int-snw-811

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.932 2.10e-15 2.63e-03 4.19e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-811 subnetwork

Genes (24)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
PSMA3 5684 120.5331.026218Yes-
PSMA2 5683 601.0931.10689Yes-
HNRNPC 3183 201.8121.026119Yes-
PSMB7 5695 480.9821.05257Yes-
PSMA1 5682 610.9961.052123Yes-
OGDH 4967 130.8471.076113Yes-
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-
CAD 790 170.8071.007333--
[ CALR ] 811 1-0.4180.93279-Yes
PSMD1 5707 120.8361.057113Yes-
PSMD13 5719 160.8481.029104Yes-
EEF2 1938 270.8901.043301Yes-
RPS11 6205 360.9931.113175Yes-
PSMD3 5709 570.9861.106146Yes-
EFTUD2 9343 70.8830.96978Yes-
PSMB2 5690 180.8771.026117Yes-
ACTB 60 1671.1531.151587Yes-
PSMD11 5717 1211.0951.106183Yes-
ITGAV 3685 20.5560.94937--
RAN 5901 50.6320.994175Yes-
HSPD1 3329 350.9131.035286Yes-
PSMD6 9861 110.8481.009131Yes-
PSMC1 5700 140.8401.018137Yes-

Interactions (98)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
OGDH 4967 PSMD6 9861 pp -- int.I2D: YeastLow
PSMA2 5683 PSMA3 5684 pp -- int.Intact: MI:0915(physical association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, IntAct_Fly, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, BIND_Yeast, HPRD;
int.HPRD: yeast 2-hybrid
PSMD3 5709 PSMD13 5719 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, MINT_Yeast, YeastHigh, BioGrid, BioGrid_Yeast, IntAct_Yeast, Krogan_Core
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMC1 5700 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, MINT_Yeast, BioGrid, IntAct_Yeast, Krogan_Core, YeastHigh
CAD 790 RPSA 3921 pp -- int.I2D: IntAct_Yeast
CAD 790 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast
PSMA3 5684 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, YeastLow
EEF2 1938 PGD 5226 pp -- int.I2D: BioGrid_Yeast
PSMD1 5707 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast
PSMB7 5695 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct
CALR 811 PSMA3 5684 pp -- int.I2D: BioGrid
PSMD11 5717 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, BioGrid, INTEROLOG
PSMA1 5682 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, YeastMedium
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 RPS11 6205 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
OGDH 4967 PSMC1 5700 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
PSMD11 5717 PSMD13 5719 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastHigh, BioGrid, INTEROLOG
ACTB 60 RAN 5901 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, NON_CORE
PSMA2 5683 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
HSPD1 3329 PSMA3 5684 pp -- int.I2D: BioGrid
PSMB7 5695 PSMD1 5707 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct
PSMA1 5682 PSMC1 5700 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct_Fly, YeastMedium, IntAct
PSMA3 5684 PSMD1 5707 pp -- int.I2D: BioGrid, BioGrid_Yeast
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
OGDH 4967 RAN 5901 pp -- int.I2D: YeastLow
EEF2 1938 PSMD13 5719 pp -- int.I2D: YeastLow
PSMD1 5707 PSMD13 5719 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: IntAct, MINT_Yeast, BioGrid, BioGrid_Yeast, IntAct_Yeast, Krogan_Core
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMA2 5683 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, YeastLow, BioGrid
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PGD 5226 PSMD3 5709 pp -- int.I2D: YeastLow
PSMA1 5682 PSMA3 5684 pp -- int.Intact: MI:0914(association), MI:0915(physical association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, CE_DATA, HPRD, IntAct, IntAct_Fly, IntAct_Mouse, IntAct_Worm, IntAct_Yeast, MINT_Worm, BioGrid, BioGrid_Fly, BIND_Fly, BIND_Yeast, FlyHigh, Krogan_Core, MINT_Fly, MINT_Yeast, YeastHigh, Yu_GoldStd;
int.HPRD: in vitro
PSMB2 5690 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
CAD 790 RAN 5901 pp -- int.I2D: IntAct_Yeast
PSMA2 5683 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast, IntAct_Fly, YeastLow
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
PSMB2 5690 PSMD13 5719 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMD3 5709 PSMD6 9861 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, IntAct, IntAct_Yeast, MINT_Worm, MINT_Yeast, YeastHigh, BioGrid, BIND_Yeast, IntAct_Worm, INTEROLOG, Krogan_Core, MIPS
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB2 5690 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMB2 5690 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
PSMA3 5684 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast
PSMC1 5700 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
PSMA2 5683 PSMD13 5719 pp -- int.I2D: YeastLow
ACTB 60 PSMA3 5684 pp -- int.I2D: BioGrid, BioGrid_Yeast
PSMA3 5684 EFTUD2 9343 pp -- int.I2D: BioGrid
OGDH 4967 PGD 5226 pp -- int.I2D: YeastLow
ACTB 60 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast
PSMD13 5719 PSMD6 9861 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, BioGrid_Yeast, IntAct, IntAct_Yeast, MINT_Yeast, YeastHigh, Krogan_Core
RAN 5901 RPS11 6205 pp -- int.I2D: IntAct_Worm, BioGrid_Worm, BIND_Worm, MINT_Worm, NON_CORE
PSMA3 5684 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
PSMD1 5707 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, IntAct, Krogan_Core
PSMC1 5700 PSMD13 5719 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, MINT_Yeast, YeastHigh, BioGrid, IntAct_Yeast, Krogan_Core
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMA2 5683 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
PSMB2 5690 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct
PSMC1 5700 PSMD1 5707 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, Krogan_Core, MINT_Yeast
RPSA 3921 RAN 5901 pp -- int.I2D: IntAct_Worm, BioGrid_Worm, BIND_Worm, CORE_2, MINT_Worm
CALR 811 RAN 5901 pp -- int.I2D: IntAct_Worm, BioGrid_Worm, BIND_Worm, CORE_2, MINT_Worm
PSMB2 5690 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMB7 5695 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast
PGD 5226 RAN 5901 pp -- int.I2D: YeastLow
ACTB 60 CAD 790 pp -- int.I2D: IntAct_Yeast
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
EEF2 1938 HSPD1 3329 pp -- int.I2D: YeastLow, YeastMedium
PSMD1 5707 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, Krogan_Core
EEF2 1938 PSMA3 5684 pp -- int.I2D: BioGrid
HSPD1 3329 RPSA 3921 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
PSMA3 5684 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, Krogan_Core
ACTB 60 EEF2 1938 pp -- int.I2D: YeastLow, IntAct_Yeast
OGDH 4967 PSMD11 5717 pp -- int.I2D: YeastLow
PSMA2 5683 PSMB2 5690 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core
PSMA3 5684 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
OGDH 4967 PSMD13 5719 pp -- int.I2D: YeastLow
PSMB2 5690 PSMD6 9861 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMA1 5682 PSMB2 5690 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
PSMA1 5682 PSMD13 5719 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: IntAct, YeastMedium, BioGrid, BioGrid_Yeast, IntAct_Yeast
PSMA2 5683 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMA1 5682 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
HNRNPC 3183 PSMA3 5684 pp -- int.I2D: BioGrid
ACTB 60 PSMD6 9861 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMA3 5684 PSMD13 5719 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: IntAct, BioGrid
OGDH 4967 PSMD3 5709 pp -- int.I2D: YeastLow
PSMC1 5700 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, YeastHigh, Krogan_Core
EEF2 1938 PSMD3 5709 pp -- int.I2D: Krogan_NonCore
CALR 811 ITGAV 3685 pp -- int.I2D: HPRD, BCI;
int.HPRD: in vitro, in vivo
ACTB 60 HSPD1 3329 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, YeastLow
HSPD1 3329 OGDH 4967 pp -- int.I2D: YeastLow
ACTB 60 PSMD13 5719 pp -- int.I2D: BioGrid_Yeast
PSMA3 5684 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast, IntAct_Mouse, MINT_Yeast, YeastLow, Krogan_Core

Related GO terms (372)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent9.09e-251.31e-206.762132072
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I1.62e-242.34e-206.703132075
GO:0002474antigen processing and presentation of peptide antigen via MHC class I2.82e-234.07e-196.408132192
GO:0006521regulation of cellular amino acid metabolic process6.44e-229.29e-187.047111750
GO:0000502proteasome complex3.90e-215.62e-176.833111758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.27e-201.83e-166.691111964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.52e-202.20e-166.668112265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.67e-205.29e-166.561112270
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle7.06e-201.02e-156.481112274
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.52e-192.19e-156.387112379
GO:0042981regulation of apoptotic process2.49e-183.59e-145.5871224150
GO:0016071mRNA metabolic process4.36e-186.30e-145.1311331223
GO:0010467gene expression4.46e-186.44e-143.9331759669
GO:0034641cellular nitrogen compound metabolic process1.25e-171.80e-135.3981220171
GO:0000209protein polyubiquitination1.28e-171.85e-135.8331120116
GO:0016070RNA metabolic process1.68e-172.42e-134.9831332247
GO:0000082G1/S transition of mitotic cell cycle2.19e-163.16e-125.4711132149
GO:0016032viral process2.67e-163.85e-124.0771555534
GO:0070062extracellular vesicular exosome4.96e-147.15e-102.395211042400
GO:0005829cytosol1.11e-131.60e-092.338211322496
GO:0022624proteasome accessory complex1.32e-131.90e-097.7296817
GO:0043066negative regulation of apoptotic process7.02e-131.01e-084.0881231424
GO:0005838proteasome regulatory particle6.43e-129.27e-087.9685712
GO:0005654nucleoplasm8.39e-121.21e-073.05915761082
GO:0000278mitotic cell cycle9.20e-121.33e-074.0801148391
GO:0016020membrane1.94e-112.80e-072.60317901681
GO:0044281small molecule metabolic process4.23e-116.11e-072.89615581211
GO:0005839proteasome core complex6.91e-119.96e-077.3835818
GO:0004298threonine-type endopeptidase activity9.36e-111.35e-067.3055819
GO:0006915apoptotic process3.93e-105.67e-063.5741133555
GO:0019773proteasome core complex, alpha-subunit complex2.25e-073.25e-037.816348
GO:0005844polysome7.01e-061.01e-016.2933423
GO:0044822poly(A) RNA binding2.79e-054.03e-012.3579491056
GO:0005634nucleus9.07e-051.00e+001.164171364559
GO:0051087chaperone binding1.24e-041.00e+004.9333659
GO:0030234enzyme regulator activity2.05e-041.00e+006.5312313
GO:0042176regulation of protein catabolic process3.14e-041.00e+006.2312316
GO:0006414translational elongation4.76e-041.00e+004.27731393
GO:0033574response to testosterone6.01e-041.00e+005.7722222
GO:0043044ATP-dependent chromatin remodeling6.57e-041.00e+005.7082423
GO:0006611protein export from nucleus7.78e-041.00e+005.5872325
GO:0019058viral life cycle8.85e-041.00e+003.971313115
GO:0031492nucleosomal DNA binding9.08e-041.00e+005.4762427
GO:0044267cellular protein metabolic process9.51e-041.00e+002.664529474
GO:0043234protein complex1.32e-031.00e+003.027418295
GO:0016887ATPase activity1.56e-031.00e+003.68737140
GO:0002842positive regulation of T cell mediated immune response to tumor cell1.66e-031.00e+009.231111
GO:0002502peptide antigen assembly with MHC class I protein complex1.66e-031.00e+009.231111
GO:0035867alphav-beta3 integrin-IGF-1-IGF1R complex1.66e-031.00e+009.231111
GO:0048291isotype switching to IgG isotypes1.66e-031.00e+009.231111
GO:0004088carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity1.66e-031.00e+009.231111
GO:0034602oxoglutarate dehydrogenase (NAD+) activity1.66e-031.00e+009.231111
GO:0070335aspartate binding1.66e-031.00e+009.231111
GO:0052066entry of symbiont into host cell by promotion of host phagocytosis1.66e-031.00e+009.231111
GO:2000425regulation of apoptotic cell clearance1.66e-031.00e+009.231111
GO:0004151dihydroorotase activity1.66e-031.00e+009.231111
GO:0019521D-gluconate metabolic process1.66e-031.00e+009.231111
GO:0004070aspartate carbamoyltransferase activity1.66e-031.00e+009.231111
GO:2000536negative regulation of entry of bacterium into host cell1.66e-031.00e+009.231111
GO:0002368B cell cytokine production1.66e-031.00e+009.231111
GO:0050681androgen receptor binding1.80e-031.00e+004.9832338
GO:0022627cytosolic small ribosomal subunit1.89e-031.00e+004.9462439
GO:0005925focal adhesion2.90e-031.00e+002.715419366
GO:0034683integrin alphav-beta3 complex3.33e-031.00e+008.231112
GO:0045252oxoglutarate dehydrogenase complex3.33e-031.00e+008.231122
GO:0034686integrin alphav-beta8 complex3.33e-031.00e+008.231112
GO:0006407rRNA export from nucleus3.33e-031.00e+008.231112
GO:0042824MHC class I peptide loading complex3.33e-031.00e+008.231112
GO:0001846opsonin binding3.33e-031.00e+008.231112
GO:1990430extracellular matrix protein binding3.33e-031.00e+008.231112
GO:0061034olfactory bulb mitral cell layer development3.33e-031.00e+008.231112
GO:0033144negative regulation of intracellular steroid hormone receptor signaling pathway3.33e-031.00e+008.231112
GO:0050748negative regulation of lipoprotein metabolic process3.33e-031.00e+008.231112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.33e-031.00e+008.231112
GO:0019322pentose biosynthetic process3.33e-031.00e+008.231122
GO:0005055laminin receptor activity3.33e-031.00e+008.231112
GO:0034684integrin alphav-beta5 complex3.33e-031.00e+008.231112
GO:0007127meiosis I3.33e-031.00e+008.231112
GO:0070409carbamoyl phosphate biosynthetic process3.33e-031.00e+008.231112
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3.47e-031.00e+004.5032553
GO:0005515protein binding3.79e-031.00e+000.762171846024
GO:0003924GTPase activity4.11e-031.00e+003.194312197
GO:0004591oxoglutarate dehydrogenase (succinyl-transferring) activity4.98e-031.00e+007.646113
GO:0022028tangential migration from the subventricular zone to the olfactory bulb4.98e-031.00e+007.646113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity4.98e-031.00e+007.646113
GO:0045715negative regulation of low-density lipoprotein particle receptor biosynthetic process4.98e-031.00e+007.646113
GO:0006458'de novo' protein folding4.98e-031.00e+007.646113
GO:0000056ribosomal small subunit export from nucleus4.98e-031.00e+007.646113
GO:0009051pentose-phosphate shunt, oxidative branch4.98e-031.00e+007.646123
GO:0030135coated vesicle4.98e-031.00e+007.646113
GO:0044205'de novo' UMP biosynthetic process4.98e-031.00e+007.646113
GO:0006207'de novo' pyrimidine nucleobase biosynthetic process4.98e-031.00e+007.646113
GO:0006184GTP catabolic process5.18e-031.00e+003.075312214
GO:0006412translation6.33e-031.00e+002.971320230
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)6.64e-031.00e+007.231114
GO:003068690S preribosome6.64e-031.00e+007.231114
GO:0038027apolipoprotein A-I-mediated signaling pathway6.64e-031.00e+007.231114
GO:0006104succinyl-CoA metabolic process6.64e-031.00e+007.231114
GO:0006543glutamine catabolic process6.64e-031.00e+007.231114
GO:0000055ribosomal large subunit export from nucleus6.64e-031.00e+007.231114
GO:0032369negative regulation of lipid transport6.64e-031.00e+007.231114
GO:0051208sequestering of calcium ion6.64e-031.00e+007.231114
GO:0006734NADH metabolic process6.64e-031.00e+007.231114
GO:2000510positive regulation of dendritic cell chemotaxis6.64e-031.00e+007.231114
GO:0071013catalytic step 2 spliceosome7.38e-031.00e+003.9462478
GO:0019083viral transcription7.94e-031.00e+003.89121081
GO:0051414response to cortisol8.29e-031.00e+006.909115
GO:0043248proteasome assembly8.29e-031.00e+006.909115
GO:0046696lipopolysaccharide receptor complex8.29e-031.00e+006.909115
GO:0030976thiamine pyrophosphate binding8.29e-031.00e+006.909115
GO:0005681spliceosomal complex8.32e-031.00e+003.8562483
GO:0006415translational termination9.11e-031.00e+003.78821087
GO:0050821protein stabilization9.31e-031.00e+003.7722288
GO:0003688DNA replication origin binding9.94e-031.00e+006.646126
GO:0021860pyramidal neuron development9.94e-031.00e+006.646116
GO:0021695cerebellar cortex development9.94e-031.00e+006.646126
GO:0030957Tat protein binding9.94e-031.00e+006.646136
GO:0046134pyrimidine nucleoside biosynthetic process9.94e-031.00e+006.646116
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex9.94e-031.00e+006.646116
GO:0050764regulation of phagocytosis9.94e-031.00e+006.646116
GO:0040020regulation of meiosis9.94e-031.00e+006.646116
GO:0001649osteoblast differentiation1.01e-021.00e+003.7082692
GO:0051082unfolded protein binding1.04e-021.00e+003.6922593
GO:0033018sarcoplasmic reticulum lumen1.16e-021.00e+006.424117
GO:0033690positive regulation of osteoblast proliferation1.16e-021.00e+006.424117
GO:0042921glucocorticoid receptor signaling pathway1.16e-021.00e+006.424117
GO:0001849complement component C1q binding1.16e-021.00e+006.424117
GO:0000028ribosomal small subunit assembly1.16e-021.00e+006.424117
GO:0010888negative regulation of lipid storage1.16e-021.00e+006.424127
GO:0031994insulin-like growth factor I binding1.16e-021.00e+006.424117
GO:0006200ATP catabolic process1.21e-021.00e+002.626315292
GO:0006614SRP-dependent cotranslational protein targeting to membrane1.28e-021.00e+003.531210104
GO:0044183protein binding involved in protein folding1.32e-021.00e+006.231118
GO:0048387negative regulation of retinoic acid receptor signaling pathway1.32e-021.00e+006.231128
GO:0070688MLL5-L complex1.32e-021.00e+006.231118
GO:0006554lysine catabolic process1.32e-021.00e+006.231128
GO:0051604protein maturation1.32e-021.00e+006.231118
GO:0005525GTP binding1.42e-021.00e+002.540312310
GO:0005730nucleolus1.47e-021.00e+001.3587691641
GO:0030529ribonucleoprotein complex1.48e-021.00e+003.42428112
GO:0014075response to amine1.49e-021.00e+006.061119
GO:0008494translation activator activity1.49e-021.00e+006.061119
GO:0006228UTP biosynthetic process1.49e-021.00e+006.061119
GO:0031000response to caffeine1.49e-021.00e+006.061129
GO:0022417protein maturation by protein folding1.49e-021.00e+006.061119
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.53e-021.00e+003.398211114
GO:0006098pentose-phosphate shunt1.65e-021.00e+005.9091410
GO:0043032positive regulation of macrophage activation1.65e-021.00e+005.9091110
GO:0021756striatum development1.65e-021.00e+005.9091110
GO:0032727positive regulation of interferon-alpha production1.82e-021.00e+005.7721111
GO:0045120pronucleus1.82e-021.00e+005.7721211
GO:0021794thalamus development1.82e-021.00e+005.7721111
GO:0009615response to virus1.84e-021.00e+003.25425126
GO:0000790nuclear chromatin1.93e-021.00e+003.22029129
GO:00709353'-UTR-mediated mRNA stabilization1.98e-021.00e+005.6461212
GO:0006413translational initiation1.98e-021.00e+003.198217131
GO:0010745negative regulation of macrophage derived foam cell differentiation2.14e-021.00e+005.5311213
GO:0043277apoptotic cell clearance2.14e-021.00e+005.5311113
GO:0001530lipopolysaccharide binding2.14e-021.00e+005.5311313
GO:0008266poly(U) RNA binding2.14e-021.00e+005.5311113
GO:0051131chaperone-mediated protein complex assembly2.14e-021.00e+005.5311113
GO:0003735structural constituent of ribosome2.16e-021.00e+003.133210137
GO:0035267NuA4 histone acetyltransferase complex2.31e-021.00e+005.4241414
GO:0071285cellular response to lithium ion2.31e-021.00e+005.4241214
GO:0006457protein folding2.34e-021.00e+003.07127143
GO:0010628positive regulation of gene expression2.43e-021.00e+003.04125146
GO:0042026protein refolding2.47e-021.00e+005.3241215
GO:0031528microvillus membrane2.47e-021.00e+005.3241115
GO:0050431transforming growth factor beta binding2.47e-021.00e+005.3241115
GO:0042562hormone binding2.63e-021.00e+005.2311116
GO:0031258lamellipodium membrane2.63e-021.00e+005.2311216
GO:0071682endocytic vesicle lumen2.63e-021.00e+005.2311116
GO:0050998nitric-oxide synthase binding2.63e-021.00e+005.2311116
GO:00061032-oxoglutarate metabolic process2.63e-021.00e+005.2311116
GO:0031589cell-substrate adhesion2.63e-021.00e+005.2311116
GO:0031527filopodium membrane2.79e-021.00e+005.1441117
GO:0010243response to organonitrogen compound2.79e-021.00e+005.1441317
GO:0017025TBP-class protein binding2.79e-021.00e+005.1441317
GO:0006541glutamine metabolic process2.79e-021.00e+005.1441117
GO:0050919negative chemotaxis2.79e-021.00e+005.1441117
GO:0003746translation elongation factor activity2.79e-021.00e+005.1441317
GO:0070371ERK1 and ERK2 cascade2.79e-021.00e+005.1441117
GO:0075733intracellular transport of virus2.79e-021.00e+005.1441317
GO:0050870positive regulation of T cell activation2.79e-021.00e+005.1441117
GO:0009986cell surface2.82e-021.00e+002.165311402
GO:0046718viral entry into host cell2.95e-021.00e+005.0611218
GO:0050840extracellular matrix binding2.95e-021.00e+005.0611118
GO:0090398cellular senescence2.95e-021.00e+005.0611118
GO:0055007cardiac muscle cell differentiation2.95e-021.00e+005.0611118
GO:0017144drug metabolic process2.95e-021.00e+005.0611118
GO:0000398mRNA splicing, via spliceosome3.01e-021.00e+002.87428164
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding3.04e-021.00e+002.86527165
GO:0006259DNA metabolic process3.12e-021.00e+004.9831219
GO:0048863stem cell differentiation3.12e-021.00e+004.9831119
GO:0032733positive regulation of interleukin-10 production3.12e-021.00e+004.9831119
GO:0034113heterotypic cell-cell adhesion3.12e-021.00e+004.9831119
GO:0030866cortical actin cytoskeleton organization3.12e-021.00e+004.9831119
GO:0042100B cell proliferation3.44e-021.00e+004.8391121
GO:0071364cellular response to epidermal growth factor stimulus3.44e-021.00e+004.8391121
GO:0009897external side of plasma membrane3.46e-021.00e+002.76423177
GO:0005790smooth endoplasmic reticulum3.60e-021.00e+004.7721122
GO:0006206pyrimidine nucleobase metabolic process3.60e-021.00e+004.7721222
GO:0045787positive regulation of cell cycle3.60e-021.00e+004.7721122
GO:0030863cortical cytoskeleton3.60e-021.00e+004.7721122
GO:0036464cytoplasmic ribonucleoprotein granule3.60e-021.00e+004.7721422
GO:0007052mitotic spindle organization3.60e-021.00e+004.7721222
GO:1900026positive regulation of substrate adhesion-dependent cell spreading3.76e-021.00e+004.7081223
GO:0050766positive regulation of phagocytosis3.76e-021.00e+004.7081123
GO:0043236laminin binding3.76e-021.00e+004.7081123
GO:0008305integrin complex3.76e-021.00e+004.7081123
GO:0001968fibronectin binding4.08e-021.00e+004.5871225
GO:0071556integral component of lumenal side of endoplasmic reticulum membrane4.08e-021.00e+004.5871125
GO:0042113B cell activation4.08e-021.00e+004.5871225
GO:0032735positive regulation of interleukin-12 production4.08e-021.00e+004.5871125
GO:0035987endodermal cell differentiation4.24e-021.00e+004.5311126
GO:0003730mRNA 3'-UTR binding4.24e-021.00e+004.5311226
GO:0050661NADP binding4.40e-021.00e+004.4761227
GO:0019843rRNA binding4.40e-021.00e+004.4761327
GO:0043022ribosome binding4.40e-021.00e+004.4761327
GO:0006099tricarboxylic acid cycle4.56e-021.00e+004.4241428
GO:0034504protein localization to nucleus4.56e-021.00e+004.4241228
GO:0019894kinesin binding4.56e-021.00e+004.4241128
GO:0001618virus receptor activity4.72e-021.00e+004.3731129
GO:0061077chaperone-mediated protein folding5.04e-021.00e+004.2771231
GO:0005245voltage-gated calcium channel activity5.20e-021.00e+004.2311132
GO:0031072heat shock protein binding5.35e-021.00e+004.1871133
GO:0045335phagocytic vesicle5.35e-021.00e+004.1871233
GO:0005759mitochondrial matrix5.47e-021.00e+002.398214228
GO:0008380RNA splicing5.47e-021.00e+002.398211228
GO:0001895retina homeostasis5.51e-021.00e+004.1441134
GO:0097192extrinsic apoptotic signaling pathway in absence of ligand5.67e-021.00e+004.1021335
GO:2001237negative regulation of extrinsic apoptotic signaling pathway5.67e-021.00e+004.1021135
GO:0042277peptide binding5.67e-021.00e+004.1021335
GO:0034332adherens junction organization5.83e-021.00e+004.0611136
GO:0034446substrate adhesion-dependent cell spreading5.83e-021.00e+004.0611236
GO:0045740positive regulation of DNA replication5.83e-021.00e+004.0611236
GO:0032755positive regulation of interleukin-6 production5.83e-021.00e+004.0611236
GO:0051084'de novo' posttranslational protein folding5.98e-021.00e+004.0221437
GO:0018107peptidyl-threonine phosphorylation5.98e-021.00e+004.0221437
GO:0021766hippocampus development6.14e-021.00e+003.9831438
GO:0006096glycolytic process6.14e-021.00e+003.9831438
GO:0032092positive regulation of protein binding6.14e-021.00e+003.9831338
GO:0070527platelet aggregation6.14e-021.00e+003.9831238
GO:0032729positive regulation of interferon-gamma production6.30e-021.00e+003.9461239
GO:0007595lactation6.30e-021.00e+003.9461239
GO:0045785positive regulation of cell adhesion6.45e-021.00e+003.9091440
GO:0017148negative regulation of translation6.45e-021.00e+003.9091240
GO:0007286spermatid development6.61e-021.00e+003.8741141
GO:0043195terminal bouton6.61e-021.00e+003.8741141
GO:0030521androgen receptor signaling pathway6.61e-021.00e+003.8741141
GO:0042110T cell activation6.76e-021.00e+003.8391342
GO:0014070response to organic cyclic compound6.92e-021.00e+003.8051443
GO:0005080protein kinase C binding6.92e-021.00e+003.8051143
GO:0021762substantia nigra development7.08e-021.00e+003.7721244
GO:0045665negative regulation of neuron differentiation7.08e-021.00e+003.7721244
GO:0015030Cajal body7.08e-021.00e+003.7721344
GO:0045727positive regulation of translation7.08e-021.00e+003.7721344
GO:0019003GDP binding7.54e-021.00e+003.6771247
GO:0001669acrosomal vesicle7.85e-021.00e+003.6161149
GO:0016049cell growth7.85e-021.00e+003.6161149
GO:0035690cellular response to drug7.85e-021.00e+003.6161249
GO:0006091generation of precursor metabolites and energy8.00e-021.00e+003.5871350
GO:0006986response to unfolded protein8.00e-021.00e+003.5871250
GO:0031100organ regeneration8.00e-021.00e+003.5871450
GO:0005905coated pit8.00e-021.00e+003.5871350
GO:0001948glycoprotein binding8.00e-021.00e+003.5871350
GO:0003725double-stranded RNA binding8.31e-021.00e+003.5311552
GO:0045216cell-cell junction organization8.62e-021.00e+003.4761254
GO:0000932cytoplasmic mRNA processing body8.62e-021.00e+003.4761354
GO:0002244hematopoietic progenitor cell differentiation8.62e-021.00e+003.4761154
GO:0002039p53 binding8.77e-021.00e+003.4501755
GO:0031966mitochondrial membrane8.77e-021.00e+003.4501155
GO:0005643nuclear pore9.07e-021.00e+003.3981457
GO:0005840ribosome9.22e-021.00e+003.3731158
GO:0042995cell projection9.53e-021.00e+003.3241660
GO:0006987activation of signaling protein activity involved in unfolded protein response9.68e-021.00e+003.3001361
GO:0019901protein kinase binding9.69e-021.00e+001.923221317
GO:0007411axon guidance9.79e-021.00e+001.914213319
GO:0030141secretory granule9.83e-021.00e+003.2771262
GO:0003697single-stranded DNA binding1.07e-011.00e+003.1441568
GO:0034329cell junction assembly1.07e-011.00e+003.1441168
GO:0006874cellular calcium ion homeostasis1.10e-011.00e+003.1021170
GO:0003723RNA binding1.10e-011.00e+001.813220342
GO:0032587ruffle membrane1.10e-011.00e+003.1021370
GO:0055086nucleobase-containing small molecule metabolic process1.10e-011.00e+003.1021270
GO:0032355response to estradiol1.12e-011.00e+003.0811571
GO:0003729mRNA binding1.13e-011.00e+003.0611372
GO:0000785chromatin1.15e-011.00e+003.0411473
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis1.16e-011.00e+003.0221674
GO:0002020protease binding1.16e-011.00e+003.0221474
GO:0001889liver development1.21e-011.00e+002.9641477
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process1.21e-011.00e+002.9641777
GO:0007229integrin-mediated signaling pathway1.22e-011.00e+002.9461278
GO:0007565female pregnancy1.22e-011.00e+002.9461178
GO:0030968endoplasmic reticulum unfolded protein response1.24e-011.00e+002.9271479
GO:0002755MyD88-dependent toll-like receptor signaling pathway1.25e-011.00e+002.9091380
GO:0007155cell adhesion1.25e-011.00e+001.70426369
GO:0018279protein N-linked glycosylation via asparagine1.27e-011.00e+002.8911281
GO:0007160cell-matrix adhesion1.28e-011.00e+002.8741382
GO:0008284positive regulation of cell proliferation1.32e-011.00e+001.65428382
GO:0016363nuclear matrix1.41e-011.00e+002.72311291
GO:0042470melanosome1.41e-011.00e+002.7231991
GO:0006928cellular component movement1.41e-011.00e+002.7231791
GO:0005200structural constituent of cytoskeleton1.41e-011.00e+002.7231891
GO:0070588calcium ion transmembrane transport1.47e-011.00e+002.6611295
GO:0005178integrin binding1.48e-011.00e+002.6461296
GO:0005737cytoplasm1.50e-011.00e+000.52291103767
GO:0014069postsynaptic density1.61e-011.00e+002.51713105
GO:0005506iron ion binding1.61e-011.00e+002.51714105
GO:0005524ATP binding1.65e-011.00e+000.8894601298
GO:0050900leukocyte migration1.68e-011.00e+002.45011110
GO:0015630microtubule cytoskeleton1.68e-011.00e+002.45014110
GO:0072562blood microparticle1.69e-011.00e+002.43713111
GO:0007596blood coagulation1.74e-011.00e+001.401218455
GO:0044237cellular metabolic process1.78e-011.00e+002.36115117
GO:0006325chromatin organization1.79e-011.00e+002.34815118
GO:0007050cell cycle arrest1.87e-011.00e+002.27719124
GO:0006511ubiquitin-dependent protein catabolic process1.90e-011.00e+002.25415126
GO:0030335positive regulation of cell migration1.91e-011.00e+002.24217127
GO:0042802identical protein binding1.92e-011.00e+001.312220484
GO:0016477cell migration1.93e-011.00e+002.23115128
GO:0030246carbohydrate binding2.01e-011.00e+002.16511134
GO:0007507heart development2.08e-011.00e+002.11217139
GO:0005615extracellular space2.11e-011.00e+000.914317957
GO:0005788endoplasmic reticulum lumen2.15e-011.00e+002.05111145
GO:0061024membrane organization2.15e-011.00e+002.05117145
GO:0005769early endosome2.25e-011.00e+001.98312152
GO:0046777protein autophosphorylation2.32e-011.00e+001.92717158
GO:0006397mRNA processing2.35e-011.00e+001.90912160
GO:0005578proteinaceous extracellular matrix2.35e-011.00e+001.90911160
GO:0043687post-translational protein modification2.38e-011.00e+001.89115162
GO:0030424axon2.43e-011.00e+001.85614166
GO:0016607nuclear speck2.50e-011.00e+001.80513172
GO:0004672protein kinase activity2.57e-011.00e+001.76416177
GO:0031625ubiquitin protein ligase binding2.58e-011.00e+001.755114178
GO:0019904protein domain specific binding2.59e-011.00e+001.74716179
GO:0001525angiogenesis2.74e-011.00e+001.65414191
GO:0005622intracellular2.93e-011.00e+001.53816207
GO:0007067mitotic nuclear division3.17e-011.00e+001.405114227
GO:0003713transcription coactivator activity3.28e-011.00e+001.342110237
GO:0043025neuronal cell body3.37e-011.00e+001.29419245
GO:0005975carbohydrate metabolic process3.46e-011.00e+001.24819253
GO:0000166nucleotide binding3.53e-011.00e+001.21415259
GO:0007283spermatogenesis3.56e-011.00e+001.19818262
GO:0043065positive regulation of apoptotic process3.63e-011.00e+001.165110268
GO:0005743mitochondrial inner membrane3.72e-011.00e+001.11718277
GO:0019899enzyme binding3.72e-011.00e+001.117112277
GO:0007264small GTPase mediated signal transduction3.74e-011.00e+001.10714279
GO:0030198extracellular matrix organization3.79e-011.00e+001.08614283
GO:0042493response to drug3.80e-011.00e+001.081113284
GO:0005856cytoskeleton3.87e-011.00e+001.046112291
GO:0005813centrosome4.23e-011.00e+000.882114326
GO:0003682chromatin binding4.24e-011.00e+000.878111327
GO:0006508proteolysis4.72e-011.00e+000.66919378
GO:0045892negative regulation of transcription, DNA-templated5.02e-011.00e+000.541115413
GO:0008270zinc ion binding5.02e-011.00e+000.270212997
GO:0005739mitochondrion5.02e-011.00e+000.268228998
GO:0055114oxidation-reduction process5.08e-011.00e+000.517112420
GO:0045893positive regulation of transcription, DNA-templated5.55e-011.00e+000.330113478
GO:0048471perinuclear region of cytoplasm5.73e-011.00e+000.260113502
GO:0005509calcium ion binding5.94e-011.00e+000.17915531
GO:0005783endoplasmic reticulum6.11e-011.00e+000.112110556
GO:0000122negative regulation of transcription from RNA polymerase II promoter6.20e-011.00e+000.076116570
GO:0045087innate immune response6.37e-011.00e+000.012124596
GO:0005794Golgi apparatus6.46e-011.00e+00-0.022115610
GO:0046872metal ion binding6.53e-011.00e+00-0.1212251307
GO:0005887integral component of plasma membrane7.83e-011.00e+00-0.56316888
GO:0007165signal transduction7.90e-011.00e+00-0.594124907
GO:0005576extracellular region8.03e-011.00e+00-0.64814942
GO:0006355regulation of transcription, DNA-templated8.21e-011.00e+00-0.730118997
GO:0005886plasma membrane8.30e-011.00e+00-0.5183452582
GO:0003677DNA binding8.80e-011.00e+00-1.0191281218