Subnetwork | Dataset | Score | p-value 1 | p-value 2 | p-value 3 | Size | Highlighted genes |
---|---|---|---|---|---|---|---|
reg-snw-56655 | wolf-screen-ratio-mammosphere-adherent | 0.828 | 9.29e-07 | 2.91e-03 | 5.53e-03 | 8 | 7 |
int-snw-5122 | wolf-screen-ratio-mammosphere-adherent | 0.940 | 1.02e-15 | 2.20e-03 | 3.69e-02 | 11 | 9 |
Gene Symbol | Entrez Gene ID | Frequency | wolf-screen-ratio-mammosphere-adherent gene score | Best subnetwork score | Degree | wolf adherent-list Hits GI | wolf mammosphere no adherent-list Hits GI |
---|---|---|---|---|---|---|---|
RPA2 | 6118 | 96 | 1.250 | 1.151 | 76 | Yes | - |
PSMD1 | 5707 | 86 | 0.836 | 0.830 | 118 | Yes | - |
PSMA2 | 5683 | 112 | 1.093 | 1.106 | 108 | Yes | - |
RBX1 | 9978 | 115 | 1.185 | 0.934 | 148 | Yes | - |
PCSK1 | 5122 | 2 | -0.050 | 0.940 | 52 | - | - |
CLTC | 1213 | 56 | 0.884 | 1.138 | 247 | Yes | - |
PSMB7 | 5695 | 118 | 0.982 | 0.934 | 90 | Yes | - |
PSMB2 | 5690 | 116 | 0.877 | 0.956 | 169 | Yes | - |
PSMD11 | 5717 | 124 | 1.095 | 1.106 | 218 | Yes | - |
VARS | 7407 | 86 | 0.549 | 1.002 | 204 | Yes | - |
ACTB | 60 | 134 | 1.153 | 1.151 | 610 | Yes | - |
ATP6V1B2 | 526 | 53 | 0.881 | 1.076 | 278 | - | - |
POLE4 | 56655 | 63 | 0.177 | 0.828 | 56 | - | - |
RPSA | 3921 | 120 | 1.327 | 1.151 | 152 | Yes | - |
POLR2B | 5431 | 12 | 0.587 | 0.940 | 146 | Yes | - |
PSMB3 | 5691 | 64 | 0.668 | 0.901 | 19 | Yes | - |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
ACTB | 60 | CLTC | 1213 | pp | -- | int.I2D: IntAct_Yeast |
PSMA2 | 5683 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast |
PSMB2 | 5690 | POLE4 | 56655 | pd | < | reg.ITFP.txt: no annot |
PSMA2 | 5683 | PSMD1 | 5707 | pp | -- | int.I2D: BioGrid_Yeast |
PSMA2 | 5683 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
RPSA | 3921 | PSMD11 | 5717 | pp | -- | int.I2D: IntAct_Yeast |
ATP6V1B2 | 526 | PCSK1 | 5122 | pp | -- | int.I2D: IntAct_Yeast |
CLTC | 1213 | PCSK1 | 5122 | pp | -- | int.I2D: IntAct_Yeast |
ACTB | 60 | PSMB2 | 5690 | pp | -- | int.I2D: BioGrid_Yeast |
RPSA | 3921 | VARS | 7407 | pp | -- | int.I2D: IntAct_Yeast |
PSMD1 | 5707 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast |
ATP6V1B2 | 526 | CLTC | 1213 | pp | -- | int.I2D: IntAct_Yeast |
ACTB | 60 | RBX1 | 9978 | pp | -- | int.I2D: BioGrid_Yeast |
ACTB | 60 | RPSA | 3921 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct |
PSMB7 | 5695 | RBX1 | 9978 | pd | < | reg.ITFP.txt: no annot |
VARS | 7407 | POLE4 | 56655 | pd | <> | reg.ITFP.txt: no annot |
PSMA2 | 5683 | PSMB3 | 5691 | pp | -- | int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Fly, IntAct_Yeast, INTEROLOG, Krogan_Core, MINT_Yeast, YeastHigh, Yu_GoldStd |
PSMB7 | 5695 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
PSMA2 | 5683 | POLE4 | 56655 | pd | < | reg.ITFP.txt: no annot |
ACTB | 60 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB7 | 5695 | POLE4 | 56655 | pd | < | reg.ITFP.txt: no annot |
PSMB2 | 5690 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct |
ATP6V1B2 | 526 | POLR2B | 5431 | pp | -- | int.I2D: IntAct_Yeast |
PSMB3 | 5691 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: BCI, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Yeast, YeastHigh, HPRD, Krogan_Core, MINT_Yeast, MIPS; int.HPRD: yeast 2-hybrid |
PCSK1 | 5122 | POLR2B | 5431 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB7 | 5695 | PSMD1 | 5707 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, IntAct |
ACTB | 60 | PSMB7 | 5695 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB2 | 5690 | PSMB3 | 5691 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct, INTEROLOG, MINT, Yu_GoldStd, BCI, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid |
ACTB | 60 | RPA2 | 6118 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct |
ACTB | 60 | PCSK1 | 5122 | pp | -- | int.I2D: BioGrid_Yeast |
ATP6V1B2 | 526 | RPSA | 3921 | pp | -- | int.I2D: IntAct_Yeast |
PSMB3 | 5691 | POLE4 | 56655 | pd | < | reg.ITFP.txt: no annot |
PSMB2 | 5690 | PSMD11 | 5717 | pd | < | reg.ITFP.txt: no annot |
PSMB2 | 5690 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
PSMB2 | 5690 | VARS | 7407 | pd | < | reg.ITFP.txt: no annot |
PSMB3 | 5691 | PSMD11 | 5717 | pp | -- | int.I2D: YeastLow |
ACTB | 60 | ATP6V1B2 | 526 | pp | -- | int.I2D: BioGrid_Yeast |
PCSK1 | 5122 | PSMD1 | 5707 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB2 | 5690 | PSMD1 | 5707 | pp | -- | int.I2D: BioGrid_Yeast |
PSMA2 | 5683 | PSMB2 | 5690 | pp | -- | int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0006521 | regulation of cellular amino acid metabolic process | 4.74e-12 | 7.74e-08 | 6.936 | 6 | 21 | 50 |
GO:0000502 | proteasome complex | 1.20e-11 | 1.96e-07 | 6.721 | 6 | 22 | 58 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 2.44e-11 | 3.99e-07 | 6.557 | 6 | 24 | 65 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 2.44e-11 | 3.99e-07 | 6.557 | 6 | 22 | 65 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 3.87e-11 | 6.32e-07 | 6.450 | 6 | 24 | 70 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 5.02e-11 | 8.19e-07 | 6.390 | 6 | 23 | 73 |
GO:0000082 | G1/S transition of mitotic cell cycle | 5.14e-11 | 8.38e-07 | 5.573 | 7 | 33 | 150 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.46e-11 | 8.91e-07 | 6.370 | 6 | 24 | 74 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 6.97e-11 | 1.14e-06 | 6.313 | 6 | 23 | 77 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 8.17e-11 | 1.33e-06 | 6.276 | 6 | 25 | 79 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 2.37e-10 | 3.87e-06 | 6.025 | 6 | 23 | 94 |
GO:0016032 | viral process | 4.14e-10 | 6.75e-06 | 4.088 | 9 | 55 | 540 |
GO:0016071 | mRNA metabolic process | 8.34e-10 | 1.36e-05 | 5.001 | 7 | 34 | 223 |
GO:0000209 | protein polyubiquitination | 8.55e-10 | 1.40e-05 | 5.721 | 6 | 21 | 116 |
GO:0016070 | RNA metabolic process | 1.70e-09 | 2.78e-05 | 4.853 | 7 | 34 | 247 |
GO:0005839 | proteasome core complex | 1.87e-09 | 3.05e-05 | 7.825 | 4 | 11 | 18 |
GO:0010467 | gene expression | 2.74e-09 | 4.47e-05 | 3.779 | 9 | 58 | 669 |
GO:0004298 | threonine-type endopeptidase activity | 2.96e-09 | 4.82e-05 | 7.673 | 4 | 11 | 20 |
GO:0042981 | regulation of apoptotic process | 4.21e-09 | 6.87e-05 | 5.341 | 6 | 26 | 151 |
GO:0005654 | nucleoplasm | 9.80e-09 | 1.60e-04 | 3.220 | 10 | 83 | 1095 |
GO:0034641 | cellular nitrogen compound metabolic process | 1.09e-08 | 1.79e-04 | 5.112 | 6 | 25 | 177 |
GO:0000278 | mitotic cell cycle | 4.60e-08 | 7.51e-04 | 4.165 | 7 | 52 | 398 |
GO:0005829 | cytosol | 2.14e-07 | 3.49e-03 | 2.256 | 12 | 125 | 2562 |
GO:0043066 | negative regulation of apoptotic process | 2.15e-06 | 3.51e-02 | 3.821 | 6 | 30 | 433 |
GO:0006915 | apoptotic process | 1.06e-05 | 1.73e-01 | 3.422 | 6 | 34 | 571 |
GO:0070062 | extracellular vesicular exosome | 2.43e-05 | 3.97e-01 | 2.019 | 10 | 98 | 2516 |
GO:0005838 | proteasome regulatory particle | 5.91e-05 | 9.65e-01 | 7.409 | 2 | 7 | 12 |
GO:0022624 | proteasome accessory complex | 1.21e-04 | 1.00e+00 | 6.907 | 2 | 9 | 17 |
GO:0033572 | transferrin transport | 4.39e-04 | 1.00e+00 | 5.994 | 2 | 6 | 32 |
GO:0016020 | membrane | 7.56e-04 | 1.00e+00 | 2.032 | 7 | 80 | 1746 |
GO:0006283 | transcription-coupled nucleotide-excision repair | 9.09e-04 | 1.00e+00 | 5.471 | 2 | 8 | 46 |
GO:0044281 | small molecule metabolic process | 9.85e-04 | 1.00e+00 | 2.241 | 6 | 57 | 1295 |
GO:0004832 | valine-tRNA ligase activity | 1.96e-03 | 1.00e+00 | 8.994 | 1 | 1 | 2 |
GO:0000461 | endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 1.96e-03 | 1.00e+00 | 8.994 | 1 | 1 | 2 |
GO:0005055 | laminin receptor activity | 1.96e-03 | 1.00e+00 | 8.994 | 1 | 1 | 2 |
GO:0006407 | rRNA export from nucleus | 1.96e-03 | 1.00e+00 | 8.994 | 1 | 1 | 2 |
GO:0006438 | valyl-tRNA aminoacylation | 1.96e-03 | 1.00e+00 | 8.994 | 1 | 1 | 2 |
GO:0006281 | DNA repair | 2.00e-03 | 1.00e+00 | 3.535 | 3 | 22 | 264 |
GO:0006289 | nucleotide-excision repair | 2.03e-03 | 1.00e+00 | 4.886 | 2 | 12 | 69 |
GO:0005515 | protein binding | 2.62e-03 | 1.00e+00 | 0.998 | 12 | 172 | 6127 |
GO:1900126 | negative regulation of hyaluronan biosynthetic process | 2.94e-03 | 1.00e+00 | 8.409 | 1 | 1 | 3 |
GO:0071439 | clathrin complex | 2.94e-03 | 1.00e+00 | 8.409 | 1 | 1 | 3 |
GO:0042470 | melanosome | 3.58e-03 | 1.00e+00 | 4.471 | 2 | 10 | 92 |
GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 3.92e-03 | 1.00e+00 | 7.994 | 1 | 1 | 4 |
GO:0030686 | 90S preribosome | 3.92e-03 | 1.00e+00 | 7.994 | 1 | 1 | 4 |
GO:0032051 | clathrin light chain binding | 3.92e-03 | 1.00e+00 | 7.994 | 1 | 1 | 4 |
GO:0031467 | Cul7-RING ubiquitin ligase complex | 3.92e-03 | 1.00e+00 | 7.994 | 1 | 1 | 4 |
GO:0019788 | NEDD8 ligase activity | 3.92e-03 | 1.00e+00 | 7.994 | 1 | 1 | 4 |
GO:1903077 | negative regulation of protein localization to plasma membrane | 3.92e-03 | 1.00e+00 | 7.994 | 1 | 1 | 4 |
GO:0032549 | ribonucleoside binding | 3.92e-03 | 1.00e+00 | 7.994 | 1 | 2 | 4 |
GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex | 4.89e-03 | 1.00e+00 | 7.673 | 1 | 2 | 5 |
GO:0031461 | cullin-RING ubiquitin ligase complex | 4.89e-03 | 1.00e+00 | 7.673 | 1 | 1 | 5 |
GO:0043248 | proteasome assembly | 4.89e-03 | 1.00e+00 | 7.673 | 1 | 1 | 5 |
GO:0030891 | VCB complex | 4.89e-03 | 1.00e+00 | 7.673 | 1 | 2 | 5 |
GO:0043043 | peptide biosynthetic process | 4.89e-03 | 1.00e+00 | 7.673 | 1 | 1 | 5 |
GO:0000730 | DNA recombinase assembly | 4.89e-03 | 1.00e+00 | 7.673 | 1 | 3 | 5 |
GO:2000001 | regulation of DNA damage checkpoint | 4.89e-03 | 1.00e+00 | 7.673 | 1 | 1 | 5 |
GO:0008622 | epsilon DNA polymerase complex | 4.89e-03 | 1.00e+00 | 7.673 | 1 | 1 | 5 |
GO:0030130 | clathrin coat of trans-Golgi network vesicle | 5.87e-03 | 1.00e+00 | 7.409 | 1 | 1 | 6 |
GO:0030957 | Tat protein binding | 5.87e-03 | 1.00e+00 | 7.409 | 1 | 4 | 6 |
GO:0030118 | clathrin coat | 5.87e-03 | 1.00e+00 | 7.409 | 1 | 1 | 6 |
GO:0031466 | Cul5-RING ubiquitin ligase complex | 5.87e-03 | 1.00e+00 | 7.409 | 1 | 1 | 6 |
GO:0033180 | proton-transporting V-type ATPase, V1 domain | 6.84e-03 | 1.00e+00 | 7.187 | 1 | 2 | 7 |
GO:0030132 | clathrin coat of coated pit | 6.84e-03 | 1.00e+00 | 7.187 | 1 | 1 | 7 |
GO:0000028 | ribosomal small subunit assembly | 6.84e-03 | 1.00e+00 | 7.187 | 1 | 1 | 7 |
GO:0002161 | aminoacyl-tRNA editing activity | 6.84e-03 | 1.00e+00 | 7.187 | 1 | 2 | 7 |
GO:0031462 | Cul2-RING ubiquitin ligase complex | 6.84e-03 | 1.00e+00 | 7.187 | 1 | 2 | 7 |
GO:0019773 | proteasome core complex, alpha-subunit complex | 7.82e-03 | 1.00e+00 | 6.994 | 1 | 5 | 8 |
GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex | 7.82e-03 | 1.00e+00 | 6.994 | 1 | 2 | 8 |
GO:0070688 | MLL5-L complex | 7.82e-03 | 1.00e+00 | 6.994 | 1 | 1 | 8 |
GO:0045116 | protein neddylation | 7.82e-03 | 1.00e+00 | 6.994 | 1 | 2 | 8 |
GO:0061024 | membrane organization | 8.78e-03 | 1.00e+00 | 3.805 | 2 | 5 | 146 |
GO:0006450 | regulation of translational fidelity | 9.76e-03 | 1.00e+00 | 6.673 | 1 | 2 | 10 |
GO:0010569 | regulation of double-strand break repair via homologous recombination | 1.07e-02 | 1.00e+00 | 6.535 | 1 | 1 | 11 |
GO:0031571 | mitotic G1 DNA damage checkpoint | 1.07e-02 | 1.00e+00 | 6.535 | 1 | 3 | 11 |
GO:0044267 | cellular protein metabolic process | 1.16e-02 | 1.00e+00 | 2.628 | 3 | 24 | 495 |
GO:0034774 | secretory granule lumen | 1.17e-02 | 1.00e+00 | 6.409 | 1 | 1 | 12 |
GO:0005662 | DNA replication factor A complex | 1.27e-02 | 1.00e+00 | 6.294 | 1 | 3 | 13 |
GO:0030234 | enzyme regulator activity | 1.27e-02 | 1.00e+00 | 6.294 | 1 | 3 | 13 |
GO:0031625 | ubiquitin protein ligase binding | 1.31e-02 | 1.00e+00 | 3.503 | 2 | 13 | 180 |
GO:0035267 | NuA4 histone acetyltransferase complex | 1.36e-02 | 1.00e+00 | 6.187 | 1 | 4 | 14 |
GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | 1.46e-02 | 1.00e+00 | 6.088 | 1 | 1 | 15 |
GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 1.46e-02 | 1.00e+00 | 6.088 | 1 | 3 | 15 |
GO:0050998 | nitric-oxide synthase binding | 1.56e-02 | 1.00e+00 | 5.994 | 1 | 1 | 16 |
GO:0016486 | peptide hormone processing | 1.56e-02 | 1.00e+00 | 5.994 | 1 | 1 | 16 |
GO:0042176 | regulation of protein catabolic process | 1.56e-02 | 1.00e+00 | 5.994 | 1 | 3 | 16 |
GO:0005665 | DNA-directed RNA polymerase II, core complex | 1.56e-02 | 1.00e+00 | 5.994 | 1 | 4 | 16 |
GO:0046034 | ATP metabolic process | 1.56e-02 | 1.00e+00 | 5.994 | 1 | 1 | 16 |
GO:0010243 | response to organonitrogen compound | 1.65e-02 | 1.00e+00 | 5.907 | 1 | 2 | 17 |
GO:0035861 | site of double-strand break | 1.75e-02 | 1.00e+00 | 5.825 | 1 | 1 | 18 |
GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 1.85e-02 | 1.00e+00 | 5.747 | 1 | 1 | 19 |
GO:0048863 | stem cell differentiation | 1.85e-02 | 1.00e+00 | 5.747 | 1 | 1 | 19 |
GO:0015078 | hydrogen ion transmembrane transporter activity | 1.94e-02 | 1.00e+00 | 5.673 | 1 | 3 | 20 |
GO:0006298 | mismatch repair | 1.94e-02 | 1.00e+00 | 5.673 | 1 | 6 | 20 |
GO:0000718 | nucleotide-excision repair, DNA damage removal | 2.04e-02 | 1.00e+00 | 5.602 | 1 | 5 | 21 |
GO:0006297 | nucleotide-excision repair, DNA gap filling | 2.14e-02 | 1.00e+00 | 5.535 | 1 | 5 | 22 |
GO:0032201 | telomere maintenance via semi-conservative replication | 2.14e-02 | 1.00e+00 | 5.535 | 1 | 7 | 22 |
GO:0030863 | cortical cytoskeleton | 2.14e-02 | 1.00e+00 | 5.535 | 1 | 1 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 2.14e-02 | 1.00e+00 | 5.535 | 1 | 4 | 22 |
GO:0043044 | ATP-dependent chromatin remodeling | 2.23e-02 | 1.00e+00 | 5.471 | 1 | 4 | 23 |
GO:0031463 | Cul3-RING ubiquitin ligase complex | 2.23e-02 | 1.00e+00 | 5.471 | 1 | 2 | 23 |
GO:0043236 | laminin binding | 2.23e-02 | 1.00e+00 | 5.471 | 1 | 1 | 23 |
GO:0006513 | protein monoubiquitination | 2.23e-02 | 1.00e+00 | 5.471 | 1 | 1 | 23 |
GO:0005634 | nucleus | 2.34e-02 | 1.00e+00 | 0.927 | 9 | 131 | 4828 |
GO:0003899 | DNA-directed RNA polymerase activity | 2.42e-02 | 1.00e+00 | 5.351 | 1 | 2 | 25 |
GO:0000722 | telomere maintenance via recombination | 2.52e-02 | 1.00e+00 | 5.294 | 1 | 7 | 26 |
GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 2.52e-02 | 1.00e+00 | 5.294 | 1 | 2 | 26 |
GO:0043022 | ribosome binding | 2.71e-02 | 1.00e+00 | 5.187 | 1 | 3 | 28 |
GO:0015991 | ATP hydrolysis coupled proton transport | 2.71e-02 | 1.00e+00 | 5.187 | 1 | 4 | 28 |
GO:0031492 | nucleosomal DNA binding | 2.71e-02 | 1.00e+00 | 5.187 | 1 | 4 | 28 |
GO:0019894 | kinesin binding | 2.71e-02 | 1.00e+00 | 5.187 | 1 | 1 | 28 |
GO:0019005 | SCF ubiquitin ligase complex | 2.81e-02 | 1.00e+00 | 5.136 | 1 | 1 | 29 |
GO:0003887 | DNA-directed DNA polymerase activity | 2.81e-02 | 1.00e+00 | 5.136 | 1 | 3 | 29 |
GO:0030669 | clathrin-coated endocytic vesicle membrane | 2.81e-02 | 1.00e+00 | 5.136 | 1 | 1 | 29 |
GO:0071897 | DNA biosynthetic process | 2.81e-02 | 1.00e+00 | 5.136 | 1 | 2 | 29 |
GO:0006370 | 7-methylguanosine mRNA capping | 2.90e-02 | 1.00e+00 | 5.088 | 1 | 4 | 30 |
GO:0006271 | DNA strand elongation involved in DNA replication | 3.00e-02 | 1.00e+00 | 5.040 | 1 | 9 | 31 |
GO:0031623 | receptor internalization | 3.00e-02 | 1.00e+00 | 5.040 | 1 | 1 | 31 |
GO:0015992 | proton transport | 3.09e-02 | 1.00e+00 | 4.994 | 1 | 3 | 32 |
GO:0051701 | interaction with host | 3.28e-02 | 1.00e+00 | 4.907 | 1 | 4 | 34 |
GO:0043234 | protein complex | 3.41e-02 | 1.00e+00 | 2.766 | 2 | 17 | 300 |
GO:0032588 | trans-Golgi network membrane | 3.47e-02 | 1.00e+00 | 4.825 | 1 | 1 | 36 |
GO:0034332 | adherens junction organization | 3.47e-02 | 1.00e+00 | 4.825 | 1 | 1 | 36 |
GO:0001895 | retina homeostasis | 3.47e-02 | 1.00e+00 | 4.825 | 1 | 1 | 36 |
GO:0051084 | 'de novo' posttranslational protein folding | 3.57e-02 | 1.00e+00 | 4.785 | 1 | 4 | 37 |
GO:0070527 | platelet aggregation | 3.66e-02 | 1.00e+00 | 4.747 | 1 | 2 | 38 |
GO:0090382 | phagosome maturation | 3.66e-02 | 1.00e+00 | 4.747 | 1 | 5 | 38 |
GO:0022627 | cytosolic small ribosomal subunit | 3.76e-02 | 1.00e+00 | 4.709 | 1 | 3 | 39 |
GO:0006284 | base-excision repair | 3.76e-02 | 1.00e+00 | 4.709 | 1 | 7 | 39 |
GO:0019901 | protein kinase binding | 3.84e-02 | 1.00e+00 | 2.673 | 2 | 21 | 320 |
GO:0000781 | chromosome, telomeric region | 3.85e-02 | 1.00e+00 | 4.673 | 1 | 2 | 40 |
GO:0006418 | tRNA aminoacylation for protein translation | 4.04e-02 | 1.00e+00 | 4.602 | 1 | 5 | 42 |
GO:0005902 | microvillus | 4.04e-02 | 1.00e+00 | 4.602 | 1 | 2 | 42 |
GO:0014070 | response to organic cyclic compound | 4.14e-02 | 1.00e+00 | 4.568 | 1 | 3 | 43 |
GO:0050434 | positive regulation of viral transcription | 4.23e-02 | 1.00e+00 | 4.535 | 1 | 5 | 44 |
GO:0006892 | post-Golgi vesicle-mediated transport | 4.23e-02 | 1.00e+00 | 4.535 | 1 | 2 | 44 |
GO:0043966 | histone H3 acetylation | 4.32e-02 | 1.00e+00 | 4.503 | 1 | 2 | 45 |
GO:0021762 | substantia nigra development | 4.42e-02 | 1.00e+00 | 4.471 | 1 | 1 | 46 |
GO:0030136 | clathrin-coated vesicle | 4.42e-02 | 1.00e+00 | 4.471 | 1 | 1 | 46 |
GO:0030133 | transport vesicle | 4.51e-02 | 1.00e+00 | 4.440 | 1 | 1 | 47 |
GO:0003684 | damaged DNA binding | 4.89e-02 | 1.00e+00 | 4.322 | 1 | 11 | 51 |
GO:0005925 | focal adhesion | 4.99e-02 | 1.00e+00 | 2.463 | 2 | 18 | 370 |
GO:0003725 | double-stranded RNA binding | 5.17e-02 | 1.00e+00 | 4.240 | 1 | 6 | 54 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 5.17e-02 | 1.00e+00 | 4.240 | 1 | 5 | 54 |
GO:0000932 | cytoplasmic mRNA processing body | 5.35e-02 | 1.00e+00 | 4.187 | 1 | 3 | 56 |
GO:0006879 | cellular iron ion homeostasis | 5.45e-02 | 1.00e+00 | 4.162 | 1 | 5 | 57 |
GO:0000724 | double-strand break repair via homologous recombination | 5.45e-02 | 1.00e+00 | 4.162 | 1 | 6 | 57 |
GO:0012505 | endomembrane system | 5.45e-02 | 1.00e+00 | 4.162 | 1 | 2 | 57 |
GO:0000723 | telomere maintenance | 5.63e-02 | 1.00e+00 | 4.112 | 1 | 8 | 59 |
GO:0045216 | cell-cell junction organization | 5.63e-02 | 1.00e+00 | 4.112 | 1 | 2 | 59 |
GO:0006302 | double-strand break repair | 5.91e-02 | 1.00e+00 | 4.040 | 1 | 8 | 62 |
GO:0019903 | protein phosphatase binding | 6.00e-02 | 1.00e+00 | 4.017 | 1 | 4 | 63 |
GO:0006368 | transcription elongation from RNA polymerase II promoter | 6.37e-02 | 1.00e+00 | 3.928 | 1 | 6 | 67 |
GO:0003697 | single-stranded DNA binding | 6.56e-02 | 1.00e+00 | 3.886 | 1 | 9 | 69 |
GO:0034329 | cell junction assembly | 6.74e-02 | 1.00e+00 | 3.845 | 1 | 1 | 71 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 7.20e-02 | 1.00e+00 | 3.747 | 1 | 3 | 76 |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 7.29e-02 | 1.00e+00 | 3.728 | 1 | 5 | 77 |
GO:0005730 | nucleolus | 7.50e-02 | 1.00e+00 | 1.277 | 4 | 70 | 1684 |
GO:0019083 | viral transcription | 7.66e-02 | 1.00e+00 | 3.655 | 1 | 8 | 81 |
GO:0050796 | regulation of insulin secretion | 7.75e-02 | 1.00e+00 | 3.637 | 1 | 2 | 82 |
GO:0001726 | ruffle | 7.75e-02 | 1.00e+00 | 3.637 | 1 | 4 | 82 |
GO:0006898 | receptor-mediated endocytosis | 8.11e-02 | 1.00e+00 | 3.568 | 1 | 2 | 86 |
GO:0047485 | protein N-terminus binding | 8.11e-02 | 1.00e+00 | 3.568 | 1 | 4 | 86 |
GO:0006415 | translational termination | 8.20e-02 | 1.00e+00 | 3.551 | 1 | 8 | 87 |
GO:0044822 | poly(A) RNA binding | 8.45e-02 | 1.00e+00 | 1.505 | 3 | 50 | 1078 |
GO:0016605 | PML body | 8.65e-02 | 1.00e+00 | 3.471 | 1 | 5 | 92 |
GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | 8.65e-02 | 1.00e+00 | 3.471 | 1 | 4 | 92 |
GO:0006928 | cellular component movement | 8.65e-02 | 1.00e+00 | 3.471 | 1 | 7 | 92 |
GO:0006414 | translational elongation | 8.74e-02 | 1.00e+00 | 3.455 | 1 | 11 | 93 |
GO:0005200 | structural constituent of cytoskeleton | 8.74e-02 | 1.00e+00 | 3.455 | 1 | 7 | 93 |
GO:0001649 | osteoblast differentiation | 8.92e-02 | 1.00e+00 | 3.425 | 1 | 6 | 95 |
GO:0071456 | cellular response to hypoxia | 9.19e-02 | 1.00e+00 | 3.380 | 1 | 4 | 98 |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 9.73e-02 | 1.00e+00 | 3.294 | 1 | 8 | 104 |
GO:0014069 | postsynaptic density | 9.90e-02 | 1.00e+00 | 3.267 | 1 | 1 | 106 |
GO:0015630 | microtubule cytoskeleton | 1.04e-01 | 1.00e+00 | 3.187 | 1 | 5 | 112 |
GO:0030529 | ribonucleoprotein complex | 1.06e-01 | 1.00e+00 | 3.162 | 1 | 8 | 114 |
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 1.06e-01 | 1.00e+00 | 3.162 | 1 | 10 | 114 |
GO:0005819 | spindle | 1.06e-01 | 1.00e+00 | 3.162 | 1 | 7 | 114 |
GO:0019058 | viral life cycle | 1.07e-01 | 1.00e+00 | 3.149 | 1 | 10 | 115 |
GO:0072562 | blood microparticle | 1.08e-01 | 1.00e+00 | 3.136 | 1 | 4 | 116 |
GO:0004252 | serine-type endopeptidase activity | 1.11e-01 | 1.00e+00 | 3.100 | 1 | 2 | 119 |
GO:0006325 | chromatin organization | 1.14e-01 | 1.00e+00 | 3.052 | 1 | 4 | 123 |
GO:0007219 | Notch signaling pathway | 1.16e-01 | 1.00e+00 | 3.029 | 1 | 4 | 125 |
GO:0006260 | DNA replication | 1.16e-01 | 1.00e+00 | 3.029 | 1 | 12 | 125 |
GO:0006511 | ubiquitin-dependent protein catabolic process | 1.18e-01 | 1.00e+00 | 3.006 | 1 | 5 | 127 |
GO:0006413 | translational initiation | 1.21e-01 | 1.00e+00 | 2.961 | 1 | 12 | 131 |
GO:0009615 | response to virus | 1.22e-01 | 1.00e+00 | 2.950 | 1 | 6 | 132 |
GO:0000790 | nuclear chromatin | 1.23e-01 | 1.00e+00 | 2.939 | 1 | 7 | 133 |
GO:0031982 | vesicle | 1.24e-01 | 1.00e+00 | 2.928 | 1 | 10 | 134 |
GO:0003735 | structural constituent of ribosome | 1.30e-01 | 1.00e+00 | 2.855 | 1 | 8 | 141 |
GO:0008286 | insulin receptor signaling pathway | 1.32e-01 | 1.00e+00 | 2.825 | 1 | 6 | 144 |
GO:0005794 | Golgi apparatus | 1.32e-01 | 1.00e+00 | 1.650 | 2 | 14 | 650 |
GO:0006457 | protein folding | 1.37e-01 | 1.00e+00 | 2.775 | 1 | 8 | 149 |
GO:0005524 | ATP binding | 1.42e-01 | 1.00e+00 | 1.176 | 3 | 46 | 1354 |
GO:0005198 | structural molecule activity | 1.45e-01 | 1.00e+00 | 2.682 | 1 | 4 | 159 |
GO:0000398 | mRNA splicing, via spliceosome | 1.50e-01 | 1.00e+00 | 2.628 | 1 | 12 | 165 |
GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 1.53e-01 | 1.00e+00 | 2.602 | 1 | 5 | 168 |
GO:0030424 | axon | 1.56e-01 | 1.00e+00 | 2.568 | 1 | 3 | 172 |
GO:0006886 | intracellular protein transport | 1.57e-01 | 1.00e+00 | 2.560 | 1 | 4 | 173 |
GO:0015629 | actin cytoskeleton | 1.65e-01 | 1.00e+00 | 2.479 | 1 | 5 | 183 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | 1.66e-01 | 1.00e+00 | 2.471 | 1 | 8 | 184 |
GO:0032403 | protein complex binding | 1.67e-01 | 1.00e+00 | 2.463 | 1 | 7 | 185 |
GO:0005765 | lysosomal membrane | 1.94e-01 | 1.00e+00 | 2.226 | 1 | 5 | 218 |
GO:0007267 | cell-cell signaling | 1.98e-01 | 1.00e+00 | 2.187 | 1 | 2 | 224 |
GO:0007067 | mitotic nuclear division | 2.04e-01 | 1.00e+00 | 2.143 | 1 | 13 | 231 |
GO:0008380 | RNA splicing | 2.05e-01 | 1.00e+00 | 2.136 | 1 | 13 | 232 |
GO:0006412 | translation | 2.07e-01 | 1.00e+00 | 2.118 | 1 | 15 | 235 |
GO:0004842 | ubiquitin-protein transferase activity | 2.24e-01 | 1.00e+00 | 1.994 | 1 | 4 | 256 |
GO:0019899 | enzyme binding | 2.48e-01 | 1.00e+00 | 1.825 | 1 | 11 | 288 |
GO:0016567 | protein ubiquitination | 2.56e-01 | 1.00e+00 | 1.770 | 1 | 5 | 299 |
GO:0008152 | metabolic process | 2.58e-01 | 1.00e+00 | 1.756 | 1 | 5 | 302 |
GO:0005615 | extracellular space | 2.60e-01 | 1.00e+00 | 1.014 | 2 | 17 | 1010 |
GO:0005856 | cytoskeleton | 2.65e-01 | 1.00e+00 | 1.714 | 1 | 8 | 311 |
GO:0005739 | mitochondrion | 2.74e-01 | 1.00e+00 | 0.964 | 2 | 24 | 1046 |
GO:0007411 | axon guidance | 2.77e-01 | 1.00e+00 | 1.641 | 1 | 9 | 327 |
GO:0043231 | intracellular membrane-bounded organelle | 2.80e-01 | 1.00e+00 | 1.619 | 1 | 8 | 332 |
GO:0003682 | chromatin binding | 2.82e-01 | 1.00e+00 | 1.611 | 1 | 12 | 334 |
GO:0043565 | sequence-specific DNA binding | 3.04e-01 | 1.00e+00 | 1.483 | 1 | 4 | 365 |
GO:0007155 | cell adhesion | 3.17e-01 | 1.00e+00 | 1.409 | 1 | 8 | 384 |
GO:0046982 | protein heterodimerization activity | 3.27e-01 | 1.00e+00 | 1.354 | 1 | 11 | 399 |
GO:0006508 | proteolysis | 3.35e-01 | 1.00e+00 | 1.315 | 1 | 9 | 410 |
GO:0006366 | transcription from RNA polymerase II promoter | 3.45e-01 | 1.00e+00 | 1.263 | 1 | 12 | 425 |
GO:0007596 | blood coagulation | 3.70e-01 | 1.00e+00 | 1.136 | 1 | 14 | 464 |
GO:0055085 | transmembrane transport | 4.01e-01 | 1.00e+00 | 0.989 | 1 | 8 | 514 |
GO:0045087 | innate immune response | 4.60e-01 | 1.00e+00 | 0.728 | 1 | 20 | 616 |
GO:0005886 | plasma membrane | 5.43e-01 | 1.00e+00 | 0.111 | 3 | 38 | 2834 |
GO:0008270 | zinc ion binding | 6.61e-01 | 1.00e+00 | -0.065 | 1 | 12 | 1067 |
GO:0003677 | DNA binding | 7.49e-01 | 1.00e+00 | -0.405 | 1 | 26 | 1351 |
GO:0046872 | metal ion binding | 7.78e-01 | 1.00e+00 | -0.522 | 1 | 24 | 1465 |
GO:0005737 | cytoplasm | 7.87e-01 | 1.00e+00 | -0.378 | 3 | 98 | 3976 |
GO:0016021 | integral component of membrane | 9.29e-01 | 1.00e+00 | -1.283 | 1 | 15 | 2483 |