int-snw-7167

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.925 3.78e-15 3.03e-03 4.63e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-7167 subnetwork

Genes (16)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
PSMA3 5684 120.5331.026218Yes-
PSMA2 5683 601.0931.10689Yes-
PSMC3 5702 90.7191.002255Yes-
HNRNPC 3183 201.8121.026119Yes-
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-
RSL24D1 51187 361.3001.02059Yes-
PCNA 5111 50.5530.974294Yes-
EEF2 1938 270.8901.043301Yes-
RPL14 9045 421.2501.113143Yes-
HNRNPK 3190 20.4880.938252Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
CFL1 1072 120.6741.020203Yes-
[ TPI1 ] 7167 1-0.1280.92552-Yes
POLR2B 5431 30.5870.940146Yes-

Interactions (36)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PSMA2 5683 PSMA3 5684 pp -- int.Intact: MI:0915(physical association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, IntAct_Fly, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, BIND_Yeast, HPRD;
int.HPRD: yeast 2-hybrid
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMA3 5684 TPI1 7167 pp -- int.I2D: BioGrid
PCNA 5111 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast
CFL1 1072 RSL24D1 51187 pp -- int.I2D: YeastLow
PSMC3 5702 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh
PSMC3 5702 TPI1 7167 pp -- int.I2D: BioGrid_Yeast
CFL1 1072 TPI1 7167 pp -- int.I2D: BCI, BioGrid, HPRD;
int.HPRD: in vivo
HNRNPK 3190 RPSA 3921 pp -- int.I2D: IntAct_Rat
PSMA2 5683 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast
EEF2 1938 PSMC3 5702 pp -- int.I2D: YeastLow, BioGrid_Yeast
PSMA3 5684 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
EEF2 1938 TPI1 7167 pp -- int.I2D: YeastLow
HNRNPC 3183 PSMA3 5684 pp -- int.I2D: BioGrid
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMA3 5684 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast, BioGrid, YeastLow
EEF2 1938 PGD 5226 pp -- int.I2D: BioGrid_Yeast
HNRNPK 3190 TPI1 7167 pp -- int.I2D: IntAct_Rat
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
EEF2 1938 POLR2B 5431 pp -- int.I2D: BioGrid_Yeast, YeastLow
PCNA 5111 TPI1 7167 pp -- int.I2D: BioGrid, MINT;
int.Mint: MI:0407(direct interaction), MI:0915(physical association)
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PSMC3 5702 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
ACTB 60 HNRNPK 3190 pp -- int.I2D: IntAct_Rat
RPSA 3921 PCNA 5111 pp -- int.I2D: MINT, BioGrid;
int.Mint: MI:0915(physical association)
ACTB 60 PSMA3 5684 pp -- int.I2D: BioGrid, BioGrid_Yeast
ACTB 60 CFL1 1072 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, MINT_Yeast, MIPS, BioGrid, BIND_Yeast, HPRD, IntAct, IntAct_Yeast, MINT, VidalHuman_core, YeastLow, Yu_GoldStd;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
POLR2B 5431 PSMC3 5702 pp -- int.I2D: YeastLow
EEF2 1938 PSMA3 5684 pp -- int.I2D: BioGrid
RPSA 3921 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast
ACTB 60 EEF2 1938 pp -- int.I2D: YeastLow, IntAct_Yeast
CFL1 1072 PGD 5226 pp -- int.I2D: YeastLow
POLR2B 5431 TPI1 7167 pp -- int.I2D: BioGrid_Yeast
CFL1 1072 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast

Related GO terms (221)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0010467gene expression2.68e-103.87e-063.7521059669
GO:0070062extracellular vesicular exosome2.48e-083.57e-042.288131042400
GO:0016032viral process3.32e-084.79e-043.755855534
GO:0016071mRNA metabolic process8.99e-081.30e-034.600631223
GO:0016070RNA metabolic process1.65e-072.38e-034.453632247
GO:0006521regulation of cellular amino acid metabolic process2.26e-073.25e-036.17241750
GO:0000502proteasome complex4.13e-075.96e-035.95841758
GO:0000082G1/S transition of mitotic cell cycle4.38e-076.32e-034.919532149
GO:0005654nucleoplasm5.14e-077.42e-032.9079761082
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest6.16e-078.89e-035.81641964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.56e-079.47e-035.79442265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle8.86e-071.28e-025.68742270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent9.93e-071.43e-025.64642072
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.11e-061.60e-025.60742274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I1.17e-061.69e-025.58742075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.44e-062.08e-025.51242379
GO:0016020membrane1.86e-062.68e-022.42310901681
GO:0002474antigen processing and presentation of peptide antigen via MHC class I2.66e-063.84e-025.29342192
GO:0000209protein polyubiquitination6.71e-069.68e-024.958420116
GO:0005829cytosol7.58e-061.09e-011.990111322496
GO:0042981regulation of apoptotic process1.86e-052.68e-014.587424150
GO:0034641cellular nitrogen compound metabolic process3.11e-054.48e-014.398420171
GO:0019773proteasome core complex, alpha-subunit complex3.22e-054.64e-017.816248
GO:0000278mitotic cell cycle4.87e-057.02e-013.527548391
GO:0006098pentose-phosphate shunt5.17e-057.45e-017.4942410
GO:0005634nucleus6.17e-058.90e-011.362131364559
GO:0043066negative regulation of apoptotic process7.16e-051.00e+003.410531424
GO:0006414translational elongation1.37e-041.00e+004.86231393
GO:0022624proteasome accessory complex1.55e-041.00e+006.7292817
GO:0005839proteasome core complex1.75e-041.00e+006.6462818
GO:0004298threonine-type endopeptidase activity1.95e-041.00e+006.5682819
GO:0005515protein binding2.18e-041.00e+001.067141846024
GO:0043044ATP-dependent chromatin remodeling2.88e-041.00e+006.2932423
GO:0000790nuclear chromatin3.59e-041.00e+004.39039129
GO:0031492nucleosomal DNA binding3.98e-041.00e+006.0612427
GO:0044822poly(A) RNA binding6.42e-041.00e+002.3576491056
GO:0000398mRNA splicing, via spliceosome7.25e-041.00e+004.04338164
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding7.38e-041.00e+004.03537165
GO:0043626PCNA complex1.11e-031.00e+009.816111
GO:0004807triose-phosphate isomerase activity1.11e-031.00e+009.816111
GO:0032077positive regulation of deoxyribonuclease activity1.11e-031.00e+009.816111
GO:0000701purine-specific mismatch base pair DNA N-glycosylase activity1.11e-031.00e+009.816111
GO:0019521D-gluconate metabolic process1.11e-031.00e+009.816111
GO:0019682glyceraldehyde-3-phosphate metabolic process1.11e-031.00e+009.816111
GO:0006283transcription-coupled nucleotide-excision repair1.16e-031.00e+005.2932746
GO:0044281small molecule metabolic process1.33e-031.00e+002.1596581211
GO:0044267cellular protein metabolic process1.53e-031.00e+002.927429474
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1.54e-031.00e+005.0882553
GO:0000932cytoplasmic mRNA processing body1.60e-031.00e+005.0612354
GO:0008380RNA splicing1.88e-031.00e+003.568311228
GO:0006412translation1.92e-031.00e+003.556320230
GO:0072369regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter2.22e-031.00e+008.816112
GO:0030337DNA polymerase processivity factor activity2.22e-031.00e+008.816112
GO:0070557PCNA-p21 complex2.22e-031.00e+008.816112
GO:0006272leading strand elongation2.22e-031.00e+008.816122
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.22e-031.00e+008.816112
GO:0019322pentose biosynthetic process2.22e-031.00e+008.816122
GO:0005055laminin receptor activity2.22e-031.00e+008.816112
GO:0006407rRNA export from nucleus2.22e-031.00e+008.816112
GO:0006289nucleotide-excision repair2.52e-031.00e+004.72921168
GO:0006915apoptotic process2.73e-031.00e+002.700433555
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis2.97e-031.00e+004.6072674
GO:0071013catalytic step 2 spliceosome3.30e-031.00e+004.5312478
GO:0001842neural fold formation3.32e-031.00e+008.231113
GO:0010988regulation of low-density lipoprotein particle clearance3.32e-031.00e+008.231113
GO:0009051pentose-phosphate shunt, oxidative branch3.32e-031.00e+008.231123
GO:0032139dinucleotide insertion or deletion binding3.32e-031.00e+008.231113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity3.32e-031.00e+008.231113
GO:0019083viral transcription3.55e-031.00e+004.47621081
GO:0006415translational termination4.09e-031.00e+004.37321087
GO:0045716positive regulation of low-density lipoprotein particle receptor biosynthetic process4.43e-031.00e+007.816114
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)4.43e-031.00e+007.816114
GO:003068690S preribosome4.43e-031.00e+007.816114
GO:0032549ribonucleoside binding4.43e-031.00e+007.816124
GO:0043248proteasome assembly5.54e-031.00e+007.494115
GO:0006614SRP-dependent cotranslational protein targeting to membrane5.79e-031.00e+004.116210104
GO:0003723RNA binding5.88e-031.00e+002.983320342
GO:0005663DNA replication factor C complex6.64e-031.00e+007.231116
GO:0030957Tat protein binding6.64e-031.00e+007.231136
GO:0030836positive regulation of actin filament depolymerization6.64e-031.00e+007.231126
GO:0032405MutLalpha complex binding6.64e-031.00e+007.231116
GO:0033993response to lipid6.64e-031.00e+007.231126
GO:0030529ribonucleoprotein complex6.68e-031.00e+004.00928112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay6.91e-031.00e+003.983211114
GO:0019058viral life cycle7.03e-031.00e+003.971213115
GO:0005925focal adhesion7.10e-031.00e+002.885319366
GO:0000028ribosomal small subunit assembly7.74e-031.00e+007.009117
GO:0043596nuclear replication fork7.74e-031.00e+007.009117
GO:0009615response to virus8.39e-031.00e+003.83925126
GO:0070688MLL5-L complex8.84e-031.00e+006.816118
GO:0030042actin filament depolymerization8.84e-031.00e+006.816128
GO:0070182DNA polymerase binding8.84e-031.00e+006.816128
GO:0006413translational initiation9.04e-031.00e+003.783217131
GO:0003735structural constituent of ribosome9.85e-031.00e+003.718210137
GO:0008494translation activator activity9.94e-031.00e+006.646119
GO:0019985translesion synthesis1.21e-021.00e+006.3571211
GO:0061001regulation of dendritic spine morphogenesis1.21e-021.00e+006.3571211
GO:0045120pronucleus1.21e-021.00e+006.3571211
GO:0006275regulation of DNA replication1.32e-021.00e+006.2311212
GO:00709353'-UTR-mediated mRNA stabilization1.32e-021.00e+006.2311212
GO:0005838proteasome regulatory particle1.32e-021.00e+006.2311712
GO:0042273ribosomal large subunit biogenesis1.43e-021.00e+006.1161413
GO:0048260positive regulation of receptor-mediated endocytosis1.43e-021.00e+006.1161213
GO:0008266poly(U) RNA binding1.43e-021.00e+006.1161113
GO:0035267NuA4 histone acetyltransferase complex1.54e-021.00e+006.0091414
GO:0050998nitric-oxide synthase binding1.76e-021.00e+005.8161116
GO:0005665DNA-directed RNA polymerase II, core complex1.76e-021.00e+005.8161416
GO:0002102podosome1.76e-021.00e+005.8161216
GO:0031258lamellipodium membrane1.76e-021.00e+005.8161216
GO:0022604regulation of cell morphogenesis1.76e-021.00e+005.8161116
GO:0003746translation elongation factor activity1.87e-021.00e+005.7291317
GO:1903506regulation of nucleic acid-templated transcription1.98e-021.00e+005.6461118
GO:0048863stem cell differentiation2.09e-021.00e+005.5681119
GO:0006298mismatch repair2.20e-021.00e+005.4941320
GO:0032201telomere maintenance via semi-conservative replication2.31e-021.00e+005.4241521
GO:0030010establishment of cell polarity2.31e-021.00e+005.4241221
GO:0000281mitotic cytokinesis2.31e-021.00e+005.4241121
GO:0006297nucleotide-excision repair, DNA gap filling2.41e-021.00e+005.3571322
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle2.41e-021.00e+005.3571222
GO:0046686response to cadmium ion2.41e-021.00e+005.3571222
GO:0030863cortical cytoskeleton2.41e-021.00e+005.3571122
GO:0036464cytoplasmic ribonucleoprotein granule2.41e-021.00e+005.3571422
GO:0005844polysome2.52e-021.00e+005.2931423
GO:0030864cortical actin cytoskeleton2.52e-021.00e+005.2931123
GO:0043236laminin binding2.52e-021.00e+005.2931123
GO:0043200response to amino acid2.52e-021.00e+005.2931123
GO:0003899DNA-directed RNA polymerase activity2.74e-021.00e+005.1721325
GO:0000722telomere maintenance via recombination2.74e-021.00e+005.1721525
GO:0005730nucleolus2.83e-021.00e+001.4585691641
GO:0003730mRNA 3'-UTR binding2.85e-021.00e+005.1161226
GO:0043022ribosome binding2.96e-021.00e+005.0611327
GO:0050661NADP binding2.96e-021.00e+005.0611227
GO:0001755neural crest cell migration3.06e-021.00e+005.0091228
GO:0019894kinesin binding3.06e-021.00e+005.0091128
GO:0005975carbohydrate metabolic process3.13e-021.00e+002.83329253
GO:0042254ribosome biogenesis3.28e-021.00e+004.9091130
GO:0006271DNA strand elongation involved in DNA replication3.28e-021.00e+004.9091730
GO:00063707-methylguanosine mRNA capping3.28e-021.00e+004.9091530
GO:0006281DNA repair3.31e-021.00e+002.788218261
GO:1903507negative regulation of nucleic acid-templated transcription3.49e-021.00e+004.8161232
GO:0030971receptor tyrosine kinase binding3.60e-021.00e+004.7721233
GO:0001895retina homeostasis3.71e-021.00e+004.7291134
GO:0034332adherens junction organization3.92e-021.00e+004.6461136
GO:0051084'de novo' posttranslational protein folding4.03e-021.00e+004.6071437
GO:0006284base-excision repair4.03e-021.00e+004.6071337
GO:0006096glycolytic process4.14e-021.00e+004.5681438
GO:0043234protein complex4.14e-021.00e+002.612218295
GO:0070527platelet aggregation4.14e-021.00e+004.5681238
GO:0022627cytosolic small ribosomal subunit4.24e-021.00e+004.5311439
GO:0006094gluconeogenesis4.67e-021.00e+004.3901543
GO:0019901protein kinase binding4.72e-021.00e+002.508221317
GO:0021762substantia nigra development4.77e-021.00e+004.3571244
GO:0050434positive regulation of viral transcription4.77e-021.00e+004.3571644
GO:0045727positive regulation of translation4.77e-021.00e+004.3571344
GO:0007411axon guidance4.77e-021.00e+002.499213319
GO:0007266Rho protein signal transduction5.09e-021.00e+004.2611247
GO:0022625cytosolic large ribosomal subunit5.30e-021.00e+004.2011649
GO:0002244hematopoietic progenitor cell differentiation5.83e-021.00e+004.0611154
GO:0045216cell-cell junction organization5.83e-021.00e+004.0611254
GO:0000723telomere maintenance6.04e-021.00e+004.0091656
GO:0006396RNA processing6.35e-021.00e+003.9331159
GO:0042995cell projection6.46e-021.00e+003.9091660
GO:0030855epithelial cell differentiation6.56e-021.00e+003.8851461
GO:0006368transcription elongation from RNA polymerase II promoter7.18e-021.00e+003.7501667
GO:0034329cell junction assembly7.29e-021.00e+003.7291168
GO:0003697single-stranded DNA binding7.29e-021.00e+003.7291568
GO:0032587ruffle membrane7.49e-021.00e+003.6871370
GO:0005615extracellular space8.54e-021.00e+001.499317957
GO:0002576platelet degranulation8.72e-021.00e+003.4591482
GO:0005681spliceosomal complex8.82e-021.00e+003.4411483
GO:0007596blood coagulation8.91e-021.00e+001.986218455
GO:0007010cytoskeleton organization9.64e-021.00e+003.3081191
GO:0016363nuclear matrix9.64e-021.00e+003.30811291
GO:0006928cellular component movement9.64e-021.00e+003.3081791
GO:0005200structural constituent of cytoskeleton9.64e-021.00e+003.3081891
GO:0005737cytoplasm9.70e-021.00e+000.74471103767
GO:0001649osteoblast differentiation9.74e-021.00e+003.2931692
GO:0042802identical protein binding9.90e-021.00e+001.897220484
GO:0006364rRNA processing9.94e-021.00e+003.2611694
GO:0014069postsynaptic density1.10e-011.00e+003.10213105
GO:0072562blood microparticle1.16e-011.00e+003.02213111
GO:0006006glucose metabolic process1.23e-011.00e+002.93317118
GO:0006325chromatin organization1.23e-011.00e+002.93315118
GO:0030036actin cytoskeleton organization1.28e-011.00e+002.87415123
GO:0006511ubiquitin-dependent protein catabolic process1.31e-011.00e+002.83915126
GO:0031982vesicle1.36e-011.00e+002.78319131
GO:0045087innate immune response1.40e-011.00e+001.597224596
GO:0005911cell-cell junction1.41e-011.00e+002.72914136
GO:0007507heart development1.44e-011.00e+002.69717139
GO:0016887ATPase activity1.45e-011.00e+002.68717140
GO:0006457protein folding1.47e-011.00e+002.65617143
GO:0061024membrane organization1.49e-011.00e+002.63617145
GO:0010628positive regulation of gene expression1.50e-011.00e+002.62615146
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription1.51e-011.00e+002.61613147
GO:0030424axon1.69e-011.00e+002.44114166
GO:0003714transcription corepressor activity1.80e-011.00e+002.34018178
GO:0006367transcription initiation from RNA polymerase II promoter1.86e-011.00e+002.29318184
GO:0003924GTPase activity1.98e-011.00e+002.194112197
GO:0030168platelet activation2.05e-011.00e+002.137110205
GO:0006184GTP catabolic process2.13e-011.00e+002.075112214
GO:0003713transcription coactivator activity2.33e-011.00e+001.927110237
GO:0000166nucleotide binding2.52e-011.00e+001.79915259
GO:0003779actin binding2.58e-011.00e+001.761112266
GO:0005856cytoskeleton2.78e-011.00e+001.631112291
GO:0006200ATP catabolic process2.79e-011.00e+001.626115292
GO:0005525GTP binding2.94e-011.00e+001.540112310
GO:0007275multicellular organismal development2.99e-011.00e+001.51215316
GO:0005813centrosome3.06e-011.00e+001.467114326
GO:0003682chromatin binding3.07e-011.00e+001.463111327
GO:0008283cell proliferation3.08e-011.00e+001.459114328
GO:0007155cell adhesion3.40e-011.00e+001.28916369
GO:0006366transcription from RNA polymerase II promoter3.76e-011.00e+001.105110419
GO:0055114oxidation-reduction process3.77e-011.00e+001.102112420
GO:0006468protein phosphorylation4.05e-011.00e+000.971118460
GO:0005524ATP binding4.29e-011.00e+000.4742601298
GO:0045944positive regulation of transcription from RNA polymerase II promoter5.94e-011.00e+000.192119789
GO:0007165signal transduction6.46e-011.00e+00-0.009124907
GO:0003677DNA binding7.56e-011.00e+00-0.4341281218
GO:0046872metal ion binding7.81e-011.00e+00-0.5361251307
GO:0006351transcription, DNA-templated8.16e-011.00e+00-0.6821311446
GO:0005886plasma membrane9.57e-011.00e+00-1.5181452582