int-snw-642

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.931	2.21e-15	2.66e-03	4.22e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-642 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
CAD	790	17	0.807	1.007	333	-	-
RBX1	9978	97	1.185	1.151	139	Yes	-
RPL14	9045	42	1.250	1.113	143	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
ATP6V1B2	526	44	0.881	1.076	278	-	-
[ BLMH ]	642	1	0.130	0.931	30	-	-
RPSA	3921	156	1.327	1.151	152	Yes	-
RPL11	6135	9	0.718	1.017	200	Yes	-

Interactions (12)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ATP6V1B2	526	BLMH	642	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast
BLMH	642	RPL11	6135	pp	--	int.I2D: HPRD, BCI, BioGrid; int.HPRD: in vitro, yeast 2-hybrid
CAD	790	RPSA	3921	pp	--	int.I2D: IntAct_Yeast
ATP6V1B2	526	RPSA	3921	pp	--	int.I2D: IntAct_Yeast
ACTB	60	ATP6V1B2	526	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
BLMH	642	RBX1	9978	pp	--	int.I2D: IntAct_Yeast
ACTB	60	CAD	790	pp	--	int.I2D: IntAct_Yeast
RPL11	6135	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
BLMH	642	CAD	790	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RPL11	6135	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct

Related GO terms (165)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005829	cytosol	7.97e-07	1.15e-02	2.531	8	132	2496
GO:0019083	viral transcription	9.36e-06	1.35e-01	6.061	3	10	81
GO:0006415	translational termination	1.16e-05	1.68e-01	5.958	3	10	87
GO:0006414	translational elongation	1.42e-05	2.05e-01	5.862	3	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	1.99e-05	2.87e-01	5.701	3	10	104
GO:0042273	ribosomal large subunit biogenesis	2.09e-05	3.02e-01	8.116	2	4	13
GO:0070062	extracellular vesicular exosome	2.40e-05	3.46e-01	2.395	7	104	2400
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	2.62e-05	3.77e-01	5.568	3	11	114
GO:0019058	viral life cycle	2.69e-05	3.87e-01	5.556	3	13	115
GO:0006413	translational initiation	3.97e-05	5.72e-01	5.368	3	17	131
GO:0003735	structural constituent of ribosome	4.53e-05	6.54e-01	5.303	3	10	137
GO:0044267	cellular protein metabolic process	7.26e-05	1.00e+00	3.927	4	29	474
GO:0016032	viral process	1.15e-04	1.00e+00	3.755	4	55	534
GO:0016071	mRNA metabolic process	1.93e-04	1.00e+00	4.600	3	31	223
GO:0006412	translation	2.11e-04	1.00e+00	4.556	3	20	230
GO:0016070	RNA metabolic process	2.61e-04	1.00e+00	4.453	3	32	247
GO:0022625	cytosolic large ribosomal subunit	3.12e-04	1.00e+00	6.201	2	6	49
GO:0004151	dihydroorotase activity	5.55e-04	1.00e+00	10.816	1	1	1
GO:0004070	aspartate carbamoyltransferase activity	5.55e-04	1.00e+00	10.816	1	1	1
GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	5.55e-04	1.00e+00	10.816	1	1	1
GO:0070335	aspartate binding	5.55e-04	1.00e+00	10.816	1	1	1
GO:0016020	membrane	8.83e-04	1.00e+00	2.423	5	90	1681
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.11e-03	1.00e+00	9.816	1	1	2
GO:0005055	laminin receptor activity	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006407	rRNA export from nucleus	1.11e-03	1.00e+00	9.816	1	1	2
GO:0070409	carbamoyl phosphate biosynthetic process	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006364	rRNA processing	1.15e-03	1.00e+00	5.261	2	6	94
GO:0044205	'de novo' UMP biosynthetic process	1.66e-03	1.00e+00	9.231	1	1	3
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	1.66e-03	1.00e+00	9.231	1	1	3
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.22e-03	1.00e+00	8.816	1	1	4
GO:0030686	90S preribosome	2.22e-03	1.00e+00	8.816	1	1	4
GO:0006543	glutamine catabolic process	2.22e-03	1.00e+00	8.816	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	2.22e-03	1.00e+00	8.816	1	1	4
GO:0019788	NEDD8 ligase activity	2.22e-03	1.00e+00	8.816	1	1	4
GO:0051414	response to cortisol	2.77e-03	1.00e+00	8.494	1	1	5
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	2.77e-03	1.00e+00	8.494	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	2.77e-03	1.00e+00	8.494	1	1	5
GO:0030891	VCB complex	2.77e-03	1.00e+00	8.494	1	2	5
GO:0030957	Tat protein binding	3.32e-03	1.00e+00	8.231	1	3	6
GO:0046134	pyrimidine nucleoside biosynthetic process	3.32e-03	1.00e+00	8.231	1	1	6
GO:0031466	Cul5-RING ubiquitin ligase complex	3.32e-03	1.00e+00	8.231	1	1	6
GO:0033180	proton-transporting V-type ATPase, V1 domain	3.88e-03	1.00e+00	8.009	1	2	7
GO:0000028	ribosomal small subunit assembly	3.88e-03	1.00e+00	8.009	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	3.88e-03	1.00e+00	8.009	1	2	7
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	4.43e-03	1.00e+00	7.816	1	2	8
GO:0070688	MLL5-L complex	4.43e-03	1.00e+00	7.816	1	1	8
GO:0045116	protein neddylation	4.43e-03	1.00e+00	7.816	1	2	8
GO:0010467	gene expression	4.67e-03	1.00e+00	3.015	3	59	669
GO:0006228	UTP biosynthetic process	4.98e-03	1.00e+00	7.646	1	1	9
GO:0014075	response to amine	4.98e-03	1.00e+00	7.646	1	1	9
GO:0031000	response to caffeine	4.98e-03	1.00e+00	7.646	1	2	9
GO:0035267	NuA4 histone acetyltransferase complex	7.74e-03	1.00e+00	7.009	1	4	14
GO:0004180	carboxypeptidase activity	7.74e-03	1.00e+00	7.009	1	1	14
GO:0046961	proton-transporting ATPase activity, rotational mechanism	8.29e-03	1.00e+00	6.909	1	3	15
GO:0046034	ATP metabolic process	8.29e-03	1.00e+00	6.909	1	1	15
GO:0050998	nitric-oxide synthase binding	8.84e-03	1.00e+00	6.816	1	1	16
GO:0006541	glutamine metabolic process	9.39e-03	1.00e+00	6.729	1	1	17
GO:0017144	drug metabolic process	9.94e-03	1.00e+00	6.646	1	1	18
GO:0015078	hydrogen ion transmembrane transporter activity	1.05e-02	1.00e+00	6.568	1	3	19
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.05e-02	1.00e+00	6.568	1	1	19
GO:0043234	protein complex	1.08e-02	1.00e+00	3.612	2	18	295
GO:0071364	cellular response to epidermal growth factor stimulus	1.16e-02	1.00e+00	6.424	1	1	21
GO:0006206	pyrimidine nucleobase metabolic process	1.21e-02	1.00e+00	6.357	1	2	22
GO:0033574	response to testosterone	1.21e-02	1.00e+00	6.357	1	2	22
GO:0030863	cortical cytoskeleton	1.21e-02	1.00e+00	6.357	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.21e-02	1.00e+00	6.357	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.27e-02	1.00e+00	6.293	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.27e-02	1.00e+00	6.293	1	3	23
GO:0043236	laminin binding	1.27e-02	1.00e+00	6.293	1	1	23
GO:0006513	protein monoubiquitination	1.27e-02	1.00e+00	6.293	1	1	23
GO:0004177	aminopeptidase activity	1.27e-02	1.00e+00	6.293	1	1	23
GO:0003723	RNA binding	1.43e-02	1.00e+00	3.398	2	20	342
GO:0015991	ATP hydrolysis coupled proton transport	1.43e-02	1.00e+00	6.116	1	4	26
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.43e-02	1.00e+00	6.116	1	3	26
GO:0019843	rRNA binding	1.49e-02	1.00e+00	6.061	1	3	27
GO:0043022	ribosome binding	1.49e-02	1.00e+00	6.061	1	3	27
GO:0031492	nucleosomal DNA binding	1.49e-02	1.00e+00	6.061	1	4	27
GO:0019894	kinesin binding	1.54e-02	1.00e+00	6.009	1	1	28
GO:0034504	protein localization to nucleus	1.54e-02	1.00e+00	6.009	1	2	28
GO:0019005	SCF ubiquitin ligase complex	1.60e-02	1.00e+00	5.958	1	1	29
GO:0015992	proton transport	1.60e-02	1.00e+00	5.958	1	3	29
GO:0033572	transferrin transport	1.65e-02	1.00e+00	5.909	1	5	30
GO:0044822	poly(A) RNA binding	1.66e-02	1.00e+00	2.357	3	49	1056
GO:0051701	interaction with host	1.76e-02	1.00e+00	5.816	1	4	32
GO:0001895	retina homeostasis	1.87e-02	1.00e+00	5.729	1	1	34
GO:0006605	protein targeting	1.93e-02	1.00e+00	5.687	1	2	35
GO:0034332	adherens junction organization	1.98e-02	1.00e+00	5.646	1	1	36
GO:0090382	phagosome maturation	1.98e-02	1.00e+00	5.646	1	5	36
GO:0008234	cysteine-type peptidase activity	2.03e-02	1.00e+00	5.607	1	3	37
GO:0018107	peptidyl-threonine phosphorylation	2.03e-02	1.00e+00	5.607	1	4	37
GO:0051084	'de novo' posttranslational protein folding	2.03e-02	1.00e+00	5.607	1	4	37
GO:0005902	microvillus	2.09e-02	1.00e+00	5.568	1	2	38
GO:0070527	platelet aggregation	2.09e-02	1.00e+00	5.568	1	2	38
GO:0022627	cytosolic small ribosomal subunit	2.14e-02	1.00e+00	5.531	1	4	39
GO:0007595	lactation	2.14e-02	1.00e+00	5.531	1	2	39
GO:0043195	terminal bouton	2.25e-02	1.00e+00	5.459	1	1	41
GO:0021762	substantia nigra development	2.42e-02	1.00e+00	5.357	1	2	44
GO:0035690	cellular response to drug	2.69e-02	1.00e+00	5.201	1	2	49
GO:0004197	cysteine-type endopeptidase activity	2.74e-02	1.00e+00	5.172	1	3	50
GO:0031100	organ regeneration	2.74e-02	1.00e+00	5.172	1	4	50
GO:0006879	cellular iron ion homeostasis	2.79e-02	1.00e+00	5.144	1	4	51
GO:0005524	ATP binding	2.88e-02	1.00e+00	2.059	3	60	1298
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.90e-02	1.00e+00	5.088	1	5	53
GO:0045216	cell-cell junction organization	2.96e-02	1.00e+00	5.061	1	2	54
GO:0012505	endomembrane system	3.06e-02	1.00e+00	5.009	1	2	56
GO:0042995	cell projection	3.28e-02	1.00e+00	4.909	1	6	60
GO:0009636	response to toxic substance	3.55e-02	1.00e+00	4.794	1	3	65
GO:0034329	cell junction assembly	3.71e-02	1.00e+00	4.729	1	1	68
GO:0055086	nucleobase-containing small molecule metabolic process	3.82e-02	1.00e+00	4.687	1	2	70
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.03e-02	1.00e+00	4.607	1	6	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.09e-02	1.00e+00	4.587	1	2	75
GO:0001889	liver development	4.19e-02	1.00e+00	4.549	1	4	77
GO:0007565	female pregnancy	4.25e-02	1.00e+00	4.531	1	1	78
GO:0001726	ruffle	4.35e-02	1.00e+00	4.494	1	4	80
GO:0042470	melanosome	4.94e-02	1.00e+00	4.308	1	9	91
GO:0016363	nuclear matrix	4.94e-02	1.00e+00	4.308	1	12	91
GO:0006928	cellular component movement	4.94e-02	1.00e+00	4.308	1	7	91
GO:0005200	structural constituent of cytoskeleton	4.94e-02	1.00e+00	4.308	1	8	91
GO:0071456	cellular response to hypoxia	4.99e-02	1.00e+00	4.293	1	6	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	4.99e-02	1.00e+00	4.293	1	21	92
GO:0014069	postsynaptic density	5.68e-02	1.00e+00	4.102	1	3	105
GO:0072562	blood microparticle	5.99e-02	1.00e+00	4.022	1	3	111
GO:0030529	ribonucleoprotein complex	6.05e-02	1.00e+00	4.009	1	8	112
GO:0005515	protein binding	6.16e-02	1.00e+00	0.845	6	184	6024
GO:0000209	protein polyubiquitination	6.26e-02	1.00e+00	3.958	1	20	116
GO:0006325	chromatin organization	6.36e-02	1.00e+00	3.933	1	5	118
GO:0007219	Notch signaling pathway	6.47e-02	1.00e+00	3.909	1	5	120
GO:0000790	nuclear chromatin	6.94e-02	1.00e+00	3.805	1	9	129
GO:0007507	heart development	7.46e-02	1.00e+00	3.697	1	7	139
GO:0008286	insulin receptor signaling pathway	7.61e-02	1.00e+00	3.666	1	7	142
GO:0006457	protein folding	7.66e-02	1.00e+00	3.656	1	7	143
GO:0061024	membrane organization	7.77e-02	1.00e+00	3.636	1	7	145
GO:0046777	protein autophosphorylation	8.44e-02	1.00e+00	3.512	1	7	158
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	8.80e-02	1.00e+00	3.450	1	7	165
GO:0030424	axon	8.85e-02	1.00e+00	3.441	1	4	166
GO:0004672	protein kinase activity	9.41e-02	1.00e+00	3.348	1	6	177
GO:0031625	ubiquitin protein ligase binding	9.46e-02	1.00e+00	3.340	1	14	178
GO:0032403	protein complex binding	9.71e-02	1.00e+00	3.300	1	10	183
GO:0008270	zinc ion binding	1.01e-01	1.00e+00	1.855	2	12	997
GO:0005765	lysosomal membrane	1.07e-01	1.00e+00	3.151	1	5	203
GO:0005654	nucleoplasm	1.16e-01	1.00e+00	1.737	2	76	1082
GO:0043025	neuronal cell body	1.28e-01	1.00e+00	2.879	1	9	245
GO:0005737	cytoplasm	1.30e-01	1.00e+00	0.937	4	110	3767
GO:0004842	ubiquitin-protein transferase activity	1.33e-01	1.00e+00	2.822	1	6	255
GO:0006281	DNA repair	1.36e-01	1.00e+00	2.788	1	18	261
GO:0019899	enzyme binding	1.44e-01	1.00e+00	2.702	1	12	277
GO:0042493	response to drug	1.47e-01	1.00e+00	2.666	1	13	284
GO:0005856	cytoskeleton	1.50e-01	1.00e+00	2.631	1	12	291
GO:0016567	protein ubiquitination	1.52e-01	1.00e+00	2.612	1	5	295
GO:0019901	protein kinase binding	1.63e-01	1.00e+00	2.508	1	21	317
GO:0043231	intracellular membrane-bounded organelle	1.63e-01	1.00e+00	2.503	1	9	318
GO:0007411	axon guidance	1.64e-01	1.00e+00	2.499	1	13	319
GO:0005925	focal adhesion	1.86e-01	1.00e+00	2.300	1	19	366
GO:0007155	cell adhesion	1.87e-01	1.00e+00	2.289	1	6	369
GO:0006508	proteolysis	1.91e-01	1.00e+00	2.254	1	9	378
GO:0055085	transmembrane transport	2.17e-01	1.00e+00	2.051	1	10	435
GO:0007596	blood coagulation	2.26e-01	1.00e+00	1.986	1	18	455
GO:0042802	identical protein binding	2.39e-01	1.00e+00	1.897	1	20	484
GO:0045087	innate immune response	2.87e-01	1.00e+00	1.597	1	24	596
GO:0005615	extracellular space	4.23e-01	1.00e+00	0.914	1	17	957
GO:0005886	plasma membrane	4.34e-01	1.00e+00	0.482	2	45	2582
GO:0005634	nucleus	4.89e-01	1.00e+00	0.247	3	136	4559
GO:0044281	small molecule metabolic process	5.04e-01	1.00e+00	0.574	1	58	1211
GO:0005730	nucleolus	6.20e-01	1.00e+00	0.136	1	69	1641
GO:0016021	integral component of membrane	6.94e-01	1.00e+00	-0.137	1	27	1982

Wolf-ratios-Mammosphere-Adherent

int-snw-642

Statistics

Genes (8)

Interactions (12)

Related GO terms (165)