int-snw-5591

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.932	2.05e-15	2.61e-03	4.17e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-5591 subnetwork

Genes (7)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
EIF2S2	8894	27	1.075	1.138	81	Yes	-
PCNA	5111	5	0.553	0.974	294	Yes	-
RUVBL1	8607	17	0.720	1.013	343	Yes	-
[ PRKDC ]	5591	1	-0.447	0.932	197	-	-
RPSA	3921	156	1.327	1.151	152	Yes	-

Interactions (8)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PCNA	5111	PRKDC	5591	pp	--	int.I2D: BCI, BioGrid, BIND, HPRD; int.HPRD: in vitro
PRKDC	5591	RUVBL1	8607	pp	--	int.Intact: MI:0914(association)
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
PRKDC	5591	RPA2	6118	pp	--	int.I2D: BioGrid, BCI, BIND, HPRD; int.HPRD: in vitro
RPSA	3921	PCNA	5111	pp	--	int.I2D: MINT, BioGrid; int.Mint: MI:0915(physical association)
ACTB	60	RUVBL1	8607	pp	--	int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
PRKDC	5591	EIF2S2	8894	pp	--	int.I2D: HPRD, BCI, BioGrid; int.HPRD: in vitro

Related GO terms (183)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0000723	telomere maintenance	1.92e-06	2.77e-02	6.786	3	6	56
GO:0006281	DNA repair	3.51e-06	5.07e-02	4.981	4	18	261
GO:0035267	NuA4 histone acetyltransferase complex	1.83e-05	2.64e-01	8.201	2	4	14
GO:0006298	mismatch repair	3.82e-05	5.51e-01	7.687	2	3	20
GO:0032201	telomere maintenance via semi-conservative replication	4.22e-05	6.09e-01	7.616	2	5	21
GO:0005654	nucleoplasm	4.35e-05	6.28e-01	3.251	5	76	1082
GO:0006297	nucleotide-excision repair, DNA gap filling	4.64e-05	6.70e-01	7.549	2	3	22
GO:0000722	telomere maintenance via recombination	6.03e-05	8.69e-01	7.365	2	5	25
GO:0006271	DNA strand elongation involved in DNA replication	8.73e-05	1.00e+00	7.102	2	7	30
GO:0006284	base-excision repair	1.33e-04	1.00e+00	6.799	2	3	37
GO:0006283	transcription-coupled nucleotide-excision repair	2.07e-04	1.00e+00	6.485	2	7	46
GO:0006302	double-strand break repair	3.77e-04	1.00e+00	6.055	2	4	62
GO:0006289	nucleotide-excision repair	4.53e-04	1.00e+00	5.921	2	11	68
GO:0072431	signal transduction involved in mitotic G1 DNA damage checkpoint	4.85e-04	1.00e+00	11.009	1	1	1
GO:0043626	PCNA complex	4.85e-04	1.00e+00	11.009	1	1	1
GO:0032077	positive regulation of deoxyribonuclease activity	4.85e-04	1.00e+00	11.009	1	1	1
GO:0000701	purine-specific mismatch base pair DNA N-glycosylase activity	4.85e-04	1.00e+00	11.009	1	1	1
GO:0030337	DNA polymerase processivity factor activity	9.70e-04	1.00e+00	10.009	1	1	2
GO:0070557	PCNA-p21 complex	9.70e-04	1.00e+00	10.009	1	1	2
GO:0006272	leading strand elongation	9.70e-04	1.00e+00	10.009	1	2	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9.70e-04	1.00e+00	10.009	1	1	2
GO:0002176	male germ cell proliferation	9.70e-04	1.00e+00	10.009	1	1	2
GO:0005055	laminin receptor activity	9.70e-04	1.00e+00	10.009	1	1	2
GO:0006407	rRNA export from nucleus	9.70e-04	1.00e+00	10.009	1	1	2
GO:0044267	cellular protein metabolic process	1.12e-03	1.00e+00	3.705	3	29	474
GO:0030529	ribonucleoprotein complex	1.22e-03	1.00e+00	5.201	2	8	112
GO:0006325	chromatin organization	1.36e-03	1.00e+00	5.126	2	5	118
GO:0005850	eukaryotic translation initiation factor 2 complex	1.46e-03	1.00e+00	9.424	1	1	3
GO:0033152	immunoglobulin V(D)J recombination	1.46e-03	1.00e+00	9.424	1	1	3
GO:0002360	T cell lineage commitment	1.46e-03	1.00e+00	9.424	1	2	3
GO:0032139	dinucleotide insertion or deletion binding	1.46e-03	1.00e+00	9.424	1	1	3
GO:0006413	translational initiation	1.67e-03	1.00e+00	4.975	2	17	131
GO:0007507	heart development	1.88e-03	1.00e+00	4.890	2	7	139
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.94e-03	1.00e+00	9.009	1	1	4
GO:0030686	90S preribosome	1.94e-03	1.00e+00	9.009	1	1	4
GO:0002326	B cell lineage commitment	1.94e-03	1.00e+00	9.009	1	2	4
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	1.94e-03	1.00e+00	9.009	1	1	4
GO:0004677	DNA-dependent protein kinase activity	1.94e-03	1.00e+00	9.009	1	1	4
GO:0000082	G1/S transition of mitotic cell cycle	2.15e-03	1.00e+00	4.790	2	32	149
GO:0005515	protein binding	2.21e-03	1.00e+00	1.260	7	184	6024
GO:0002328	pro-B cell differentiation	2.42e-03	1.00e+00	8.687	1	1	5
GO:0000730	DNA recombinase assembly	2.42e-03	1.00e+00	8.687	1	1	5
GO:2000001	regulation of DNA damage checkpoint	2.42e-03	1.00e+00	8.687	1	1	5
GO:0033153	T cell receptor V(D)J recombination	2.42e-03	1.00e+00	8.687	1	1	5
GO:0070419	nonhomologous end joining complex	2.91e-03	1.00e+00	8.424	1	1	6
GO:0005663	DNA replication factor C complex	2.91e-03	1.00e+00	8.424	1	1	6
GO:0030957	Tat protein binding	2.91e-03	1.00e+00	8.424	1	3	6
GO:0032405	MutLalpha complex binding	2.91e-03	1.00e+00	8.424	1	1	6
GO:0033993	response to lipid	2.91e-03	1.00e+00	8.424	1	2	6
GO:0000028	ribosomal small subunit assembly	3.39e-03	1.00e+00	8.201	1	1	7
GO:0043596	nuclear replication fork	3.39e-03	1.00e+00	8.201	1	1	7
GO:0035234	ectopic germ cell programmed cell death	3.39e-03	1.00e+00	8.201	1	1	7
GO:0070688	MLL5-L complex	3.88e-03	1.00e+00	8.009	1	1	8
GO:0000812	Swr1 complex	3.88e-03	1.00e+00	8.009	1	3	8
GO:0070182	DNA polymerase binding	3.88e-03	1.00e+00	8.009	1	2	8
GO:0005730	nucleolus	4.40e-03	1.00e+00	2.328	4	69	1641
GO:0016020	membrane	4.81e-03	1.00e+00	2.294	4	90	1681
GO:0010569	regulation of double-strand break repair via homologous recombination	4.84e-03	1.00e+00	7.687	1	1	10
GO:0006412	translation	5.04e-03	1.00e+00	4.163	2	20	230
GO:0019985	translesion synthesis	5.33e-03	1.00e+00	7.549	1	2	11
GO:0031571	mitotic G1 DNA damage checkpoint	5.33e-03	1.00e+00	7.549	1	4	11
GO:0006275	regulation of DNA replication	5.81e-03	1.00e+00	7.424	1	2	12
GO:0043968	histone H2A acetylation	5.81e-03	1.00e+00	7.424	1	3	12
GO:0005662	DNA replication factor A complex	6.29e-03	1.00e+00	7.308	1	1	13
GO:0031011	Ino80 complex	6.78e-03	1.00e+00	7.201	1	3	14
GO:0019899	enzyme binding	7.24e-03	1.00e+00	3.895	2	12	277
GO:0050998	nitric-oxide synthase binding	7.74e-03	1.00e+00	7.009	1	1	16
GO:0003678	DNA helicase activity	8.22e-03	1.00e+00	6.921	1	3	17
GO:0035861	site of double-strand break	8.71e-03	1.00e+00	6.839	1	1	18
GO:0006303	double-strand break repair via nonhomologous end joining	8.71e-03	1.00e+00	6.839	1	2	18
GO:0031648	protein destabilization	1.01e-02	1.00e+00	6.616	1	1	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.01e-02	1.00e+00	6.616	1	4	21
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	1.06e-02	1.00e+00	6.549	1	2	22
GO:0046686	response to cadmium ion	1.06e-02	1.00e+00	6.549	1	2	22
GO:0030863	cortical cytoskeleton	1.06e-02	1.00e+00	6.549	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.06e-02	1.00e+00	6.549	1	4	22
GO:0044822	poly(A) RNA binding	1.10e-02	1.00e+00	2.549	3	49	1056
GO:0043044	ATP-dependent chromatin remodeling	1.11e-02	1.00e+00	6.485	1	4	23
GO:0043236	laminin binding	1.11e-02	1.00e+00	6.485	1	1	23
GO:0008135	translation factor activity, nucleic acid binding	1.16e-02	1.00e+00	6.424	1	7	24
GO:0034080	CENP-A containing nucleosome assembly	1.21e-02	1.00e+00	6.365	1	1	25
GO:0043022	ribosome binding	1.30e-02	1.00e+00	6.254	1	3	27
GO:0071339	MLL1 complex	1.30e-02	1.00e+00	6.254	1	3	27
GO:0043967	histone H4 acetylation	1.30e-02	1.00e+00	6.254	1	3	27
GO:0031492	nucleosomal DNA binding	1.30e-02	1.00e+00	6.254	1	4	27
GO:0010332	response to gamma radiation	1.35e-02	1.00e+00	6.201	1	3	28
GO:0019894	kinesin binding	1.35e-02	1.00e+00	6.201	1	1	28
GO:0000278	mitotic cell cycle	1.41e-02	1.00e+00	3.398	2	48	391
GO:0001756	somitogenesis	1.59e-02	1.00e+00	5.964	1	2	33
GO:0030971	receptor tyrosine kinase binding	1.59e-02	1.00e+00	5.964	1	2	33
GO:0033077	T cell differentiation in thymus	1.59e-02	1.00e+00	5.964	1	2	33
GO:0001895	retina homeostasis	1.64e-02	1.00e+00	5.921	1	1	34
GO:0034332	adherens junction organization	1.73e-02	1.00e+00	5.839	1	1	36
GO:0001933	negative regulation of protein phosphorylation	1.73e-02	1.00e+00	5.839	1	2	36
GO:0070062	extracellular vesicular exosome	1.75e-02	1.00e+00	1.780	4	104	2400
GO:0051084	'de novo' posttranslational protein folding	1.78e-02	1.00e+00	5.799	1	4	37
GO:0042752	regulation of circadian rhythm	1.78e-02	1.00e+00	5.799	1	2	37
GO:0070527	platelet aggregation	1.83e-02	1.00e+00	5.761	1	2	38
GO:0022627	cytosolic small ribosomal subunit	1.88e-02	1.00e+00	5.723	1	4	39
GO:0000781	chromosome, telomeric region	1.88e-02	1.00e+00	5.723	1	3	39
GO:0005524	ATP binding	1.93e-02	1.00e+00	2.252	3	60	1298
GO:0032508	DNA duplex unwinding	1.97e-02	1.00e+00	5.651	1	3	41
GO:0005829	cytosol	2.01e-02	1.00e+00	1.723	4	132	2496
GO:0021762	substantia nigra development	2.12e-02	1.00e+00	5.549	1	2	44
GO:0048511	rhythmic process	2.16e-02	1.00e+00	5.517	1	3	45
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	2.35e-02	1.00e+00	5.394	1	5	49
GO:0003743	translation initiation factor activity	2.35e-02	1.00e+00	5.394	1	8	49
GO:0003684	damaged DNA binding	2.35e-02	1.00e+00	5.394	1	7	49
GO:0040008	regulation of growth	2.40e-02	1.00e+00	5.365	1	5	50
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.54e-02	1.00e+00	5.281	1	5	53
GO:0045216	cell-cell junction organization	2.59e-02	1.00e+00	5.254	1	2	54
GO:0000724	double-strand break repair via homologous recombination	2.64e-02	1.00e+00	5.227	1	3	55
GO:0032481	positive regulation of type I interferon production	2.92e-02	1.00e+00	5.078	1	6	61
GO:0030855	epithelial cell differentiation	2.92e-02	1.00e+00	5.078	1	4	61
GO:0019903	protein phosphatase binding	2.97e-02	1.00e+00	5.055	1	4	62
GO:0032869	cellular response to insulin stimulus	3.02e-02	1.00e+00	5.031	1	3	63
GO:0006310	DNA recombination	3.11e-02	1.00e+00	4.986	1	2	65
GO:0045087	innate immune response	3.12e-02	1.00e+00	2.790	2	24	596
GO:0034329	cell junction assembly	3.25e-02	1.00e+00	4.921	1	1	68
GO:0003697	single-stranded DNA binding	3.25e-02	1.00e+00	4.921	1	5	68
GO:0018105	peptidyl-serine phosphorylation	3.30e-02	1.00e+00	4.900	1	5	69
GO:0006334	nucleosome assembly	3.44e-02	1.00e+00	4.839	1	2	72
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	3.54e-02	1.00e+00	4.799	1	6	74
GO:0008584	male gonad development	3.58e-02	1.00e+00	4.780	1	3	75
GO:0005634	nucleus	3.60e-02	1.00e+00	1.176	5	136	4559
GO:0010467	gene expression	3.86e-02	1.00e+00	2.623	2	59	669
GO:0019083	viral transcription	3.87e-02	1.00e+00	4.669	1	10	81
GO:0006464	cellular protein modification process	4.01e-02	1.00e+00	4.616	1	2	84
GO:0047485	protein N-terminus binding	4.10e-02	1.00e+00	4.582	1	5	86
GO:0006415	translational termination	4.15e-02	1.00e+00	4.566	1	10	87
GO:0016605	PML body	4.19e-02	1.00e+00	4.549	1	3	88
GO:0016363	nuclear matrix	4.33e-02	1.00e+00	4.501	1	12	91
GO:0006928	cellular component movement	4.33e-02	1.00e+00	4.501	1	7	91
GO:0005200	structural constituent of cytoskeleton	4.33e-02	1.00e+00	4.501	1	8	91
GO:0006414	translational elongation	4.43e-02	1.00e+00	4.470	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	4.94e-02	1.00e+00	4.308	1	10	104
GO:0014069	postsynaptic density	4.99e-02	1.00e+00	4.294	1	3	105
GO:0005815	microtubule organizing center	5.17e-02	1.00e+00	4.241	1	5	109
GO:0072562	blood microparticle	5.27e-02	1.00e+00	4.214	1	3	111
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	5.40e-02	1.00e+00	4.176	1	11	114
GO:0019058	viral life cycle	5.45e-02	1.00e+00	4.163	1	13	115
GO:0006260	DNA replication	5.73e-02	1.00e+00	4.090	1	9	121
GO:0000790	nuclear chromatin	6.10e-02	1.00e+00	3.998	1	9	129
GO:0003735	structural constituent of ribosome	6.46e-02	1.00e+00	3.911	1	10	137
GO:0016887	ATPase activity	6.60e-02	1.00e+00	3.879	1	7	140
GO:0006457	protein folding	6.74e-02	1.00e+00	3.849	1	7	143
GO:0061024	membrane organization	6.83e-02	1.00e+00	3.829	1	7	145
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	7.74e-02	1.00e+00	3.642	1	7	165
GO:0030424	axon	7.79e-02	1.00e+00	3.634	1	4	166
GO:0007420	brain development	7.83e-02	1.00e+00	3.625	1	2	167
GO:0005737	cytoplasm	8.13e-02	1.00e+00	1.130	4	110	3767
GO:0005667	transcription factor complex	8.19e-02	1.00e+00	3.558	1	4	175
GO:0004672	protein kinase activity	8.28e-02	1.00e+00	3.541	1	6	177
GO:0031625	ubiquitin protein ligase binding	8.33e-02	1.00e+00	3.533	1	14	178
GO:0001701	in utero embryonic development	9.36e-02	1.00e+00	3.358	1	8	201
GO:0016071	mRNA metabolic process	1.03e-01	1.00e+00	3.208	1	31	223
GO:0007067	mitotic nuclear division	1.05e-01	1.00e+00	3.182	1	14	227
GO:0008134	transcription factor binding	1.12e-01	1.00e+00	3.090	1	8	242
GO:0016070	RNA metabolic process	1.14e-01	1.00e+00	3.060	1	32	247
GO:0007283	spermatogenesis	1.20e-01	1.00e+00	2.975	1	8	262
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.21e-01	1.00e+00	2.964	1	8	264
GO:0043065	positive regulation of apoptotic process	1.23e-01	1.00e+00	2.943	1	10	268
GO:0005856	cytoskeleton	1.33e-01	1.00e+00	2.824	1	12	291
GO:0043234	protein complex	1.35e-01	1.00e+00	2.804	1	18	295
GO:0004674	protein serine/threonine kinase activity	1.40e-01	1.00e+00	2.742	1	12	308
GO:0019901	protein kinase binding	1.44e-01	1.00e+00	2.700	1	21	317
GO:0043231	intracellular membrane-bounded organelle	1.45e-01	1.00e+00	2.696	1	9	318
GO:0007411	axon guidance	1.45e-01	1.00e+00	2.691	1	13	319
GO:0005813	centrosome	1.48e-01	1.00e+00	2.660	1	14	326
GO:0008283	cell proliferation	1.49e-01	1.00e+00	2.651	1	14	328
GO:0003723	RNA binding	1.55e-01	1.00e+00	2.591	1	20	342
GO:0005925	focal adhesion	1.65e-01	1.00e+00	2.493	1	19	366
GO:0007155	cell adhesion	1.66e-01	1.00e+00	2.481	1	6	369
GO:0007596	blood coagulation	2.01e-01	1.00e+00	2.179	1	18	455
GO:0042802	identical protein binding	2.13e-01	1.00e+00	2.090	1	20	484
GO:0016032	viral process	2.32e-01	1.00e+00	1.948	1	55	534
GO:0005794	Golgi apparatus	2.61e-01	1.00e+00	1.756	1	15	610
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	3.26e-01	1.00e+00	1.385	1	19	789
GO:0005615	extracellular space	3.82e-01	1.00e+00	1.106	1	17	957
GO:0003677	DNA binding	4.61e-01	1.00e+00	0.758	1	28	1218
GO:0046872	metal ion binding	4.86e-01	1.00e+00	0.657	1	25	1307
GO:0006351	transcription, DNA-templated	5.23e-01	1.00e+00	0.511	1	31	1446
GO:0005886	plasma membrane	7.49e-01	1.00e+00	-0.326	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-5591

Statistics

Genes (7)

Interactions (8)

Related GO terms (183)