meta-int-snw-51477

Interacting subnets

Subnetwork	Dataset	Score	p-value 1	p-value 2	p-value 3	Size	Highlighted genes
reg-snw-5887	wolf-screen-ratio-mammosphere-adherent	0.858	2.95e-07	1.57e-03	3.19e-03	5	5
int-snw-51477	wolf-screen-ratio-mammosphere-adherent	0.934	1.79e-15	2.53e-03	4.07e-02	9	8
reg-snw-5905	wolf-screen-ratio-mammosphere-adherent	0.816	1.47e-06	3.71e-03	6.88e-03	6	6

wolf-screen-ratio-mammosphere-adherent-meta-int-snw-51477 subnetwork

Genes (13)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
ACO2	50	65	1.000	1.076	191	Yes	-
EIF2S2	8894	39	1.075	0.940	103	Yes	-
EEF2	1938	64	0.890	1.043	301	Yes	-
PSMD3	5709	100	0.986	1.106	201	Yes	-
PSMC3	5702	51	0.719	1.002	276	Yes	-
CLTC	1213	56	0.884	1.138	247	Yes	-
RAD23B	5887	7	0.158	0.858	11	Yes	-
TUBG1	7283	98	0.974	0.973	91	Yes	-
RANGAP1	5905	11	-0.046	0.816	74	Yes	-
PSMD11	5717	124	1.095	1.106	218	Yes	-
ACTB	60	134	1.153	1.151	610	Yes	-
ISYNA1	51477	3	-0.120	0.934	48	-	-
PGD	5226	89	1.201	1.106	152	Yes	-

Interactions (29)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
EEF2	1938	PGD	5226	pp	--	int.I2D: BioGrid_Yeast
EEF2	1938	PSMC3	5702	pp	--	int.I2D: YeastLow, BioGrid_Yeast
EEF2	1938	ISYNA1	51477	pp	--	int.I2D: BioGrid_Yeast, MINT_Yeast, Tarassov_PCA, IntAct_Yeast
PSMD11	5717	RAD23B	5887	pp	--	int.I2D: YeastLow, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast
ACTB	60	CLTC	1213	pp	--	int.I2D: IntAct_Yeast
PSMD3	5709	RAD23B	5887	pd	>	reg.ITFP.txt: no annot
PSMD3	5709	RAD23B	5887	pp	--	int.I2D: YeastLow, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast
ACO2	50	PSMD11	5717	pp	--	int.I2D: YeastLow
ACTB	60	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast
PSMC3	5702	PSMD3	5709	pd	<	reg.ITFP.txt: no annot
PSMC3	5702	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, Krogan_NonCore, YeastHigh
PSMD3	5709	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
ACTB	60	EEF2	1938	pp	--	int.I2D: YeastLow, IntAct_Yeast
CLTC	1213	EIF2S2	8894	pp	--	int.I2D: YeastLow
EEF2	1938	RAD23B	5887	pp	--	int.I2D: Krogan_NonCore
EEF2	1938	PSMD3	5709	pp	--	int.I2D: Krogan_NonCore
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
ACO2	50	RANGAP1	5905	pp	--	int.I2D: YeastLow
PSMD3	5709	TUBG1	7283	pd	>	reg.ITFP.txt: no annot
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
PGD	5226	PSMD3	5709	pp	--	int.I2D: YeastLow
PSMD3	5709	RANGAP1	5905	pd	>	reg.ITFP.txt: no annot
ACO2	50	ISYNA1	51477	pp	--	int.I2D: BioGrid_Yeast
PSMD11	5717	TUBG1	7283	pd	>	reg.ITFP.txt: no annot
ACTB	60	PSMC3	5702	pp	--	int.I2D: BioGrid_Yeast
PSMC3	5702	PSMD11	5717	pd	<	reg.ITFP.txt: no annot
PSMC3	5702	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh
ACTB	60	RAD23B	5887	pp	--	int.I2D: IntAct_Rat
PSMC3	5702	RAD23B	5887	pp	--	int.I2D: BioGrid_Yeast, IntAct_Rat, Krogan_Core, MINT_Yeast
ACO2	50	PGD	5226	pp	--	int.I2D: YeastLow
CLTC	1213	ISYNA1	51477	pp	--	int.I2D: BioGrid_Yeast, MINT_Yeast, Tarassov_PCA, IntAct_Yeast
PSMD11	5717	EIF2S2	8894	pd	>	reg.ITFP.txt: no annot

Related GO terms (181)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005829	cytosol	8.02e-08	1.31e-03	2.430	11	125	2562
GO:0000502	proteasome complex	1.00e-07	1.64e-03	6.436	4	22	58
GO:0022624	proteasome accessory complex	2.67e-07	4.35e-03	7.792	3	9	17
GO:0006521	regulation of cellular amino acid metabolic process	7.57e-06	1.24e-01	6.235	3	21	50
GO:0000278	mitotic cell cycle	9.21e-06	1.50e-01	3.979	5	52	398
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.68e-05	2.74e-01	5.857	3	24	65
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	1.68e-05	2.74e-01	5.857	3	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.10e-05	3.42e-01	5.750	3	24	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	2.38e-05	3.88e-01	5.689	3	23	73
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.48e-05	4.04e-01	5.670	3	24	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	2.79e-05	4.56e-01	5.612	3	23	77
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	3.01e-05	4.92e-01	5.575	3	25	79
GO:0005838	proteasome regulatory particle	3.85e-05	6.28e-01	7.709	2	7	12
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	5.07e-05	8.28e-01	5.324	3	23	94
GO:0000209	protein polyubiquitination	9.50e-05	1.00e+00	5.021	3	21	116
GO:0010467	gene expression	1.12e-04	1.00e+00	3.230	5	58	669
GO:0000082	G1/S transition of mitotic cell cycle	2.03e-04	1.00e+00	4.650	3	33	150
GO:0042981	regulation of apoptotic process	2.07e-04	1.00e+00	4.641	3	26	151
GO:0044281	small molecule metabolic process	2.60e-04	1.00e+00	2.540	6	57	1295
GO:0034641	cellular nitrogen compound metabolic process	3.31e-04	1.00e+00	4.411	3	25	177
GO:0016071	mRNA metabolic process	6.50e-04	1.00e+00	4.078	3	34	223
GO:0004512	inositol-3-phosphate synthase activity	7.97e-04	1.00e+00	10.294	1	1	1
GO:0019521	D-gluconate metabolic process	7.97e-04	1.00e+00	10.294	1	1	1
GO:0005098	Ran GTPase activator activity	7.97e-04	1.00e+00	10.294	1	1	1
GO:0016070	RNA metabolic process	8.75e-04	1.00e+00	3.931	3	34	247
GO:0005654	nucleoplasm	1.10e-03	1.00e+00	2.519	5	83	1095
GO:0016020	membrane	1.31e-03	1.00e+00	2.109	6	80	1746
GO:0051538	3 iron, 4 sulfur cluster binding	1.59e-03	1.00e+00	9.294	1	1	2
GO:0002176	male germ cell proliferation	1.59e-03	1.00e+00	9.294	1	1	2
GO:0019322	pentose biosynthetic process	1.59e-03	1.00e+00	9.294	1	1	2
GO:0003994	aconitate hydratase activity	1.59e-03	1.00e+00	9.294	1	1	2
GO:0000715	nucleotide-excision repair, DNA damage recognition	1.59e-03	1.00e+00	9.294	1	1	2
GO:0019901	protein kinase binding	1.85e-03	1.00e+00	3.557	3	21	320
GO:0005850	eukaryotic translation initiation factor 2 complex	2.39e-03	1.00e+00	8.709	1	1	3
GO:1900126	negative regulation of hyaluronan biosynthetic process	2.39e-03	1.00e+00	8.709	1	1	3
GO:0006021	inositol biosynthetic process	2.39e-03	1.00e+00	8.709	1	1	3
GO:0009051	pentose-phosphate shunt, oxidative branch	2.39e-03	1.00e+00	8.709	1	1	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	2.39e-03	1.00e+00	8.709	1	1	3
GO:0071439	clathrin complex	2.39e-03	1.00e+00	8.709	1	1	3
GO:0071942	XPC complex	2.39e-03	1.00e+00	8.709	1	1	3
GO:0005200	structural constituent of cytoskeleton	2.41e-03	1.00e+00	4.755	2	7	93
GO:0000212	meiotic spindle organization	3.18e-03	1.00e+00	8.294	1	1	4
GO:0032051	clathrin light chain binding	3.18e-03	1.00e+00	8.294	1	1	4
GO:1903077	negative regulation of protein localization to plasma membrane	3.18e-03	1.00e+00	8.294	1	1	4
GO:0030529	ribonucleoprotein complex	3.59e-03	1.00e+00	4.461	2	8	114
GO:0043248	proteasome assembly	3.98e-03	1.00e+00	7.972	1	1	5
GO:0006102	isocitrate metabolic process	3.98e-03	1.00e+00	7.972	1	1	5
GO:0005827	polar microtubule	3.98e-03	1.00e+00	7.972	1	1	5
GO:0043066	negative regulation of apoptotic process	4.35e-03	1.00e+00	3.121	3	30	433
GO:0030130	clathrin coat of trans-Golgi network vesicle	4.77e-03	1.00e+00	7.709	1	1	6
GO:0030957	Tat protein binding	4.77e-03	1.00e+00	7.709	1	4	6
GO:0006101	citrate metabolic process	4.77e-03	1.00e+00	7.709	1	1	6
GO:0030118	clathrin coat	4.77e-03	1.00e+00	7.709	1	1	6
GO:0032853	positive regulation of Ran GTPase activity	4.77e-03	1.00e+00	7.709	1	1	6
GO:0030132	clathrin coat of coated pit	5.56e-03	1.00e+00	7.487	1	1	7
GO:0000930	gamma-tubulin complex	5.56e-03	1.00e+00	7.487	1	1	7
GO:0046826	negative regulation of protein export from nucleus	5.56e-03	1.00e+00	7.487	1	1	7
GO:0061024	membrane organization	5.81e-03	1.00e+00	4.104	2	5	146
GO:0044267	cellular protein metabolic process	6.32e-03	1.00e+00	2.928	3	24	495
GO:0070688	MLL5-L complex	6.36e-03	1.00e+00	7.294	1	1	8
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	7.15e-03	1.00e+00	7.124	1	1	9
GO:0008494	translation activator activity	7.15e-03	1.00e+00	7.124	1	1	9
GO:0016032	viral process	8.04e-03	1.00e+00	2.802	3	55	540
GO:0070062	extracellular vesicular exosome	8.60e-03	1.00e+00	1.582	6	98	2516
GO:0006098	pentose-phosphate shunt	8.73e-03	1.00e+00	6.835	1	3	11
GO:0006915	apoptotic process	9.37e-03	1.00e+00	2.722	3	34	571
GO:0030234	enzyme regulator activity	1.03e-02	1.00e+00	6.594	1	3	13
GO:0003924	GTPase activity	1.10e-02	1.00e+00	3.629	2	9	203
GO:0035267	NuA4 histone acetyltransferase complex	1.11e-02	1.00e+00	6.487	1	4	14
GO:0007020	microtubule nucleation	1.11e-02	1.00e+00	6.487	1	1	14
GO:0008654	phospholipid biosynthetic process	1.19e-02	1.00e+00	6.387	1	1	15
GO:0050998	nitric-oxide synthase binding	1.27e-02	1.00e+00	6.294	1	1	16
GO:0042176	regulation of protein catabolic process	1.27e-02	1.00e+00	6.294	1	3	16
GO:0006184	GTP catabolic process	1.28e-02	1.00e+00	3.513	2	9	220
GO:0003746	translation elongation factor activity	1.35e-02	1.00e+00	6.207	1	3	17
GO:0031122	cytoplasmic microtubule organization	1.42e-02	1.00e+00	6.124	1	2	18
GO:0006412	translation	1.45e-02	1.00e+00	3.417	2	15	235
GO:1903506	regulation of nucleic acid-templated transcription	1.50e-02	1.00e+00	6.046	1	1	19
GO:0048863	stem cell differentiation	1.50e-02	1.00e+00	6.046	1	1	19
GO:0000718	nucleotide-excision repair, DNA damage removal	1.66e-02	1.00e+00	5.902	1	5	21
GO:0030863	cortical cytoskeleton	1.74e-02	1.00e+00	5.835	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.74e-02	1.00e+00	5.835	1	4	22
GO:0031593	polyubiquitin binding	1.82e-02	1.00e+00	5.770	1	1	23
GO:0043044	ATP-dependent chromatin remodeling	1.82e-02	1.00e+00	5.770	1	4	23
GO:0008135	translation factor activity, nucleic acid binding	1.90e-02	1.00e+00	5.709	1	4	24
GO:0000794	condensed nuclear chromosome	1.90e-02	1.00e+00	5.709	1	2	24
GO:0005844	polysome	1.97e-02	1.00e+00	5.650	1	4	25
GO:0005515	protein binding	2.06e-02	1.00e+00	0.883	9	172	6127
GO:0031492	nucleosomal DNA binding	2.21e-02	1.00e+00	5.487	1	4	28
GO:0019894	kinesin binding	2.21e-02	1.00e+00	5.487	1	1	28
GO:0006099	tricarboxylic acid cycle	2.29e-02	1.00e+00	5.436	1	3	29
GO:0030669	clathrin-coated endocytic vesicle membrane	2.29e-02	1.00e+00	5.436	1	1	29
GO:0043234	protein complex	2.30e-02	1.00e+00	3.065	2	17	300
GO:0031623	receptor internalization	2.44e-02	1.00e+00	5.340	1	1	31
GO:0033572	transferrin transport	2.52e-02	1.00e+00	5.294	1	6	32
GO:0050661	NADP binding	2.52e-02	1.00e+00	5.294	1	1	32
GO:1903507	negative regulation of nucleic acid-templated transcription	2.52e-02	1.00e+00	5.294	1	2	32
GO:0005525	GTP binding	2.71e-02	1.00e+00	2.936	2	11	328
GO:0032588	trans-Golgi network membrane	2.83e-02	1.00e+00	5.124	1	1	36
GO:0034332	adherens junction organization	2.83e-02	1.00e+00	5.124	1	1	36
GO:0001895	retina homeostasis	2.83e-02	1.00e+00	5.124	1	1	36
GO:0051084	'de novo' posttranslational protein folding	2.91e-02	1.00e+00	5.085	1	4	37
GO:0051539	4 iron, 4 sulfur cluster binding	2.91e-02	1.00e+00	5.085	1	3	37
GO:0070527	platelet aggregation	2.99e-02	1.00e+00	5.046	1	2	38
GO:0043647	inositol phosphate metabolic process	3.30e-02	1.00e+00	4.902	1	1	42
GO:0005925	focal adhesion	3.39e-02	1.00e+00	2.763	2	18	370
GO:0006892	post-Golgi vesicle-mediated transport	3.45e-02	1.00e+00	4.835	1	2	44
GO:0021762	substantia nigra development	3.60e-02	1.00e+00	4.770	1	1	46
GO:0030136	clathrin-coated vesicle	3.60e-02	1.00e+00	4.770	1	1	46
GO:0045727	positive regulation of translation	3.60e-02	1.00e+00	4.770	1	4	46
GO:0003743	translation initiation factor activity	3.83e-02	1.00e+00	4.679	1	4	49
GO:0006091	generation of precursor metabolites and energy	3.99e-02	1.00e+00	4.622	1	3	51
GO:0003684	damaged DNA binding	3.99e-02	1.00e+00	4.622	1	11	51
GO:0003725	double-stranded RNA binding	4.22e-02	1.00e+00	4.539	1	6	54
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	4.22e-02	1.00e+00	4.539	1	5	54
GO:0000226	microtubule cytoskeleton organization	4.29e-02	1.00e+00	4.513	1	3	55
GO:0000932	cytoplasmic mRNA processing body	4.37e-02	1.00e+00	4.487	1	3	56
GO:0002244	hematopoietic progenitor cell differentiation	4.52e-02	1.00e+00	4.436	1	1	58
GO:0045216	cell-cell junction organization	4.60e-02	1.00e+00	4.411	1	2	59
GO:0005643	nuclear pore	4.60e-02	1.00e+00	4.411	1	4	59
GO:0000776	kinetochore	4.91e-02	1.00e+00	4.317	1	4	63
GO:0044822	poly(A) RNA binding	4.99e-02	1.00e+00	1.805	3	50	1078
GO:0000777	condensed chromosome kinetochore	5.28e-02	1.00e+00	4.207	1	2	68
GO:0006289	nucleotide-excision repair	5.36e-02	1.00e+00	4.185	1	12	69
GO:0003697	single-stranded DNA binding	5.36e-02	1.00e+00	4.185	1	9	69
GO:0034329	cell junction assembly	5.51e-02	1.00e+00	4.144	1	1	71
GO:0005634	nucleus	5.81e-02	1.00e+00	0.864	7	131	4828
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.89e-02	1.00e+00	4.046	1	3	76
GO:0008584	male gonad development	5.96e-02	1.00e+00	4.027	1	2	77
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.96e-02	1.00e+00	4.027	1	5	77
GO:0006898	receptor-mediated endocytosis	6.64e-02	1.00e+00	3.868	1	2	86
GO:0000922	spindle pole	7.01e-02	1.00e+00	3.786	1	4	91
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	7.09e-02	1.00e+00	3.770	1	4	92
GO:0042470	melanosome	7.09e-02	1.00e+00	3.770	1	10	92
GO:0006928	cellular component movement	7.09e-02	1.00e+00	3.770	1	7	92
GO:0006414	translational elongation	7.16e-02	1.00e+00	3.755	1	11	93
GO:0001649	osteoblast differentiation	7.31e-02	1.00e+00	3.724	1	6	95
GO:0014069	postsynaptic density	8.12e-02	1.00e+00	3.566	1	1	106
GO:0005819	spindle	8.71e-02	1.00e+00	3.461	1	7	114
GO:0072562	blood microparticle	8.86e-02	1.00e+00	3.436	1	4	116
GO:0044237	cellular metabolic process	9.00e-02	1.00e+00	3.411	1	3	118
GO:0006325	chromatin organization	9.37e-02	1.00e+00	3.351	1	4	123
GO:0005506	iron ion binding	9.66e-02	1.00e+00	3.305	1	3	127
GO:0006511	ubiquitin-dependent protein catabolic process	9.66e-02	1.00e+00	3.305	1	5	127
GO:0006413	translational initiation	9.95e-02	1.00e+00	3.261	1	12	131
GO:0000790	nuclear chromatin	1.01e-01	1.00e+00	3.239	1	7	133
GO:0031982	vesicle	1.02e-01	1.00e+00	3.228	1	10	134
GO:0000086	G2/M transition of mitotic cell cycle	1.04e-01	1.00e+00	3.196	1	7	137
GO:0016887	ATPase activity	1.09e-01	1.00e+00	3.124	1	7	144
GO:0010628	positive regulation of gene expression	1.12e-01	1.00e+00	3.075	1	4	149
GO:0006457	protein folding	1.12e-01	1.00e+00	3.075	1	8	149
GO:0005198	structural molecule activity	1.20e-01	1.00e+00	2.981	1	4	159
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.26e-01	1.00e+00	2.902	1	5	168
GO:0030424	axon	1.29e-01	1.00e+00	2.868	1	3	172
GO:0006886	intracellular protein transport	1.29e-01	1.00e+00	2.859	1	4	173
GO:0031965	nuclear membrane	1.32e-01	1.00e+00	2.835	1	4	176
GO:0003714	transcription corepressor activity	1.34e-01	1.00e+00	2.810	1	7	179
GO:0001701	in utero embryonic development	1.55e-01	1.00e+00	2.580	1	6	210
GO:0007067	mitotic nuclear division	1.69e-01	1.00e+00	2.442	1	13	231
GO:0005759	mitochondrial matrix	1.71e-01	1.00e+00	2.430	1	12	233
GO:0003713	transcription coactivator activity	1.75e-01	1.00e+00	2.393	1	10	239
GO:0005737	cytoplasm	1.90e-01	1.00e+00	0.659	5	98	3976
GO:0006281	DNA repair	1.91e-01	1.00e+00	2.250	1	22	264
GO:0005975	carbohydrate metabolic process	1.98e-01	1.00e+00	2.196	1	5	274
GO:0007283	spermatogenesis	1.99e-01	1.00e+00	2.185	1	6	276
GO:0006200	ATP catabolic process	2.16e-01	1.00e+00	2.051	1	14	303
GO:0005856	cytoskeleton	2.21e-01	1.00e+00	2.013	1	8	311
GO:0007411	axon guidance	2.31e-01	1.00e+00	1.941	1	9	327
GO:0005813	centrosome	2.39e-01	1.00e+00	1.889	1	12	339
GO:0003723	RNA binding	2.49e-01	1.00e+00	1.822	1	19	355
GO:0005524	ATP binding	2.94e-01	1.00e+00	0.891	2	46	1354
GO:0007596	blood coagulation	3.13e-01	1.00e+00	1.436	1	14	464
GO:0055114	oxidation-reduction process	3.22e-01	1.00e+00	1.384	1	11	481
GO:0048471	perinuclear region of cytoplasm	3.45e-01	1.00e+00	1.263	1	12	523
GO:0005730	nucleolus	3.94e-01	1.00e+00	0.576	2	70	1684
GO:0045087	innate immune response	3.94e-01	1.00e+00	1.027	1	20	616
GO:0007165	signal transduction	5.42e-01	1.00e+00	0.402	1	17	950
GO:0005615	extracellular space	5.64e-01	1.00e+00	0.314	1	17	1010
GO:0005739	mitochondrion	5.77e-01	1.00e+00	0.263	1	24	1046
GO:0046872	metal ion binding	7.06e-01	1.00e+00	-0.223	1	24	1465
GO:0005886	plasma membrane	9.16e-01	1.00e+00	-1.175	1	38	2834

Wolf-ratios-Mammosphere-Adherent

meta-int-snw-51477

Interacting subnets

Genes (13)

Interactions (29)

Related GO terms (181)