meta-int-snw-535

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
reg-snw-4522 wolf-screen-ratio-mammosphere-adherent 0.815 1.50e-06 3.75e-03 6.95e-03 14 12
int-snw-535 wolf-screen-ratio-mammosphere-adherent 0.927 3.27e-15 2.92e-03 4.52e-02 14 13
reg-snw-56655 wolf-screen-ratio-mammosphere-adherent 0.828 9.29e-07 2.91e-03 5.53e-03 8 7
reg-snw-317781 wolf-screen-ratio-mammosphere-adherent 0.823 1.13e-06 3.23e-03 6.07e-03 9 9
wolf-screen-ratio-mammosphere-adherent-meta-int-snw-535 subnetwork

Genes (30)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
PSMA2 5683 1121.0931.106108Yes-
RBX1 9978 1151.1850.934148Yes-
POLR2F 5435 620.8910.95626Yes-
PSMB7 5695 1180.9820.93490Yes-
HNRNPC 3183 1081.8120.973181Yes-
ATP6V0A1 535 4-0.1300.92766-Yes
PSMA1 5682 1000.9960.878152Yes-
VARS 7407 860.5491.002204Yes-
ATP6V1B2 526 530.8811.076278--
DDX51 317781 530.0590.823210Yes-
POLE4 56655 630.1770.82856--
RPSA 3921 1201.3271.151152Yes-
PSMB3 5691 640.6680.90119Yes-
RPA1 6117 510.4250.86574--
EIF6 3692 670.7000.876316Yes-
ACO2 50 651.0001.076191Yes-
CDC16 8881 530.9501.02080Yes-
RUVBL1 8607 950.7200.973469Yes-
PSMD3 5709 1000.9861.106201Yes-
CLTC 1213 560.8841.138247Yes-
EFTUD2 9343 930.8830.956108Yes-
PSMB2 5690 1160.8770.956169Yes-
TUBG1 7283 980.9740.97391Yes-
PSMD11 5717 1241.0951.106218Yes-
ACTB 60 1341.1531.151610Yes-
ATP6V0C 527 90.6601.07669Yes-
RUVBL2 10856 950.6930.956532Yes-
PSMC1 5700 510.8401.018137Yes-
PRMT3 10196 490.4310.81526--
MTHFD1 4522 490.1940.81526Yes-

Interactions (106)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ATP6V1B2 526 DDX51 317781 pp -- int.I2D: IntAct_Yeast
ACO2 50 RPA1 6117 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastLow
PSMA1 5682 PSMB2 5690 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
ACTB 60 ATP6V0C 527 pp -- int.I2D: BioGrid_Yeast
PSMD11 5717 RUVBL1 8607 pp -- int.I2D: YeastLow
ATP6V0A1 535 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast
EFTUD2 9343 RUVBL2 10856 pd < reg.ITFP.txt: no annot
EFTUD2 9343 RUVBL2 10856 pp -- int.I2D: BioGrid
ACTB 60 CLTC 1213 pp -- int.I2D: IntAct_Yeast
ACTB 60 RUVBL1 8607 pp -- int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
PSMC1 5700 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, YeastHigh, Krogan_Core
RPA1 6117 RUVBL1 8607 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastLow
RPA1 6117 VARS 7407 pp -- int.I2D: YeastLow
PSMB2 5690 POLE4 56655 pd < reg.ITFP.txt: no annot
PSMB7 5695 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast
PSMB3 5691 PSMD3 5709 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
RPA1 6117 RUVBL2 10856 pp -- int.I2D: YeastLow
ACO2 50 PSMD11 5717 pp -- int.I2D: YeastLow
ACTB 60 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMB3 5691 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct, IntAct_Fly, IntAct_Mouse, IntAct_Yeast, YeastHigh, BioGrid_Yeast
RPSA 3921 VARS 7407 pp -- int.I2D: IntAct_Yeast
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
CLTC 1213 RUVBL1 8607 pp -- int.I2D: MINT_Worm, IntAct_Worm
ACTB 60 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast
ATP6V1B2 526 CLTC 1213 pp -- int.I2D: IntAct_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
PSMC1 5700 RPA1 6117 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastLow
PSMA1 5682 PSMA2 5683 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
TUBG1 7283 VARS 7407 pd < reg.ITFP.txt: no annot
RUVBL1 8607 RUVBL2 10856 pd <> reg.ITFP.txt: no annot
RUVBL1 8607 RUVBL2 10856 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid, BioGrid_Mouse, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct, IntAct_Fly, IntAct_Worm, IntAct_Yeast, INTEROLOG, MINT_Worm, MINT_Yeast, BCI, BioGrid_Fly, BIND_Fly, BIND_Worm, FlyHigh, INNATEDB, Krogan_Core, MIPS, YeastHigh, Yu_GoldStd;
int.Ravasi: -;
int.HPRD: in vitro, in vivo, yeast 2-hybrid;
int.DIP: MI:0915(physical association)
ATP6V0C 527 ATP6V0A1 535 pp -- int.I2D: BioGrid_Yeast
ACO2 50 EIF6 3692 pp -- int.I2D: YeastLow
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
MTHFD1 4522 PRMT3 10196 pd < reg.ITFP.txt: no annot
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 RPA1 6117 pd < reg.ITFP.txt: no annot
PSMB7 5695 RBX1 9978 pd < reg.ITFP.txt: no annot
HNRNPC 3183 RUVBL1 8607 pd < reg.ITFP.txt: no annot
PSMD3 5709 RUVBL2 10856 pp -- int.I2D: YeastLow
VARS 7407 POLE4 56655 pd <> reg.ITFP.txt: no annot
PSMA2 5683 PSMB3 5691 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Fly, IntAct_Yeast, INTEROLOG, Krogan_Core, MINT_Yeast, YeastHigh, Yu_GoldStd
PSMD3 5709 TUBG1 7283 pd > reg.ITFP.txt: no annot
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
ATP6V1B2 526 ATP6V0A1 535 pp -- int.I2D: BioGrid_Yeast, YeastMedium, IntAct_Yeast
ATP6V1B2 526 ATP6V0C 527 pp -- int.I2D: YeastMedium, INTEROLOG
HNRNPC 3183 RUVBL2 10856 pd < reg.ITFP.txt: no annot
ATP6V1B2 526 CDC16 8881 pp -- int.I2D: IntAct_Yeast
PSMA2 5683 POLE4 56655 pd < reg.ITFP.txt: no annot
VARS 7407 RUVBL1 8607 pd <> reg.ITFP.txt: no annot
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB2 5690 RUVBL2 10856 pd < reg.ITFP.txt: no annot
ACO2 50 PSMC1 5700 pp -- int.I2D: YeastLow
PSMC1 5700 RUVBL2 10856 pp -- int.I2D: YeastLow
PSMB7 5695 DDX51 317781 pd < reg.ITFP.txt: no annot
PSMB3 5691 PSMC1 5700 pp -- int.I2D: YeastLow
PSMB7 5695 POLE4 56655 pd < reg.ITFP.txt: no annot
MTHFD1 4522 RUVBL1 8607 pd < reg.ITFP.txt: no annot
MTHFD1 4522 VARS 7407 pd < reg.ITFP.txt: no annot
MTHFD1 4522 RUVBL2 10856 pd < reg.ITFP.txt: no annot
PSMB2 5690 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct
TUBG1 7283 RUVBL2 10856 pd < reg.ITFP.txt: no annot
TUBG1 7283 RUVBL1 8607 pd < reg.ITFP.txt: no annot
POLR2F 5435 RUVBL2 10856 pd < reg.ITFP.txt: no annot
PSMB3 5691 PSMB7 5695 pp -- int.Intact: MI:0915(physical association);
int.I2D: BCI, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Yeast, YeastHigh, HPRD, Krogan_Core, MINT_Yeast, MIPS;
int.HPRD: yeast 2-hybrid
PSMB2 5690 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
MTHFD1 4522 RPA1 6117 pd < reg.ITFP.txt: no annot
VARS 7407 DDX51 317781 pd <> reg.ITFP.txt: no annot
PSMD3 5709 VARS 7407 pd <> reg.ITFP.txt: no annot
ATP6V1B2 526 RUVBL2 10856 pp -- int.I2D: IntAct_Yeast
PSMA2 5683 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMD11 5717 TUBG1 7283 pd > reg.ITFP.txt: no annot
PSMC1 5700 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
RPSA 3921 RUVBL2 10856 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
PSMB2 5690 PSMB3 5691 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, INTEROLOG, MINT, Yu_GoldStd, BCI, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
PSMA2 5683 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast, IntAct_Fly, YeastLow
PSMB2 5690 DDX51 317781 pd < reg.ITFP.txt: no annot
PSMD11 5717 EFTUD2 9343 pd > reg.ITFP.txt: no annot
ATP6V1B2 526 RPSA 3921 pp -- int.I2D: IntAct_Yeast
ACTB 60 CDC16 8881 pp -- int.I2D: YeastLow
PSMD11 5717 RUVBL2 10856 pp -- int.I2D: YeastLow
PSMB3 5691 POLE4 56655 pd < reg.ITFP.txt: no annot
VARS 7407 RUVBL2 10856 pd <> reg.ITFP.txt: no annot
ACO2 50 RUVBL1 8607 pp -- int.I2D: YeastLow
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMB2 5690 PSMD11 5717 pd < reg.ITFP.txt: no annot
PSMB2 5690 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMB2 5690 VARS 7407 pd < reg.ITFP.txt: no annot
PSMA1 5682 PSMC1 5700 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct_Fly, YeastMedium, IntAct
ACTB 60 RPA1 6117 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMB3 5691 PSMD11 5717 pp -- int.I2D: YeastLow
ACTB 60 ATP6V1B2 526 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 RPA1 6117 pd < reg.ITFP.txt: no annot
PSMC1 5700 RUVBL1 8607 pp -- int.I2D: YeastLow
EIF6 3692 DDX51 317781 pd < reg.ITFP.txt: no annot
EIF6 3692 PSMB3 5691 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 RUVBL2 10856 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow, BioGrid
PSMB2 5690 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
POLR2F 5435 VARS 7407 pd < reg.ITFP.txt: no annot
PSMA2 5683 PSMB2 5690 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core
EIF6 3692 RUVBL1 8607 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct

Related GO terms (344)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.90e-153.10e-116.23592465
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.84e-156.26e-116.12892470
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.49e-151.06e-106.04892474
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.20e-141.96e-105.95492579
GO:0006521regulation of cellular amino acid metabolic process2.40e-143.91e-106.44482150
GO:0000502proteasome complex8.48e-141.38e-096.23082258
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest2.21e-133.61e-096.06582265
GO:0005654nucleoplasm5.22e-138.51e-093.07817831095
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent5.84e-139.53e-095.89882373
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I9.09e-131.48e-085.82182377
GO:0000082G1/S transition of mitotic cell cycle4.46e-127.28e-085.029933150
GO:0002474antigen processing and presentation of peptide antigen via MHC class I4.71e-127.69e-085.53382394
GO:0000209protein polyubiquitination2.62e-114.28e-075.230821116
GO:0010467gene expression5.17e-118.44e-073.4021358669
GO:0000278mitotic cell cycle5.70e-119.30e-073.9101152398
GO:0016032viral process7.66e-111.25e-063.5961255540
GO:0005839proteasome core complex1.25e-102.03e-067.24051118
GO:0016071mRNA metabolic process1.57e-102.57e-064.457934223
GO:0042981regulation of apoptotic process2.19e-103.58e-064.849826151
GO:0004298threonine-type endopeptidase activity2.25e-103.67e-067.08851120
GO:0016070RNA metabolic process3.90e-106.37e-064.309934247
GO:0005829cytosol4.68e-107.64e-062.086201252562
GO:0034641cellular nitrogen compound metabolic process7.80e-101.27e-054.620825177
GO:0070062extracellular vesicular exosome3.04e-084.96e-041.96118982516
GO:0033572transferrin transport3.22e-075.25e-036.0884632
GO:0005730nucleolus4.33e-077.06e-032.17714701684
GO:0043066negative regulation of apoptotic process8.06e-071.32e-023.329830433
GO:0005838proteasome regulatory particle1.22e-061.99e-027.0883712
GO:0035267NuA4 histone acetyltransferase complex2.01e-063.28e-026.8653414
GO:0022624proteasome accessory complex3.75e-066.11e-026.5853917
GO:0016020membrane4.77e-067.78e-022.01813801746
GO:0006915apoptotic process6.33e-061.03e-012.930834571
GO:0005515protein binding1.46e-052.38e-011.030231726127
GO:0015991ATP hydrolysis coupled proton transport1.78e-052.90e-015.8653428
GO:0051701interaction with host3.23e-055.27e-015.5853434
GO:0090382phagosome maturation4.53e-057.39e-015.4253538
GO:0044281small molecule metabolic process6.57e-051.00e+002.07110571295
GO:0000812Swr1 complex9.08e-051.00e+007.088238
GO:0019773proteasome core complex, alpha-subunit complex9.08e-051.00e+007.088258
GO:0006281DNA repair1.09e-041.00e+003.365522264
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1.30e-041.00e+004.9183554
GO:0005634nucleus1.30e-041.00e+001.098191314828
GO:0006879cellular iron ion homeostasis1.53e-041.00e+004.8403557
GO:0043968histone H2A acetylation2.13e-041.00e+006.5032312
GO:0006310DNA recombination2.48e-041.00e+004.6063467
GO:0031011Ino80 complex2.93e-041.00e+006.2802314
GO:0046961proton-transporting ATPase activity, rotational mechanism3.38e-041.00e+006.1812315
GO:0003678DNA helicase activity5.48e-041.00e+005.8402319
GO:0015078hydrogen ion transmembrane transporter activity6.08e-041.00e+005.7662320
GO:0042470melanosome6.30e-041.00e+004.14931092
GO:0043044ATP-dependent chromatin remodeling8.07e-041.00e+005.5642423
GO:0071339MLL1 complex1.11e-031.00e+005.3332327
GO:0030529ribonucleoprotein complex1.17e-031.00e+003.84038114
GO:0043022ribosome binding1.20e-031.00e+005.2802328
GO:0043967histone H4 acetylation1.20e-031.00e+005.2802328
GO:0031492nucleosomal DNA binding1.20e-031.00e+005.2802428
GO:0006325chromatin organization1.46e-031.00e+003.73034123
GO:0015992proton transport1.57e-031.00e+005.0882332
GO:0000054ribosomal subunit export from nucleus1.84e-031.00e+009.088111
GO:0004486methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity1.84e-031.00e+009.088111
GO:0008286insulin receptor signaling pathway2.29e-031.00e+003.50336144
GO:0016887ATPase activity2.29e-031.00e+003.50337144
GO:0005524ATP binding2.46e-031.00e+001.6858461354
GO:0032508DNA duplex unwinding2.69e-031.00e+004.6952442
GO:0006283transcription-coupled nucleotide-excision repair3.21e-031.00e+004.5642846
GO:0000398mRNA splicing, via spliceosome3.37e-031.00e+003.306312165
GO:0030670phagocytic vesicle membrane3.64e-031.00e+004.4732349
GO:0004832valine-tRNA ligase activity3.67e-031.00e+008.088112
GO:00515383 iron, 4 sulfur cluster binding3.67e-031.00e+008.088112
GO:0003994aconitate hydratase activity3.67e-031.00e+008.088112
GO:0006407rRNA export from nucleus3.67e-031.00e+008.088112
GO:0006438valyl-tRNA aminoacylation3.67e-031.00e+008.088112
GO:0000105histidine biosynthetic process3.67e-031.00e+008.088112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.67e-031.00e+008.088112
GO:0005055laminin receptor activity3.67e-031.00e+008.088112
GO:0040008regulation of growth3.94e-031.00e+004.4152351
GO:0003684damaged DNA binding3.94e-031.00e+004.41521151
GO:0071899negative regulation of estrogen receptor binding5.50e-031.00e+007.503113
GO:1900126negative regulation of hyaluronan biosynthetic process5.50e-031.00e+007.503113
GO:0071733transcriptional activation by promoter-enhancer looping5.50e-031.00e+007.503113
GO:0071439clathrin complex5.50e-031.00e+007.503113
GO:0005737cytoplasm6.37e-031.00e+000.93814983976
GO:0006289nucleotide-excision repair7.10e-031.00e+003.97921269
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)7.33e-031.00e+007.088114
GO:0000212meiotic spindle organization7.33e-031.00e+007.088114
GO:003068690S preribosome7.33e-031.00e+007.088114
GO:0032051clathrin light chain binding7.33e-031.00e+007.088114
GO:0019788NEDD8 ligase activity7.33e-031.00e+007.088114
GO:0016274protein-arginine N-methyltransferase activity7.33e-031.00e+007.088114
GO:0004488methylenetetrahydrofolate dehydrogenase (NADP+) activity7.33e-031.00e+007.088114
GO:0004329formate-tetrahydrofolate ligase activity7.33e-031.00e+007.088114
GO:0043141ATP-dependent 5'-3' DNA helicase activity7.33e-031.00e+007.088114
GO:0034969histone arginine methylation7.33e-031.00e+007.088114
GO:0009396folic acid-containing compound biosynthetic process7.33e-031.00e+007.088114
GO:0004477methenyltetrahydrofolate cyclohydrolase activity7.33e-031.00e+007.088114
GO:0031467Cul7-RING ubiquitin ligase complex7.33e-031.00e+007.088114
GO:0000220vacuolar proton-transporting V-type ATPase, V0 domain7.33e-031.00e+007.088114
GO:1903077negative regulation of protein localization to plasma membrane7.33e-031.00e+007.088114
GO:0007067mitotic nuclear division8.57e-031.00e+002.821313231
GO:0008380RNA splicing8.67e-031.00e+002.815313232
GO:0031465Cul4B-RING E3 ubiquitin ligase complex9.16e-031.00e+006.766125
GO:0042256mature ribosome assembly9.16e-031.00e+006.766115
GO:0009086methionine biosynthetic process9.16e-031.00e+006.766115
GO:0008622epsilon DNA polymerase complex9.16e-031.00e+006.766115
GO:0031461cullin-RING ubiquitin ligase complex9.16e-031.00e+006.766115
GO:0071169establishment of protein localization to chromatin9.16e-031.00e+006.766115
GO:0043248proteasome assembly9.16e-031.00e+006.766115
GO:0006102isocitrate metabolic process9.16e-031.00e+006.766115
GO:0030891VCB complex9.16e-031.00e+006.766125
GO:0005827polar microtubule9.16e-031.00e+006.766115
GO:0000730DNA recombinase assembly9.16e-031.00e+006.766135
GO:0005638lamin filament9.16e-031.00e+006.766115
GO:0071013catalytic step 2 spliceosome9.22e-031.00e+003.7842779
GO:0005681spliceosomal complex1.01e-021.00e+003.7132383
GO:0030130clathrin coat of trans-Golgi network vesicle1.10e-021.00e+006.503116
GO:0006101citrate metabolic process1.10e-021.00e+006.503116
GO:0030118clathrin coat1.10e-021.00e+006.503116
GO:0043023ribosomal large subunit binding1.10e-021.00e+006.503126
GO:0031466Cul5-RING ubiquitin ligase complex1.10e-021.00e+006.503116
GO:0030957Tat protein binding1.10e-021.00e+006.503146
GO:0033179proton-transporting V-type ATPase, V0 domain1.10e-021.00e+006.503116
GO:0008469histone-arginine N-methyltransferase activity1.10e-021.00e+006.503116
GO:0016363nuclear matrix1.23e-021.00e+003.56421192
GO:0044822poly(A) RNA binding1.24e-021.00e+001.5986501078
GO:0005200structural constituent of cytoskeleton1.26e-021.00e+003.5482793
GO:0000028ribosomal small subunit assembly1.28e-021.00e+006.280117
GO:0002161aminoacyl-tRNA editing activity1.28e-021.00e+006.280127
GO:0035242protein-arginine omega-N asymmetric methyltransferase activity1.28e-021.00e+006.280117
GO:0031462Cul2-RING ubiquitin ligase complex1.28e-021.00e+006.280127
GO:0033180proton-transporting V-type ATPase, V1 domain1.28e-021.00e+006.280127
GO:0030132clathrin coat of coated pit1.28e-021.00e+006.280117
GO:0035999tetrahydrofolate interconversion1.28e-021.00e+006.280117
GO:0072341modified amino acid binding1.28e-021.00e+006.280117
GO:0000930gamma-tubulin complex1.28e-021.00e+006.280117
GO:0019919peptidyl-arginine methylation, to asymmetrical-dimethyl arginine1.28e-021.00e+006.280117
GO:0001649osteoblast differentiation1.31e-021.00e+003.5182695
GO:0031464Cul4A-RING E3 ubiquitin ligase complex1.46e-021.00e+006.088128
GO:0001055RNA polymerase II activity1.46e-021.00e+006.088138
GO:0070688MLL5-L complex1.46e-021.00e+006.088118
GO:0045116protein neddylation1.46e-021.00e+006.088128
GO:0000800lateral element1.46e-021.00e+006.088118
GO:0006164purine nucleotide biosynthetic process1.46e-021.00e+006.088128
GO:0046933proton-transporting ATP synthase activity, rotational mechanism1.64e-021.00e+005.918119
GO:0043234protein complex1.73e-021.00e+002.444317300
GO:0006200ATP catabolic process1.78e-021.00e+002.429314303
GO:0046655folic acid metabolic process1.82e-021.00e+005.7661110
GO:0006450regulation of translational fidelity1.82e-021.00e+005.7661210
GO:0005819spindle1.85e-021.00e+003.25527114
GO:0001054RNA polymerase I activity2.00e-021.00e+005.6281311
GO:0045120pronucleus2.00e-021.00e+005.6281111
GO:00709353'-UTR-mediated mRNA stabilization2.18e-021.00e+005.5031212
GO:0005736DNA-directed RNA polymerase I complex2.18e-021.00e+005.5031312
GO:0043231intracellular membrane-bounded organelle2.26e-021.00e+002.29738332
GO:0042273ribosomal large subunit biogenesis2.36e-021.00e+005.3871413
GO:0005662DNA replication factor A complex2.36e-021.00e+005.3871313
GO:0030234enzyme regulator activity2.36e-021.00e+005.3871313
GO:0008266poly(U) RNA binding2.36e-021.00e+005.3871113
GO:0005813centrosome2.38e-021.00e+002.267312339
GO:0006413translational initiation2.40e-021.00e+003.054212131
GO:0000790nuclear chromatin2.47e-021.00e+003.03227133
GO:0007020microtubule nucleation2.54e-021.00e+005.2801114
GO:0035066positive regulation of histone acetylation2.72e-021.00e+005.1811115
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex2.72e-021.00e+005.1811115
GO:0006261DNA-dependent DNA replication2.72e-021.00e+005.1811215
GO:0042176regulation of protein catabolic process2.90e-021.00e+005.0881316
GO:0005665DNA-directed RNA polymerase II, core complex2.90e-021.00e+005.0881416
GO:0046034ATP metabolic process2.90e-021.00e+005.0881116
GO:0050998nitric-oxide synthase binding2.90e-021.00e+005.0881116
GO:0001673male germ cell nucleus2.90e-021.00e+005.0881116
GO:0001056RNA polymerase III activity2.90e-021.00e+005.0881316
GO:0061024membrane organization2.94e-021.00e+002.89825146
GO:0005925focal adhesion2.98e-021.00e+002.141318370
GO:0006457protein folding3.05e-021.00e+002.86828149
GO:0010243response to organonitrogen compound3.08e-021.00e+005.0001217
GO:0005666DNA-directed RNA polymerase III complex3.08e-021.00e+005.0001317
GO:0007126meiotic nuclear division3.08e-021.00e+005.0001117
GO:0006386termination of RNA polymerase III transcription3.26e-021.00e+004.9181318
GO:0017025TBP-class protein binding3.26e-021.00e+004.9181218
GO:0071392cellular response to estradiol stimulus3.26e-021.00e+004.9181118
GO:0031122cytoplasmic microtubule organization3.26e-021.00e+004.9181218
GO:0006385transcription elongation from RNA polymerase III promoter3.26e-021.00e+004.9181318
GO:0010008endosome membrane3.35e-021.00e+002.79326157
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process3.44e-021.00e+004.8401119
GO:0048863stem cell differentiation3.44e-021.00e+004.8401119
GO:0007088regulation of mitosis3.44e-021.00e+004.8401119
GO:0048873homeostasis of number of cells within a tissue3.61e-021.00e+004.7661120
GO:0005680anaphase-promoting complex3.61e-021.00e+004.7661420
GO:0005719nuclear euchromatin3.61e-021.00e+004.7661220
GO:0006298mismatch repair3.61e-021.00e+004.7661620
GO:0000718nucleotide-excision repair, DNA damage removal3.79e-021.00e+004.6951521
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding3.80e-021.00e+002.69525168
GO:0006297nucleotide-excision repair, DNA gap filling3.97e-021.00e+004.6281522
GO:0032201telomere maintenance via semi-conservative replication3.97e-021.00e+004.6281722
GO:0030863cortical cytoskeleton3.97e-021.00e+004.6281122
GO:0036464cytoplasmic ribonucleoprotein granule3.97e-021.00e+004.6281422
GO:0031463Cul3-RING ubiquitin ligase complex4.15e-021.00e+004.5641223
GO:0043236laminin binding4.15e-021.00e+004.5641123
GO:0006513protein monoubiquitination4.15e-021.00e+004.5641123
GO:0031625ubiquitin protein ligase binding4.30e-021.00e+002.596213180
GO:0000794condensed nuclear chromosome4.32e-021.00e+004.5031224
GO:0015629actin cytoskeleton4.43e-021.00e+002.57225183
GO:0005844polysome4.50e-021.00e+004.4441425
GO:0070979protein K11-linked ubiquitination4.67e-021.00e+004.3871326
GO:0000722telomere maintenance via recombination4.67e-021.00e+004.3871726
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia4.67e-021.00e+004.3871226
GO:0006730one-carbon metabolic process4.67e-021.00e+004.3871126
GO:0004003ATP-dependent DNA helicase activity4.85e-021.00e+004.3331327
GO:0034080CENP-A containing nucleosome assembly4.85e-021.00e+004.3331227
GO:0030177positive regulation of Wnt signaling pathway5.03e-021.00e+004.2801328
GO:0019894kinesin binding5.03e-021.00e+004.2801128
GO:0006099tricarboxylic acid cycle5.20e-021.00e+004.2301329
GO:0019005SCF ubiquitin ligase complex5.20e-021.00e+004.2301129
GO:0003730mRNA 3'-UTR binding5.20e-021.00e+004.2301229
GO:0003887DNA-directed DNA polymerase activity5.20e-021.00e+004.2301329
GO:0030669clathrin-coated endocytic vesicle membrane5.20e-021.00e+004.2301129
GO:0071897DNA biosynthetic process5.20e-021.00e+004.2301229
GO:0003924GTPase activity5.33e-021.00e+002.42229203
GO:00063707-methylguanosine mRNA capping5.37e-021.00e+004.1811430
GO:0006360transcription from RNA polymerase I promoter5.37e-021.00e+004.1811430
GO:0031623receptor internalization5.55e-021.00e+004.1331131
GO:0006271DNA strand elongation involved in DNA replication5.55e-021.00e+004.1331931
GO:0007094mitotic spindle assembly checkpoint5.55e-021.00e+004.1331531
GO:0031397negative regulation of protein ubiquitination5.72e-021.00e+004.0881132
GO:0034644cellular response to UV5.72e-021.00e+004.0881532
GO:0005765lysosomal membrane6.05e-021.00e+002.31925218
GO:0005876spindle microtubule6.07e-021.00e+004.0001334
GO:0006184GTP catabolic process6.15e-021.00e+002.30629220
GO:0032588trans-Golgi network membrane6.42e-021.00e+003.9181136
GO:0034332adherens junction organization6.42e-021.00e+003.9181136
GO:0001895retina homeostasis6.42e-021.00e+003.9181136
GO:0051084'de novo' posttranslational protein folding6.59e-021.00e+003.8781437
GO:00515394 iron, 4 sulfur cluster binding6.59e-021.00e+003.8781337
GO:0055085transmembrane transport6.73e-021.00e+001.66738514
GO:0070527platelet aggregation6.76e-021.00e+003.8401238
GO:0006383transcription from RNA polymerase III promoter6.93e-021.00e+003.8021339
GO:0008026ATP-dependent helicase activity6.93e-021.00e+003.8021339
GO:0031490chromatin DNA binding6.93e-021.00e+003.8021239
GO:0006284base-excision repair6.93e-021.00e+003.8021739
GO:0022627cytosolic small ribosomal subunit6.93e-021.00e+003.8021339
GO:0051117ATPase binding7.27e-021.00e+003.7301141
GO:0006418tRNA aminoacylation for protein translation7.45e-021.00e+003.6951542
GO:0005902microvillus7.45e-021.00e+003.6951242
GO:0014070response to organic cyclic compound7.62e-021.00e+003.6611343
GO:0006892post-Golgi vesicle-mediated transport7.79e-021.00e+003.6281244
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding7.79e-021.00e+003.6281244
GO:0050434positive regulation of viral transcription7.79e-021.00e+003.6281544
GO:0015030Cajal body7.96e-021.00e+003.5961245
GO:0043966histone H3 acetylation7.96e-021.00e+003.5961245
GO:0021762substantia nigra development8.13e-021.00e+003.5641146
GO:0030136clathrin-coated vesicle8.13e-021.00e+003.5641146
GO:0003743translation initiation factor activity8.63e-021.00e+003.4731449
GO:0006091generation of precursor metabolites and energy8.97e-021.00e+003.4151351
GO:0008168methyltransferase activity9.14e-021.00e+003.3871152
GO:0003725double-stranded RNA binding9.47e-021.00e+003.3331654
GO:0000226microtubule cytoskeleton organization9.64e-021.00e+003.3061355
GO:0000932cytoplasmic mRNA processing body9.81e-021.00e+003.2801356
GO:0000724double-strand break repair via homologous recombination9.97e-021.00e+003.2551657
GO:0012505endomembrane system9.97e-021.00e+003.2551257
GO:0030097hemopoiesis1.01e-011.00e+003.2301358
GO:0005840ribosome1.03e-011.00e+003.2051259
GO:0045216cell-cell junction organization1.03e-011.00e+003.2051259
GO:0000723telomere maintenance1.03e-011.00e+003.2051859
GO:0032481positive regulation of type I interferon production1.06e-011.00e+003.1571661
GO:0006302double-strand break repair1.08e-011.00e+003.1331862
GO:0006368transcription elongation from RNA polymerase II promoter1.16e-011.00e+003.0211667
GO:0005794Golgi apparatus1.16e-011.00e+001.328314650
GO:0019901protein kinase binding1.17e-011.00e+001.766221320
GO:0006338chromatin remodeling1.18e-011.00e+003.0001468
GO:0003697single-stranded DNA binding1.19e-011.00e+002.9791969
GO:0005525GTP binding1.21e-011.00e+001.730211328
GO:0005739mitochondrion1.23e-011.00e+001.0574241046
GO:0034329cell junction assembly1.23e-011.00e+002.9381171
GO:0006767water-soluble vitamin metabolic process1.29e-011.00e+002.8591375
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process1.31e-011.00e+002.8401376
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis1.32e-011.00e+002.8211577
GO:0006766vitamin metabolic process1.34e-011.00e+002.8021378
GO:0006334nucleosome assembly1.36e-011.00e+002.7841479
GO:0003723RNA binding1.38e-011.00e+001.616219355
GO:0019083viral transcription1.39e-011.00e+002.7481881
GO:0001726ruffle1.40e-011.00e+002.7301482
GO:0006898receptor-mediated endocytosis1.47e-011.00e+002.6611286
GO:0006415translational termination1.48e-011.00e+002.6451887
GO:0016605PML body1.56e-011.00e+002.5641592
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II1.56e-011.00e+002.5641492
GO:0006928cellular component movement1.56e-011.00e+002.5641792
GO:0006414translational elongation1.58e-011.00e+002.54811193
GO:0051082unfolded protein binding1.61e-011.00e+002.5181695
GO:0006364rRNA processing1.62e-011.00e+002.5031596
GO:0071456cellular response to hypoxia1.65e-011.00e+002.4731498
GO:0006614SRP-dependent cotranslational protein targeting to membrane1.75e-011.00e+002.38718104
GO:0014069postsynaptic density1.78e-011.00e+002.36011106
GO:0005815microtubule organizing center1.84e-011.00e+002.30614110
GO:0015630microtubule cytoskeleton1.87e-011.00e+002.28015112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.90e-011.00e+002.255110114
GO:0019058viral life cycle1.91e-011.00e+002.242110115
GO:0072562blood microparticle1.93e-011.00e+002.23014116
GO:0044237cellular metabolic process1.96e-011.00e+002.20513118
GO:0007219Notch signaling pathway2.06e-011.00e+002.12214125
GO:0006260DNA replication2.06e-011.00e+002.122112125
GO:0005506iron ion binding2.09e-011.00e+002.09913127
GO:0006511ubiquitin-dependent protein catabolic process2.09e-011.00e+002.09915127
GO:0009615response to virus2.16e-011.00e+002.04316132
GO:0031982vesicle2.19e-011.00e+002.021110134
GO:0000086G2/M transition of mitotic cell cycle2.24e-011.00e+001.99017137
GO:0042802identical protein binding2.28e-011.00e+001.148218491
GO:0003735structural constituent of ribosome2.29e-011.00e+001.94818141
GO:0044267cellular protein metabolic process2.31e-011.00e+001.136224495
GO:0005198structural molecule activity2.55e-011.00e+001.77514159
GO:0006397mRNA processing2.68e-011.00e+001.68713169
GO:0030424axon2.72e-011.00e+001.66113172
GO:0006886intracellular protein transport2.74e-011.00e+001.65314173
GO:0016607nuclear speck2.77e-011.00e+001.63614175
GO:0006367transcription initiation from RNA polymerase II promoter2.89e-011.00e+001.56418184
GO:0032403protein complex binding2.90e-011.00e+001.55617185
GO:0045087innate immune response3.14e-011.00e+000.821220616
GO:0001701in utero embryonic development3.22e-011.00e+001.37316210
GO:0005622intracellular3.42e-011.00e+001.26715226
GO:0005759mitochondrial matrix3.51e-011.00e+001.223112233
GO:0006412translation3.53e-011.00e+001.211115235
GO:0004842ubiquitin-protein transferase activity3.78e-011.00e+001.08814256
GO:0000166nucleotide binding3.96e-011.00e+001.00016272
GO:0006357regulation of transcription from RNA polymerase II promoter4.00e-011.00e+000.98416275
GO:0007283spermatogenesis4.01e-011.00e+000.97916276
GO:0016567protein ubiquitination4.26e-011.00e+000.86415299
GO:0005856cytoskeleton4.39e-011.00e+000.80718311
GO:0007411axon guidance4.55e-011.00e+000.73419327
GO:0008283cell proliferation4.59e-011.00e+000.717112331
GO:0003682chromatin binding4.63e-011.00e+000.704112334
GO:0043565sequence-specific DNA binding4.93e-011.00e+000.57614365
GO:0007155cell adhesion5.11e-011.00e+000.50318384
GO:0008284positive regulation of cell proliferation5.18e-011.00e+000.47318392
GO:0046982protein heterodimerization activity5.24e-011.00e+000.447111399
GO:0006366transcription from RNA polymerase II promoter5.47e-011.00e+000.356112425
GO:0007596blood coagulation5.79e-011.00e+000.230114464
GO:0055114oxidation-reduction process5.93e-011.00e+000.178111481
GO:0046872metal ion binding7.65e-011.00e+00-0.4292241465
GO:0045944positive regulation of transcription from RNA polymerase II promoter7.84e-011.00e+00-0.576119811
GO:0005886plasma membrane7.90e-011.00e+00-0.3814382834
GO:0006351transcription, DNA-templated8.03e-011.00e+00-0.5432251585
GO:0005615extracellular space8.53e-011.00e+00-0.8931171010
GO:0016021integral component of membrane8.56e-011.00e+00-0.6053152483
GO:0008270zinc ion binding8.69e-011.00e+00-0.9721121067
GO:0006355regulation of transcription, DNA-templated8.78e-011.00e+00-1.0211171104
GO:0003677DNA binding9.25e-011.00e+00-1.3121261351