meta-int-snw-8295

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
reg-snw-317781 wolf-screen-ratio-mammosphere-adherent 0.823 1.13e-06 3.23e-03 6.07e-03 9 9
int-snw-8295 wolf-screen-ratio-mammosphere-adherent 1.013 1.13e-18 4.02e-04 1.03e-02 11 11
reg-snw-5925 wolf-screen-ratio-mammosphere-adherent 0.802 2.42e-06 4.82e-03 8.69e-03 8 5
wolf-screen-ratio-mammosphere-adherent-meta-int-snw-8295 subnetwork

Genes (22)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
PPCS 79717 31-0.5690.8022-Yes
DDX18 8886 250.6601.013215Yes-
RBX1 9978 1151.1850.934148Yes-
PPIE 10450 310.5670.80241--
PSMB7 5695 1180.9820.93490Yes-
VARS 7407 860.5491.002204Yes-
OGDH 4967 720.8470.802126Yes-
DDX51 317781 530.0590.823210Yes-
TFRC 7037 310.7300.80217--
RPSA 3921 1201.3271.151152Yes-
PGD 5226 891.2011.106152Yes-
RPA2 6118 961.2501.15176Yes-
EIF6 3692 670.7000.876316Yes-
RB1 5925 31-0.1020.802351--
RSL24D1 51187 381.3001.02059Yes-
TRRAP 8295 30.5511.013127Yes-
RUVBL1 8607 950.7200.973469Yes-
PSMD3 5709 1000.9861.106201Yes-
PSMB2 5690 1160.8770.956169Yes-
TUBG1 7283 980.9740.97391Yes-
PSMD11 5717 1241.0951.106218Yes-
ACTB 60 1341.1531.151610Yes-

Interactions (58)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
EIF6 3692 DDX18 8886 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh
PSMD11 5717 RUVBL1 8607 pp -- int.I2D: YeastLow
RB1 5925 PPCS 79717 pd > reg.pazar.txt: no annot
RB1 5925 RPA2 6118 pd > reg.pazar.txt: no annot
ACTB 60 RUVBL1 8607 pp -- int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
PGD 5226 RB1 5925 pd < reg.pazar.txt: no annot
OGDH 4967 RUVBL1 8607 pp -- int.I2D: YeastLow
ACTB 60 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast
RBX1 9978 PPIE 10450 pd <> reg.ITFP.txt: no annot
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
EIF6 3692 OGDH 4967 pp -- int.I2D: YeastLow
RPSA 3921 VARS 7407 pp -- int.I2D: IntAct_Yeast
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
EIF6 3692 PGD 5226 pp -- int.I2D: YeastLow
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
EIF6 3692 TRRAP 8295 pp -- int.I2D: YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
TUBG1 7283 VARS 7407 pd < reg.ITFP.txt: no annot
OGDH 4967 RB1 5925 pd < reg.ITFP.txt: no annot
OGDH 4967 PGD 5226 pp -- int.I2D: YeastLow
PSMD11 5717 DDX18 8886 pp -- int.I2D: YeastLow
PSMB7 5695 RBX1 9978 pd < reg.ITFP.txt: no annot
TRRAP 8295 RUVBL1 8607 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
PSMD3 5709 TUBG1 7283 pd > reg.ITFP.txt: no annot
RUVBL1 8607 DDX18 8886 pp -- int.I2D: YeastLow
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RB1 5925 pd < reg.ITFP.txt: no annot
VARS 7407 RUVBL1 8607 pd <> reg.ITFP.txt: no annot
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
OGDH 4967 DDX18 8886 pp -- int.I2D: YeastLow
PGD 5226 PSMD3 5709 pp -- int.I2D: YeastLow
TRRAP 8295 DDX18 8886 pp -- int.I2D: YeastLow
PSMB7 5695 DDX51 317781 pd < reg.ITFP.txt: no annot
PSMB2 5690 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct
TUBG1 7283 RUVBL1 8607 pd < reg.ITFP.txt: no annot
PSMB2 5690 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
VARS 7407 DDX51 317781 pd <> reg.ITFP.txt: no annot
PSMD3 5709 VARS 7407 pd <> reg.ITFP.txt: no annot
PSMD11 5717 TUBG1 7283 pd > reg.ITFP.txt: no annot
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
EIF6 3692 RSL24D1 51187 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
OGDH 4967 PSMD3 5709 pp -- int.I2D: YeastLow
PSMB2 5690 DDX51 317781 pd < reg.ITFP.txt: no annot
DDX18 8886 RSL24D1 51187 pp -- int.I2D: YeastLow, BioGrid_Yeast
OGDH 4967 PSMD11 5717 pp -- int.I2D: YeastLow
PSMB7 5695 PPIE 10450 pd < reg.ITFP.txt: no annot
RB1 5925 TFRC 7037 pd > reg.ITFP.txt: no annot
PSMB2 5690 PSMD11 5717 pd < reg.ITFP.txt: no annot
PSMB2 5690 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMB2 5690 VARS 7407 pd < reg.ITFP.txt: no annot
ACTB 60 TRRAP 8295 pp -- int.I2D: IntAct_Yeast, YeastLow
RB1 5925 PPIE 10450 pd > reg.pazar.txt: no annot
EIF6 3692 DDX51 317781 pd < reg.ITFP.txt: no annot
PGD 5226 DDX18 8886 pp -- int.I2D: YeastLow
EIF6 3692 RUVBL1 8607 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct

Related GO terms (327)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0000082G1/S transition of mitotic cell cycle3.60e-085.88e-044.891633150
GO:0016032viral process2.90e-074.73e-033.458855540
GO:0005654nucleoplasm5.45e-078.90e-032.76010831095
GO:0006521regulation of cellular amino acid metabolic process5.47e-078.93e-035.89142150
GO:0000278mitotic cell cycle6.05e-079.87e-033.706752398
GO:0035267NuA4 histone acetyltransferase complex7.66e-071.25e-027.3133414
GO:0000502proteasome complex1.00e-061.63e-025.67742258
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.59e-062.59e-025.51342465
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.59e-062.59e-025.51342265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.14e-063.49e-025.40642470
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent2.53e-064.14e-025.34542373
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.68e-064.37e-025.32642474
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I3.14e-065.13e-025.26842377
GO:0034641cellular nitrogen compound metabolic process3.21e-065.25e-024.389525177
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process3.48e-065.68e-025.23142579
GO:0002474antigen processing and presentation of peptide antigen via MHC class I6.97e-061.14e-014.98042394
GO:0016071mRNA metabolic process9.92e-061.62e-014.056534223
GO:0000209protein polyubiquitination1.61e-052.62e-014.677421116
GO:0016070RNA metabolic process1.63e-052.65e-013.909534247
GO:0042981regulation of apoptotic process4.52e-057.38e-014.297426151
GO:0000812Swr1 complex4.83e-057.89e-017.535238
GO:0043968histone H2A acetylation1.14e-041.00e+006.9502312
GO:0005838proteasome regulatory particle1.14e-041.00e+006.9502712
GO:0070062extracellular vesicular exosome1.54e-041.00e+001.69811982516
GO:0005829cytosol1.82e-041.00e+001.671111252562
GO:0005730nucleolus1.85e-041.00e+001.9879701684
GO:0010467gene expression1.97e-041.00e+002.734658669
GO:0022624proteasome accessory complex2.33e-041.00e+006.4482917
GO:0016020membrane2.44e-041.00e+001.9359801746
GO:0005839proteasome core complex2.62e-041.00e+006.36521118
GO:0004298threonine-type endopeptidase activity3.25e-041.00e+006.21321120
GO:0006325chromatin organization5.79e-041.00e+004.17734123
GO:0043022ribosome binding6.42e-041.00e+005.7282328
GO:0043967histone H4 acetylation6.42e-041.00e+005.7282328
GO:0007093mitotic cell cycle checkpoint7.88e-041.00e+005.5812231
GO:0044281small molecule metabolic process1.15e-031.00e+002.0047571295
GO:0034602oxoglutarate dehydrogenase (NAD+) activity1.35e-031.00e+009.535111
GO:0090230regulation of centromere complex assembly1.35e-031.00e+009.535111
GO:0004632phosphopantothenate--cysteine ligase activity1.35e-031.00e+009.535111
GO:0000054ribosomal subunit export from nucleus1.35e-031.00e+009.535111
GO:0019521D-gluconate metabolic process1.35e-031.00e+009.535111
GO:0031625ubiquitin protein ligase binding1.74e-031.00e+003.628313180
GO:0043066negative regulation of apoptotic process2.45e-031.00e+002.777430433
GO:0004832valine-tRNA ligase activity2.69e-031.00e+008.535112
GO:0045252oxoglutarate dehydrogenase complex2.69e-031.00e+008.535122
GO:0097286iron ion import2.69e-031.00e+008.535112
GO:0006407rRNA export from nucleus2.69e-031.00e+008.535112
GO:0006438valyl-tRNA aminoacylation2.69e-031.00e+008.535112
GO:0061034olfactory bulb mitral cell layer development2.69e-031.00e+008.535112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.69e-031.00e+008.535112
GO:0004998transferrin receptor activity2.69e-031.00e+008.535112
GO:0019322pentose biosynthetic process2.69e-031.00e+008.535112
GO:0031134sister chromatid biorientation2.69e-031.00e+008.535112
GO:0005055laminin receptor activity2.69e-031.00e+008.535112
GO:0007070negative regulation of transcription from RNA polymerase II promoter during mitosis2.69e-031.00e+008.535122
GO:0005515protein binding3.47e-031.00e+000.861151726127
GO:0004591oxoglutarate dehydrogenase (succinyl-transferring) activity4.04e-031.00e+007.950113
GO:0022028tangential migration from the subventricular zone to the olfactory bulb4.04e-031.00e+007.950113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity4.04e-031.00e+007.950113
GO:0071459protein localization to chromosome, centromeric region4.04e-031.00e+007.950113
GO:0009051pentose-phosphate shunt, oxidative branch4.04e-031.00e+007.950113
GO:0071930negative regulation of transcription involved in G1/S transition of mitotic cell cycle4.04e-031.00e+007.950113
GO:0006281DNA repair5.13e-031.00e+003.076322264
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)5.38e-031.00e+007.535114
GO:0000212meiotic spindle organization5.38e-031.00e+007.535114
GO:003068690S preribosome5.38e-031.00e+007.535114
GO:0071922regulation of cohesin localization to chromatin5.38e-031.00e+007.535114
GO:0019788NEDD8 ligase activity5.38e-031.00e+007.535114
GO:0006104succinyl-CoA metabolic process5.38e-031.00e+007.535114
GO:0031467Cul7-RING ubiquitin ligase complex5.38e-031.00e+007.535114
GO:0043550regulation of lipid kinase activity5.38e-031.00e+007.535114
GO:0035189Rb-E2F complex5.38e-031.00e+007.535114
GO:0034088maintenance of mitotic sister chromatid cohesion5.38e-031.00e+007.535114
GO:0034349glial cell apoptotic process5.38e-031.00e+007.535114
GO:0006915apoptotic process6.56e-031.00e+002.378434571
GO:0031465Cul4B-RING E3 ubiquitin ligase complex6.72e-031.00e+007.213125
GO:0042256mature ribosome assembly6.72e-031.00e+007.213115
GO:2000001regulation of DNA damage checkpoint6.72e-031.00e+007.213115
GO:0031461cullin-RING ubiquitin ligase complex6.72e-031.00e+007.213115
GO:0043248proteasome assembly6.72e-031.00e+007.213115
GO:0048667cell morphogenesis involved in neuron differentiation6.72e-031.00e+007.213115
GO:0030891VCB complex6.72e-031.00e+007.213125
GO:0005827polar microtubule6.72e-031.00e+007.213115
GO:0000730DNA recombinase assembly6.72e-031.00e+007.213135
GO:0005638lamin filament6.72e-031.00e+007.213115
GO:0006734NADH metabolic process6.72e-031.00e+007.213115
GO:0030976thiamine pyrophosphate binding6.72e-031.00e+007.213115
GO:0016605PML body6.75e-031.00e+004.0112592
GO:0005200structural constituent of cytoskeleton6.89e-031.00e+003.9962793
GO:0043353enucleate erythrocyte differentiation8.06e-031.00e+006.950116
GO:0009108coenzyme biosynthetic process8.06e-031.00e+006.950116
GO:0045842positive regulation of mitotic metaphase/anaphase transition8.06e-031.00e+006.950116
GO:0021860pyramidal neuron development8.06e-031.00e+006.950116
GO:0043023ribosomal large subunit binding8.06e-031.00e+006.950126
GO:0031466Cul5-RING ubiquitin ligase complex8.06e-031.00e+006.950116
GO:0016773phosphotransferase activity, alcohol group as acceptor8.06e-031.00e+006.950116
GO:0021695cerebellar cortex development8.06e-031.00e+006.950116
GO:0030957Tat protein binding8.06e-031.00e+006.950146
GO:0000125PCAF complex8.06e-031.00e+006.950116
GO:0000028ribosomal small subunit assembly9.40e-031.00e+006.728117
GO:0002161aminoacyl-tRNA editing activity9.40e-031.00e+006.728127
GO:0031462Cul2-RING ubiquitin ligase complex9.40e-031.00e+006.728127
GO:0000930gamma-tubulin complex9.40e-031.00e+006.728117
GO:0016018cyclosporin A binding9.40e-031.00e+006.728117
GO:0030529ribonucleoprotein complex1.02e-021.00e+003.70228114
GO:0072562blood microparticle1.05e-021.00e+003.67724116
GO:0031464Cul4A-RING E3 ubiquitin ligase complex1.07e-021.00e+006.535128
GO:0070688MLL5-L complex1.07e-021.00e+006.535118
GO:0006554lysine catabolic process1.07e-021.00e+006.535128
GO:0045116protein neddylation1.07e-021.00e+006.535128
GO:0015937coenzyme A biosynthetic process1.21e-021.00e+006.365119
GO:0097284hepatocyte apoptotic process1.21e-021.00e+006.365129
GO:0000075cell cycle checkpoint1.21e-021.00e+006.365129
GO:0005634nucleus1.24e-021.00e+000.883121314828
GO:0044822poly(A) RNA binding1.28e-021.00e+001.7835501078
GO:0006413translational initiation1.33e-021.00e+003.502212131
GO:0006450regulation of translational fidelity1.34e-021.00e+006.2131210
GO:0015939pantothenate metabolic process1.34e-021.00e+006.2131110
GO:0021756striatum development1.34e-021.00e+006.2131110
GO:0006098pentose-phosphate shunt1.47e-021.00e+006.0761311
GO:0010569regulation of double-strand break repair via homologous recombination1.47e-021.00e+006.0761111
GO:0031571mitotic G1 DNA damage checkpoint1.47e-021.00e+006.0761311
GO:0042551neuron maturation1.47e-021.00e+006.0761211
GO:0045651positive regulation of macrophage differentiation1.47e-021.00e+006.0761211
GO:0016578histone deubiquitination1.47e-021.00e+006.0761111
GO:0051146striated muscle cell differentiation1.61e-021.00e+005.9501112
GO:0021794thalamus development1.61e-021.00e+005.9501112
GO:0006457protein folding1.70e-021.00e+003.31628149
GO:0042273ribosomal large subunit biogenesis1.74e-021.00e+005.8351413
GO:0005662DNA replication factor A complex1.74e-021.00e+005.8351313
GO:0045780positive regulation of bone resorption1.74e-021.00e+005.8351113
GO:0030914STAGA complex1.74e-021.00e+005.8351113
GO:0030234enzyme regulator activity1.74e-021.00e+005.8351313
GO:0033276transcription factor TFTC complex1.87e-021.00e+005.7281114
GO:0031011Ino80 complex1.87e-021.00e+005.7281314
GO:0007020microtubule nucleation1.87e-021.00e+005.7281114
GO:0045445myoblast differentiation2.00e-021.00e+005.6281215
GO:0016514SWI/SNF complex2.00e-021.00e+005.6281315
GO:0042176regulation of protein catabolic process2.14e-021.00e+005.5351316
GO:0050998nitric-oxide synthase binding2.14e-021.00e+005.5351116
GO:00061032-oxoglutarate metabolic process2.14e-021.00e+005.5351116
GO:0010243response to organonitrogen compound2.27e-021.00e+005.4481217
GO:0045070positive regulation of viral genome replication2.27e-021.00e+005.4481117
GO:0031122cytoplasmic microtubule organization2.40e-021.00e+005.3651218
GO:0035861site of double-strand break2.40e-021.00e+005.3651118
GO:0004004ATP-dependent RNA helicase activity2.40e-021.00e+005.3651218
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process2.53e-021.00e+005.2871119
GO:0048863stem cell differentiation2.53e-021.00e+005.2871119
GO:0003678DNA helicase activity2.53e-021.00e+005.2871319
GO:2000134negative regulation of G1/S transition of mitotic cell cycle2.66e-021.00e+005.2131220
GO:0006298mismatch repair2.66e-021.00e+005.2131620
GO:0000718nucleotide-excision repair, DNA damage removal2.79e-021.00e+005.1431521
GO:0030316osteoclast differentiation2.93e-021.00e+005.0761222
GO:0006297nucleotide-excision repair, DNA gap filling2.93e-021.00e+005.0761522
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle2.93e-021.00e+005.0761322
GO:0032201telomere maintenance via semi-conservative replication2.93e-021.00e+005.0761722
GO:0030863cortical cytoskeleton2.93e-021.00e+005.0761122
GO:0036464cytoplasmic ribonucleoprotein granule2.93e-021.00e+005.0761422
GO:0031463Cul3-RING ubiquitin ligase complex3.06e-021.00e+005.0111223
GO:0043236laminin binding3.06e-021.00e+005.0111123
GO:0006513protein monoubiquitination3.06e-021.00e+005.0111123
GO:0016573histone acetylation3.06e-021.00e+005.0111223
GO:0043044ATP-dependent chromatin remodeling3.06e-021.00e+005.0111423
GO:0045879negative regulation of smoothened signaling pathway3.06e-021.00e+005.0111123
GO:0005524ATP binding3.12e-021.00e+001.4545461354
GO:0000794condensed nuclear chromosome3.19e-021.00e+004.9501224
GO:0000722telomere maintenance via recombination3.45e-021.00e+004.8351726
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia3.45e-021.00e+004.8351226
GO:0034080CENP-A containing nucleosome assembly3.58e-021.00e+004.7801227
GO:0048565digestive tract development3.58e-021.00e+004.7801127
GO:0071339MLL1 complex3.58e-021.00e+004.7801327
GO:0031492nucleosomal DNA binding3.71e-021.00e+004.7281428
GO:0019894kinesin binding3.71e-021.00e+004.7281128
GO:0006099tricarboxylic acid cycle3.84e-021.00e+004.6771329
GO:0019005SCF ubiquitin ligase complex3.84e-021.00e+004.6771129
GO:0042254ribosome biogenesis3.97e-021.00e+004.6281130
GO:0007346regulation of mitotic cell cycle3.97e-021.00e+004.6281330
GO:0003713transcription coactivator activity4.07e-021.00e+002.634210239
GO:0006271DNA strand elongation involved in DNA replication4.10e-021.00e+004.5811931
GO:0050661NADP binding4.23e-021.00e+004.5351132
GO:0051219phosphoprotein binding4.23e-021.00e+004.5351332
GO:0033572transferrin transport4.23e-021.00e+004.5351632
GO:0031072heat shock protein binding4.36e-021.00e+004.4911233
GO:0000413protein peptidyl-prolyl isomerization4.49e-021.00e+004.4481134
GO:0003755peptidyl-prolyl cis-trans isomerase activity4.49e-021.00e+004.4481134
GO:0034332adherens junction organization4.74e-021.00e+004.3651136
GO:0051402neuron apoptotic process4.74e-021.00e+004.3651236
GO:0001895retina homeostasis4.74e-021.00e+004.3651136
GO:0001102RNA polymerase II activating transcription factor binding4.87e-021.00e+004.3261437
GO:0051084'de novo' posttranslational protein folding4.87e-021.00e+004.3261437
GO:0070527platelet aggregation5.00e-021.00e+004.2871238
GO:0050681androgen receptor binding5.00e-021.00e+004.2871438
GO:0021766hippocampus development5.13e-021.00e+004.2501439
GO:0008026ATP-dependent helicase activity5.13e-021.00e+004.2501339
GO:0006284base-excision repair5.13e-021.00e+004.2501739
GO:0006096glycolytic process5.13e-021.00e+004.2501439
GO:0022627cytosolic small ribosomal subunit5.13e-021.00e+004.2501339
GO:0000781chromosome, telomeric region5.26e-021.00e+004.2131240
GO:0030521androgen receptor signaling pathway5.39e-021.00e+004.1771241
GO:0006418tRNA aminoacylation for protein translation5.51e-021.00e+004.1431542
GO:0035914skeletal muscle cell differentiation5.51e-021.00e+004.1431142
GO:0032508DNA duplex unwinding5.51e-021.00e+004.1431442
GO:0014070response to organic cyclic compound5.64e-021.00e+004.1091343
GO:0003712transcription cofactor activity5.77e-021.00e+004.0761144
GO:0021762substantia nigra development6.02e-021.00e+004.0111146
GO:0001047core promoter binding6.02e-021.00e+004.0111246
GO:0006283transcription-coupled nucleotide-excision repair6.02e-021.00e+004.0111846
GO:0006200ATP catabolic process6.22e-021.00e+002.292214303
GO:0003743translation initiation factor activity6.40e-021.00e+003.9201449
GO:0006091generation of precursor metabolites and energy6.66e-021.00e+003.8631351
GO:0005905coated pit6.66e-021.00e+003.8631251
GO:0040008regulation of growth6.66e-021.00e+003.8631351
GO:0003684damaged DNA binding6.66e-021.00e+003.86311151
GO:0003725double-stranded RNA binding7.04e-021.00e+003.7801654
GO:0019900kinase binding7.04e-021.00e+003.7801154
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding7.04e-021.00e+003.7801554
GO:0050680negative regulation of epithelial cell proliferation7.04e-021.00e+003.7801154
GO:0000226microtubule cytoskeleton organization7.16e-021.00e+003.7541355
GO:0043231intracellular membrane-bounded organelle7.30e-021.00e+002.16028332
GO:0006879cellular iron ion homeostasis7.41e-021.00e+003.7021557
GO:0000724double-strand break repair via homologous recombination7.41e-021.00e+003.7021657
GO:0051087chaperone binding7.66e-021.00e+003.6521659
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity7.66e-021.00e+003.6521459
GO:0045216cell-cell junction organization7.66e-021.00e+003.6521259
GO:0000723telomere maintenance7.66e-021.00e+003.6521859
GO:0031966mitochondrial membrane7.66e-021.00e+003.6521159
GO:0006302double-strand break repair8.04e-021.00e+003.5811862
GO:0019903protein phosphatase binding8.16e-021.00e+003.5581463
GO:0006469negative regulation of protein kinase activity8.41e-021.00e+003.5131265
GO:0001558regulation of cell growth8.53e-021.00e+003.4911466
GO:0006310DNA recombination8.66e-021.00e+003.4691467
GO:0006338chromatin remodeling8.78e-021.00e+003.4481468
GO:0006289nucleotide-excision repair8.90e-021.00e+003.42611269
GO:0003697single-stranded DNA binding8.90e-021.00e+003.4261969
GO:0034329cell junction assembly9.15e-021.00e+003.3851171
GO:0055037recycling endosome9.40e-021.00e+003.3451273
GO:0000785chromatin9.40e-021.00e+003.3451573
GO:0006767water-soluble vitamin metabolic process9.64e-021.00e+003.3061375
GO:0007265Ras protein signal transduction9.64e-021.00e+003.3061375
GO:0031175neuron projection development9.64e-021.00e+003.3061175
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process9.76e-021.00e+003.2871376
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis9.89e-021.00e+003.2681577
GO:0006766vitamin metabolic process1.00e-011.00e+003.2501378
GO:0006334nucleosome assembly1.01e-011.00e+003.2311479
GO:0071013catalytic step 2 spliceosome1.01e-011.00e+003.2311779
GO:0019083viral transcription1.04e-011.00e+003.1951881
GO:0047485protein N-terminus binding1.10e-011.00e+003.1091486
GO:0006898receptor-mediated endocytosis1.10e-011.00e+003.1091286
GO:0006415translational termination1.11e-011.00e+003.0921887
GO:0016363nuclear matrix1.17e-011.00e+003.01111192
GO:0042470melanosome1.17e-011.00e+003.01111092
GO:0006928cellular component movement1.17e-011.00e+003.0111792
GO:0006414translational elongation1.18e-011.00e+002.99611193
GO:0006364rRNA processing1.22e-011.00e+002.9501596
GO:0071456cellular response to hypoxia1.24e-011.00e+002.9201498
GO:0006614SRP-dependent cotranslational protein targeting to membrane1.31e-011.00e+002.83518104
GO:0014069postsynaptic density1.34e-011.00e+002.80711106
GO:0016023cytoplasmic membrane-bounded vesicle1.35e-011.00e+002.79413107
GO:0005815microtubule organizing center1.38e-011.00e+002.75414110
GO:0042127regulation of cell proliferation1.39e-011.00e+002.74114111
GO:0042802identical protein binding1.41e-011.00e+001.595218491
GO:0015630microtubule cytoskeleton1.41e-011.00e+002.72815112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.43e-011.00e+002.702110114
GO:0044267cellular protein metabolic process1.43e-011.00e+001.584224495
GO:0005819spindle1.43e-011.00e+002.70217114
GO:0019058viral life cycle1.44e-011.00e+002.690110115
GO:0044237cellular metabolic process1.48e-011.00e+002.65213118
GO:0007219Notch signaling pathway1.56e-011.00e+002.56914125
GO:0006260DNA replication1.56e-011.00e+002.569112125
GO:0007050cell cycle arrest1.57e-011.00e+002.55817126
GO:0006511ubiquitin-dependent protein catabolic process1.58e-011.00e+002.54615127
GO:0000790nuclear chromatin1.65e-011.00e+002.48017133
GO:0031982vesicle1.66e-011.00e+002.469110134
GO:0000086G2/M transition of mitotic cell cycle1.69e-011.00e+002.43717137
GO:0003735structural constituent of ribosome1.74e-011.00e+002.39518141
GO:0016887ATPase activity1.77e-011.00e+002.36517144
GO:0061024membrane organization1.79e-011.00e+002.34515146
GO:0000398mRNA splicing, via spliceosome2.00e-011.00e+002.169112165
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2.04e-011.00e+002.14315168
GO:0030424axon2.08e-011.00e+002.10913172
GO:0005768endosome2.10e-011.00e+002.09215174
GO:0009897external side of plasma membrane2.20e-011.00e+002.01914183
GO:0032403protein complex binding2.22e-011.00e+002.00417185
GO:0003924GTPase activity2.41e-011.00e+001.87019203
GO:0006184GTP catabolic process2.58e-011.00e+001.75419220
GO:0007067mitotic nuclear division2.69e-011.00e+001.683113231
GO:0005759mitochondrial matrix2.71e-011.00e+001.671112233
GO:0006412translation2.73e-011.00e+001.658115235
GO:0008134transcription factor binding2.84e-011.00e+001.59218246
GO:0004842ubiquitin-protein transferase activity2.94e-011.00e+001.53514256
GO:0000166nucleotide binding3.09e-011.00e+001.44816272
GO:0005975carbohydrate metabolic process3.11e-011.00e+001.43715274
GO:0006357regulation of transcription from RNA polymerase II promoter3.12e-011.00e+001.43216275
GO:0007283spermatogenesis3.13e-011.00e+001.42616276
GO:0019899enzyme binding3.24e-011.00e+001.365111288
GO:0016567protein ubiquitination3.34e-011.00e+001.31115299
GO:0043234protein complex3.35e-011.00e+001.306117300
GO:0005856cytoskeleton3.45e-011.00e+001.25418311
GO:0019901protein kinase binding3.53e-011.00e+001.213121320
GO:0007411axon guidance3.60e-011.00e+001.18219327
GO:0005525GTP binding3.60e-011.00e+001.177111328
GO:0006351transcription, DNA-templated3.62e-011.00e+000.4903251585
GO:0005813centrosome3.70e-011.00e+001.130112339
GO:0003723RNA binding3.84e-011.00e+001.063119355
GO:0005925focal adhesion3.96e-011.00e+001.004118370
GO:0005615extracellular space3.99e-011.00e+000.5552171010
GO:0007155cell adhesion4.08e-011.00e+000.95018384
GO:0005739mitochondrion4.16e-011.00e+000.5042241046
GO:0009986cell surface4.38e-011.00e+000.81419422
GO:0045892negative regulation of transcription, DNA-templated4.40e-011.00e+000.807114424
GO:0006355regulation of transcription, DNA-templated4.44e-011.00e+000.4262171104
GO:0005737cytoplasm4.55e-011.00e+000.1636983976
GO:0007596blood coagulation4.70e-011.00e+000.677114464
GO:0055114oxidation-reduction process4.82e-011.00e+000.625111481
GO:0045893positive regulation of transcription, DNA-templated4.87e-011.00e+000.607117487
GO:0055085transmembrane transport5.06e-011.00e+000.52918514
GO:0048471perinuclear region of cytoplasm5.12e-011.00e+000.504112523
GO:0045087innate immune response5.71e-011.00e+000.268120616
GO:0005794Golgi apparatus5.91e-011.00e+000.191114650
GO:0003700sequence-specific DNA binding transcription factor activity6.44e-011.00e+00-0.012111748
GO:0045944positive regulation of transcription from RNA polymerase II promoter6.74e-011.00e+00-0.129119811
GO:0005887integral component of plasma membrane7.37e-011.00e+00-0.37317961
GO:0005576extracellular region7.68e-011.00e+00-0.500191049
GO:0008270zinc ion binding7.74e-011.00e+00-0.5241121067
GO:0003677DNA binding8.51e-011.00e+00-0.8651261351
GO:0046872metal ion binding8.74e-011.00e+00-0.9821241465
GO:0005886plasma membrane9.15e-011.00e+00-0.9342382834