reg-snw-4522

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.815	1.50e-06	3.75e-03	6.95e-03

wolf-screen-ratio-mammosphere-adherent-reg-snw-4522 subnetwork

Genes (14)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	Transcription factor	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RUVBL1	8607	24	0.720	0.973	126	TF	Yes	-
POLR2F	5435	14	0.891	0.956	5	-	Yes	-
PSMD3	5709	9	0.986	0.938	55	TF	Yes	-
EFTUD2	9343	17	0.883	0.956	30	-	Yes	-
PSMB7	5695	10	0.982	0.934	33	-	Yes	-
HNRNPC	3183	40	1.812	0.973	62	-	Yes	-
PSMA1	5682	5	0.996	0.878	29	-	Yes	-
PSMB2	5690	23	0.877	0.956	52	-	Yes	-
TUBG1	7283	39	0.974	0.973	36	-	Yes	-
VARS	7407	7	0.549	0.938	124	TF	Yes	-
RUVBL2	10856	20	0.693	0.956	187	TF	Yes	-
PRMT3	10196	1	0.431	0.815	26	TF	-	-
[ MTHFD1 ]	4522	1	0.194	0.815	26	-	Yes	-
RPA1	6117	2	0.425	0.865	74	TF	-	-

Interactions (22)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMB2	5690	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
PSMD3	5709	TUBG1	7283	pd	>	reg.ITFP.txt: no annot
PSMD3	5709	VARS	7407	pd	<>	reg.ITFP.txt: no annot
VARS	7407	RUVBL2	10856	pd	<>	reg.ITFP.txt: no annot
MTHFD1	4522	RPA1	6117	pd	<	reg.ITFP.txt: no annot
PSMB2	5690	VARS	7407	pd	<	reg.ITFP.txt: no annot
MTHFD1	4522	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
MTHFD1	4522	RUVBL1	8607	pd	<	reg.ITFP.txt: no annot
TUBG1	7283	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
HNRNPC	3183	RUVBL1	8607	pd	<	reg.ITFP.txt: no annot
TUBG1	7283	RUVBL1	8607	pd	<	reg.ITFP.txt: no annot
HNRNPC	3183	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
MTHFD1	4522	VARS	7407	pd	<	reg.ITFP.txt: no annot
POLR2F	5435	VARS	7407	pd	<	reg.ITFP.txt: no annot
TUBG1	7283	VARS	7407	pd	<	reg.ITFP.txt: no annot
RUVBL1	8607	RUVBL2	10856	pd	<>	reg.ITFP.txt: no annot
PSMA1	5682	RPA1	6117	pd	<	reg.ITFP.txt: no annot
POLR2F	5435	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
EFTUD2	9343	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
PSMB7	5695	RPA1	6117	pd	<	reg.ITFP.txt: no annot
MTHFD1	4522	PRMT3	10196	pd	<	reg.ITFP.txt: no annot
VARS	7407	RUVBL1	8607	pd	<>	reg.ITFP.txt: no annot

Related GO terms (195)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005654	nucleoplasm	2.30e-08	2.25e-04	2.993	10	55	876
GO:0010467	gene expression	1.73e-07	1.69e-03	3.383	8	31	535
GO:0006521	regulation of cellular amino acid metabolic process	2.60e-07	2.54e-03	6.088	4	16	41
GO:0000502	proteasome complex	4.55e-07	4.45e-03	5.891	4	17	47
GO:0005730	nucleolus	5.44e-07	5.31e-03	2.519	10	41	1217
GO:0000082	G1/S transition of mitotic cell cycle	5.79e-07	5.65e-03	4.802	5	24	125
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	6.88e-07	6.72e-03	5.746	4	17	52
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	7.44e-07	7.26e-03	5.718	4	17	53
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	9.30e-07	9.09e-03	5.639	4	17	56
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	1.00e-06	9.76e-03	5.613	4	16	57
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.23e-06	1.20e-02	5.539	4	17	60
GO:0005839	proteasome core complex	1.30e-06	1.27e-02	7.031	3	9	16
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	1.32e-06	1.29e-02	5.515	4	16	61
GO:0004298	threonine-type endopeptidase activity	1.58e-06	1.54e-02	6.944	3	9	17
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	1.70e-06	1.66e-02	5.424	4	17	65
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	2.30e-06	2.24e-02	5.317	4	16	70
GO:0000278	mitotic cell cycle	2.55e-06	2.49e-02	3.736	6	35	314
GO:0000209	protein polyubiquitination	6.87e-06	6.71e-02	4.922	4	16	92
GO:0034641	cellular nitrogen compound metabolic process	1.16e-05	1.14e-01	4.732	4	18	105
GO:0042981	regulation of apoptotic process	1.50e-05	1.47e-01	4.639	4	18	112
GO:0005829	cytosol	2.01e-05	1.96e-01	1.965	10	58	1787
GO:0000812	Swr1 complex	3.99e-05	3.90e-01	7.639	2	2	7
GO:0006310	DNA recombination	4.42e-05	4.32e-01	5.387	3	6	50
GO:0031011	Ino80 complex	5.32e-05	5.19e-01	7.446	2	2	8
GO:0016071	mRNA metabolic process	7.74e-05	7.56e-01	4.037	4	21	170
GO:0043968	histone H2A acetylation	8.53e-05	8.33e-01	7.124	2	2	10
GO:0016070	RNA metabolic process	1.15e-04	1.00e+00	3.891	4	21	188
GO:0035267	NuA4 histone acetyltransferase complex	1.25e-04	1.00e+00	6.861	2	3	12
GO:0006281	DNA repair	1.54e-04	1.00e+00	3.781	4	19	203
GO:0016032	viral process	2.28e-04	1.00e+00	3.027	5	32	428
GO:0003678	DNA helicase activity	2.88e-04	1.00e+00	6.276	2	3	18
GO:0071339	MLL1 complex	2.88e-04	1.00e+00	6.276	2	2	18
GO:0043967	histone H4 acetylation	4.34e-04	1.00e+00	5.987	2	2	22
GO:0016020	membrane	6.75e-04	1.00e+00	2.016	7	38	1207
GO:0070062	extracellular vesicular exosome	7.20e-04	1.00e+00	1.766	8	43	1641
GO:0000398	mRNA splicing, via spliceosome	7.21e-04	1.00e+00	4.031	3	8	128
GO:0043066	negative regulation of apoptotic process	8.94e-04	1.00e+00	3.115	4	20	322
GO:0040008	regulation of growth	1.24e-03	1.00e+00	5.237	2	2	37
GO:0032508	DNA duplex unwinding	1.30e-03	1.00e+00	5.198	2	5	38
GO:0004832	valine-tRNA ligase activity	1.43e-03	1.00e+00	9.446	1	1	1
GO:0006438	valyl-tRNA aminoacylation	1.43e-03	1.00e+00	9.446	1	1	1
GO:0004486	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	1.43e-03	1.00e+00	9.446	1	1	1
GO:0006283	transcription-coupled nucleotide-excision repair	1.44e-03	1.00e+00	5.124	2	6	40
GO:0008380	RNA splicing	1.50e-03	1.00e+00	3.665	3	7	165
GO:0003684	damaged DNA binding	1.52e-03	1.00e+00	5.088	2	9	41
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.16e-03	1.00e+00	4.831	2	3	49
GO:0006915	apoptotic process	2.21e-03	1.00e+00	2.763	4	21	411
GO:0006289	nucleotide-excision repair	2.52e-03	1.00e+00	4.718	2	9	53
GO:0005681	spliceosomal complex	2.71e-03	1.00e+00	4.665	2	2	55
GO:0034969	histone arginine methylation	2.87e-03	1.00e+00	8.446	1	1	2
GO:0000105	histidine biosynthetic process	2.87e-03	1.00e+00	8.446	1	1	2
GO:0071013	catalytic step 2 spliceosome	3.33e-03	1.00e+00	4.515	2	5	61
GO:0005634	nucleus	3.92e-03	1.00e+00	1.104	10	67	3246
GO:0071733	transcriptional activation by promoter-enhancer looping	4.30e-03	1.00e+00	7.861	1	1	3
GO:0043141	ATP-dependent 5'-3' DNA helicase activity	4.30e-03	1.00e+00	7.861	1	1	3
GO:0009086	methionine biosynthetic process	4.30e-03	1.00e+00	7.861	1	1	3
GO:0016274	protein-arginine N-methyltransferase activity	4.30e-03	1.00e+00	7.861	1	1	3
GO:0071899	negative regulation of estrogen receptor binding	4.30e-03	1.00e+00	7.861	1	1	3
GO:0008469	histone-arginine N-methyltransferase activity	4.30e-03	1.00e+00	7.861	1	1	3
GO:0006325	chromatin organization	4.36e-03	1.00e+00	4.317	2	3	70
GO:0016363	nuclear matrix	4.73e-03	1.00e+00	4.256	2	7	73
GO:0044281	small molecule metabolic process	4.92e-03	1.00e+00	2.047	5	32	844
GO:0000212	meiotic spindle organization	5.72e-03	1.00e+00	7.446	1	1	4
GO:0071169	establishment of protein localization to chromatin	5.72e-03	1.00e+00	7.446	1	1	4
GO:0009396	folic acid-containing compound biosynthetic process	5.72e-03	1.00e+00	7.446	1	1	4
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	5.72e-03	1.00e+00	7.446	1	1	4
GO:0072341	modified amino acid binding	5.72e-03	1.00e+00	7.446	1	1	4
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	5.72e-03	1.00e+00	7.446	1	1	4
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	5.72e-03	1.00e+00	7.446	1	1	4
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	5.72e-03	1.00e+00	7.446	1	1	4
GO:0004329	formate-tetrahydrofolate ligase activity	5.72e-03	1.00e+00	7.446	1	1	4
GO:0030529	ribonucleoprotein complex	5.94e-03	1.00e+00	4.088	2	4	82
GO:0005827	polar microtubule	7.15e-03	1.00e+00	7.124	1	1	5
GO:0002161	aminoacyl-tRNA editing activity	7.15e-03	1.00e+00	7.124	1	1	5
GO:0000730	DNA recombinase assembly	7.15e-03	1.00e+00	7.124	1	3	5
GO:0000930	gamma-tubulin complex	7.15e-03	1.00e+00	7.124	1	1	5
GO:0000800	lateral element	7.15e-03	1.00e+00	7.124	1	1	5
GO:0019773	proteasome core complex, alpha-subunit complex	8.57e-03	1.00e+00	6.861	1	4	6
GO:0001055	RNA polymerase II activity	8.57e-03	1.00e+00	6.861	1	2	6
GO:0035999	tetrahydrofolate interconversion	8.57e-03	1.00e+00	6.861	1	1	6
GO:0016887	ATPase activity	8.72e-03	1.00e+00	3.802	2	6	100
GO:0006164	purine nucleotide biosynthetic process	1.00e-02	1.00e+00	6.639	1	2	7
GO:0005662	DNA replication factor A complex	1.14e-02	1.00e+00	6.446	1	3	8
GO:0006450	regulation of translational fidelity	1.14e-02	1.00e+00	6.446	1	1	8
GO:0031122	cytoplasmic microtubule organization	1.14e-02	1.00e+00	6.446	1	2	8
GO:0003924	GTPase activity	1.22e-02	1.00e+00	3.551	2	3	119
GO:0046655	folic acid metabolic process	1.28e-02	1.00e+00	6.276	1	1	9
GO:0008266	poly(U) RNA binding	1.28e-02	1.00e+00	6.276	1	1	9
GO:0005736	DNA-directed RNA polymerase I complex	1.43e-02	1.00e+00	6.124	1	2	10
GO:0001673	male germ cell nucleus	1.43e-02	1.00e+00	6.124	1	1	10
GO:0006261	DNA-dependent DNA replication	1.43e-02	1.00e+00	6.124	1	2	10
GO:0001054	RNA polymerase I activity	1.43e-02	1.00e+00	6.124	1	2	10
GO:0005838	proteasome regulatory particle	1.43e-02	1.00e+00	6.124	1	4	10
GO:0007126	meiotic nuclear division	1.43e-02	1.00e+00	6.124	1	1	10
GO:0006184	GTP catabolic process	1.44e-02	1.00e+00	3.424	2	3	130
GO:0007020	microtubule nucleation	1.57e-02	1.00e+00	5.987	1	1	11
GO:0070935	3'-UTR-mediated mRNA stabilization	1.57e-02	1.00e+00	5.987	1	2	11
GO:0030234	enzyme regulator activity	1.57e-02	1.00e+00	5.987	1	2	11
GO:0045120	pronucleus	1.57e-02	1.00e+00	5.987	1	1	11
GO:0071392	cellular response to estradiol stimulus	1.85e-02	1.00e+00	5.746	1	1	13
GO:0005666	DNA-directed RNA polymerase III complex	1.85e-02	1.00e+00	5.746	1	2	13
GO:0005665	DNA-directed RNA polymerase II, core complex	1.85e-02	1.00e+00	5.746	1	2	13
GO:0001056	RNA polymerase III activity	1.85e-02	1.00e+00	5.746	1	2	13
GO:0035066	positive regulation of histone acetylation	1.85e-02	1.00e+00	5.746	1	1	13
GO:0006386	termination of RNA polymerase III transcription	1.99e-02	1.00e+00	5.639	1	2	14
GO:0010243	response to organonitrogen compound	1.99e-02	1.00e+00	5.639	1	1	14
GO:0042176	regulation of protein catabolic process	1.99e-02	1.00e+00	5.639	1	2	14
GO:0006385	transcription elongation from RNA polymerase III promoter	1.99e-02	1.00e+00	5.639	1	2	14
GO:0048873	homeostasis of number of cells within a tissue	1.99e-02	1.00e+00	5.639	1	1	14
GO:0022624	proteasome accessory complex	1.99e-02	1.00e+00	5.639	1	7	14
GO:0005719	nuclear euchromatin	2.27e-02	1.00e+00	5.446	1	1	16
GO:0006298	mismatch repair	2.41e-02	1.00e+00	5.359	1	4	17
GO:0006730	one-carbon metabolic process	2.41e-02	1.00e+00	5.359	1	1	17
GO:0000718	nucleotide-excision repair, DNA damage removal	2.41e-02	1.00e+00	5.359	1	5	17
GO:0006297	nucleotide-excision repair, DNA gap filling	2.55e-02	1.00e+00	5.276	1	5	18
GO:0031397	negative regulation of protein ubiquitination	2.55e-02	1.00e+00	5.276	1	1	18
GO:0000794	condensed nuclear chromosome	2.55e-02	1.00e+00	5.276	1	3	18
GO:0005515	protein binding	2.65e-02	1.00e+00	0.758	10	76	4124
GO:0005844	polysome	2.69e-02	1.00e+00	5.198	1	1	19
GO:0043044	ATP-dependent chromatin remodeling	2.83e-02	1.00e+00	5.124	1	2	20
GO:0034080	CENP-A containing nucleosome assembly	2.83e-02	1.00e+00	5.124	1	2	20
GO:0032201	telomere maintenance via semi-conservative replication	2.83e-02	1.00e+00	5.124	1	7	20
GO:0000722	telomere maintenance via recombination	3.11e-02	1.00e+00	4.987	1	7	22
GO:0005525	GTP binding	3.14e-02	1.00e+00	2.824	2	5	197
GO:0005524	ATP binding	3.29e-02	1.00e+00	1.645	4	23	892
GO:0006370	7-methylguanosine mRNA capping	3.39e-02	1.00e+00	4.861	1	2	24
GO:0004003	ATP-dependent DNA helicase activity	3.53e-02	1.00e+00	4.802	1	2	25
GO:0003730	mRNA 3'-UTR binding	3.53e-02	1.00e+00	4.802	1	2	25
GO:0031492	nucleosomal DNA binding	3.53e-02	1.00e+00	4.802	1	2	25
GO:0005813	centrosome	3.75e-02	1.00e+00	2.684	2	8	217
GO:0006360	transcription from RNA polymerase I promoter	3.80e-02	1.00e+00	4.691	1	2	27
GO:0034644	cellular response to UV	3.94e-02	1.00e+00	4.639	1	2	28
GO:0006418	tRNA aminoacylation for protein translation	4.08e-02	1.00e+00	4.588	1	1	29
GO:0006271	DNA strand elongation involved in DNA replication	4.08e-02	1.00e+00	4.588	1	8	29
GO:0006383	transcription from RNA polymerase III promoter	4.08e-02	1.00e+00	4.588	1	2	29
GO:0008168	methyltransferase activity	4.22e-02	1.00e+00	4.539	1	1	30
GO:0031490	chromatin DNA binding	4.36e-02	1.00e+00	4.492	1	1	31
GO:0015030	Cajal body	4.49e-02	1.00e+00	4.446	1	2	32
GO:0006284	base-excision repair	4.49e-02	1.00e+00	4.446	1	8	32
GO:0003723	RNA binding	4.75e-02	1.00e+00	2.498	2	11	247
GO:0014070	response to organic cyclic compound	4.77e-02	1.00e+00	4.359	1	1	34
GO:0050434	positive regulation of viral transcription	4.91e-02	1.00e+00	4.317	1	2	35
GO:0000226	microtubule cytoskeleton organization	5.04e-02	1.00e+00	4.276	1	2	36
GO:0005737	cytoplasm	5.58e-02	1.00e+00	0.891	7	50	2633
GO:0005840	ribosome	5.59e-02	1.00e+00	4.124	1	1	40
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	5.59e-02	1.00e+00	4.124	1	2	40
GO:0000724	double-strand break repair via homologous recombination	5.86e-02	1.00e+00	4.054	1	5	42
GO:0000723	telomere maintenance	6.54e-02	1.00e+00	3.891	1	8	47
GO:0032481	positive regulation of type I interferon production	6.67e-02	1.00e+00	3.861	1	5	48
GO:0030097	hemopoiesis	6.67e-02	1.00e+00	3.861	1	3	48
GO:0006767	water-soluble vitamin metabolic process	6.94e-02	1.00e+00	3.802	1	2	50
GO:0006334	nucleosome assembly	7.07e-02	1.00e+00	3.774	1	4	51
GO:0006368	transcription elongation from RNA polymerase II promoter	7.21e-02	1.00e+00	3.746	1	3	52
GO:0006302	double-strand break repair	7.21e-02	1.00e+00	3.746	1	8	52
GO:0006766	vitamin metabolic process	7.34e-02	1.00e+00	3.718	1	2	53
GO:0006338	chromatin remodeling	7.61e-02	1.00e+00	3.665	1	2	55
GO:0003697	single-stranded DNA binding	7.87e-02	1.00e+00	3.613	1	6	57
GO:0042802	identical protein binding	8.95e-02	1.00e+00	1.978	2	7	354
GO:0005200	structural constituent of cytoskeleton	9.33e-02	1.00e+00	3.359	1	2	68
GO:0051082	unfolded protein binding	9.59e-02	1.00e+00	3.317	1	4	70
GO:0001649	osteoblast differentiation	1.01e-01	1.00e+00	3.237	1	2	74
GO:0015630	microtubule cytoskeleton	1.02e-01	1.00e+00	3.217	1	2	75
GO:0005815	microtubule organizing center	1.05e-01	1.00e+00	3.179	1	1	77
GO:0016605	PML body	1.08e-01	1.00e+00	3.142	1	4	79
GO:0006260	DNA replication	1.27e-01	1.00e+00	2.891	1	11	94
GO:0000086	G2/M transition of mitotic cell cycle	1.31e-01	1.00e+00	2.846	1	5	97
GO:0006457	protein folding	1.31e-01	1.00e+00	2.846	1	4	97
GO:0000790	nuclear chromatin	1.46e-01	1.00e+00	2.678	1	3	109
GO:0006397	mRNA processing	1.47e-01	1.00e+00	2.665	1	2	110
GO:0016607	nuclear speck	1.61e-01	1.00e+00	2.515	1	3	122
GO:0015629	actin cytoskeleton	1.78e-01	1.00e+00	2.359	1	2	136
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.86e-01	1.00e+00	2.296	1	2	142
GO:0005622	intracellular	1.89e-01	1.00e+00	2.266	1	1	145
GO:0001701	in utero embryonic development	2.00e-01	1.00e+00	2.179	1	3	154
GO:0006367	transcription initiation from RNA polymerase II promoter	2.08e-01	1.00e+00	2.115	1	4	161
GO:0007067	mitotic nuclear division	2.12e-01	1.00e+00	2.080	1	8	165
GO:0007283	spermatogenesis	2.16e-01	1.00e+00	2.054	1	2	168
GO:0000166	nucleotide binding	2.25e-01	1.00e+00	1.987	1	6	176
GO:0005739	mitochondrion	2.43e-01	1.00e+00	1.082	2	11	659
GO:0006357	regulation of transcription from RNA polymerase II promoter	2.55e-01	1.00e+00	1.781	1	1	203
GO:0043234	protein complex	2.63e-01	1.00e+00	1.732	1	8	210
GO:0043231	intracellular membrane-bounded organelle	2.71e-01	1.00e+00	1.678	1	7	218
GO:0006200	ATP catabolic process	2.72e-01	1.00e+00	1.671	1	8	219
GO:0003682	chromatin binding	3.07e-01	1.00e+00	1.469	1	6	252
GO:0044822	poly(A) RNA binding	3.20e-01	1.00e+00	0.804	2	25	799
GO:0008284	positive regulation of cell proliferation	3.34e-01	1.00e+00	1.322	1	2	279
GO:0055114	oxidation-reduction process	3.62e-01	1.00e+00	1.179	1	3	308
GO:0006366	transcription from RNA polymerase II promoter	3.92e-01	1.00e+00	1.032	1	6	341
GO:0046872	metal ion binding	3.93e-01	1.00e+00	0.579	2	10	934
GO:0005794	Golgi apparatus	4.56e-01	1.00e+00	0.749	1	5	415
GO:0006351	transcription, DNA-templated	4.67e-01	1.00e+00	0.375	2	9	1076
GO:0045087	innate immune response	4.85e-01	1.00e+00	0.626	1	7	452
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	6.15e-01	1.00e+00	0.115	1	8	644
GO:0006355	regulation of transcription, DNA-templated	6.55e-01	1.00e+00	-0.036	1	7	715
GO:0003677	DNA binding	7.60e-01	1.00e+00	-0.441	1	18	947

Wolf-ratios-Mammosphere-Adherent

reg-snw-4522

Statistics

Genes (14)

Interactions (22)

Related GO terms (195)