int-snw-65125

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.968 8.37e-17 1.19e-03 2.34e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-65125 subnetwork

Genes (10)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
[ WNK1 ] 65125 10.0340.968184--
ACO2 50 501.0001.076191Yes-
EIF2S2 8894 271.0751.13881Yes-
NACA 4666 20.9960.96845Yes-
CLTC 1213 350.8841.138247Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
HSPD1 3329 350.9131.035286Yes-
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-

Interactions (15)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
HSPD1 3329 RPSA 3921 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ACTB 60 CLTC 1213 pp -- int.I2D: IntAct_Yeast
CLTC 1213 EIF2S2 8894 pp -- int.I2D: YeastLow
ACO2 50 WNK1 65125 pp -- int.I2D: IntAct, SOURAV_MAPK_LOW
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
CLTC 1213 WNK1 65125 pp -- int.I2D: IntAct, BioGrid, SOURAV_MAPK_HIGH
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
NACA 4666 WNK1 65125 pp -- int.I2D: IntAct, SOURAV_MAPK_LOW
ACTB 60 HSPD1 3329 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, YeastLow
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
ACO2 50 PGD 5226 pp -- int.I2D: YeastLow
HSPD1 3329 WNK1 65125 pp -- int.I2D: IntAct
ACO2 50 HSPD1 3329 pp -- int.I2D: IntAct_Yeast
ACO2 50 PSMD11 5717 pp -- int.I2D: YeastLow

Related GO terms (212)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0070062extracellular vesicular exosome2.63e-041.00e+002.07371042400
GO:0016032viral process3.27e-041.00e+003.433455534
GO:0005829cytosol3.39e-041.00e+002.01671322496
GO:0006412translation4.42e-041.00e+004.234320230
GO:0003725double-stranded RNA binding5.63e-041.00e+005.7942552
GO:0002842positive regulation of T cell mediated immune response to tumor cell6.93e-041.00e+0010.494111
GO:1901227negative regulation of transcription from RNA polymerase II promoter involved in heart development6.93e-041.00e+0010.494111
GO:0005854nascent polypeptide-associated complex6.93e-041.00e+0010.494111
GO:0048291isotype switching to IgG isotypes6.93e-041.00e+0010.494111
GO:0019521D-gluconate metabolic process6.93e-041.00e+0010.494111
GO:1901228positive regulation of transcription from RNA polymerase II promoter involved in heart development6.93e-041.00e+0010.494111
GO:0002368B cell cytokine production6.93e-041.00e+0010.494111
GO:0043234protein complex9.14e-041.00e+003.875318295
GO:0050794regulation of cellular process1.39e-031.00e+009.494112
GO:00515383 iron, 4 sulfur cluster binding1.39e-031.00e+009.494112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.39e-031.00e+009.494112
GO:0002176male germ cell proliferation1.39e-031.00e+009.494112
GO:0019322pentose biosynthetic process1.39e-031.00e+009.494122
GO:0003994aconitate hydratase activity1.39e-031.00e+009.494112
GO:0005055laminin receptor activity1.39e-031.00e+009.494112
GO:0006407rRNA export from nucleus1.39e-031.00e+009.494112
GO:0048633positive regulation of skeletal muscle tissue growth1.39e-031.00e+009.494112
GO:0005850eukaryotic translation initiation factor 2 complex2.08e-031.00e+008.909113
GO:1900126negative regulation of hyaluronan biosynthetic process2.08e-031.00e+008.909123
GO:0006458'de novo' protein folding2.08e-031.00e+008.909113
GO:0090188negative regulation of pancreatic juice secretion2.08e-031.00e+008.909113
GO:0061384heart trabecula morphogenesis2.08e-031.00e+008.909113
GO:0003231cardiac ventricle development2.08e-031.00e+008.909113
GO:0009051pentose-phosphate shunt, oxidative branch2.08e-031.00e+008.909123
GO:0030135coated vesicle2.08e-031.00e+008.909113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.08e-031.00e+008.909113
GO:0071439clathrin complex2.08e-031.00e+008.909123
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.77e-031.00e+008.494114
GO:003068690S preribosome2.77e-031.00e+008.494114
GO:0032051clathrin light chain binding2.77e-031.00e+008.494114
GO:2000138positive regulation of cell proliferation involved in heart morphogenesis2.77e-031.00e+008.494114
GO:1903077negative regulation of protein localization to plasma membrane2.77e-031.00e+008.494114
GO:0010664negative regulation of striated muscle cell apoptotic process2.77e-031.00e+008.494114
GO:0016020membrane3.25e-031.00e+002.1015901681
GO:0048742regulation of skeletal muscle fiber development3.46e-031.00e+008.172115
GO:0043248proteasome assembly3.46e-031.00e+008.172115
GO:0046696lipopolysaccharide receptor complex3.46e-031.00e+008.172115
GO:0006102isocitrate metabolic process3.46e-031.00e+008.172115
GO:0006413translational initiation3.51e-031.00e+004.461217131
GO:0044267cellular protein metabolic process3.56e-031.00e+003.190329474
GO:0003688DNA replication origin binding4.15e-031.00e+007.909126
GO:0030130clathrin coat of trans-Golgi network vesicle4.15e-031.00e+007.909136
GO:0030957Tat protein binding4.15e-031.00e+007.909136
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex4.15e-031.00e+007.909116
GO:0006101citrate metabolic process4.15e-031.00e+007.909116
GO:0030118clathrin coat4.15e-031.00e+007.909126
GO:0044822poly(A) RNA binding4.19e-031.00e+002.4504491056
GO:0061024membrane organization4.28e-031.00e+004.31427145
GO:0030132clathrin coat of coated pit4.84e-031.00e+007.687127
GO:0000028ribosomal small subunit assembly4.84e-031.00e+007.687117
GO:0003084positive regulation of systemic arterial blood pressure4.84e-031.00e+007.687117
GO:0070688MLL5-L complex5.53e-031.00e+007.494118
GO:0051604protein maturation5.53e-031.00e+007.494118
GO:0019869chloride channel inhibitor activity6.22e-031.00e+007.324119
GO:0006098pentose-phosphate shunt6.91e-031.00e+007.1721410
GO:0043032positive regulation of macrophage activation6.91e-031.00e+007.1721110
GO:0032727positive regulation of interferon-alpha production7.60e-031.00e+007.0351111
GO:0043403skeletal muscle tissue regeneration7.60e-031.00e+007.0351211
GO:0005838proteasome regulatory particle8.29e-031.00e+006.9091712
GO:0001530lipopolysaccharide binding8.98e-031.00e+006.7941313
GO:0051131chaperone-mediated protein complex assembly8.98e-031.00e+006.7941113
GO:0010467gene expression9.33e-031.00e+002.693359669
GO:0035267NuA4 histone acetyltransferase complex9.67e-031.00e+006.6871414
GO:0016071mRNA metabolic process9.87e-031.00e+003.693231223
GO:0005759mitochondrial matrix1.03e-021.00e+003.661214228
GO:0042026protein refolding1.04e-021.00e+006.5871215
GO:0050998nitric-oxide synthase binding1.10e-021.00e+006.4941116
GO:0017025TBP-class protein binding1.17e-021.00e+006.4071317
GO:0050870positive regulation of T cell activation1.17e-021.00e+006.4071117
GO:0022624proteasome accessory complex1.17e-021.00e+006.4071817
GO:0016070RNA metabolic process1.20e-021.00e+003.546232247
GO:0032733positive regulation of interleukin-10 production1.31e-021.00e+006.2461119
GO:0048863stem cell differentiation1.31e-021.00e+006.2461119
GO:0042100B cell proliferation1.45e-021.00e+006.1021121
GO:0004860protein kinase inhibitor activity1.45e-021.00e+006.1021221
GO:0030863cortical cytoskeleton1.52e-021.00e+006.0351122
GO:0036464cytoplasmic ribonucleoprotein granule1.52e-021.00e+006.0351422
GO:0043044ATP-dependent chromatin remodeling1.58e-021.00e+005.9711423
GO:0043236laminin binding1.58e-021.00e+005.9711123
GO:0008135translation factor activity, nucleic acid binding1.65e-021.00e+005.9091724
GO:0005515protein binding1.65e-021.00e+000.93881846024
GO:0042113B cell activation1.72e-021.00e+005.8501225
GO:0032735positive regulation of interleukin-12 production1.72e-021.00e+005.8501125
GO:0043022ribosome binding1.86e-021.00e+005.7391327
GO:0050661NADP binding1.86e-021.00e+005.7391227
GO:0031492nucleosomal DNA binding1.86e-021.00e+005.7391427
GO:0019901protein kinase binding1.93e-021.00e+003.186221317
GO:0006099tricarboxylic acid cycle1.93e-021.00e+005.6871428
GO:0030669clathrin-coated endocytic vesicle membrane1.93e-021.00e+005.6871428
GO:0019894kinesin binding1.93e-021.00e+005.6871128
GO:0033572transferrin transport2.06e-021.00e+005.5871530
GO:0031623receptor internalization2.13e-021.00e+005.5401231
GO:0032588trans-Golgi network membrane2.33e-021.00e+005.4071234
GO:0001895retina homeostasis2.33e-021.00e+005.4071134
GO:0048666neuron development2.33e-021.00e+005.4071234
GO:00515394 iron, 4 sulfur cluster binding2.40e-021.00e+005.3651335
GO:0034332adherens junction organization2.47e-021.00e+005.3241136
GO:0032755positive regulation of interleukin-6 production2.47e-021.00e+005.3241236
GO:0005925focal adhesion2.53e-021.00e+002.978219366
GO:0018107peptidyl-threonine phosphorylation2.54e-021.00e+005.2851437
GO:0051084'de novo' posttranslational protein folding2.54e-021.00e+005.2851437
GO:0070527platelet aggregation2.60e-021.00e+005.2461238
GO:0032729positive regulation of interferon-gamma production2.67e-021.00e+005.2091239
GO:0022627cytosolic small ribosomal subunit2.67e-021.00e+005.2091439
GO:0042110T cell activation2.88e-021.00e+005.1021342
GO:0030136clathrin-coated vesicle2.88e-021.00e+005.1021442
GO:0019902phosphatase binding2.88e-021.00e+005.1021242
GO:0006892post-Golgi vesicle-mediated transport2.94e-021.00e+005.0681343
GO:0021762substantia nigra development3.01e-021.00e+005.0351244
GO:0010923negative regulation of phosphatase activity3.28e-021.00e+004.9091148
GO:0043066negative regulation of apoptotic process3.32e-021.00e+002.766231424
GO:0003743translation initiation factor activity3.35e-021.00e+004.8791849
GO:0006091generation of precursor metabolites and energy3.41e-021.00e+004.8501350
GO:0006521regulation of cellular amino acid metabolic process3.41e-021.00e+004.85011750
GO:0006986response to unfolded protein3.41e-021.00e+004.8501250
GO:0005905coated pit3.41e-021.00e+004.8501350
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3.62e-021.00e+004.7661553
GO:0045216cell-cell junction organization3.68e-021.00e+004.7391254
GO:0002039p53 binding3.75e-021.00e+004.7131755
GO:0000502proteasome complex3.95e-021.00e+004.63611758
GO:0051087chaperone binding4.02e-021.00e+004.6121659
GO:0030141secretory granule4.22e-021.00e+004.5401262
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest4.35e-021.00e+004.49411964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.42e-021.00e+004.47212265
GO:0006469negative regulation of protein kinase activity4.42e-021.00e+004.4721465
GO:0044281small molecule metabolic process4.53e-021.00e+001.8373581211
GO:0034329cell junction assembly4.62e-021.00e+004.4071168
GO:0003697single-stranded DNA binding4.62e-021.00e+004.4071568
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.75e-021.00e+004.36512270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent4.88e-021.00e+004.32412072
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis5.02e-021.00e+004.2851674
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.02e-021.00e+004.28512274
GO:0008584male gonad development5.08e-021.00e+004.2651375
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I5.08e-021.00e+004.26512075
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process5.21e-021.00e+004.2271777
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process5.35e-021.00e+004.19012379
GO:0005524ATP binding5.40e-021.00e+001.7373601298
GO:0002755MyD88-dependent toll-like receptor signaling pathway5.41e-021.00e+004.1721380
GO:0019083viral transcription5.48e-021.00e+004.15411081
GO:0006898receptor-mediated endocytosis5.68e-021.00e+004.1021384
GO:0006415translational termination5.87e-021.00e+004.05111087
GO:0050821protein stabilization5.94e-021.00e+004.0351288
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II6.07e-021.00e+004.0021790
GO:0042470melanosome6.14e-021.00e+003.9861991
GO:0006928cellular component movement6.14e-021.00e+003.9861791
GO:0005200structural constituent of cytoskeleton6.14e-021.00e+003.9861891
GO:0001649osteoblast differentiation6.20e-021.00e+003.9711692
GO:0002474antigen processing and presentation of peptide antigen via MHC class I6.20e-021.00e+003.97112192
GO:0006414translational elongation6.27e-021.00e+003.95511393
GO:0051082unfolded protein binding6.27e-021.00e+003.9551593
GO:0006614SRP-dependent cotranslational protein targeting to membrane6.98e-021.00e+003.794110104
GO:0014069postsynaptic density7.05e-021.00e+003.78013105
GO:0005506iron ion binding7.05e-021.00e+003.78014105
GO:0006811ion transport7.18e-021.00e+003.75311107
GO:0072562blood microparticle7.44e-021.00e+003.70013111
GO:0030529ribonucleoprotein complex7.50e-021.00e+003.68718112
GO:0005819spindle7.50e-021.00e+003.68717112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay7.63e-021.00e+003.661111114
GO:0019058viral life cycle7.70e-021.00e+003.649113115
GO:0000209protein polyubiquitination7.76e-021.00e+003.636120116
GO:0044237cellular metabolic process7.82e-021.00e+003.62415117
GO:0006325chromatin organization7.89e-021.00e+003.61215118
GO:0006511ubiquitin-dependent protein catabolic process8.40e-021.00e+003.51715126
GO:0000790nuclear chromatin8.60e-021.00e+003.48319129
GO:0031982vesicle8.72e-021.00e+003.46119131
GO:0003735structural constituent of ribosome9.11e-021.00e+003.396110137
GO:0005737cytoplasm9.18e-021.00e+000.93751103767
GO:0016887ATPase activity9.30e-021.00e+003.36517140
GO:0006457protein folding9.49e-021.00e+003.33417143
GO:0000082G1/S transition of mitotic cell cycle9.87e-021.00e+003.275132149
GO:0005198structural molecule activity9.93e-021.00e+003.26515150
GO:0042981regulation of apoptotic process9.93e-021.00e+003.265124150
GO:0005769early endosome1.01e-011.00e+003.24612152
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.09e-011.00e+003.12817165
GO:0030424axon1.09e-011.00e+003.11914166
GO:0006886intracellular protein transport1.12e-011.00e+003.07615171
GO:0034641cellular nitrogen compound metabolic process1.12e-011.00e+003.076120171
GO:0001701in utero embryonic development1.31e-011.00e+002.84318201
GO:0005615extracellular space1.39e-011.00e+001.592217957
GO:0007067mitotic nuclear division1.47e-011.00e+002.668114227
GO:0005739mitochondrion1.49e-011.00e+001.531228998
GO:0003713transcription coactivator activity1.53e-011.00e+002.605110237
GO:0005975carbohydrate metabolic process1.62e-011.00e+002.51119253
GO:0005654nucleoplasm1.70e-011.00e+001.4152761082
GO:0043065positive regulation of apoptotic process1.71e-011.00e+002.428110268
GO:0005743mitochondrial inner membrane1.76e-011.00e+002.38018277
GO:0005634nucleus1.79e-011.00e+000.66251364559
GO:0005856cytoskeleton1.84e-011.00e+002.309112291
GO:0006200ATP catabolic process1.85e-011.00e+002.304115292
GO:0035556intracellular signal transduction1.91e-011.00e+002.25119303
GO:0004674protein serine/threonine kinase activity1.94e-011.00e+002.227112308
GO:0007411axon guidance2.00e-011.00e+002.177113319
GO:0015031protein transport2.13e-011.00e+002.08115341
GO:0003723RNA binding2.13e-011.00e+002.076120342
GO:0007155cell adhesion2.28e-011.00e+001.96716369
GO:0000278mitotic cell cycle2.40e-011.00e+001.883148391
GO:0009986cell surface2.46e-011.00e+001.843111402
GO:0055114oxidation-reduction process2.56e-011.00e+001.780112420
GO:0005886plasma membrane2.60e-011.00e+000.7453452582
GO:0007596blood coagulation2.74e-011.00e+001.664118455
GO:0006468protein phosphorylation2.77e-011.00e+001.649118460
GO:0006915apoptotic process3.25e-011.00e+001.378133555
GO:0045087innate immune response3.44e-011.00e+001.275124596
GO:0006355regulation of transcription, DNA-templated5.12e-011.00e+000.533118997
GO:0003677DNA binding5.86e-011.00e+000.2441281218
GO:0046872metal ion binding6.13e-011.00e+000.1421251307
GO:0006351transcription, DNA-templated6.52e-011.00e+00-0.0041311446