int-snw-3875

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.938 1.21e-15 2.30e-03 3.80e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-3875 subnetwork

Genes (8)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
TUBG1 7283 30.9740.93855Yes-
RPA2 6118 981.2501.15169Yes-
ACTB 60 1671.1531.151587Yes-
CASP8 841 80.8041.041141--
[ KRT18 ] 3875 1-0.3530.93894-Yes
RBX1 9978 971.1851.151139Yes-
RPSA 3921 1561.3271.151152Yes-
ORC5 5001 2-0.4610.99231-Yes

Interactions (7)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ORC5 5001 RPA2 6118 pp -- int.I2D: BioGrid
KRT18 3875 TUBG1 7283 pp -- int.I2D: HPRD, BIND;
int.HPRD: in vivo
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
CASP8 841 KRT18 3875 pp -- int.I2D: HPRD;
int.HPRD: in vitro
KRT18 3875 ORC5 5001 pp -- int.Intact: MI:0915(physical association)

Related GO terms (220)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0097284hepatocyte apoptotic process9.67e-061.40e-018.646239
GO:0031625ubiquitin protein ligase binding9.89e-051.00e+004.925314178
GO:0016032viral process1.15e-041.00e+003.755455534
GO:0097110scaffold protein binding1.50e-041.00e+006.7292334
GO:0097191extrinsic apoptotic signaling pathway1.87e-041.00e+006.5682338
GO:0043000Golgi to plasma membrane CFTR protein transport5.55e-041.00e+0010.816111
GO:0030690Noc1p-Noc2p complex5.55e-041.00e+0010.816111
GO:0070243regulation of thymocyte apoptotic process5.55e-041.00e+0010.816111
GO:0005515protein binding9.24e-041.00e+001.26081846024
GO:0000278mitotic cell cycle1.00e-031.00e+003.790348391
GO:0005200structural constituent of cytoskeleton1.08e-031.00e+005.3082891
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.11e-031.00e+009.816112
GO:0097199cysteine-type endopeptidase activity involved in apoptotic signaling pathway1.11e-031.00e+009.816112
GO:0005055laminin receptor activity1.11e-031.00e+009.816112
GO:0006407rRNA export from nucleus1.11e-031.00e+009.816112
GO:0005815microtubule organizing center1.54e-031.00e+005.04825109
GO:0060715syncytiotrophoblast cell differentiation involved in labyrinthine layer development1.66e-031.00e+009.231113
GO:0036462TRAIL-activated apoptotic signaling pathway1.66e-031.00e+009.231113
GO:0005654nucleoplasm1.73e-031.00e+002.7374761082
GO:0006260DNA replication1.89e-031.00e+004.89729121
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.22e-031.00e+008.816114
GO:0000212meiotic spindle organization2.22e-031.00e+008.816114
GO:003068690S preribosome2.22e-031.00e+008.816114
GO:0097153cysteine-type endopeptidase activity involved in apoptotic process2.22e-031.00e+008.816114
GO:0035877death effector domain binding2.22e-031.00e+008.816114
GO:0031467Cul7-RING ubiquitin ligase complex2.22e-031.00e+008.816114
GO:0019788NEDD8 ligase activity2.22e-031.00e+008.816114
GO:0031465Cul4B-RING E3 ubiquitin ligase complex2.77e-031.00e+008.494135
GO:0031461cullin-RING ubiquitin ligase complex2.77e-031.00e+008.494115
GO:0030891VCB complex2.77e-031.00e+008.494125
GO:0005827polar microtubule2.77e-031.00e+008.494115
GO:0000730DNA recombinase assembly2.77e-031.00e+008.494115
GO:2000001regulation of DNA damage checkpoint2.77e-031.00e+008.494115
GO:0032025response to cobalt ion2.77e-031.00e+008.494115
GO:0000082G1/S transition of mitotic cell cycle2.85e-031.00e+004.597232149
GO:0003688DNA replication origin binding3.32e-031.00e+008.231126
GO:0031265CD95 death-inducing signaling complex3.32e-031.00e+008.231116
GO:0030957Tat protein binding3.32e-031.00e+008.231136
GO:0031264death-inducing signaling complex3.32e-031.00e+008.231116
GO:0000808origin recognition complex3.32e-031.00e+008.231116
GO:0031466Cul5-RING ubiquitin ligase complex3.32e-031.00e+008.231116
GO:0060546negative regulation of necroptotic process3.88e-031.00e+008.009117
GO:0097342ripoptosome3.88e-031.00e+008.009117
GO:0000028ribosomal small subunit assembly3.88e-031.00e+008.009117
GO:0000930gamma-tubulin complex3.88e-031.00e+008.009117
GO:0031462Cul2-RING ubiquitin ligase complex3.88e-031.00e+008.009127
GO:0032403protein complex binding4.26e-031.00e+004.300210183
GO:0031464Cul4A-RING E3 ubiquitin ligase complex4.43e-031.00e+007.816128
GO:0097202activation of cysteine-type endopeptidase activity4.43e-031.00e+007.816118
GO:0070688MLL5-L complex4.43e-031.00e+007.816118
GO:0005664nuclear origin of replication recognition complex4.43e-031.00e+007.816118
GO:0045116protein neddylation4.43e-031.00e+007.816128
GO:0005737cytoplasm5.35e-031.00e+001.52261103767
GO:0005829cytosol5.45e-031.00e+001.85351322496
GO:0001841neural tube formation5.53e-031.00e+007.4941110
GO:0010569regulation of double-strand break repair via homologous recombination5.53e-031.00e+007.4941110
GO:2001239regulation of extrinsic apoptotic signaling pathway in absence of ligand6.09e-031.00e+007.3571111
GO:0031571mitotic G1 DNA damage checkpoint6.09e-031.00e+007.3571411
GO:0045651positive regulation of macrophage differentiation6.09e-031.00e+007.3571111
GO:0005662DNA replication factor A complex7.19e-031.00e+007.1161113
GO:0045104intermediate filament cytoskeleton organization7.19e-031.00e+007.1161113
GO:0035267NuA4 histone acetyltransferase complex7.74e-031.00e+007.0091414
GO:0007020microtubule nucleation7.74e-031.00e+007.0091114
GO:0034451centriolar satellite8.29e-031.00e+006.9091115
GO:0030225macrophage differentiation8.29e-031.00e+006.9091115
GO:0005123death receptor binding8.29e-031.00e+006.9091115
GO:0006281DNA repair8.50e-031.00e+003.788218261
GO:0050998nitric-oxide synthase binding8.84e-031.00e+006.8161116
GO:0030101natural killer cell activation8.84e-031.00e+006.8161116
GO:0051603proteolysis involved in cellular protein catabolic process8.84e-031.00e+006.8161216
GO:0031122cytoplasmic microtubule organization9.94e-031.00e+006.6461118
GO:0035861site of double-strand break9.94e-031.00e+006.6461118
GO:0097194execution phase of apoptosis1.05e-021.00e+006.5681119
GO:0005856cytoskeleton1.05e-021.00e+003.631212291
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.05e-021.00e+006.5681119
GO:0006298mismatch repair1.10e-021.00e+006.4941320
GO:0032201telomere maintenance via semi-conservative replication1.16e-021.00e+006.4241521
GO:0045862positive regulation of proteolysis1.16e-021.00e+006.4241121
GO:0000718nucleotide-excision repair, DNA damage removal1.16e-021.00e+006.4241421
GO:0006297nucleotide-excision repair, DNA gap filling1.21e-021.00e+006.3571322
GO:0030863cortical cytoskeleton1.21e-021.00e+006.3571122
GO:0036464cytoplasmic ribonucleoprotein granule1.21e-021.00e+006.3571422
GO:0006270DNA replication initiation1.21e-021.00e+006.3571622
GO:0043044ATP-dependent chromatin remodeling1.27e-021.00e+006.2931423
GO:0031463Cul3-RING ubiquitin ligase complex1.27e-021.00e+006.2931323
GO:0043236laminin binding1.27e-021.00e+006.2931123
GO:0006513protein monoubiquitination1.27e-021.00e+006.2931123
GO:0071944cell periphery1.27e-021.00e+006.2931123
GO:0000794condensed nuclear chromosome1.32e-021.00e+006.2311224
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway1.38e-021.00e+006.1721325
GO:0000722telomere maintenance via recombination1.38e-021.00e+006.1721525
GO:0042113B cell activation1.38e-021.00e+006.1721225
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway1.43e-021.00e+006.1161426
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.43e-021.00e+006.1161326
GO:0009409response to cold1.43e-021.00e+006.1161226
GO:0043022ribosome binding1.49e-021.00e+006.0611327
GO:2001238positive regulation of extrinsic apoptotic signaling pathway1.49e-021.00e+006.0611227
GO:0034612response to tumor necrosis factor1.49e-021.00e+006.0611227
GO:0031492nucleosomal DNA binding1.49e-021.00e+006.0611427
GO:0033209tumor necrosis factor-mediated signaling pathway1.54e-021.00e+006.0091228
GO:0019894kinesin binding1.54e-021.00e+006.0091128
GO:0019005SCF ubiquitin ligase complex1.60e-021.00e+005.9581129
GO:0006271DNA strand elongation involved in DNA replication1.65e-021.00e+005.9091730
GO:0005164tumor necrosis factor receptor binding1.65e-021.00e+005.9091230
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling1.65e-021.00e+005.9091130
GO:0046677response to antibiotic1.71e-021.00e+005.8621231
GO:0001895retina homeostasis1.87e-021.00e+005.7291134
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors1.87e-021.00e+005.7291234
GO:0034332adherens junction organization1.98e-021.00e+005.6461136
GO:0008234cysteine-type peptidase activity2.03e-021.00e+005.6071337
GO:0051084'de novo' posttranslational protein folding2.03e-021.00e+005.6071437
GO:0006284base-excision repair2.03e-021.00e+005.6071337
GO:0045095keratin filament2.03e-021.00e+005.6071137
GO:0071407cellular response to organic cyclic compound2.09e-021.00e+005.5681238
GO:0070527platelet aggregation2.09e-021.00e+005.5681238
GO:0022627cytosolic small ribosomal subunit2.14e-021.00e+005.5311439
GO:0000781chromosome, telomeric region2.14e-021.00e+005.5311339
GO:0042110T cell activation2.31e-021.00e+005.4241342
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway2.36e-021.00e+005.3901443
GO:0021762substantia nigra development2.42e-021.00e+005.3571244
GO:0006283transcription-coupled nucleotide-excision repair2.52e-021.00e+005.2931746
GO:0044297cell body2.52e-021.00e+005.2931246
GO:0006921cellular component disassembly involved in execution phase of apoptosis2.58e-021.00e+005.2611547
GO:0044267cellular protein metabolic process2.65e-021.00e+002.927229474
GO:0003684damaged DNA binding2.69e-021.00e+005.2011749
GO:0004197cysteine-type endopeptidase activity2.74e-021.00e+005.1721350
GO:0000226microtubule cytoskeleton organization2.85e-021.00e+005.1161352
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding2.90e-021.00e+005.0881553
GO:0008233peptidase activity2.96e-021.00e+005.0611254
GO:0045216cell-cell junction organization2.96e-021.00e+005.0611254
GO:0097193intrinsic apoptotic signaling pathway3.01e-021.00e+005.0351655
GO:0000724double-strand break repair via homologous recombination3.01e-021.00e+005.0351355
GO:0051291protein heterooligomerization3.06e-021.00e+005.0091256
GO:0000723telomere maintenance3.06e-021.00e+005.0091656
GO:0005882intermediate filament3.33e-021.00e+004.8851261
GO:0019903protein phosphatase binding3.39e-021.00e+004.8621462
GO:0006302double-strand break repair3.39e-021.00e+004.8621462
GO:0071260cellular response to mechanical stimulus3.55e-021.00e+004.7941565
GO:0006289nucleotide-excision repair3.71e-021.00e+004.72911168
GO:0034329cell junction assembly3.71e-021.00e+004.7291168
GO:0003697single-stranded DNA binding3.71e-021.00e+004.7291568
GO:0032355response to estradiol3.87e-021.00e+004.6661571
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis4.03e-021.00e+004.6071674
GO:0045087innate immune response4.05e-021.00e+002.597224596
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process4.09e-021.00e+004.5871275
GO:0035666TRIF-dependent toll-like receptor signaling pathway4.14e-021.00e+004.5681376
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process4.19e-021.00e+004.5491777
GO:0002756MyD88-independent toll-like receptor signaling pathway4.25e-021.00e+004.5311378
GO:0034138toll-like receptor 3 signaling pathway4.30e-021.00e+004.5121379
GO:0019083viral transcription4.41e-021.00e+004.47611081
GO:0009653anatomical structure morphogenesis4.51e-021.00e+004.4411383
GO:0047485protein N-terminus binding4.67e-021.00e+004.3901586
GO:0045471response to ethanol4.67e-021.00e+004.3901386
GO:0006415translational termination4.73e-021.00e+004.37311087
GO:0016605PML body4.78e-021.00e+004.3571388
GO:0006928cellular component movement4.94e-021.00e+004.3081791
GO:0071456cellular response to hypoxia4.99e-021.00e+004.2931692
GO:0006414translational elongation5.04e-021.00e+004.27711393
GO:0034142toll-like receptor 4 signaling pathway5.20e-021.00e+004.2311396
GO:0005730nucleolus5.31e-021.00e+001.7213691641
GO:0006614SRP-dependent cotranslational protein targeting to membrane5.63e-021.00e+004.116110104
GO:0014069postsynaptic density5.68e-021.00e+004.10213105
GO:0005741mitochondrial outer membrane5.68e-021.00e+004.10217105
GO:0002224toll-like receptor signaling pathway5.89e-021.00e+004.04813109
GO:0072562blood microparticle5.99e-021.00e+004.02213111
GO:0030529ribonucleoprotein complex6.05e-021.00e+004.00918112
GO:0097190apoptotic signaling pathway6.10e-021.00e+003.99616113
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay6.15e-021.00e+003.983111114
GO:0019058viral life cycle6.20e-021.00e+003.971113115
GO:0006325chromatin organization6.36e-021.00e+003.93315118
GO:0007219Notch signaling pathway6.47e-021.00e+003.90915120
GO:0032496response to lipopolysaccharide6.52e-021.00e+003.89714121
GO:0000790nuclear chromatin6.94e-021.00e+003.80519129
GO:0006413translational initiation7.04e-021.00e+003.783117131
GO:0000086G2/M transition of mitotic cell cycle7.30e-021.00e+003.72919136
GO:0003735structural constituent of ribosome7.35e-021.00e+003.718110137
GO:0007507heart development7.46e-021.00e+003.69717139
GO:0006457protein folding7.66e-021.00e+003.65617143
GO:0061024membrane organization7.77e-021.00e+003.63617145
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling7.77e-021.00e+003.63614145
GO:0005198structural molecule activity8.03e-021.00e+003.58715150
GO:0045121membrane raft8.33e-021.00e+003.53118156
GO:0043005neuron projection8.39e-021.00e+003.52116157
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding8.80e-021.00e+003.45017165
GO:0030424axon8.85e-021.00e+003.44114166
GO:0007049cell cycle9.26e-021.00e+003.37312174
GO:0001525angiogenesis1.01e-011.00e+003.23914191
GO:0003924GTPase activity1.04e-011.00e+003.194112197
GO:0044822poly(A) RNA binding1.12e-011.00e+001.7722491056
GO:0006184GTP catabolic process1.13e-011.00e+003.075112214
GO:0016071mRNA metabolic process1.17e-011.00e+003.015131223
GO:0006412translation1.21e-011.00e+002.971120230
GO:0016070RNA metabolic process1.29e-011.00e+002.868132247
GO:0004842ubiquitin-protein transferase activity1.33e-011.00e+002.82216255
GO:0070062extracellular vesicular exosome1.34e-011.00e+001.17231042400
GO:0000166nucleotide binding1.35e-011.00e+002.79915259
GO:0019899enzyme binding1.44e-011.00e+002.702112277
GO:0043234protein complex1.52e-011.00e+002.612118295
GO:0016567protein ubiquitination1.52e-011.00e+002.61215295
GO:0005524ATP binding1.58e-011.00e+001.4742601298
GO:0005525GTP binding1.60e-011.00e+002.540112310
GO:0019901protein kinase binding1.63e-011.00e+002.508121317
GO:0007411axon guidance1.64e-011.00e+002.499113319
GO:0005813centrosome1.67e-011.00e+002.467114326
GO:0005925focal adhesion1.86e-011.00e+002.300119366
GO:0007155cell adhesion1.87e-011.00e+002.28916369
GO:0006508proteolysis1.91e-011.00e+002.25419378
GO:0046982protein heterodimerization activity1.92e-011.00e+002.246113380
GO:0043066negative regulation of apoptotic process2.12e-011.00e+002.088131424
GO:0003674molecular_function2.21e-011.00e+002.02214444
GO:0005634nucleus2.24e-011.00e+000.66241364559
GO:0007596blood coagulation2.26e-011.00e+001.986118455
GO:0016020membrane2.37e-011.00e+001.1012901681
GO:0048471perinuclear region of cytoplasm2.47e-011.00e+001.845113502
GO:0006915apoptotic process2.69e-011.00e+001.700133555
GO:0010467gene expression3.16e-011.00e+001.430159669
GO:0005615extracellular space4.23e-011.00e+000.914117957
GO:0008270zinc ion binding4.36e-011.00e+000.855112997
GO:0005739mitochondrion4.37e-011.00e+000.853128998
GO:0005886plasma membrane7.94e-011.00e+00-0.5181452582