e-021.00e+006.0111311
GO:0042551neuron maturation1.54e-021.00e+006.0111211
GO:0061001regulation of dendritic spine morphogenesis1.54e-021.00e+006.0111211
GO:0045651positive regulation of macrophage differentiation1.54e-021.00e+006.0111211
GO:0045120pronucleus1.54e-021.00e+006.0111111
GO:0044822poly(A) RNA binding1.54e-021.00e+001.7195501078
GO:0035458cellular response to interferon-beta1.54e-021.00e+006.0111211
GO:00709353'-UTR-mediated mRNA stabilization1.68e-021.00e+005.8861212
GO:0051146striated muscle cell differentiation1.68e-021.00e+005.8861112
GO:0021794thalamus development1.68e-021.00e+005.8861112
GO:0005838proteasome regulatory particle1.68e-021.00e+005.8861712
GO:0016887ATPase activity1.73e-021.00e+003.30127144
GO:0032479regulation of type I interferon production1.82e-021.00e+005.7701213
GO:0005662DNA replication factor A complex1.82e-021.00e+005.7701313
GO:0045780positive regulation of bone resorption1.82e-021.00e+005.7701113
GO:0000738DNA catabolic process, exonucleolytic1.82e-021.00e+005.7701213
GO:0008266poly(U) RNA binding1.82e-021.00e+005.7701113
GO:0045445myoblast differentiation2.09e-021.00e+005.5641215
GO:0035066positive regulation of histone acetylation2.09e-021.00e+005.5641115
GO:0016514SWI/SNF complex2.09e-021.00e+005.5641315
GO:0050998nitric-oxide synthase binding2.23e-021.00e+005.4711116
GO:00061032-oxoglutarate metabolic process2.23e-021.00e+005.4711116
GO:00084083'-5' exonuclease activity2.23e-021.00e+005.4711216
GO:0000398mRNA splicing, via spliceosome2.24e-021.00e+003.105212165
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2.31e-021.00e+003.07925168
GO:0010243response to organonitrogen compound2.37e-021.00e+005.3831217
GO:0045070positive regulation of viral genome replication2.37e-021.00e+005.3831117
GO:0031258lamellipodium membrane2.37e-021.00e+005.3831217
GO:0075733intracellular transport of virus2.37e-021.00e+005.3831217
GO:0022624proteasome accessory complex2.37e-021.00e+005.3831917
GO:0002102podosome2.37e-021.00e+005.3831217
GO:0022604regulation of cell morphogenesis2.37e-021.00e+005.3831117
GO:0071392cellular response to estradiol stimulus2.51e-021.00e+005.3011118
GO:0006541glutamine metabolic process2.51e-021.00e+005.3011118
GO:0035861site of double-strand break2.51e-021.00e+005.3011118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process2.65e-021.00e+005.2231119
GO:0048863stem cell differentiation2.65e-021.00e+005.2231119
GO:0007596blood coagulation2.65e-021.00e+002.198314464
GO:2000134negative regulation of G1/S transition of mitotic cell cycle2.78e-021.00e+005.1491220
GO:0005719nuclear euchromatin2.78e-021.00e+005.1491220
GO:0030010establishment of cell polarity2.92e-021.00e+005.0791221
GO:0000718nucleotide-excision repair, DNA damage removal2.92e-021.00e+005.0791521
GO:0071364cellular response to epidermal growth factor stimulus2.92e-021.00e+005.0791121
GO:0000281mitotic cytokinesis2.92e-021.00e+005.0791221
GO:0030316osteoclast differentiation3.06e-021.00e+005.0111222
GO:0006297nucleotide-excision repair, DNA gap filling3.06e-021.00e+005.0111522
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle3.06e-021.00e+005.0111322
GO:0033574response to testosterone3.06e-021.00e+005.0111222
GO:0032201telomere maintenance via semi-conservative replication3.06e-021.00e+005.0111722
GO:0030863cortical cytoskeleton3.06e-021.00e+005.0111122
GO:0036464cytoplasmic ribonucleoprotein granule3.06e-021.00e+005.0111422
GO:0007052mitotic spindle organization3.06e-021.00e+005.0111222
GO:0031463Cul3-RING ubiquitin ligase complex3.19e-021.00e+004.9471223
GO:0043236laminin binding3.19e-021.00e+004.9471123
GO:0043200response to amino acid3.19e-021.00e+004.9471123
GO:0006513protein monoubiquitination3.19e-021.00e+004.9471123
GO:0045879negative regulation of smoothened signaling pathway3.19e-021.00e+004.9471123
GO:0006206pyrimidine nucleobase metabolic process3.33e-021.00e+004.8861224
GO:0030168platelet activation3.34e-021.00e+002.79129205
GO:0006611protein export from nucleus3.47e-021.00e+004.8271425
GO:0030864cortical actin cytoskeleton3.47e-021.00e+004.8271125
GO:0017144drug metabolic process3.47e-021.00e+004.8271125
GO:0000722telomere maintenance via recombination3.60e-021.00e+004.7701726
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia3.60e-021.00e+004.7701226
GO:0004003ATP-dependent DNA helicase activity3.74e-021.00e+004.7161327
GO:0034080CENP-A containing nucleosome assembly3.74e-021.00e+004.7161227
GO:0048565digestive tract development3.74e-021.00e+004.7161127
GO:0043022ribosome binding3.87e-021.00e+004.6641328
GO:0019894kinesin binding3.87e-021.00e+004.6641128
GO:0006099tricarboxylic acid cycle4.01e-021.00e+004.6131329
GO:0019005SCF ubiquitin ligase complex4.01e-021.00e+004.6131129
GO:0003730mRNA 3'-UTR binding4.01e-021.00e+004.6131229
GO:0007067mitotic nuclear division4.15e-021.00e+002.619213231
GO:0001755neural crest cell migration4.15e-021.00e+004.5641230
GO:0042254ribosome biogenesis4.15e-021.00e+004.5641130
GO:0007346regulation of mitotic cell cycle4.15e-021.00e+004.5641330
GO:0006271DNA strand elongation involved in DNA replication4.28e-021.00e+004.5171931
GO:0007093mitotic cell cycle checkpoint4.28e-021.00e+004.5171231
GO:0050661NADP binding4.42e-021.00e+004.4711132
GO:0051219phosphoprotein binding4.42e-021.00e+004.4711332
GO:0003713transcription coactivator activity4.42e-021.00e+002.570210239
GO:0034644cellular response to UV4.42e-021.00e+004.4711532
GO:0033572transferrin transport4.42e-021.00e+004.4711632
GO:0031072heat shock protein binding4.55e-021.00e+004.4261233
GO:0000413protein peptidyl-prolyl isomerization4.69e-021.00e+004.3831134
GO:0003755peptidyl-prolyl cis-trans isomerase activity4.69e-021.00e+004.3831134
GO:0034332adherens junction organization4.96e-021.00e+004.3011136
GO:0051402neuron apoptotic process4.96e-021.00e+004.3011236
GO:0001895retina homeostasis4.96e-021.00e+004.3011136
GO:0001102RNA polymerase II activating transcription factor binding5.09e-021.00e+004.2611437
GO:0051084'de novo' posttranslational protein folding5.09e-021.00e+004.2611437
GO:0018107peptidyl-threonine phosphorylation5.09e-021.00e+004.2611137
GO:0070527platelet aggregation5.22e-021.00e+004.2231238
GO:0021766hippocampus development5.36e-021.00e+004.1851439
GO:0031490chromatin DNA binding5.36e-021.00e+004.1851239
GO:0006284base-excision repair5.36e-021.00e+004.1851739
GO:0006096glycolytic process5.36e-021.00e+004.1851439
GO:0022627cytosolic small ribosomal subunit5.36e-021.00e+004.1851339
GO:0032092positive regulation of protein binding5.36e-021.00e+004.1851339
GO:0007595lactation5.36e-021.00e+004.1851239
GO:0045087innate immune response5.41e-021.00e+001.789320616
GO:0000781chromosome, telomeric region5.49e-021.00e+004.1491240
GO:0000166nucleotide binding5.56e-021.00e+002.38326272
GO:0043195terminal bouton5.62e-021.00e+004.1131141
GO:0003779actin binding5.67e-021.00e+002.36827275
GO:0035914skeletal muscle cell differentiation5.76e-021.00e+004.0791142
GO:0014070response to organic cyclic compound5.89e-021.00e+004.0451343
GO:0007286spermatid development6.02e-021.00e+004.0111144
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding6.02e-021.00e+004.0111244
GO:0019899enzyme binding6.16e-021.00e+002.301211288
GO:0021762substantia nigra development6.29e-021.00e+003.9471146
GO:0001047core promoter binding6.29e-021.00e+003.9471246
GO:0006283transcription-coupled nucleotide-excision repair6.29e-021.00e+003.9471846
GO:0005884actin filament6.29e-021.00e+003.9471246
GO:0019003GDP binding6.55e-021.00e+003.8861248
GO:0007266Rho protein signal transduction6.55e-021.00e+003.8861248
GO:0031100organ regeneration6.82e-021.00e+003.8271450
GO:0035690cellular response to drug6.82e-021.00e+003.8271250
GO:0006091generation of precursor metabolites and energy6.95e-021.00e+003.7981351
GO:0005905coated pit6.95e-021.00e+003.7981251
GO:0003725double-stranded RNA binding7.34e-021.00e+003.7161654
GO:0090305nucleic acid phosphodiester bond hydrolysis7.34e-021.00e+003.7161254
GO:0019900kinase binding7.34e-021.00e+003.7161154
GO:0050680negative regulation of epithelial cell proliferation7.34e-021.00e+003.7161154
GO:0007411axon guidance7.68e-021.00e+002.11829327
GO:0006879cellular iron ion homeostasis7.74e-021.00e+003.6381557
GO:0000724double-strand break repair via homologous recombination7.74e-021.00e+003.6381657
GO:0043231intracellular membrane-bounded organelle7.89e-021.00e+002.09628332
GO:0051087chaperone binding8.00e-021.00e+003.5881659
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity8.00e-021.00e+003.5881459
GO:0045216cell-cell junction organization8.00e-021.00e+003.5881259
GO:0000723telomere maintenance8.00e-021.00e+003.5881859
GO:0005643nuclear pore8.00e-021.00e+003.5881459
GO:0031966mitochondrial membrane8.00e-021.00e+003.5881159
GO:0032481positive regulation of type I interferon production8.26e-021.00e+003.5401661
GO:0006302double-strand break repair8.39e-021.00e+003.5171862
GO:0019903protein phosphatase binding8.52e-021.00e+003.4941463
GO:0006469negative regulation of protein kinase activity8.78e-021.00e+003.4491265
GO:0003723RNA binding8.85e-021.00e+001.999219355
GO:0001558regulation of cell growth8.90e-021.00e+003.4261466
GO:0006289nucleotide-excision repair9.29e-021.00e+003.36211269
GO:0005925focal adhesion9.49e-021.00e+001.939218370
GO:0034329cell junction assembly9.55e-021.00e+003.3211171
GO:0032587ruffle membrane9.68e-021.00e+003.3011472
GO:0055037recycling endosome9.80e-021.00e+003.2811273
GO:0055086nucleobase-containing small molecule metabolic process9.80e-021.00e+003.2811573
GO:0006767water-soluble vitamin metabolic process1.01e-011.00e+003.2421375
GO:0007265Ras protein signal transduction1.01e-011.00e+003.2421375
GO:0031175neuron projection development1.01e-011.00e+003.2421175
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process1.02e-011.00e+003.2231376
GO:0006766vitamin metabolic process1.04e-011.00e+003.1851378
GO:0006334nucleosome assembly1.06e-011.00e+003.1671479
GO:0007565female pregnancy1.07e-011.00e+003.1491280
GO:0019083viral transcription1.08e-011.00e+003.1311881
GO:0001889liver development1.09e-011.00e+003.1131382
GO:0005681spliceosomal complex1.11e-011.00e+003.0961383
GO:0047485protein N-terminus binding1.14e-011.00e+003.0451486
GO:0006898receptor-mediated endocytosis1.14e-011.00e+003.0451286
GO:0006415translational termination1.16e-011.00e+003.0281887
GO:0005524ATP binding1.18e-011.00e+001.0684461354
GO:0003690double-stranded DNA binding1.21e-011.00e+002.9631491
GO:0006928cellular component movement1.22e-011.00e+002.9471792
GO:0006414translational elongation1.23e-011.00e+002.93211193
GO:0005200structural constituent of cytoskeleton1.23e-011.00e+002.9321793
GO:0051082unfolded protein binding1.26e-011.00e+002.9011695
GO:0001649osteoblast differentiation1.26e-011.00e+002.9011695
GO:0007010cytoskeleton organization1.27e-011.00e+002.8861296
GO:0071456cellular response to hypoxia1.29e-011.00e+002.8561498
GO:0006614SRP-dependent cotranslational protein targeting to membrane1.37e-011.00e+002.77018104
GO:0014069postsynaptic density1.39e-011.00e+002.74311106
GO:0016023cytoplasmic membrane-bounded vesicle1.40e-011.00e+002.72913107
GO:0005815microtubule organizing center1.44e-011.00e+002.69014110
GO:0042127regulation of cell proliferation1.45e-011.00e+002.67614111
GO:0007605sensory perception of sound1.45e-011.00e+002.67611111
GO:0015630microtubule cytoskeleton1.47e-011.00e+002.66415112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.49e-011.00e+002.638110114
GO:0045893positive regulation of transcription, DNA-templated1.49e-011.00e+001.543217487
GO:0005819spindle1.49e-011.00e+002.63817114
GO:0005635nuclear envelope1.51e-011.00e+002.61316116
GO:0044267cellular protein metabolic process1.53e-011.00e+001.520224495
GO:0044237cellular metabolic process1.54e-011.00e+002.58813118
GO:0007219Notch signaling pathway1.62e-011.00e+002.50514125
GO:0007050cell cycle arrest1.63e-011.00e+002.49417126
GO:0006511ubiquitin-dependent protein catabolic process1.65e-011.00e+002.48215127
GO:0005615extracellular space1.67e-011.00e+001.0763171010
GO:0030036actin cytoskeleton organization1.67e-011.00e+002.46015129
GO:0006413translational initiation1.69e-011.00e+002.437112131
GO:0009615response to virus1.70e-011.00e+002.42616132
GO:0003735structural constituent of ribosome1.81e-011.00e+002.33118141
GO:0007507heart development1.81e-011.00e+002.33115141
GO:0005911cell-cell junction1.82e-011.00e+002.32113142
GO:0061024membrane organization1.87e-011.00e+002.28115146
GO:0046777protein autophosphorylation2.01e-011.00e+002.16713158
GO:0030424axon2.16e-011.00e+002.04513172
GO:0005768endosome2.19e-011.00e+002.02815174
GO:0004672protein kinase activity2.23e-011.00e+001.99512178
GO:0019904protein domain specific binding2.26e-011.00e+001.97116181
GO:0009897external side of plasma membrane2.29e-011.00e+001.95514183
GO:0032403protein complex binding2.31e-011.00e+001.93917185
GO:0003924GTPase activity2.50e-011.00e+001.80619203
GO:0006184GTP catabolic process2.68e-011.00e+001.69019220
GO:0005622intracellular2.75e-011.00e+001.65115226
GO:0008380RNA splicing2.81e-011.00e+001.613113232
GO:0005759mitochondrial matrix2.82e-011.00e+001.607112233
GO:0006412translation2.84e-011.00e+001.594115235
GO:0008134transcription factor binding2.95e-011.00e+001.52818246
GO:0043025neuronal cell body3.03e-011.00e+001.48214254
GO:0004842ubiquitin-protein transferase activity3.05e-011.00e+001.47114256
GO:0045944positive regulation of transcription from RNA polymerase II promoter3.18e-011.00e+000.807219811
GO:0005737cytoplasm3.20e-011.00e+000.3217983976
GO:0005975carbohydrate metabolic process3.23e-011.00e+001.37315274
GO:0006357regulation of transcription from RNA polymerase II promoter3.24e-011.00e+001.36816275
GO:0007283spermatogenesis3.25e-011.00e+001.36216276
GO:0007264small GTPase mediated signal transduction3.38e-011.00e+001.29113290
GO:0016567protein ubiquitination3.47e-011.00e+001.24715299
GO:0006200ATP catabolic process3.50e-011.00e+001.228114303
GO:0005856cytoskeleton3.58e-011.00e+001.19018311
GO:0019901protein kinase binding3.66e-011.00e+001.149121320
GO:0005525GTP binding3.73e-011.00e+001.113111328
GO:0003682chromatin binding3.79e-011.00e+001.087112334
GO:0006351transcription, DNA-templated3.89e-011.00e+000.4263251585
GO:0030054cell junction3.98e-011.00e+000.99512356
GO:0007155cell adhesion4.22e-011.00e+000.88618384
GO:0005576extracellular region4.40e-011.00e+000.436291049
GO:0008270zinc ion binding4.49e-011.00e+000.4122121067
GO:0009986cell surface4.53e-011.00e+000.75019422
GO:0045892negative regulation of transcription, DNA-templated4.54e-011.00e+000.743114424
GO:0006468protein phosphorylation4.87e-011.00e+000.604110467
GO:0055114oxidation-reduction process4.98e-011.00e+000.561111481
GO:0055085transmembrane transport5.21e-011.00e+000.46518514
GO:0048471perinuclear region of cytoplasm5.27e-011.00e+000.440112523
GO:0042803protein homodimerization activity5.88e-011.00e+000.202111617
GO:0005789endoplasmic reticulum membrane5.99e-011.00e+000.158110636
GO:0005794Golgi apparatus6.08e-011.00e+000.127114650
GO:0046872metal ion binding6.24e-011.00e+00-0.0462241465
GO:0003700sequence-specific DNA binding transcription factor activity6.60e-011.00e+00-0.076111748
GO:0007165signal transduction7.48e-011.00e+00-0.421117950
GO:0005887integral component of plasma membrane7.53e-011.00e+00-0.43817961
GO:0005739mitochondrion7.82e-011.00e+00-0.5601241046
GO:0006355regulation of transcription, DNA-templated8.01e-011.00e+00-0.6381171104
GO:0003677DNA binding8.63e-011.00e+00-0.9291261351
GO:0005886plasma membrane9.28e-011.00e+00-0.9982382834