int-snw-6240

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.989	1.11e-17	7.18e-04	1.60e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-6240 subnetwork

Genes (12)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
ACO2	50	50	1.000	1.076	191	Yes	-
RSL24D1	51187	36	1.300	1.020	59	Yes	-
EIF6	3692	14	0.700	1.013	267	Yes	-
PSMD13	5719	16	0.848	1.029	104	Yes	-
PSMA2	5683	60	1.093	1.106	89	Yes	-
PSMD3	5709	57	0.986	1.106	146	Yes	-
[ RRM1 ]	6240	2	0.587	0.989	39	Yes	-
PSMA1	5682	61	0.996	1.052	123	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
HSPD1	3329	35	0.913	1.035	286	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (26)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMD3	5709	PSMD13	5719	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, MINT_Yeast, YeastHigh, BioGrid, BioGrid_Yeast, IntAct_Yeast, Krogan_Core
PSMA1	5682	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, YeastMedium
PSMD3	5709	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
HSPD1	3329	EIF6	3692	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast
PSMD11	5717	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastHigh, BioGrid, INTEROLOG
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMA1	5682	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PGD	5226	PSMD3	5709	pp	--	int.I2D: YeastLow
EIF6	3692	RSL24D1	51187	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMA2	5683	PSMD13	5719	pp	--	int.I2D: YeastLow
EIF6	3692	RRM1	6240	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
PSMA1	5682	PSMA2	5683	pp	--	int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh; int.HPRD: yeast 2-hybrid
EIF6	3692	PGD	5226	pp	--	int.I2D: YeastLow
ACO2	50	EIF6	3692	pp	--	int.I2D: YeastLow
ACTB	60	PSMA1	5682	pp	--	int.I2D: BioGrid_Yeast
ACO2	50	PSMD11	5717	pp	--	int.I2D: YeastLow
ACO2	50	PGD	5226	pp	--	int.I2D: YeastLow
PSMA1	5682	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct, YeastMedium, BioGrid, BioGrid_Yeast, IntAct_Yeast
ACO2	50	HSPD1	3329	pp	--	int.I2D: IntAct_Yeast
PSMA2	5683	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	HSPD1	3329	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, YeastLow
PSMD13	5719	RRM1	6240	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB	60	PSMD13	5719	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (168)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006521	regulation of cellular amino acid metabolic process	3.17e-10	4.57e-06	6.909	5	17	50
GO:0000502	proteasome complex	6.83e-10	9.86e-06	6.695	5	17	58
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	1.13e-09	1.64e-05	6.553	5	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.23e-09	1.77e-05	6.531	5	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.80e-09	2.59e-05	6.424	5	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	2.07e-09	2.99e-05	6.383	5	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.39e-09	3.44e-05	6.344	5	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	2.56e-09	3.69e-05	6.324	5	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	3.33e-09	4.81e-05	6.249	5	23	79
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	7.23e-09	1.04e-04	6.029	5	21	92
GO:0000209	protein polyubiquitination	2.34e-08	3.37e-04	5.695	5	20	116
GO:0000082	G1/S transition of mitotic cell cycle	8.22e-08	1.19e-03	5.334	5	32	149
GO:0042981	regulation of apoptotic process	8.50e-08	1.23e-03	5.324	5	24	150
GO:0005838	proteasome regulatory particle	9.64e-08	1.39e-03	8.231	3	7	12
GO:0034641	cellular nitrogen compound metabolic process	1.64e-07	2.36e-03	5.135	5	20	171
GO:0022624	proteasome accessory complex	2.97e-07	4.29e-03	7.729	3	8	17
GO:0000278	mitotic cell cycle	3.07e-07	4.44e-03	4.205	6	48	391
GO:0043066	negative regulation of apoptotic process	4.96e-07	7.15e-03	4.088	6	31	424
GO:0016071	mRNA metabolic process	6.13e-07	8.84e-03	4.752	5	31	223
GO:0070062	extracellular vesicular exosome	7.63e-07	1.10e-02	2.324	10	104	2400
GO:0044281	small molecule metabolic process	8.80e-07	1.27e-02	2.989	8	58	1211
GO:0016070	RNA metabolic process	1.02e-06	1.46e-02	4.605	5	32	247
GO:0016032	viral process	1.91e-06	2.76e-02	3.755	6	55	534
GO:0005654	nucleoplasm	7.43e-06	1.07e-01	2.959	7	76	1082
GO:0019773	proteasome core complex, alpha-subunit complex	1.77e-05	2.56e-01	8.231	2	4	8
GO:0005829	cytosol	1.83e-05	2.63e-01	2.116	9	132	2496
GO:0006915	apoptotic process	5.24e-05	7.56e-01	3.437	5	33	555
GO:0005839	proteasome core complex	9.64e-05	1.00e+00	7.061	2	8	18
GO:0004298	threonine-type endopeptidase activity	1.08e-04	1.00e+00	6.983	2	8	19
GO:0010467	gene expression	1.28e-04	1.00e+00	3.167	5	59	669
GO:0002842	positive regulation of T cell mediated immune response to tumor cell	8.32e-04	1.00e+00	10.231	1	1	1
GO:0048291	isotype switching to IgG isotypes	8.32e-04	1.00e+00	10.231	1	1	1
GO:0000054	ribosomal subunit export from nucleus	8.32e-04	1.00e+00	10.231	1	1	1
GO:0019521	D-gluconate metabolic process	8.32e-04	1.00e+00	10.231	1	1	1
GO:0002368	B cell cytokine production	8.32e-04	1.00e+00	10.231	1	1	1
GO:0051538	3 iron, 4 sulfur cluster binding	1.66e-03	1.00e+00	9.231	1	1	2
GO:0019322	pentose biosynthetic process	1.66e-03	1.00e+00	9.231	1	2	2
GO:0003994	aconitate hydratase activity	1.66e-03	1.00e+00	9.231	1	1	2
GO:0007127	meiosis I	1.66e-03	1.00e+00	9.231	1	1	2
GO:0009263	deoxyribonucleotide biosynthetic process	2.49e-03	1.00e+00	8.646	1	1	3
GO:0006458	'de novo' protein folding	2.49e-03	1.00e+00	8.646	1	1	3
GO:0009051	pentose-phosphate shunt, oxidative branch	2.49e-03	1.00e+00	8.646	1	2	3
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	2.49e-03	1.00e+00	8.646	1	1	3
GO:0030135	coated vesicle	2.49e-03	1.00e+00	8.646	1	1	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	2.49e-03	1.00e+00	8.646	1	1	3
GO:0042256	mature ribosome assembly	4.15e-03	1.00e+00	7.909	1	1	5
GO:0043248	proteasome assembly	4.15e-03	1.00e+00	7.909	1	1	5
GO:0046696	lipopolysaccharide receptor complex	4.15e-03	1.00e+00	7.909	1	1	5
GO:0006102	isocitrate metabolic process	4.15e-03	1.00e+00	7.909	1	1	5
GO:0005638	lamin filament	4.15e-03	1.00e+00	7.909	1	1	5
GO:0043023	ribosomal large subunit binding	4.15e-03	1.00e+00	7.909	1	1	5
GO:0003688	DNA replication origin binding	4.98e-03	1.00e+00	7.646	1	2	6
GO:0030957	Tat protein binding	4.98e-03	1.00e+00	7.646	1	3	6
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	4.98e-03	1.00e+00	7.646	1	1	6
GO:0006101	citrate metabolic process	4.98e-03	1.00e+00	7.646	1	1	6
GO:0070688	MLL5-L complex	6.64e-03	1.00e+00	7.231	1	1	8
GO:0051604	protein maturation	6.64e-03	1.00e+00	7.231	1	1	8
GO:0006098	pentose-phosphate shunt	8.29e-03	1.00e+00	6.909	1	4	10
GO:0021846	cell proliferation in forebrain	8.29e-03	1.00e+00	6.909	1	1	10
GO:0043032	positive regulation of macrophage activation	8.29e-03	1.00e+00	6.909	1	1	10
GO:0016020	membrane	8.36e-03	1.00e+00	1.838	5	90	1681
GO:0032727	positive regulation of interferon-alpha production	9.12e-03	1.00e+00	6.772	1	1	11
GO:0051290	protein heterotetramerization	9.12e-03	1.00e+00	6.772	1	2	11
GO:0042273	ribosomal large subunit biogenesis	1.08e-02	1.00e+00	6.531	1	4	13
GO:0030234	enzyme regulator activity	1.08e-02	1.00e+00	6.531	1	3	13
GO:0001530	lipopolysaccharide binding	1.08e-02	1.00e+00	6.531	1	3	13
GO:0051131	chaperone-mediated protein complex assembly	1.08e-02	1.00e+00	6.531	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	1.16e-02	1.00e+00	6.424	1	4	14
GO:0042026	protein refolding	1.24e-02	1.00e+00	6.324	1	2	15
GO:0050998	nitric-oxide synthase binding	1.32e-02	1.00e+00	6.231	1	1	16
GO:0042176	regulation of protein catabolic process	1.32e-02	1.00e+00	6.231	1	3	16
GO:0005634	nucleus	1.33e-02	1.00e+00	1.077	8	136	4559
GO:0050870	positive regulation of T cell activation	1.41e-02	1.00e+00	6.144	1	1	17
GO:0005759	mitochondrial matrix	1.48e-02	1.00e+00	3.398	2	14	228
GO:0015949	nucleobase-containing small molecule interconversion	1.49e-02	1.00e+00	6.061	1	1	18
GO:0032733	positive regulation of interleukin-10 production	1.57e-02	1.00e+00	5.983	1	1	19
GO:0048863	stem cell differentiation	1.57e-02	1.00e+00	5.983	1	1	19
GO:0042100	B cell proliferation	1.73e-02	1.00e+00	5.839	1	1	21
GO:0006206	pyrimidine nucleobase metabolic process	1.82e-02	1.00e+00	5.772	1	2	22
GO:0030863	cortical cytoskeleton	1.82e-02	1.00e+00	5.772	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.82e-02	1.00e+00	5.772	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.90e-02	1.00e+00	5.708	1	4	23
GO:0005844	polysome	1.90e-02	1.00e+00	5.708	1	4	23
GO:0042113	B cell activation	2.06e-02	1.00e+00	5.587	1	2	25
GO:0032735	positive regulation of interleukin-12 production	2.06e-02	1.00e+00	5.587	1	1	25
GO:0043022	ribosome binding	2.22e-02	1.00e+00	5.476	1	3	27
GO:0050661	NADP binding	2.22e-02	1.00e+00	5.476	1	2	27
GO:0031492	nucleosomal DNA binding	2.22e-02	1.00e+00	5.476	1	4	27
GO:0006099	tricarboxylic acid cycle	2.31e-02	1.00e+00	5.424	1	4	28
GO:0019894	kinesin binding	2.31e-02	1.00e+00	5.424	1	1	28
GO:0043234	protein complex	2.40e-02	1.00e+00	3.027	2	18	295
GO:0042254	ribosome biogenesis	2.47e-02	1.00e+00	5.324	1	1	30
GO:0001895	retina homeostasis	2.79e-02	1.00e+00	5.144	1	1	34
GO:0051539	4 iron, 4 sulfur cluster binding	2.87e-02	1.00e+00	5.102	1	3	35
GO:0034332	adherens junction organization	2.96e-02	1.00e+00	5.061	1	1	36
GO:0032755	positive regulation of interleukin-6 production	2.96e-02	1.00e+00	5.061	1	2	36
GO:0051084	'de novo' posttranslational protein folding	3.04e-02	1.00e+00	5.022	1	4	37
GO:0070527	platelet aggregation	3.12e-02	1.00e+00	4.983	1	2	38
GO:0032729	positive regulation of interferon-gamma production	3.20e-02	1.00e+00	4.946	1	2	39
GO:0042110	T cell activation	3.44e-02	1.00e+00	4.839	1	3	42
GO:0010212	response to ionizing radiation	3.44e-02	1.00e+00	4.839	1	1	42
GO:0021762	substantia nigra development	3.60e-02	1.00e+00	4.772	1	2	44
GO:0005730	nucleolus	3.91e-02	1.00e+00	1.551	4	69	1641
GO:0003743	translation initiation factor activity	4.00e-02	1.00e+00	4.616	1	8	49
GO:0006091	generation of precursor metabolites and energy	4.08e-02	1.00e+00	4.587	1	3	50
GO:0006986	response to unfolded protein	4.08e-02	1.00e+00	4.587	1	2	50
GO:0005905	coated pit	4.08e-02	1.00e+00	4.587	1	3	50
GO:0060041	retina development in camera-type eye	4.16e-02	1.00e+00	4.559	1	2	51
GO:0003725	double-stranded RNA binding	4.24e-02	1.00e+00	4.531	1	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	4.32e-02	1.00e+00	4.503	1	5	53
GO:0045216	cell-cell junction organization	4.40e-02	1.00e+00	4.476	1	2	54
GO:0000932	cytoplasmic mRNA processing body	4.40e-02	1.00e+00	4.476	1	3	54
GO:0002039	p53 binding	4.48e-02	1.00e+00	4.450	1	7	55
GO:0055114	oxidation-reduction process	4.60e-02	1.00e+00	2.517	2	12	420
GO:0051087	chaperone binding	4.80e-02	1.00e+00	4.348	1	6	59
GO:0042995	cell projection	4.88e-02	1.00e+00	4.324	1	6	60
GO:0030141	secretory granule	5.04e-02	1.00e+00	4.277	1	2	62
GO:0034329	cell junction assembly	5.52e-02	1.00e+00	4.144	1	1	68
GO:0003697	single-stranded DNA binding	5.52e-02	1.00e+00	4.144	1	5	68
GO:0055086	nucleobase-containing small molecule metabolic process	5.67e-02	1.00e+00	4.102	1	2	70
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.99e-02	1.00e+00	4.022	1	6	74
GO:0008584	male gonad development	6.07e-02	1.00e+00	4.002	1	3	75
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	6.22e-02	1.00e+00	3.964	1	7	77
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	6.46e-02	1.00e+00	3.909	1	3	80
GO:0050821	protein stabilization	7.08e-02	1.00e+00	3.772	1	2	88
GO:0006928	cellular component movement	7.32e-02	1.00e+00	3.723	1	7	91
GO:0005200	structural constituent of cytoskeleton	7.32e-02	1.00e+00	3.723	1	8	91
GO:0051082	unfolded protein binding	7.47e-02	1.00e+00	3.692	1	5	93
GO:0014069	postsynaptic density	8.40e-02	1.00e+00	3.517	1	3	105
GO:0005506	iron ion binding	8.40e-02	1.00e+00	3.517	1	4	105
GO:0005524	ATP binding	8.65e-02	1.00e+00	1.474	3	60	1298
GO:0072562	blood microparticle	8.86e-02	1.00e+00	3.437	1	3	111
GO:0030529	ribonucleoprotein complex	8.93e-02	1.00e+00	3.424	1	8	112
GO:0005635	nuclear envelope	9.01e-02	1.00e+00	3.411	1	6	113
GO:0044237	cellular metabolic process	9.32e-02	1.00e+00	3.361	1	5	117
GO:0006325	chromatin organization	9.39e-02	1.00e+00	3.348	1	5	118
GO:0006260	DNA replication	9.62e-02	1.00e+00	3.312	1	9	121
GO:0006511	ubiquitin-dependent protein catabolic process	1.00e-01	1.00e+00	3.254	1	5	126
GO:0009615	response to virus	1.00e-01	1.00e+00	3.254	1	5	126
GO:0000790	nuclear chromatin	1.02e-01	1.00e+00	3.220	1	9	129
GO:0006413	translational initiation	1.04e-01	1.00e+00	3.198	1	17	131
GO:0016887	ATPase activity	1.10e-01	1.00e+00	3.102	1	7	140
GO:0006457	protein folding	1.13e-01	1.00e+00	3.071	1	7	143
GO:0061024	membrane organization	1.14e-01	1.00e+00	3.051	1	7	145
GO:0005769	early endosome	1.19e-01	1.00e+00	2.983	1	2	152
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.29e-01	1.00e+00	2.865	1	7	165
GO:0030424	axon	1.30e-01	1.00e+00	2.856	1	4	166
GO:0005737	cytoplasm	1.81e-01	1.00e+00	0.674	5	110	3767
GO:0043025	neuronal cell body	1.86e-01	1.00e+00	2.294	1	9	245
GO:0005615	extracellular space	1.87e-01	1.00e+00	1.329	2	17	957
GO:0005975	carbohydrate metabolic process	1.91e-01	1.00e+00	2.248	1	9	253
GO:0005515	protein binding	1.91e-01	1.00e+00	0.482	7	184	6024
GO:0005739	mitochondrion	2.00e-01	1.00e+00	1.268	2	28	998
GO:0043065	positive regulation of apoptotic process	2.02e-01	1.00e+00	2.165	1	10	268
GO:0005743	mitochondrial inner membrane	2.08e-01	1.00e+00	2.117	1	8	277
GO:0005856	cytoskeleton	2.17e-01	1.00e+00	2.046	1	12	291
GO:0006200	ATP catabolic process	2.18e-01	1.00e+00	2.041	1	15	292
GO:0019901	protein kinase binding	2.34e-01	1.00e+00	1.923	1	21	317
GO:0007411	axon guidance	2.35e-01	1.00e+00	1.914	1	13	319
GO:0005813	centrosome	2.40e-01	1.00e+00	1.882	1	14	326
GO:0003723	RNA binding	2.50e-01	1.00e+00	1.813	1	20	342
GO:0005925	focal adhesion	2.65e-01	1.00e+00	1.715	1	19	366
GO:0009986	cell surface	2.88e-01	1.00e+00	1.580	1	11	402
GO:0007596	blood coagulation	3.19e-01	1.00e+00	1.401	1	18	455
GO:0044267	cellular protein metabolic process	3.30e-01	1.00e+00	1.342	1	29	474
GO:0045087	innate immune response	3.97e-01	1.00e+00	1.012	1	24	596
GO:0044822	poly(A) RNA binding	5.99e-01	1.00e+00	0.187	1	49	1056
GO:0005886	plasma membrane	9.06e-01	1.00e+00	-1.103	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-6240

Statistics

Genes (12)

Interactions (26)

Related GO terms (168)