int-snw-8317

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.925 3.70e-15 3.01e-03 4.62e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-8317 subnetwork

Genes (17)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
PSMA2 5683 601.0931.10689Yes-
POLA1 5422 20.5930.93869Yes-
PSMC3 5702 90.7191.002255Yes-
PSMB7 5695 480.9821.05257Yes-
PSMA1 5682 610.9961.052123Yes-
RPSA 3921 1561.3271.151152Yes-
RPA2 6118 981.2501.15169Yes-
ACO2 50 501.0001.076191Yes-
PSMD1 5707 120.8361.057113Yes-
PSMD3 5709 570.9861.106146Yes-
MCM5 4174 40.5780.992121Yes-
RPS11 6205 360.9931.113175Yes-
[ CDC7 ] 8317 10.0420.92593--
RPL14 9045 421.2501.113143Yes-
ACTB 60 1671.1531.151587Yes-
PSMD11 5717 1211.0951.106183Yes-
PSMC1 5700 140.8401.018137Yes-

Interactions (50)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
ACTB 60 MCM5 4174 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
PSMD1 5707 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 RPS11 6205 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
PSMA2 5683 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
MCM5 4174 RPA2 6118 pp -- int.I2D: BioGrid, HPRD;
int.HPRD: yeast 2-hybrid
PSMC3 5702 CDC7 8317 pp -- int.I2D: IntAct_Yeast
ACO2 50 PSMC1 5700 pp -- int.I2D: YeastLow
PSMA2 5683 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
PSMB7 5695 PSMD1 5707 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct
PSMA1 5682 PSMC1 5700 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct_Fly, YeastMedium, IntAct
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMC1 5700 CDC7 8317 pp -- int.I2D: IntAct_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
POLA1 5422 CDC7 8317 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast, IntAct_Fly, YeastLow
PSMC3 5702 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
PSMC3 5702 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, Krogan_NonCore, YeastHigh
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
PSMC3 5702 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
PSMC1 5700 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
MCM5 4174 CDC7 8317 pp -- int.I2D: BioGrid, BioGrid_Yeast, BIND_Mouse, HPRD;
int.HPRD: yeast 2-hybrid
PSMC3 5702 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh
ACTB 60 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
PSMC1 5700 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, Krogan_Core, Tarassov_PCA
PSMA1 5682 PSMA2 5683 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
PSMA1 5682 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMC1 5700 PSMD1 5707 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, Krogan_Core, MINT_Yeast
PSMC3 5702 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast
PSMB7 5695 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
ACO2 50 PSMD11 5717 pp -- int.I2D: YeastLow
PSMD1 5707 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, Krogan_Core
PSMA2 5683 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
RPSA 3921 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast
PSMD1 5707 CDC7 8317 pp -- int.I2D: IntAct_Yeast
RPS11 6205 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMC1 5700 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, YeastHigh, Krogan_Core

Related GO terms (194)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0000082G1/S transition of mitotic cell cycle5.58e-218.04e-176.0941232149
GO:0016071mRNA metabolic process1.08e-161.55e-125.3871131223
GO:0006521regulation of cellular amino acid metabolic process2.75e-163.97e-127.08581750
GO:0016070RNA metabolic process3.36e-164.85e-125.2401132247
GO:0000278mitotic cell cycle7.30e-161.05e-114.7031248391
GO:0000502proteasome complex9.78e-161.41e-116.87181758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest2.25e-153.25e-116.72981964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.56e-153.70e-116.70682265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.78e-156.90e-116.59982270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent6.06e-158.74e-116.55982072
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle7.62e-151.10e-106.51982274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I8.52e-151.23e-106.50082075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.32e-141.90e-106.42582379
GO:0016032viral process3.07e-144.43e-104.2531255534
GO:0002474antigen processing and presentation of peptide antigen via MHC class I4.66e-146.72e-106.20582192
GO:0000209protein polyubiquitination3.14e-134.53e-095.871820116
GO:0042981regulation of apoptotic process2.55e-123.67e-085.500824150
GO:0005654nucleoplasm3.99e-125.75e-083.35013761082
GO:0022624proteasome accessory complex7.31e-121.05e-077.9635817
GO:0034641cellular nitrogen compound metabolic process7.35e-121.06e-075.311820171
GO:0010467gene expression1.89e-112.73e-073.8021159669
GO:0005838proteasome regulatory particle6.50e-109.37e-068.1444712
GO:0043066negative regulation of apoptotic process1.01e-081.45e-044.001831424
GO:0006915apoptotic process8.18e-081.18e-033.612833555
GO:0005839proteasome core complex1.10e-061.58e-027.1443818
GO:0004298threonine-type endopeptidase activity1.30e-061.88e-027.0663819
GO:0005829cytosol1.84e-062.65e-022.028121322496
GO:0044281small molecule metabolic process2.63e-063.80e-022.6579581211
GO:0016020membrane4.04e-065.82e-022.33510901681
GO:0006271DNA strand elongation involved in DNA replication5.41e-067.81e-026.4073730
GO:0006260DNA replication1.03e-051.49e-014.81049121
GO:0019773proteasome core complex, alpha-subunit complex3.65e-055.26e-017.729248
GO:0070062extracellular vesicular exosome9.98e-051.00e+001.822101042400
GO:0030234enzyme regulator activity1.01e-041.00e+007.0282313
GO:0019083viral transcription1.10e-041.00e+004.97431081
GO:0006415translational termination1.36e-041.00e+004.87131087
GO:0042176regulation of protein catabolic process1.55e-041.00e+006.7292316
GO:0006414translational elongation1.65e-041.00e+004.77431393
GO:0005634nucleus1.86e-041.00e+001.275131364559
GO:0006614SRP-dependent cotranslational protein targeting to membrane2.30e-041.00e+004.613310104
GO:0005730nucleolus2.60e-041.00e+002.0488691641
GO:0032201telomere maintenance via semi-conservative replication2.71e-041.00e+006.3362521
GO:0006297nucleotide-excision repair, DNA gap filling2.98e-041.00e+006.2692322
GO:0006270DNA replication initiation2.98e-041.00e+006.2692622
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay3.02e-041.00e+004.481311114
GO:0019058viral life cycle3.10e-041.00e+004.468313115
GO:0000722telomere maintenance via recombination3.86e-041.00e+006.0852525
GO:0006413translational initiation4.54e-041.00e+004.280317131
GO:0003735structural constituent of ribosome5.17e-041.00e+004.216310137
GO:0005515protein binding7.59e-041.00e+000.979141846024
GO:00515394 iron, 4 sulfur cluster binding7.60e-041.00e+005.5992335
GO:0022627cytosolic small ribosomal subunit9.44e-041.00e+005.4432439
GO:0000932cytoplasmic mRNA processing body1.80e-031.00e+004.9742354
GO:0000723telomere maintenance1.94e-031.00e+004.9212656
GO:0044267cellular protein metabolic process1.95e-031.00e+002.840429474
GO:0006412translation2.31e-031.00e+003.468320230
GO:0006272leading strand elongation2.36e-031.00e+008.729122
GO:00515383 iron, 4 sulfur cluster binding2.36e-031.00e+008.729112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.36e-031.00e+008.729112
GO:0003994aconitate hydratase activity2.36e-031.00e+008.729112
GO:0005055laminin receptor activity2.36e-031.00e+008.729112
GO:0006407rRNA export from nucleus2.36e-031.00e+008.729112
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)4.71e-031.00e+007.729114
GO:003068690S preribosome4.71e-031.00e+007.729114
GO:0005658alpha DNA polymerase:primase complex4.71e-031.00e+007.729124
GO:0001882nucleoside binding4.71e-031.00e+007.729114
GO:0006273lagging strand elongation4.71e-031.00e+007.729114
GO:0003896DNA primase activity4.71e-031.00e+007.729124
GO:0044770cell cycle phase transition5.88e-031.00e+007.407115
GO:0006269DNA replication, synthesis of RNA primer5.88e-031.00e+007.407125
GO:0010571positive regulation of nuclear cell cycle DNA replication5.88e-031.00e+007.407115
GO:0043248proteasome assembly5.88e-031.00e+007.407115
GO:0006102isocitrate metabolic process5.88e-031.00e+007.407115
GO:0000730DNA recombinase assembly5.88e-031.00e+007.407115
GO:2000001regulation of DNA damage checkpoint5.88e-031.00e+007.407115
GO:0030957Tat protein binding7.05e-031.00e+007.144136
GO:0006101citrate metabolic process7.05e-031.00e+007.144116
GO:0015630microtubule cytoskeleton7.27e-031.00e+003.94724110
GO:0000028ribosomal small subunit assembly8.22e-031.00e+006.921117
GO:0070688MLL5-L complex9.39e-031.00e+006.729118
GO:0042555MCM complex1.06e-021.00e+006.559129
GO:0016887ATPase activity1.16e-021.00e+003.59927140
GO:0000731DNA synthesis involved in DNA repair1.17e-021.00e+006.4071110
GO:0010569regulation of double-strand break repair via homologous recombination1.17e-021.00e+006.4071110
GO:0019985translesion synthesis1.29e-021.00e+006.2691211
GO:0031571mitotic G1 DNA damage checkpoint1.29e-021.00e+006.2691411
GO:0010971positive regulation of G2/M transition of mitotic cell cycle1.29e-021.00e+006.2691211
GO:0005524ATP binding1.45e-021.00e+001.7085601298
GO:0042273ribosomal large subunit biogenesis1.52e-021.00e+006.0281413
GO:0005662DNA replication factor A complex1.52e-021.00e+006.0281113
GO:0035267NuA4 histone acetyltransferase complex1.64e-021.00e+005.9211414
GO:0050998nitric-oxide synthase binding1.87e-021.00e+005.7291116
GO:00084083'-5' exonuclease activity1.87e-021.00e+005.7291116
GO:0017025TBP-class protein binding1.99e-021.00e+005.6411317
GO:0003678DNA helicase activity1.99e-021.00e+005.6411317
GO:1903506regulation of nucleic acid-templated transcription2.10e-021.00e+005.5591118
GO:0035861site of double-strand break2.10e-021.00e+005.5591118
GO:0006303double-strand break repair via nonhomologous end joining2.10e-021.00e+005.5591218
GO:0048863stem cell differentiation2.22e-021.00e+005.4811119
GO:0006298mismatch repair2.33e-021.00e+005.4071320
GO:0000718nucleotide-excision repair, DNA damage removal2.45e-021.00e+005.3361421
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle2.56e-021.00e+005.2691222
GO:0030863cortical cytoskeleton2.56e-021.00e+005.2691122
GO:0036464cytoplasmic ribonucleoprotein granule2.56e-021.00e+005.2691422
GO:0043044ATP-dependent chromatin remodeling2.68e-021.00e+005.2051423
GO:0005844polysome2.68e-021.00e+005.2051423
GO:0043236laminin binding2.68e-021.00e+005.2051123
GO:0019843rRNA binding3.14e-021.00e+004.9741327
GO:0043022ribosome binding3.14e-021.00e+004.9741327
GO:0031492nucleosomal DNA binding3.14e-021.00e+004.9741427
GO:0044822poly(A) RNA binding3.15e-021.00e+001.6844491056
GO:0006099tricarboxylic acid cycle3.25e-021.00e+004.9211428
GO:0003887DNA-directed DNA polymerase activity3.25e-021.00e+004.9211328
GO:0019894kinesin binding3.25e-021.00e+004.9211128
GO:0045171intercellular bridge3.48e-021.00e+004.8221230
GO:1903507negative regulation of nucleic acid-templated transcription3.71e-021.00e+004.7291232
GO:0006281DNA repair3.71e-021.00e+002.701218261
GO:0016301kinase activity3.82e-021.00e+004.6841333
GO:0001895retina homeostasis3.93e-021.00e+004.6411134
GO:0034332adherens junction organization4.16e-021.00e+004.5591136
GO:0051084'de novo' posttranslational protein folding4.28e-021.00e+004.5191437
GO:0006284base-excision repair4.28e-021.00e+004.5191337
GO:0070527platelet aggregation4.39e-021.00e+004.4811238
GO:0000781chromosome, telomeric region4.50e-021.00e+004.4431339
GO:0006200ATP catabolic process4.55e-021.00e+002.539215292
GO:0032508DNA duplex unwinding4.73e-021.00e+004.3711341
GO:0021762substantia nigra development5.06e-021.00e+004.2691244
GO:0019901protein kinase binding5.27e-021.00e+002.420221317
GO:0006283transcription-coupled nucleotide-excision repair5.29e-021.00e+004.2051746
GO:0022625cytosolic large ribosomal subunit5.62e-021.00e+004.1141649
GO:0003684damaged DNA binding5.62e-021.00e+004.1141749
GO:0006091generation of precursor metabolites and energy5.74e-021.00e+004.0851350
GO:0003723RNA binding6.03e-021.00e+002.311220342
GO:0090305nucleic acid phosphodiester bond hydrolysis6.07e-021.00e+004.0011153
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding6.07e-021.00e+004.0011553
GO:0045216cell-cell junction organization6.18e-021.00e+003.9741254
GO:0000724double-strand break repair via homologous recombination6.29e-021.00e+003.9471355
GO:0005840ribosome6.62e-021.00e+003.8711158
GO:0005925focal adhesion6.80e-021.00e+002.213219366
GO:0019903protein phosphatase binding7.07e-021.00e+003.7741462
GO:0006302double-strand break repair7.07e-021.00e+003.7741462
GO:0006289nucleotide-excision repair7.72e-021.00e+003.64111168
GO:0034329cell junction assembly7.72e-021.00e+003.6411168
GO:0003697single-stranded DNA binding7.72e-021.00e+003.6411568
GO:0000785chromatin8.27e-021.00e+003.5391473
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis8.38e-021.00e+003.5191674
GO:0051301cell division9.13e-021.00e+003.3891581
GO:0047485protein N-terminus binding9.67e-021.00e+003.3021586
GO:0016605PML body9.89e-021.00e+003.2691388
GO:0016363nuclear matrix1.02e-011.00e+003.22111291
GO:0006928cellular component movement1.02e-011.00e+003.2211791
GO:0005200structural constituent of cytoskeleton1.02e-011.00e+003.2211891
GO:0001649osteoblast differentiation1.03e-011.00e+003.2051692
GO:0006364rRNA processing1.05e-011.00e+003.1741694
GO:0014069postsynaptic density1.17e-011.00e+003.01413105
GO:0005506iron ion binding1.17e-011.00e+003.01414105
GO:0072562blood microparticle1.23e-011.00e+002.93413111
GO:0030529ribonucleoprotein complex1.24e-011.00e+002.92118112
GO:0005635nuclear envelope1.25e-011.00e+002.90816113
GO:0005737cytoplasm1.29e-011.00e+000.65771103767
GO:0044237cellular metabolic process1.29e-011.00e+002.85815117
GO:0006325chromatin organization1.30e-011.00e+002.84615118
GO:0006511ubiquitin-dependent protein catabolic process1.39e-011.00e+002.75115126
GO:0009615response to virus1.39e-011.00e+002.75115126
GO:0000790nuclear chromatin1.42e-011.00e+002.71719129
GO:0006457protein folding1.56e-011.00e+002.56917143
GO:0061024membrane organization1.58e-011.00e+002.54917145
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.78e-011.00e+002.36217165
GO:0030424axon1.79e-011.00e+002.35414166
GO:0004672protein kinase activity1.89e-011.00e+002.26116177
GO:0031625ubiquitin protein ligase binding1.90e-011.00e+002.253114178
GO:0003714transcription corepressor activity1.90e-011.00e+002.25318178
GO:0005759mitochondrial matrix2.37e-011.00e+001.896114228
GO:0003713transcription coactivator activity2.46e-011.00e+001.840110237
GO:0000166nucleotide binding2.65e-011.00e+001.71215259
GO:0019899enzyme binding2.81e-011.00e+001.615112277
GO:0005856cytoskeleton2.93e-011.00e+001.544112291
GO:0043234protein complex2.96e-011.00e+001.524118295
GO:0004674protein serine/threonine kinase activity3.07e-011.00e+001.462112308
GO:0007411axon guidance3.16e-011.00e+001.411113319
GO:0005813centrosome3.22e-011.00e+001.380114326
GO:0003682chromatin binding3.23e-011.00e+001.375111327
GO:0008283cell proliferation3.24e-011.00e+001.371114328
GO:0007155cell adhesion3.57e-011.00e+001.20116369
GO:0046982protein heterodimerization activity3.65e-011.00e+001.159113380
GO:0008284positive regulation of cell proliferation3.67e-011.00e+001.15118382
GO:0007596blood coagulation4.20e-011.00e+000.899118455
GO:0006468protein phosphorylation4.24e-011.00e+000.883118460
GO:0003677DNA binding4.27e-011.00e+000.4782281218
GO:0046872metal ion binding4.64e-011.00e+000.3772251307
GO:0045087innate immune response5.12e-011.00e+000.509124596
GO:0005615extracellular space6.89e-011.00e+00-0.174117957
GO:0005739mitochondrion7.05e-011.00e+00-0.234128998
GO:0005886plasma membrane9.65e-011.00e+00-1.6061452582