int-snw-4174

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.983	2.08e-17	8.40e-04	1.81e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-4174 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
CAD	790	17	0.807	1.007	333	-	-
RPA2	6118	98	1.250	1.151	69	Yes	-
RSL24D1	51187	36	1.300	1.020	59	Yes	-
EIF6	3692	14	0.700	1.013	267	Yes	-
PSMD13	5719	16	0.848	1.029	104	Yes	-
[ MCM5 ]	4174	4	0.578	0.992	121	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
ATP6V1B2	526	44	0.881	1.076	278	-	-
RPSA	3921	156	1.327	1.151	152	Yes	-

Interactions (14)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
MCM5	4174	PSMD13	5719	pp	--	int.I2D: YeastLow
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
ACTB	60	MCM5	4174	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
CAD	790	RPSA	3921	pp	--	int.I2D: IntAct_Yeast
ATP6V1B2	526	RPSA	3921	pp	--	int.I2D: IntAct_Yeast
ACTB	60	ATP6V1B2	526	pp	--	int.I2D: BioGrid_Yeast
MCM5	4174	RPA2	6118	pp	--	int.I2D: BioGrid, HPRD; int.HPRD: yeast 2-hybrid
EIF6	3692	MCM5	4174	pp	--	int.I2D: YeastLow
CAD	790	MCM5	4174	pp	--	int.I2D: IntAct_Yeast
ATP6V1B2	526	MCM5	4174	pp	--	int.I2D: IntAct_Yeast
EIF6	3692	RSL24D1	51187	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	PSMD13	5719	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	CAD	790	pp	--	int.I2D: IntAct_Yeast

Related GO terms (186)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0000082	G1/S transition of mitotic cell cycle	8.67e-05	1.00e+00	5.012	3	32	149
GO:0043022	ribosome binding	1.21e-04	1.00e+00	6.891	2	3	27
GO:0006271	DNA strand elongation involved in DNA replication	1.49e-04	1.00e+00	6.739	2	7	30
GO:0004151	dihydroorotase activity	6.24e-04	1.00e+00	10.646	1	1	1
GO:0000054	ribosomal subunit export from nucleus	6.24e-04	1.00e+00	10.646	1	1	1
GO:0004070	aspartate carbamoyltransferase activity	6.24e-04	1.00e+00	10.646	1	1	1
GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	6.24e-04	1.00e+00	10.646	1	1	1
GO:0070335	aspartate binding	6.24e-04	1.00e+00	10.646	1	1	1
GO:0070062	extracellular vesicular exosome	1.12e-03	1.00e+00	2.002	6	104	2400
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.25e-03	1.00e+00	9.646	1	1	2
GO:0005055	laminin receptor activity	1.25e-03	1.00e+00	9.646	1	1	2
GO:0006407	rRNA export from nucleus	1.25e-03	1.00e+00	9.646	1	1	2
GO:0007127	meiosis I	1.25e-03	1.00e+00	9.646	1	1	2
GO:0070409	carbamoyl phosphate biosynthetic process	1.25e-03	1.00e+00	9.646	1	1	2
GO:0000278	mitotic cell cycle	1.47e-03	1.00e+00	3.620	3	48	391
GO:0016020	membrane	1.80e-03	1.00e+00	2.253	5	90	1681
GO:0044205	'de novo' UMP biosynthetic process	1.87e-03	1.00e+00	9.061	1	1	3
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	1.87e-03	1.00e+00	9.061	1	1	3
GO:0006260	DNA replication	2.42e-03	1.00e+00	4.727	2	9	121
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.49e-03	1.00e+00	8.646	1	1	4
GO:0030686	90S preribosome	2.49e-03	1.00e+00	8.646	1	1	4
GO:0006543	glutamine catabolic process	2.49e-03	1.00e+00	8.646	1	1	4
GO:0006413	translational initiation	2.83e-03	1.00e+00	4.613	2	17	131
GO:0005654	nucleoplasm	2.92e-03	1.00e+00	2.567	4	76	1082
GO:0051414	response to cortisol	3.12e-03	1.00e+00	8.324	1	1	5
GO:0042256	mature ribosome assembly	3.12e-03	1.00e+00	8.324	1	1	5
GO:0000730	DNA recombinase assembly	3.12e-03	1.00e+00	8.324	1	1	5
GO:2000001	regulation of DNA damage checkpoint	3.12e-03	1.00e+00	8.324	1	1	5
GO:0005638	lamin filament	3.12e-03	1.00e+00	8.324	1	1	5
GO:0043023	ribosomal large subunit binding	3.12e-03	1.00e+00	8.324	1	1	5
GO:0030957	Tat protein binding	3.74e-03	1.00e+00	8.061	1	3	6
GO:0046134	pyrimidine nucleoside biosynthetic process	3.74e-03	1.00e+00	8.061	1	1	6
GO:0033180	proton-transporting V-type ATPase, V1 domain	4.36e-03	1.00e+00	7.839	1	2	7
GO:0000028	ribosomal small subunit assembly	4.36e-03	1.00e+00	7.839	1	1	7
GO:0070688	MLL5-L complex	4.98e-03	1.00e+00	7.646	1	1	8
GO:0006228	UTP biosynthetic process	5.60e-03	1.00e+00	7.476	1	1	9
GO:0014075	response to amine	5.60e-03	1.00e+00	7.476	1	1	9
GO:0031000	response to caffeine	5.60e-03	1.00e+00	7.476	1	2	9
GO:0042555	MCM complex	5.60e-03	1.00e+00	7.476	1	2	9
GO:0005524	ATP binding	5.68e-03	1.00e+00	2.304	4	60	1298
GO:0010569	regulation of double-strand break repair via homologous recombination	6.22e-03	1.00e+00	7.324	1	1	10
GO:0031571	mitotic G1 DNA damage checkpoint	6.85e-03	1.00e+00	7.187	1	4	11
GO:0005838	proteasome regulatory particle	7.47e-03	1.00e+00	7.061	1	7	12
GO:0016071	mRNA metabolic process	7.98e-03	1.00e+00	3.845	2	31	223
GO:0042273	ribosomal large subunit biogenesis	8.09e-03	1.00e+00	6.946	1	4	13
GO:0005662	DNA replication factor A complex	8.09e-03	1.00e+00	6.946	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	8.70e-03	1.00e+00	6.839	1	4	14
GO:0046961	proton-transporting ATPase activity, rotational mechanism	9.32e-03	1.00e+00	6.739	1	3	15
GO:0046034	ATP metabolic process	9.32e-03	1.00e+00	6.739	1	1	15
GO:0016070	RNA metabolic process	9.71e-03	1.00e+00	3.698	2	32	247
GO:0050998	nitric-oxide synthase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0005829	cytosol	1.05e-02	1.00e+00	1.683	5	132	2496
GO:0006541	glutamine metabolic process	1.06e-02	1.00e+00	6.559	1	1	17
GO:0003678	DNA helicase activity	1.06e-02	1.00e+00	6.559	1	3	17
GO:0022624	proteasome accessory complex	1.06e-02	1.00e+00	6.559	1	8	17
GO:0035861	site of double-strand break	1.12e-02	1.00e+00	6.476	1	1	18
GO:0017144	drug metabolic process	1.12e-02	1.00e+00	6.476	1	1	18
GO:0015078	hydrogen ion transmembrane transporter activity	1.18e-02	1.00e+00	6.398	1	3	19
GO:0019899	enzyme binding	1.21e-02	1.00e+00	3.532	2	12	277
GO:0006298	mismatch repair	1.24e-02	1.00e+00	6.324	1	3	20
GO:0071364	cellular response to epidermal growth factor stimulus	1.30e-02	1.00e+00	6.254	1	1	21
GO:0032201	telomere maintenance via semi-conservative replication	1.30e-02	1.00e+00	6.254	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.30e-02	1.00e+00	6.254	1	4	21
GO:0005730	nucleolus	1.31e-02	1.00e+00	1.966	4	69	1641
GO:0006206	pyrimidine nucleobase metabolic process	1.36e-02	1.00e+00	6.187	1	2	22
GO:0006297	nucleotide-excision repair, DNA gap filling	1.36e-02	1.00e+00	6.187	1	3	22
GO:0033574	response to testosterone	1.36e-02	1.00e+00	6.187	1	2	22
GO:0030863	cortical cytoskeleton	1.36e-02	1.00e+00	6.187	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.36e-02	1.00e+00	6.187	1	4	22
GO:0006270	DNA replication initiation	1.36e-02	1.00e+00	6.187	1	6	22
GO:0043234	protein complex	1.37e-02	1.00e+00	3.442	2	18	295
GO:0043044	ATP-dependent chromatin remodeling	1.43e-02	1.00e+00	6.123	1	4	23
GO:0043236	laminin binding	1.43e-02	1.00e+00	6.123	1	1	23
GO:0000722	telomere maintenance via recombination	1.55e-02	1.00e+00	6.002	1	5	25
GO:0015991	ATP hydrolysis coupled proton transport	1.61e-02	1.00e+00	5.946	1	4	26
GO:0031492	nucleosomal DNA binding	1.67e-02	1.00e+00	5.891	1	4	27
GO:0019894	kinesin binding	1.73e-02	1.00e+00	5.839	1	1	28
GO:0015992	proton transport	1.80e-02	1.00e+00	5.788	1	3	29
GO:0042254	ribosome biogenesis	1.86e-02	1.00e+00	5.739	1	1	30
GO:0033572	transferrin transport	1.86e-02	1.00e+00	5.739	1	5	30
GO:0051701	interaction with host	1.98e-02	1.00e+00	5.646	1	4	32
GO:0001895	retina homeostasis	2.10e-02	1.00e+00	5.559	1	1	34
GO:0034332	adherens junction organization	2.22e-02	1.00e+00	5.476	1	1	36
GO:0090382	phagosome maturation	2.22e-02	1.00e+00	5.476	1	5	36
GO:0018107	peptidyl-threonine phosphorylation	2.29e-02	1.00e+00	5.437	1	4	37
GO:0051084	'de novo' posttranslational protein folding	2.29e-02	1.00e+00	5.437	1	4	37
GO:0006284	base-excision repair	2.29e-02	1.00e+00	5.437	1	3	37
GO:0005902	microvillus	2.35e-02	1.00e+00	5.398	1	2	38
GO:0070527	platelet aggregation	2.35e-02	1.00e+00	5.398	1	2	38
GO:0022627	cytosolic small ribosomal subunit	2.41e-02	1.00e+00	5.361	1	4	39
GO:0000781	chromosome, telomeric region	2.41e-02	1.00e+00	5.361	1	3	39
GO:0007595	lactation	2.41e-02	1.00e+00	5.361	1	2	39
GO:0043195	terminal bouton	2.53e-02	1.00e+00	5.289	1	1	41
GO:0032508	DNA duplex unwinding	2.53e-02	1.00e+00	5.289	1	3	41
GO:0021762	substantia nigra development	2.71e-02	1.00e+00	5.187	1	2	44
GO:0006283	transcription-coupled nucleotide-excision repair	2.83e-02	1.00e+00	5.123	1	7	46
GO:0003743	translation initiation factor activity	3.02e-02	1.00e+00	5.031	1	8	49
GO:0035690	cellular response to drug	3.02e-02	1.00e+00	5.031	1	2	49
GO:0003684	damaged DNA binding	3.02e-02	1.00e+00	5.031	1	7	49
GO:0006521	regulation of cellular amino acid metabolic process	3.08e-02	1.00e+00	5.002	1	17	50
GO:0031100	organ regeneration	3.08e-02	1.00e+00	5.002	1	4	50
GO:0006879	cellular iron ion homeostasis	3.14e-02	1.00e+00	4.974	1	4	51
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.26e-02	1.00e+00	4.918	1	5	53
GO:0005634	nucleus	3.27e-02	1.00e+00	1.077	6	136	4559
GO:0045216	cell-cell junction organization	3.32e-02	1.00e+00	4.891	1	2	54
GO:0044267	cellular protein metabolic process	3.33e-02	1.00e+00	2.757	2	29	474
GO:0000724	double-strand break repair via homologous recombination	3.38e-02	1.00e+00	4.865	1	3	55
GO:0000723	telomere maintenance	3.44e-02	1.00e+00	4.839	1	6	56
GO:0012505	endomembrane system	3.44e-02	1.00e+00	4.839	1	2	56
GO:0000502	proteasome complex	3.56e-02	1.00e+00	4.788	1	17	58
GO:0042995	cell projection	3.68e-02	1.00e+00	4.739	1	6	60
GO:0019903	protein phosphatase binding	3.80e-02	1.00e+00	4.692	1	4	62
GO:0006302	double-strand break repair	3.80e-02	1.00e+00	4.692	1	4	62
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	3.92e-02	1.00e+00	4.646	1	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.98e-02	1.00e+00	4.624	1	22	65
GO:0016032	viral process	4.14e-02	1.00e+00	2.585	2	55	534
GO:0006289	nucleotide-excision repair	4.17e-02	1.00e+00	4.559	1	11	68
GO:0034329	cell junction assembly	4.17e-02	1.00e+00	4.559	1	1	68
GO:0003697	single-stranded DNA binding	4.17e-02	1.00e+00	4.559	1	5	68
GO:0055086	nucleobase-containing small molecule metabolic process	4.29e-02	1.00e+00	4.517	1	2	70
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.29e-02	1.00e+00	4.517	1	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	4.41e-02	1.00e+00	4.476	1	20	72
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.53e-02	1.00e+00	4.437	1	6	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.53e-02	1.00e+00	4.437	1	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	4.59e-02	1.00e+00	4.417	1	20	75
GO:0001889	liver development	4.70e-02	1.00e+00	4.379	1	4	77
GO:0007565	female pregnancy	4.76e-02	1.00e+00	4.361	1	1	78
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	4.82e-02	1.00e+00	4.342	1	23	79
GO:0001726	ruffle	4.88e-02	1.00e+00	4.324	1	4	80
GO:0019083	viral transcription	4.94e-02	1.00e+00	4.306	1	10	81
GO:0047485	protein N-terminus binding	5.24e-02	1.00e+00	4.220	1	5	86
GO:0006415	translational termination	5.30e-02	1.00e+00	4.203	1	10	87
GO:0016605	PML body	5.36e-02	1.00e+00	4.187	1	3	88
GO:0042470	melanosome	5.54e-02	1.00e+00	4.138	1	9	91
GO:0016363	nuclear matrix	5.54e-02	1.00e+00	4.138	1	12	91
GO:0006928	cellular component movement	5.54e-02	1.00e+00	4.138	1	7	91
GO:0005200	structural constituent of cytoskeleton	5.54e-02	1.00e+00	4.138	1	8	91
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	5.60e-02	1.00e+00	4.123	1	21	92
GO:0006414	translational elongation	5.66e-02	1.00e+00	4.107	1	13	93
GO:0010467	gene expression	6.23e-02	1.00e+00	2.260	2	59	669
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	6.31e-02	1.00e+00	3.946	1	10	104
GO:0014069	postsynaptic density	6.37e-02	1.00e+00	3.932	1	3	105
GO:0072562	blood microparticle	6.72e-02	1.00e+00	3.852	1	3	111
GO:0030529	ribonucleoprotein complex	6.78e-02	1.00e+00	3.839	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6.89e-02	1.00e+00	3.813	1	11	114
GO:0019058	viral life cycle	6.95e-02	1.00e+00	3.801	1	13	115
GO:0000209	protein polyubiquitination	7.01e-02	1.00e+00	3.788	1	20	116
GO:0006325	chromatin organization	7.13e-02	1.00e+00	3.764	1	5	118
GO:0000790	nuclear chromatin	7.77e-02	1.00e+00	3.635	1	9	129
GO:0003735	structural constituent of ribosome	8.23e-02	1.00e+00	3.548	1	10	137
GO:0007507	heart development	8.35e-02	1.00e+00	3.527	1	7	139
GO:0008286	insulin receptor signaling pathway	8.52e-02	1.00e+00	3.496	1	7	142
GO:0006457	protein folding	8.58e-02	1.00e+00	3.486	1	7	143
GO:0061024	membrane organization	8.69e-02	1.00e+00	3.466	1	7	145
GO:0042981	regulation of apoptotic process	8.98e-02	1.00e+00	3.417	1	24	150
GO:0046777	protein autophosphorylation	9.44e-02	1.00e+00	3.342	1	7	158
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	9.84e-02	1.00e+00	3.280	1	7	165
GO:0030424	axon	9.90e-02	1.00e+00	3.271	1	4	166
GO:0034641	cellular nitrogen compound metabolic process	1.02e-01	1.00e+00	3.228	1	20	171
GO:0004672	protein kinase activity	1.05e-01	1.00e+00	3.179	1	6	177
GO:0031625	ubiquitin protein ligase binding	1.06e-01	1.00e+00	3.170	1	14	178
GO:0005765	lysosomal membrane	1.20e-01	1.00e+00	2.981	1	5	203
GO:0006412	translation	1.35e-01	1.00e+00	2.801	1	20	230
GO:0043025	neuronal cell body	1.43e-01	1.00e+00	2.710	1	9	245
GO:0006281	DNA repair	1.52e-01	1.00e+00	2.618	1	18	261
GO:0005856	cytoskeleton	1.68e-01	1.00e+00	2.461	1	12	291
GO:0044281	small molecule metabolic process	1.71e-01	1.00e+00	1.404	2	58	1211
GO:0019901	protein kinase binding	1.81e-01	1.00e+00	2.338	1	21	317
GO:0043231	intracellular membrane-bounded organelle	1.82e-01	1.00e+00	2.333	1	9	318
GO:0007411	axon guidance	1.82e-01	1.00e+00	2.329	1	13	319
GO:0005925	focal adhesion	2.07e-01	1.00e+00	2.130	1	19	366
GO:0007155	cell adhesion	2.08e-01	1.00e+00	2.119	1	6	369
GO:0043066	negative regulation of apoptotic process	2.36e-01	1.00e+00	1.918	1	31	424
GO:0055085	transmembrane transport	2.41e-01	1.00e+00	1.881	1	10	435
GO:0007596	blood coagulation	2.51e-01	1.00e+00	1.816	1	18	455
GO:0042802	identical protein binding	2.65e-01	1.00e+00	1.727	1	20	484
GO:0006915	apoptotic process	2.98e-01	1.00e+00	1.530	1	33	555
GO:0005515	protein binding	3.04e-01	1.00e+00	0.412	5	184	6024
GO:0045087	innate immune response	3.16e-01	1.00e+00	1.427	1	24	596
GO:0005737	cytoplasm	4.31e-01	1.00e+00	0.352	3	110	3767
GO:0005615	extracellular space	4.61e-01	1.00e+00	0.744	1	17	957
GO:0008270	zinc ion binding	4.75e-01	1.00e+00	0.685	1	12	997
GO:0044822	poly(A) RNA binding	4.96e-01	1.00e+00	0.602	1	49	1056
GO:0005886	plasma membrane	4.98e-01	1.00e+00	0.312	2	45	2582
GO:0003677	DNA binding	5.48e-01	1.00e+00	0.396	1	28	1218
GO:0016021	integral component of membrane	7.36e-01	1.00e+00	-0.307	1	27	1982

Wolf-ratios-Mammosphere-Adherent

int-snw-4174

Statistics

Genes (9)

Interactions (14)

Related GO terms (186)