int-snw-5001

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.992	8.37e-18	6.68e-04	1.52e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-5001 subnetwork

Genes (6)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
RBX1	9978	97	1.185	1.151	139	Yes	-
MCM5	4174	4	0.578	0.992	121	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-
[ ORC5 ]	5001	2	-0.461	0.992	31	-	Yes

Interactions (7)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
MCM5	4174	RPA2	6118	pp	--	int.I2D: BioGrid, HPRD; int.HPRD: yeast 2-hybrid
MCM5	4174	ORC5	5001	pp	--	int.Intact: MI:0407(direct interaction); int.I2D: HPRD, BCI, BIND, IntAct; int.HPRD: in vitro
ORC5	5001	RPA2	6118	pp	--	int.I2D: BioGrid
ACTB	60	MCM5	4174	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct

Related GO terms (133)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006260	DNA replication	1.13e-05	1.63e-01	5.897	3	9	121
GO:0005654	nucleoplasm	1.33e-05	1.91e-01	3.474	5	76	1082
GO:0000082	G1/S transition of mitotic cell cycle	2.11e-05	3.05e-01	5.597	3	32	149
GO:0006270	DNA replication initiation	3.32e-05	4.79e-01	7.772	2	6	22
GO:0006271	DNA strand elongation involved in DNA replication	6.24e-05	9.00e-01	7.324	2	7	30
GO:0000278	mitotic cell cycle	3.72e-04	1.00e+00	4.205	3	48	391
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	8.32e-04	1.00e+00	10.231	1	1	2
GO:0005055	laminin receptor activity	8.32e-04	1.00e+00	10.231	1	1	2
GO:0006407	rRNA export from nucleus	8.32e-04	1.00e+00	10.231	1	1	2
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.66e-03	1.00e+00	9.231	1	1	4
GO:0030686	90S preribosome	1.66e-03	1.00e+00	9.231	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	1.66e-03	1.00e+00	9.231	1	1	4
GO:0019788	NEDD8 ligase activity	1.66e-03	1.00e+00	9.231	1	1	4
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	2.08e-03	1.00e+00	8.909	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	2.08e-03	1.00e+00	8.909	1	1	5
GO:0030891	VCB complex	2.08e-03	1.00e+00	8.909	1	2	5
GO:0000730	DNA recombinase assembly	2.08e-03	1.00e+00	8.909	1	1	5
GO:2000001	regulation of DNA damage checkpoint	2.08e-03	1.00e+00	8.909	1	1	5
GO:0031625	ubiquitin protein ligase binding	2.20e-03	1.00e+00	4.755	2	14	178
GO:0003688	DNA replication origin binding	2.49e-03	1.00e+00	8.646	1	2	6
GO:0030957	Tat protein binding	2.49e-03	1.00e+00	8.646	1	3	6
GO:0000808	origin recognition complex	2.49e-03	1.00e+00	8.646	1	1	6
GO:0031466	Cul5-RING ubiquitin ligase complex	2.49e-03	1.00e+00	8.646	1	1	6
GO:0000028	ribosomal small subunit assembly	2.91e-03	1.00e+00	8.424	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	2.91e-03	1.00e+00	8.424	1	2	7
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	3.32e-03	1.00e+00	8.231	1	2	8
GO:0070688	MLL5-L complex	3.32e-03	1.00e+00	8.231	1	1	8
GO:0005664	nuclear origin of replication recognition complex	3.32e-03	1.00e+00	8.231	1	1	8
GO:0045116	protein neddylation	3.32e-03	1.00e+00	8.231	1	2	8
GO:0042555	MCM complex	3.74e-03	1.00e+00	8.061	1	2	9
GO:0010569	regulation of double-strand break repair via homologous recombination	4.15e-03	1.00e+00	7.909	1	1	10
GO:0031571	mitotic G1 DNA damage checkpoint	4.57e-03	1.00e+00	7.772	1	4	11
GO:0006281	DNA repair	4.66e-03	1.00e+00	4.203	2	18	261
GO:0005515	protein binding	5.30e-03	1.00e+00	1.260	6	184	6024
GO:0005662	DNA replication factor A complex	5.40e-03	1.00e+00	7.531	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	5.81e-03	1.00e+00	7.424	1	4	14
GO:0050998	nitric-oxide synthase binding	6.64e-03	1.00e+00	7.231	1	1	16
GO:0003678	DNA helicase activity	7.05e-03	1.00e+00	7.144	1	3	17
GO:0035861	site of double-strand break	7.47e-03	1.00e+00	7.061	1	1	18
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7.88e-03	1.00e+00	6.983	1	1	19
GO:0006298	mismatch repair	8.29e-03	1.00e+00	6.909	1	3	20
GO:0032201	telomere maintenance via semi-conservative replication	8.71e-03	1.00e+00	6.839	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	8.71e-03	1.00e+00	6.839	1	4	21
GO:0006297	nucleotide-excision repair, DNA gap filling	9.12e-03	1.00e+00	6.772	1	3	22
GO:0030863	cortical cytoskeleton	9.12e-03	1.00e+00	6.772	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	9.12e-03	1.00e+00	6.772	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	9.53e-03	1.00e+00	6.708	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	9.53e-03	1.00e+00	6.708	1	3	23
GO:0043236	laminin binding	9.53e-03	1.00e+00	6.708	1	1	23
GO:0006513	protein monoubiquitination	9.53e-03	1.00e+00	6.708	1	1	23
GO:0000722	telomere maintenance via recombination	1.04e-02	1.00e+00	6.587	1	5	25
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.08e-02	1.00e+00	6.531	1	3	26
GO:0043022	ribosome binding	1.12e-02	1.00e+00	6.476	1	3	27
GO:0031492	nucleosomal DNA binding	1.12e-02	1.00e+00	6.476	1	4	27
GO:0019894	kinesin binding	1.16e-02	1.00e+00	6.424	1	1	28
GO:0005524	ATP binding	1.18e-02	1.00e+00	2.474	3	60	1298
GO:0019005	SCF ubiquitin ligase complex	1.20e-02	1.00e+00	6.373	1	1	29
GO:0001895	retina homeostasis	1.41e-02	1.00e+00	6.144	1	1	34
GO:0044267	cellular protein metabolic process	1.48e-02	1.00e+00	3.342	2	29	474
GO:0034332	adherens junction organization	1.49e-02	1.00e+00	6.061	1	1	36
GO:0051084	'de novo' posttranslational protein folding	1.53e-02	1.00e+00	6.022	1	4	37
GO:0006284	base-excision repair	1.53e-02	1.00e+00	6.022	1	3	37
GO:0070527	platelet aggregation	1.57e-02	1.00e+00	5.983	1	2	38
GO:0022627	cytosolic small ribosomal subunit	1.61e-02	1.00e+00	5.946	1	4	39
GO:0000781	chromosome, telomeric region	1.61e-02	1.00e+00	5.946	1	3	39
GO:0032508	DNA duplex unwinding	1.69e-02	1.00e+00	5.874	1	3	41
GO:0021762	substantia nigra development	1.82e-02	1.00e+00	5.772	1	2	44
GO:0016032	viral process	1.86e-02	1.00e+00	3.170	2	55	534
GO:0006283	transcription-coupled nucleotide-excision repair	1.90e-02	1.00e+00	5.708	1	7	46
GO:0003684	damaged DNA binding	2.02e-02	1.00e+00	5.616	1	7	49
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.19e-02	1.00e+00	5.503	1	5	53
GO:0045216	cell-cell junction organization	2.23e-02	1.00e+00	5.476	1	2	54
GO:0000724	double-strand break repair via homologous recombination	2.27e-02	1.00e+00	5.450	1	3	55
GO:0000723	telomere maintenance	2.31e-02	1.00e+00	5.424	1	6	56
GO:0016020	membrane	2.41e-02	1.00e+00	2.101	3	90	1681
GO:0019903	protein phosphatase binding	2.55e-02	1.00e+00	5.277	1	4	62
GO:0006302	double-strand break repair	2.55e-02	1.00e+00	5.277	1	4	62
GO:0006289	nucleotide-excision repair	2.80e-02	1.00e+00	5.144	1	11	68
GO:0034329	cell junction assembly	2.80e-02	1.00e+00	5.144	1	1	68
GO:0003697	single-stranded DNA binding	2.80e-02	1.00e+00	5.144	1	5	68
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	3.04e-02	1.00e+00	5.022	1	6	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	3.08e-02	1.00e+00	5.002	1	2	75
GO:0019083	viral transcription	3.32e-02	1.00e+00	4.891	1	10	81
GO:0047485	protein N-terminus binding	3.53e-02	1.00e+00	4.805	1	5	86
GO:0006415	translational termination	3.57e-02	1.00e+00	4.788	1	10	87
GO:0016605	PML body	3.61e-02	1.00e+00	4.772	1	3	88
GO:0006928	cellular component movement	3.73e-02	1.00e+00	4.723	1	7	91
GO:0005200	structural constituent of cytoskeleton	3.73e-02	1.00e+00	4.723	1	8	91
GO:0071456	cellular response to hypoxia	3.77e-02	1.00e+00	4.708	1	6	92
GO:0006414	translational elongation	3.81e-02	1.00e+00	4.692	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	4.25e-02	1.00e+00	4.531	1	10	104
GO:0014069	postsynaptic density	4.29e-02	1.00e+00	4.517	1	3	105
GO:0072562	blood microparticle	4.53e-02	1.00e+00	4.437	1	3	111
GO:0030529	ribonucleoprotein complex	4.57e-02	1.00e+00	4.424	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	4.65e-02	1.00e+00	4.398	1	11	114
GO:0019058	viral life cycle	4.69e-02	1.00e+00	4.386	1	13	115
GO:0006325	chromatin organization	4.81e-02	1.00e+00	4.348	1	5	118
GO:0007219	Notch signaling pathway	4.89e-02	1.00e+00	4.324	1	5	120
GO:0000790	nuclear chromatin	5.25e-02	1.00e+00	4.220	1	9	129
GO:0006413	translational initiation	5.33e-02	1.00e+00	4.198	1	17	131
GO:0003735	structural constituent of ribosome	5.57e-02	1.00e+00	4.133	1	10	137
GO:0006457	protein folding	5.80e-02	1.00e+00	4.071	1	7	143
GO:0061024	membrane organization	5.88e-02	1.00e+00	4.051	1	7	145
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	6.67e-02	1.00e+00	3.865	1	7	165
GO:0030424	axon	6.71e-02	1.00e+00	3.856	1	4	166
GO:0005829	cytosol	6.86e-02	1.00e+00	1.531	3	132	2496
GO:0032403	protein complex binding	7.38e-02	1.00e+00	3.715	1	10	183
GO:0005634	nucleus	8.39e-02	1.00e+00	1.077	4	136	4559
GO:0016071	mRNA metabolic process	8.93e-02	1.00e+00	3.430	1	31	223
GO:0006412	translation	9.20e-02	1.00e+00	3.386	1	20	230
GO:0016070	RNA metabolic process	9.85e-02	1.00e+00	3.283	1	32	247
GO:0004842	ubiquitin-protein transferase activity	1.02e-01	1.00e+00	3.237	1	6	255
GO:0000166	nucleotide binding	1.03e-01	1.00e+00	3.214	1	5	259
GO:0019899	enzyme binding	1.10e-01	1.00e+00	3.117	1	12	277
GO:0005856	cytoskeleton	1.15e-01	1.00e+00	3.046	1	12	291
GO:0043234	protein complex	1.17e-01	1.00e+00	3.027	1	18	295
GO:0016567	protein ubiquitination	1.17e-01	1.00e+00	3.027	1	5	295
GO:0019901	protein kinase binding	1.25e-01	1.00e+00	2.923	1	21	317
GO:0007411	axon guidance	1.26e-01	1.00e+00	2.914	1	13	319
GO:0005730	nucleolus	1.42e-01	1.00e+00	1.551	2	69	1641
GO:0005925	focal adhesion	1.43e-01	1.00e+00	2.715	1	19	366
GO:0007155	cell adhesion	1.44e-01	1.00e+00	2.704	1	6	369
GO:0003674	molecular_function	1.71e-01	1.00e+00	2.437	1	4	444
GO:0007596	blood coagulation	1.75e-01	1.00e+00	2.401	1	18	455
GO:0005737	cytoplasm	1.87e-01	1.00e+00	0.937	3	110	3767
GO:0045087	innate immune response	2.24e-01	1.00e+00	2.012	1	24	596
GO:0010467	gene expression	2.48e-01	1.00e+00	1.845	1	59	669
GO:0070062	extracellular vesicular exosome	2.63e-01	1.00e+00	1.002	2	104	2400
GO:0005615	extracellular space	3.38e-01	1.00e+00	1.329	1	17	957
GO:0008270	zinc ion binding	3.49e-01	1.00e+00	1.270	1	12	997
GO:0044822	poly(A) RNA binding	3.66e-01	1.00e+00	1.187	1	49	1056
GO:0003677	DNA binding	4.11e-01	1.00e+00	0.981	1	28	1218
GO:0005886	plasma membrane	6.94e-01	1.00e+00	-0.103	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-5001

Statistics

Genes (6)

Interactions (7)

Related GO terms (133)