int-snw-8861

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.937 1.33e-15 2.35e-03 3.86e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-8861 subnetwork

Genes (13)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
ACO2 50 501.0001.076191Yes-
EEF2 1938 270.8901.043301Yes-
PSMA2 5683 601.0931.10689Yes-
PSMD3 5709 570.9861.106146Yes-
[ LDB1 ] 8861 10.3850.93745Yes-
PSMB7 5695 480.9821.05257Yes-
PSMB2 5690 180.8771.026117Yes-
PSMA1 5682 610.9961.052123Yes-
ACTB 60 1671.1531.151587Yes-
PSMD11 5717 1211.0951.106183Yes-
POLR1B 84172 40.6130.988184Yes-
HSPD1 3329 350.9131.035286Yes-
PGD 5226 751.2011.106138Yes-

Interactions (39)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PGD 5226 POLR1B 84172 pp -- int.I2D: YeastLow
HSPD1 3329 POLR1B 84172 pp -- int.I2D: YeastLow
ACTB 60 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
PSMD3 5709 POLR1B 84172 pp -- int.I2D: IntAct_Yeast, YeastLow
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMA2 5683 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
EEF2 1938 PGD 5226 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 LDB1 8861 pp -- int.Intact: MI:0915(physical association);
int.I2D: VidalHuman_non_core
PSMB2 5690 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
ACTB 60 POLR1B 84172 pp -- int.I2D: BIND, BIND_Mouse
PSMB2 5690 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMA2 5683 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
PSMD11 5717 POLR1B 84172 pp -- int.I2D: YeastLow
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
ACO2 50 PSMD11 5717 pp -- int.I2D: YeastLow
EEF2 1938 HSPD1 3329 pp -- int.I2D: YeastLow, YeastMedium
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 EEF2 1938 pp -- int.I2D: YeastLow, IntAct_Yeast
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
EEF2 1938 POLR1B 84172 pp -- int.I2D: YeastLow
PGD 5226 PSMD3 5709 pp -- int.I2D: YeastLow
ACO2 50 POLR1B 84172 pp -- int.I2D: YeastLow
PSMA2 5683 PSMB2 5690 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core
LDB1 8861 POLR1B 84172 pp -- int.Intact: MI:0915(physical association)
ACO2 50 PGD 5226 pp -- int.I2D: YeastLow
ACO2 50 HSPD1 3329 pp -- int.I2D: IntAct_Yeast
PSMA1 5682 PSMB2 5690 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
PSMA2 5683 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB2 5690 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
EEF2 1938 PSMD3 5709 pp -- int.I2D: Krogan_NonCore
ACTB 60 HSPD1 3329 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, YeastLow
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast

Related GO terms (196)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0006521regulation of cellular amino acid metabolic process2.14e-123.09e-087.05761750
GO:0000502proteasome complex5.44e-127.85e-086.84361758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.01e-111.45e-076.70161964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.11e-111.60e-076.67862265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.75e-112.53e-076.57162270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent2.09e-113.01e-076.53162072
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.47e-113.57e-076.49162274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I2.69e-113.88e-076.47262075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process3.70e-115.34e-076.39762379
GO:0002474antigen processing and presentation of peptide antigen via MHC class I9.45e-111.36e-066.17762192
GO:0000209protein polyubiquitination3.89e-105.62e-065.843620116
GO:0005839proteasome core complex1.21e-091.74e-057.9464818
GO:0004298threonine-type endopeptidase activity1.53e-092.20e-057.8684819
GO:0000082G1/S transition of mitotic cell cycle1.78e-092.56e-055.481632149
GO:0042981regulation of apoptotic process1.85e-092.67e-055.472624150
GO:0034641cellular nitrogen compound metabolic process4.08e-095.88e-055.283620171
GO:0016071mRNA metabolic process2.00e-082.89e-044.900631223
GO:0010467gene expression2.15e-083.10e-043.730859669
GO:0043066negative regulation of apoptotic process2.66e-083.84e-044.195731424
GO:0016070RNA metabolic process3.68e-085.31e-044.752632247
GO:0016032viral process1.30e-071.87e-033.862755534
GO:0000278mitotic cell cycle5.58e-078.05e-034.090648391
GO:0005654nucleoplasm8.95e-071.29e-023.0368761082
GO:0044281small molecule metabolic process2.12e-063.06e-022.8748581211
GO:0070062extracellular vesicular exosome2.81e-064.05e-022.209101042400
GO:0005829cytosol4.07e-065.87e-022.152101322496
GO:0006915apoptotic process4.30e-066.21e-023.584633555
GO:0019773proteasome core complex, alpha-subunit complex2.09e-053.02e-018.116248
GO:0005838proteasome regulatory particle4.92e-057.10e-017.5312712
GO:0022624proteasome accessory complex1.01e-041.00e+007.0282817
GO:0005844polysome1.88e-041.00e+006.5922423
GO:0002842positive regulation of T cell mediated immune response to tumor cell9.01e-041.00e+0010.116111
GO:0022607cellular component assembly9.01e-041.00e+0010.116111
GO:0048291isotype switching to IgG isotypes9.01e-041.00e+0010.116111
GO:0000972transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery9.01e-041.00e+0010.116111
GO:0019521D-gluconate metabolic process9.01e-041.00e+0010.116111
GO:0043973histone H3-K4 acetylation9.01e-041.00e+0010.116111
GO:0002368B cell cytokine production9.01e-041.00e+0010.116111
GO:0005634nucleus1.03e-031.00e+001.283101364559
GO:00515383 iron, 4 sulfur cluster binding1.80e-031.00e+009.116112
GO:0046985positive regulation of hemoglobin biosynthetic process1.80e-031.00e+009.116112
GO:0019322pentose biosynthetic process1.80e-031.00e+009.116122
GO:0003994aconitate hydratase activity1.80e-031.00e+009.116112
GO:0016020membrane2.06e-031.00e+001.9866901681
GO:0043234protein complex2.08e-031.00e+003.496318295
GO:0006458'de novo' protein folding2.70e-031.00e+008.531113
GO:0009051pentose-phosphate shunt, oxidative branch2.70e-031.00e+008.531123
GO:0030135coated vesicle2.70e-031.00e+008.531113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.70e-031.00e+008.531113
GO:0010669epithelial structure maintenance3.60e-031.00e+008.116114
GO:0032549ribonucleoside binding3.60e-031.00e+008.116124
GO:0030529ribonucleoprotein complex4.41e-031.00e+004.30828112
GO:0043248proteasome assembly4.50e-031.00e+007.794115
GO:0046696lipopolysaccharide receptor complex4.50e-031.00e+007.794115
GO:0006102isocitrate metabolic process4.50e-031.00e+007.794115
GO:0003688DNA replication origin binding5.40e-031.00e+007.531126
GO:0030957Tat protein binding5.40e-031.00e+007.531136
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex5.40e-031.00e+007.531116
GO:0006101citrate metabolic process5.40e-031.00e+007.531116
GO:0000790nuclear chromatin5.80e-031.00e+004.10429129
GO:0030274LIM domain binding6.29e-031.00e+007.308117
GO:0045647negative regulation of erythrocyte differentiation6.29e-031.00e+007.308117
GO:0070688MLL5-L complex7.19e-031.00e+007.116118
GO:0051604protein maturation7.19e-031.00e+007.116118
GO:0060322head development8.09e-031.00e+006.946119
GO:0008494translation activator activity8.09e-031.00e+006.946119
GO:0006098pentose-phosphate shunt8.98e-031.00e+006.7941410
GO:0043032positive regulation of macrophage activation8.98e-031.00e+006.7941110
GO:0032727positive regulation of interferon-alpha production9.87e-031.00e+006.6561111
GO:0032784regulation of DNA-templated transcription, elongation1.08e-021.00e+006.5311112
GO:0021702cerebellar Purkinje cell differentiation1.08e-021.00e+006.5311112
GO:0005730nucleolus1.11e-021.00e+001.7575691641
GO:0030234enzyme regulator activity1.17e-021.00e+006.4151313
GO:0001530lipopolysaccharide binding1.17e-021.00e+006.4151313
GO:0051131chaperone-mediated protein complex assembly1.17e-021.00e+006.4151113
GO:0035267NuA4 histone acetyltransferase complex1.26e-021.00e+006.3081414
GO:0009948anterior/posterior axis specification1.26e-021.00e+006.3081214
GO:0042026protein refolding1.34e-021.00e+006.2091215
GO:0050998nitric-oxide synthase binding1.43e-021.00e+006.1161116
GO:0042176regulation of protein catabolic process1.43e-021.00e+006.1161316
GO:0001158enhancer sequence-specific DNA binding1.43e-021.00e+006.1161116
GO:0010243response to organonitrogen compound1.52e-021.00e+006.0281317
GO:0050870positive regulation of T cell activation1.52e-021.00e+006.0281117
GO:0003746translation elongation factor activity1.52e-021.00e+006.0281317
GO:0032733positive regulation of interleukin-10 production1.70e-021.00e+005.8681119
GO:0048863stem cell differentiation1.70e-021.00e+005.8681119
GO:0005759mitochondrial matrix1.73e-021.00e+003.283214228
GO:0042100B cell proliferation1.88e-021.00e+005.7231121
GO:0001702gastrulation with mouth forming second1.88e-021.00e+005.7231221
GO:0030863cortical cytoskeleton1.97e-021.00e+005.6561122
GO:0036464cytoplasmic ribonucleoprotein granule1.97e-021.00e+005.6561422
GO:0043044ATP-dependent chromatin remodeling2.05e-021.00e+005.5921423
GO:0006362transcription elongation from RNA polymerase I promoter2.05e-021.00e+005.5921323
GO:0006363termination of RNA polymerase I transcription2.14e-021.00e+005.5311324
GO:0003899DNA-directed RNA polymerase activity2.23e-021.00e+005.4721325
GO:0042113B cell activation2.23e-021.00e+005.4721225
GO:0032735positive regulation of interleukin-12 production2.23e-021.00e+005.4721125
GO:0006361transcription initiation from RNA polymerase I promoter2.32e-021.00e+005.4151326
GO:0050661NADP binding2.41e-021.00e+005.3611227
GO:0031492nucleosomal DNA binding2.41e-021.00e+005.3611427
GO:0006099tricarboxylic acid cycle2.50e-021.00e+005.3081428
GO:0019894kinesin binding2.50e-021.00e+005.3081128
GO:0006360transcription from RNA polymerase I promoter2.67e-021.00e+005.2091530
GO:0001895retina homeostasis3.02e-021.00e+005.0281134
GO:0001942hair follicle development3.11e-021.00e+004.9861135
GO:00515394 iron, 4 sulfur cluster binding3.11e-021.00e+004.9861335
GO:0034332adherens junction organization3.20e-021.00e+004.9461136
GO:0019901protein kinase binding3.20e-021.00e+002.807221317
GO:0001102RNA polymerase II activating transcription factor binding3.20e-021.00e+004.9461236
GO:0043621protein self-association3.20e-021.00e+004.9461236
GO:0032755positive regulation of interleukin-6 production3.20e-021.00e+004.9461236
GO:0051084'de novo' posttranslational protein folding3.29e-021.00e+004.9061437
GO:0070527platelet aggregation3.37e-021.00e+004.8681238
GO:0032729positive regulation of interferon-gamma production3.46e-021.00e+004.8301239
GO:0035019somatic stem cell maintenance3.55e-021.00e+004.7941140
GO:0045785positive regulation of cell adhesion3.55e-021.00e+004.7941440
GO:0042110T cell activation3.72e-021.00e+004.7231342
GO:0014070response to organic cyclic compound3.81e-021.00e+004.6891443
GO:0021762substantia nigra development3.90e-021.00e+004.6561244
GO:0045727positive regulation of translation3.90e-021.00e+004.6561344
GO:0005515protein binding4.29e-021.00e+000.72991846024
GO:0006091generation of precursor metabolites and energy4.42e-021.00e+004.4721350
GO:0006986response to unfolded protein4.42e-021.00e+004.4721250
GO:0005905coated pit4.42e-021.00e+004.4721350
GO:0003725double-stranded RNA binding4.59e-021.00e+004.4151552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.68e-021.00e+004.3881553
GO:0002244hematopoietic progenitor cell differentiation4.76e-021.00e+004.3611154
GO:0045216cell-cell junction organization4.76e-021.00e+004.3611254
GO:0000932cytoplasmic mRNA processing body4.76e-021.00e+004.3611354
GO:0002039p53 binding4.85e-021.00e+004.3341755
GO:0051087chaperone binding5.19e-021.00e+004.2331659
GO:0030141secretory granule5.45e-021.00e+004.1611262
GO:0034329cell junction assembly5.96e-021.00e+004.0281168
GO:0003697single-stranded DNA binding5.96e-021.00e+004.0281568
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis6.47e-021.00e+003.9061674
GO:0044267cellular protein metabolic process6.62e-021.00e+002.227229474
GO:0030182neuron differentiation6.64e-021.00e+003.8681176
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process6.72e-021.00e+003.8491777
GO:0002755MyD88-dependent toll-like receptor signaling pathway6.98e-021.00e+003.7941380
GO:0050821protein stabilization7.65e-021.00e+003.6561288
GO:0006928cellular component movement7.90e-021.00e+003.6081791
GO:0005200structural constituent of cytoskeleton7.90e-021.00e+003.6081891
GO:0006414translational elongation8.07e-021.00e+003.57611393
GO:0051082unfolded protein binding8.07e-021.00e+003.5761593
GO:0014069postsynaptic density9.07e-021.00e+003.40113105
GO:0005506iron ion binding9.07e-021.00e+003.40114105
GO:0015630microtubule cytoskeleton9.48e-021.00e+003.33414110
GO:0072562blood microparticle9.56e-021.00e+003.32113111
GO:0044237cellular metabolic process1.01e-011.00e+003.24515117
GO:0006325chromatin organization1.01e-011.00e+003.23315118
GO:0006511ubiquitin-dependent protein catabolic process1.08e-011.00e+003.13815126
GO:0009615response to virus1.08e-011.00e+003.13815126
GO:0016055Wnt signaling pathway1.18e-011.00e+003.00717138
GO:0016887ATPase activity1.19e-011.00e+002.98617140
GO:0006457protein folding1.22e-011.00e+002.95617143
GO:0061024membrane organization1.23e-011.00e+002.93617145
GO:0010628positive regulation of gene expression1.24e-011.00e+002.92615146
GO:0005769early endosome1.29e-011.00e+002.86812152
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.39e-011.00e+002.74917165
GO:0030424axon1.40e-011.00e+002.74114166
GO:0005667transcription factor complex1.47e-011.00e+002.66414175
GO:0003714transcription corepressor activity1.49e-011.00e+002.64018178
GO:0003924GTPase activity1.64e-011.00e+002.494112197
GO:0006184GTP catabolic process1.77e-011.00e+002.374112214
GO:0006412translation1.89e-011.00e+002.270120230
GO:0005975carbohydrate metabolic process2.06e-011.00e+002.13319253
GO:0005615extracellular space2.12e-011.00e+001.213217957
GO:0043065positive regulation of apoptotic process2.16e-011.00e+002.050110268
GO:0005743mitochondrial inner membrane2.23e-011.00e+002.00218277
GO:0019899enzyme binding2.23e-011.00e+002.002112277
GO:0005739mitochondrion2.26e-011.00e+001.153228998
GO:0005856cytoskeleton2.33e-011.00e+001.931112291
GO:0006200ATP catabolic process2.34e-011.00e+001.926115292
GO:0044822poly(A) RNA binding2.46e-011.00e+001.0712491056
GO:0005525GTP binding2.46e-011.00e+001.840112310
GO:0007275multicellular organismal development2.50e-011.00e+001.81215316
GO:0007411axon guidance2.52e-011.00e+001.798113319
GO:0005813centrosome2.57e-011.00e+001.767114326
GO:0003682chromatin binding2.58e-011.00e+001.762111327
GO:0003723RNA binding2.68e-011.00e+001.698120342
GO:0005925focal adhesion2.84e-011.00e+001.600119366
GO:0009986cell surface3.08e-011.00e+001.465111402
GO:0045892negative regulation of transcription, DNA-templated3.15e-011.00e+001.426115413
GO:0006366transcription from RNA polymerase II promoter3.18e-011.00e+001.405110419
GO:0055114oxidation-reduction process3.19e-011.00e+001.401112420
GO:0005524ATP binding3.29e-011.00e+000.7742601298
GO:0007596blood coagulation3.41e-011.00e+001.286118455
GO:0042803protein homodimerization activity4.22e-011.00e+000.899112595
GO:0045087innate immune response4.22e-011.00e+000.896124596
GO:0005737cytoplasm4.53e-011.00e+000.23641103767
GO:0045944positive regulation of transcription from RNA polymerase II promoter5.19e-011.00e+000.492119789
GO:0006355regulation of transcription, DNA-templated6.06e-011.00e+000.154118997
GO:0003677DNA binding6.83e-011.00e+00-0.1351281218
GO:0046872metal ion binding7.09e-011.00e+00-0.2361251307
GO:0006351transcription, DNA-templated7.47e-011.00e+00-0.3821311446
GO:0005886plasma membrane9.23e-011.00e+00-1.2191452582