int-snw-7407

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	1.002	3.42e-18	5.32e-04	1.28e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-7407 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
ACACB	32	5	0.656	1.002	184	Yes	-
RSL24D1	51187	36	1.300	1.020	59	Yes	-
PSMA2	5683	60	1.093	1.106	89	Yes	-
PSMC3	5702	9	0.719	1.002	255	Yes	-
RPL14	9045	42	1.250	1.113	143	Yes	-
[ VARS ]	7407	4	0.549	1.002	80	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
CFL1	1072	12	0.674	1.020	203	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (20)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
CFL1	1072	VARS	7407	pp	--	int.I2D: YeastLow
CFL1	1072	RSL24D1	51187	pp	--	int.I2D: YeastLow
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
RPSA	3921	VARS	7407	pp	--	int.I2D: IntAct_Yeast
RPSA	3921	PSMC3	5702	pp	--	int.I2D: BioGrid_Yeast
CFL1	1072	PGD	5226	pp	--	int.I2D: YeastLow
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMC3	5702	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh
PSMA2	5683	PSMC3	5702	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	PSMC3	5702	pp	--	int.I2D: BioGrid_Yeast
ACACB	32	VARS	7407	pp	--	int.I2D: IntAct_Yeast
ACACB	32	PGD	5226	pp	--	int.I2D: YeastLow
PSMC3	5702	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
PSMC3	5702	VARS	7407	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	CFL1	1072	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, MINT_Yeast, MIPS, BioGrid, BIND_Yeast, HPRD, IntAct, IntAct_Yeast, MINT, VidalHuman_core, YeastLow, Yu_GoldStd; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
ACACB	32	RPSA	3921	pp	--	int.I2D: IntAct_Yeast, YeastMedium
CFL1	1072	PSMC3	5702	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (166)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0016071	mRNA metabolic process	3.62e-07	5.22e-03	4.878	5	31	223
GO:0016070	RNA metabolic process	6.01e-07	8.67e-03	4.730	5	32	247
GO:0010467	gene expression	3.68e-06	5.31e-02	3.556	6	59	669
GO:0005829	cytosol	5.40e-06	7.79e-02	2.241	9	132	2496
GO:0006521	regulation of cellular amino acid metabolic process	6.34e-06	9.15e-02	6.298	3	17	50
GO:0000502	proteasome complex	9.95e-06	1.44e-01	6.084	3	17	58
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	1.34e-05	1.93e-01	5.942	3	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.40e-05	2.03e-01	5.919	3	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.76e-05	2.53e-01	5.812	3	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	1.91e-05	2.76e-01	5.772	3	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.08e-05	3.00e-01	5.732	3	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	2.16e-05	3.12e-01	5.713	3	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	2.53e-05	3.65e-01	5.638	3	23	79
GO:0016032	viral process	2.62e-05	3.78e-01	3.618	5	55	534
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	3.99e-05	5.76e-01	5.418	3	21	92
GO:0022624	proteasome accessory complex	7.15e-05	1.00e+00	7.269	2	8	17
GO:0000209	protein polyubiquitination	7.98e-05	1.00e+00	5.084	3	20	116
GO:0000082	G1/S transition of mitotic cell cycle	1.68e-04	1.00e+00	4.722	3	32	149
GO:0042981	regulation of apoptotic process	1.71e-04	1.00e+00	4.713	3	24	150
GO:0043066	negative regulation of apoptotic process	2.06e-04	1.00e+00	3.629	4	31	424
GO:0034641	cellular nitrogen compound metabolic process	2.52e-04	1.00e+00	4.524	3	20	171
GO:0070062	extracellular vesicular exosome	6.19e-04	1.00e+00	1.935	7	104	2400
GO:0016020	membrane	6.82e-04	1.00e+00	2.227	6	90	1681
GO:0000932	cytoplasmic mRNA processing body	7.41e-04	1.00e+00	5.602	2	3	54
GO:0019521	D-gluconate metabolic process	7.63e-04	1.00e+00	10.357	1	1	1
GO:0044281	small molecule metabolic process	1.24e-03	1.00e+00	2.437	5	58	1211
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	1.39e-03	1.00e+00	5.147	2	6	74
GO:0004832	valine-tRNA ligase activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:2001295	malonyl-CoA biosynthetic process	1.52e-03	1.00e+00	9.357	1	1	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.52e-03	1.00e+00	9.357	1	1	2
GO:0003989	acetyl-CoA carboxylase activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0019322	pentose biosynthetic process	1.52e-03	1.00e+00	9.357	1	2	2
GO:0005055	laminin receptor activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0006407	rRNA export from nucleus	1.52e-03	1.00e+00	9.357	1	1	2
GO:0006438	valyl-tRNA aminoacylation	1.52e-03	1.00e+00	9.357	1	1	2
GO:0019083	viral transcription	1.66e-03	1.00e+00	5.017	2	10	81
GO:0006415	translational termination	1.91e-03	1.00e+00	4.914	2	10	87
GO:0006414	translational elongation	2.18e-03	1.00e+00	4.817	2	13	93
GO:0001842	neural fold formation	2.29e-03	1.00e+00	8.772	1	1	3
GO:0006084	acetyl-CoA metabolic process	2.29e-03	1.00e+00	8.772	1	1	3
GO:0009051	pentose-phosphate shunt, oxidative branch	2.29e-03	1.00e+00	8.772	1	2	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	2.29e-03	1.00e+00	8.772	1	1	3
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	2.71e-03	1.00e+00	4.656	2	10	104
GO:0000278	mitotic cell cycle	2.77e-03	1.00e+00	3.331	3	48	391
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3.05e-03	1.00e+00	8.357	1	1	4
GO:0030686	90S preribosome	3.05e-03	1.00e+00	8.357	1	1	4
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	3.25e-03	1.00e+00	4.524	2	11	114
GO:0019058	viral life cycle	3.31e-03	1.00e+00	4.511	2	13	115
GO:0043248	proteasome assembly	3.81e-03	1.00e+00	8.035	1	1	5
GO:0004075	biotin carboxylase activity	3.81e-03	1.00e+00	8.035	1	1	5
GO:0009374	biotin binding	3.81e-03	1.00e+00	8.035	1	1	5
GO:0009615	response to virus	3.96e-03	1.00e+00	4.379	2	5	126
GO:0006413	translational initiation	4.27e-03	1.00e+00	4.323	2	17	131
GO:0030957	Tat protein binding	4.57e-03	1.00e+00	7.772	1	3	6
GO:0030836	positive regulation of actin filament depolymerization	4.57e-03	1.00e+00	7.772	1	2	6
GO:0003735	structural constituent of ribosome	4.66e-03	1.00e+00	4.259	2	10	137
GO:0044267	cellular protein metabolic process	4.78e-03	1.00e+00	3.053	3	29	474
GO:0000028	ribosomal small subunit assembly	5.33e-03	1.00e+00	7.549	1	1	7
GO:0002161	aminoacyl-tRNA editing activity	5.33e-03	1.00e+00	7.549	1	2	7
GO:0019773	proteasome core complex, alpha-subunit complex	6.09e-03	1.00e+00	7.357	1	4	8
GO:0006853	carnitine shuttle	6.09e-03	1.00e+00	7.357	1	1	8
GO:0031325	positive regulation of cellular metabolic process	6.09e-03	1.00e+00	7.357	1	1	8
GO:0070688	MLL5-L complex	6.09e-03	1.00e+00	7.357	1	1	8
GO:0030042	actin filament depolymerization	6.09e-03	1.00e+00	7.357	1	2	8
GO:0005654	nucleoplasm	6.78e-03	1.00e+00	2.277	4	76	1082
GO:0006450	regulation of translational fidelity	6.85e-03	1.00e+00	7.187	1	2	9
GO:0006768	biotin metabolic process	6.85e-03	1.00e+00	7.187	1	1	9
GO:0006915	apoptotic process	7.42e-03	1.00e+00	2.825	3	33	555
GO:0006098	pentose-phosphate shunt	7.60e-03	1.00e+00	7.035	1	4	10
GO:0061001	regulation of dendritic spine morphogenesis	8.36e-03	1.00e+00	6.897	1	2	11
GO:0005838	proteasome regulatory particle	9.12e-03	1.00e+00	6.772	1	7	12
GO:0042273	ribosomal large subunit biogenesis	9.87e-03	1.00e+00	6.656	1	4	13
GO:0035267	NuA4 histone acetyltransferase complex	1.06e-02	1.00e+00	6.549	1	4	14
GO:0050998	nitric-oxide synthase binding	1.21e-02	1.00e+00	6.357	1	1	16
GO:0031258	lamellipodium membrane	1.21e-02	1.00e+00	6.357	1	2	16
GO:0022604	regulation of cell morphogenesis	1.21e-02	1.00e+00	6.357	1	1	16
GO:0006412	translation	1.27e-02	1.00e+00	3.511	2	20	230
GO:0005524	ATP binding	1.29e-02	1.00e+00	2.015	4	60	1298
GO:1903506	regulation of nucleic acid-templated transcription	1.36e-02	1.00e+00	6.187	1	1	18
GO:0005839	proteasome core complex	1.36e-02	1.00e+00	6.187	1	8	18
GO:0048863	stem cell differentiation	1.44e-02	1.00e+00	6.109	1	1	19
GO:0004298	threonine-type endopeptidase activity	1.44e-02	1.00e+00	6.109	1	8	19
GO:0030010	establishment of cell polarity	1.59e-02	1.00e+00	5.964	1	2	21
GO:0000281	mitotic cytokinesis	1.59e-02	1.00e+00	5.964	1	1	21
GO:0030863	cortical cytoskeleton	1.67e-02	1.00e+00	5.897	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.67e-02	1.00e+00	5.897	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.74e-02	1.00e+00	5.833	1	4	23
GO:0030864	cortical actin cytoskeleton	1.74e-02	1.00e+00	5.833	1	1	23
GO:0043236	laminin binding	1.74e-02	1.00e+00	5.833	1	1	23
GO:0043200	response to amino acid	1.74e-02	1.00e+00	5.833	1	1	23
GO:0043022	ribosome binding	2.04e-02	1.00e+00	5.602	1	3	27
GO:0050661	NADP binding	2.04e-02	1.00e+00	5.602	1	2	27
GO:0031492	nucleosomal DNA binding	2.04e-02	1.00e+00	5.602	1	4	27
GO:0001755	neural crest cell migration	2.12e-02	1.00e+00	5.549	1	2	28
GO:0019894	kinesin binding	2.12e-02	1.00e+00	5.549	1	1	28
GO:0042254	ribosome biogenesis	2.27e-02	1.00e+00	5.450	1	1	30
GO:0007411	axon guidance	2.35e-02	1.00e+00	3.039	2	13	319
GO:1903507	negative regulation of nucleic acid-templated transcription	2.41e-02	1.00e+00	5.357	1	2	32
GO:0006633	fatty acid biosynthetic process	2.41e-02	1.00e+00	5.357	1	3	32
GO:0001895	retina homeostasis	2.56e-02	1.00e+00	5.269	1	1	34
GO:0034332	adherens junction organization	2.71e-02	1.00e+00	5.187	1	1	36
GO:0051084	'de novo' posttranslational protein folding	2.79e-02	1.00e+00	5.147	1	4	37
GO:0070527	platelet aggregation	2.86e-02	1.00e+00	5.109	1	2	38
GO:0005634	nucleus	2.89e-02	1.00e+00	1.010	7	136	4559
GO:0022627	cytosolic small ribosomal subunit	2.94e-02	1.00e+00	5.071	1	4	39
GO:0005925	focal adhesion	3.04e-02	1.00e+00	2.841	2	19	366
GO:0006418	tRNA aminoacylation for protein translation	3.16e-02	1.00e+00	4.964	1	9	42
GO:0014070	response to organic cyclic compound	3.23e-02	1.00e+00	4.930	1	4	43
GO:0021762	substantia nigra development	3.31e-02	1.00e+00	4.897	1	2	44
GO:0007266	Rho protein signal transduction	3.53e-02	1.00e+00	4.802	1	2	47
GO:0022625	cytosolic large ribosomal subunit	3.68e-02	1.00e+00	4.742	1	6	49
GO:0051289	protein homotetramerization	3.82e-02	1.00e+00	4.684	1	1	51
GO:0005515	protein binding	3.84e-02	1.00e+00	0.800	8	184	6024
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.97e-02	1.00e+00	4.629	1	5	53
GO:0045216	cell-cell junction organization	4.04e-02	1.00e+00	4.602	1	2	54
GO:0012505	endomembrane system	4.19e-02	1.00e+00	4.549	1	2	56
GO:0007596	blood coagulation	4.52e-02	1.00e+00	2.527	2	18	455
GO:0006767	water-soluble vitamin metabolic process	5.07e-02	1.00e+00	4.269	1	1	68
GO:0034329	cell junction assembly	5.07e-02	1.00e+00	4.269	1	1	68
GO:0032587	ruffle membrane	5.21e-02	1.00e+00	4.227	1	3	70
GO:0006766	vitamin metabolic process	5.29e-02	1.00e+00	4.207	1	1	71
GO:0002576	platelet degranulation	6.08e-02	1.00e+00	3.999	1	4	82
GO:0007010	cytoskeleton organization	6.73e-02	1.00e+00	3.849	1	1	91
GO:0016363	nuclear matrix	6.73e-02	1.00e+00	3.849	1	12	91
GO:0006928	cellular component movement	6.73e-02	1.00e+00	3.849	1	7	91
GO:0005200	structural constituent of cytoskeleton	6.73e-02	1.00e+00	3.849	1	8	91
GO:0006364	rRNA processing	6.94e-02	1.00e+00	3.802	1	6	94
GO:0006112	energy reserve metabolic process	7.01e-02	1.00e+00	3.787	1	3	95
GO:0045087	innate immune response	7.32e-02	1.00e+00	2.137	2	24	596
GO:0014069	postsynaptic density	7.73e-02	1.00e+00	3.642	1	3	105
GO:0005741	mitochondrial outer membrane	7.73e-02	1.00e+00	3.642	1	7	105
GO:0072562	blood microparticle	8.15e-02	1.00e+00	3.562	1	3	111
GO:0030529	ribonucleoprotein complex	8.22e-02	1.00e+00	3.549	1	8	112
GO:0006325	chromatin organization	8.64e-02	1.00e+00	3.474	1	5	118
GO:0030036	actin cytoskeleton organization	8.99e-02	1.00e+00	3.414	1	5	123
GO:0006511	ubiquitin-dependent protein catabolic process	9.20e-02	1.00e+00	3.379	1	5	126
GO:0000790	nuclear chromatin	9.41e-02	1.00e+00	3.345	1	9	129
GO:0031982	vesicle	9.55e-02	1.00e+00	3.323	1	9	131
GO:0044255	cellular lipid metabolic process	9.69e-02	1.00e+00	3.301	1	6	133
GO:0005911	cell-cell junction	9.90e-02	1.00e+00	3.269	1	4	136
GO:0016887	ATPase activity	1.02e-01	1.00e+00	3.227	1	7	140
GO:0006457	protein folding	1.04e-01	1.00e+00	3.197	1	7	143
GO:0061024	membrane organization	1.05e-01	1.00e+00	3.177	1	7	145
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.19e-01	1.00e+00	2.990	1	7	165
GO:0030424	axon	1.20e-01	1.00e+00	2.982	1	4	166
GO:0003714	transcription corepressor activity	1.28e-01	1.00e+00	2.881	1	8	178
GO:0030168	platelet activation	1.46e-01	1.00e+00	2.677	1	10	205
GO:0005615	extracellular space	1.63e-01	1.00e+00	1.454	2	17	957
GO:0003713	transcription coactivator activity	1.67e-01	1.00e+00	2.468	1	10	237
GO:0005739	mitochondrion	1.74e-01	1.00e+00	1.394	2	28	998
GO:0005975	carbohydrate metabolic process	1.77e-01	1.00e+00	2.374	1	9	253
GO:0003779	actin binding	1.85e-01	1.00e+00	2.301	1	12	266
GO:0044822	poly(A) RNA binding	1.90e-01	1.00e+00	1.312	2	49	1056
GO:0042493	response to drug	1.97e-01	1.00e+00	2.207	1	13	284
GO:0005856	cytoskeleton	2.01e-01	1.00e+00	2.172	1	12	291
GO:0006200	ATP catabolic process	2.02e-01	1.00e+00	2.167	1	15	292
GO:0043234	protein complex	2.03e-01	1.00e+00	2.152	1	18	295
GO:0019901	protein kinase binding	2.17e-01	1.00e+00	2.048	1	21	317
GO:0003723	RNA binding	2.32e-01	1.00e+00	1.939	1	20	342
GO:0007155	cell adhesion	2.48e-01	1.00e+00	1.829	1	6	369
GO:0055114	oxidation-reduction process	2.78e-01	1.00e+00	1.642	1	12	420
GO:0006468	protein phosphorylation	3.00e-01	1.00e+00	1.511	1	18	460
GO:0005737	cytoplasm	3.18e-01	1.00e+00	0.477	4	110	3767
GO:0046872	metal ion binding	6.48e-01	1.00e+00	0.005	1	25	1307
GO:0005730	nucleolus	7.35e-01	1.00e+00	-0.324	1	69	1641
GO:0005886	plasma membrane	8.86e-01	1.00e+00	-0.978	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-7407

Statistics

Genes (11)

Interactions (20)

Related GO terms (166)