int-snw-3778

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.930 2.40e-15 2.72e-03 4.28e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-3778 subnetwork

Genes (9)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
RSL24D1 51187 361.3001.02059Yes-
ACO2 50 501.0001.076191Yes-
RUVBL1 8607 170.7201.013343Yes-
[ KCNMA1 ] 3778 10.0360.930180--
ACTB 60 1671.1531.151587Yes-
HSPD1 3329 350.9131.035286Yes-
RPSA 3921 1561.3271.151152Yes-
CFL1 1072 120.6741.020203Yes-

Interactions (17)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
HSPD1 3329 RPSA 3921 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB 60 RUVBL1 8607 pp -- int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
ACO2 50 RUVBL1 8607 pp -- int.I2D: YeastLow
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
ACTB 60 CFL1 1072 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, MINT_Yeast, MIPS, BioGrid, BIND_Yeast, HPRD, IntAct, IntAct_Yeast, MINT, VidalHuman_core, YeastLow, Yu_GoldStd;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
KCNMA1 3778 RPSA 3921 pp -- int.I2D: IntAct_Mouse
ACO2 50 HSPD1 3329 pp -- int.I2D: IntAct_Yeast
ACTB 60 KCNMA1 3778 pp -- int.I2D: IntAct_Mouse
ACO2 50 CFL1 1072 pp -- int.I2D: YeastLow
CFL1 1072 KCNMA1 3778 pp -- int.I2D: IntAct_Mouse
HSPD1 3329 KCNMA1 3778 pp -- int.I2D: IntAct_Mouse
ACO2 50 KCNMA1 3778 pp -- int.I2D: IntAct_Mouse
CFL1 1072 RUVBL1 8607 pp -- int.I2D: YeastLow
CFL1 1072 RSL24D1 51187 pp -- int.I2D: YeastLow
ACTB 60 HSPD1 3329 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, YeastLow
KCNMA1 3778 RUVBL1 8607 pp -- int.I2D: IntAct_Mouse

Related GO terms (216)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0035267NuA4 histone acetyltransferase complex3.14e-054.53e-017.8392414
GO:0002842positive regulation of T cell mediated immune response to tumor cell6.24e-041.00e+0010.646111
GO:0060072large conductance calcium-activated potassium channel activity6.24e-041.00e+0010.646111
GO:0048291isotype switching to IgG isotypes6.24e-041.00e+0010.646111
GO:0002368B cell cytokine production6.24e-041.00e+0010.646111
GO:0003697single-stranded DNA binding7.72e-041.00e+005.5592568
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis9.13e-041.00e+005.4372674
GO:0070062extracellular vesicular exosome1.12e-031.00e+002.00261042400
GO:0045794negative regulation of cell volume1.25e-031.00e+009.646112
GO:00515383 iron, 4 sulfur cluster binding1.25e-031.00e+009.646112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.25e-031.00e+009.646112
GO:0003994aconitate hydratase activity1.25e-031.00e+009.646112
GO:0005055laminin receptor activity1.25e-031.00e+009.646112
GO:0006407rRNA export from nucleus1.25e-031.00e+009.646112
GO:0060073micturition1.25e-031.00e+009.646112
GO:0016363nuclear matrix1.38e-031.00e+005.13821291
GO:0016020membrane1.80e-031.00e+002.2535901681
GO:0001842neural fold formation1.87e-031.00e+009.061113
GO:0060083smooth muscle contraction involved in micturition1.87e-031.00e+009.061113
GO:0006458'de novo' protein folding1.87e-031.00e+009.061113
GO:0030135coated vesicle1.87e-031.00e+009.061113
GO:0030529ribonucleoprotein complex2.08e-031.00e+004.83928112
GO:0007596blood coagulation2.27e-031.00e+003.401318455
GO:0006325chromatin organization2.30e-031.00e+004.76425118
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.49e-031.00e+008.646114
GO:003068690S preribosome2.49e-031.00e+008.646114
GO:0034465response to carbon monoxide2.49e-031.00e+008.646114
GO:0046696lipopolysaccharide receptor complex3.12e-031.00e+008.324115
GO:0006102isocitrate metabolic process3.12e-031.00e+008.324115
GO:0000730DNA recombinase assembly3.12e-031.00e+008.324115
GO:2000001regulation of DNA damage checkpoint3.12e-031.00e+008.324115
GO:0016887ATPase activity3.22e-031.00e+004.51727140
GO:0003688DNA replication origin binding3.74e-031.00e+008.061126
GO:0030957Tat protein binding3.74e-031.00e+008.061136
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex3.74e-031.00e+008.061116
GO:0030836positive regulation of actin filament depolymerization3.74e-031.00e+008.061126
GO:0006101citrate metabolic process3.74e-031.00e+008.061116
GO:0000028ribosomal small subunit assembly4.36e-031.00e+007.839117
GO:0070688MLL5-L complex4.98e-031.00e+007.646118
GO:0030042actin filament depolymerization4.98e-031.00e+007.646128
GO:0000812Swr1 complex4.98e-031.00e+007.646138
GO:0051604protein maturation4.98e-031.00e+007.646118
GO:0030007cellular potassium ion homeostasis5.60e-031.00e+007.476129
GO:0015269calcium-activated potassium channel activity5.60e-031.00e+007.476119
GO:0010569regulation of double-strand break repair via homologous recombination6.22e-031.00e+007.3241110
GO:0043032positive regulation of macrophage activation6.22e-031.00e+007.3241110
GO:0032727positive regulation of interferon-alpha production6.85e-031.00e+007.1871111
GO:0031571mitotic G1 DNA damage checkpoint6.85e-031.00e+007.1871411
GO:0061001regulation of dendritic spine morphogenesis6.85e-031.00e+007.1871211
GO:0043968histone H2A acetylation7.47e-031.00e+007.0611312
GO:0005662DNA replication factor A complex8.09e-031.00e+006.9461113
GO:0006970response to osmotic stress8.09e-031.00e+006.9461113
GO:0001530lipopolysaccharide binding8.09e-031.00e+006.9461313
GO:0051131chaperone-mediated protein complex assembly8.09e-031.00e+006.9461113
GO:0005759mitochondrial matrix8.32e-031.00e+003.813214228
GO:0031011Ino80 complex8.70e-031.00e+006.8391314
GO:0042026protein refolding9.32e-031.00e+006.7391215
GO:0050998nitric-oxide synthase binding9.94e-031.00e+006.6461116
GO:0031258lamellipodium membrane9.94e-031.00e+006.6461216
GO:0022604regulation of cell morphogenesis9.94e-031.00e+006.6461116
GO:0003678DNA helicase activity1.06e-021.00e+006.5591317
GO:0050870positive regulation of T cell activation1.06e-021.00e+006.5591117
GO:0006281DNA repair1.08e-021.00e+003.618218261
GO:0035861site of double-strand break1.12e-021.00e+006.4761118
GO:0003779actin binding1.12e-021.00e+003.591212266
GO:0043065positive regulation of apoptotic process1.14e-021.00e+003.580210268
GO:0032733positive regulation of interleukin-10 production1.18e-021.00e+006.3981119
GO:0006298mismatch repair1.24e-021.00e+006.3241320
GO:0042100B cell proliferation1.30e-021.00e+006.2541121
GO:0032201telomere maintenance via semi-conservative replication1.30e-021.00e+006.2541521
GO:0030010establishment of cell polarity1.30e-021.00e+006.2541221
GO:0000281mitotic cytokinesis1.30e-021.00e+006.2541121
GO:0000718nucleotide-excision repair, DNA damage removal1.30e-021.00e+006.2541421
GO:0006297nucleotide-excision repair, DNA gap filling1.36e-021.00e+006.1871322
GO:0030863cortical cytoskeleton1.36e-021.00e+006.1871122
GO:0036464cytoplasmic ribonucleoprotein granule1.36e-021.00e+006.1871422
GO:0043234protein complex1.37e-021.00e+003.442218295
GO:0043044ATP-dependent chromatin remodeling1.43e-021.00e+006.1231423
GO:0030864cortical actin cytoskeleton1.43e-021.00e+006.1231123
GO:0043236laminin binding1.43e-021.00e+006.1231123
GO:0043200response to amino acid1.43e-021.00e+006.1231123
GO:0034080CENP-A containing nucleosome assembly1.55e-021.00e+006.0021125
GO:0000722telomere maintenance via recombination1.55e-021.00e+006.0021525
GO:0042113B cell activation1.55e-021.00e+006.0021225
GO:0032735positive regulation of interleukin-12 production1.55e-021.00e+006.0021125
GO:0007411axon guidance1.58e-021.00e+003.329213319
GO:0043022ribosome binding1.67e-021.00e+005.8911327
GO:0071339MLL1 complex1.67e-021.00e+005.8911327
GO:0043967histone H4 acetylation1.67e-021.00e+005.8911327
GO:0031492nucleosomal DNA binding1.67e-021.00e+005.8911427
GO:0001755neural crest cell migration1.73e-021.00e+005.8391228
GO:0006099tricarboxylic acid cycle1.73e-021.00e+005.8391428
GO:0005249voltage-gated potassium channel activity1.73e-021.00e+005.8391128
GO:0019894kinesin binding1.73e-021.00e+005.8391128
GO:0005615extracellular space1.81e-021.00e+002.329317957
GO:0042254ribosome biogenesis1.86e-021.00e+005.7391130
GO:0006271DNA strand elongation involved in DNA replication1.86e-021.00e+005.7391730
GO:0005925focal adhesion2.05e-021.00e+003.130219366
GO:0001895retina homeostasis2.10e-021.00e+005.5591134
GO:00515394 iron, 4 sulfur cluster binding2.16e-021.00e+005.5171335
GO:0034332adherens junction organization2.22e-021.00e+005.4761136
GO:0032755positive regulation of interleukin-6 production2.22e-021.00e+005.4761236
GO:0051084'de novo' posttranslational protein folding2.29e-021.00e+005.4371437
GO:0006284base-excision repair2.29e-021.00e+005.4371337
GO:0070527platelet aggregation2.35e-021.00e+005.3981238
GO:0032729positive regulation of interferon-gamma production2.41e-021.00e+005.3611239
GO:0022627cytosolic small ribosomal subunit2.41e-021.00e+005.3611439
GO:0000781chromosome, telomeric region2.41e-021.00e+005.3611339
GO:0005654nucleoplasm2.51e-021.00e+002.1523761082
GO:0032508DNA duplex unwinding2.53e-021.00e+005.2891341
GO:0042110T cell activation2.59e-021.00e+005.2541342
GO:0021762substantia nigra development2.71e-021.00e+005.1871244
GO:0043066negative regulation of apoptotic process2.71e-021.00e+002.918231424
GO:0006283transcription-coupled nucleotide-excision repair2.83e-021.00e+005.1231746
GO:0007266Rho protein signal transduction2.90e-021.00e+005.0921247
GO:0003684damaged DNA binding3.02e-021.00e+005.0311749
GO:0006091generation of precursor metabolites and energy3.08e-021.00e+005.0021350
GO:0006986response to unfolded protein3.08e-021.00e+005.0021250
GO:0042391regulation of membrane potential3.08e-021.00e+005.0021150
GO:0005905coated pit3.08e-021.00e+005.0021350
GO:0040008regulation of growth3.08e-021.00e+005.0021550
GO:0003725double-stranded RNA binding3.20e-021.00e+004.9461552
GO:0005515protein binding3.23e-021.00e+000.89771846024
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3.26e-021.00e+004.9181553
GO:0008076voltage-gated potassium channel complex3.32e-021.00e+004.8911154
GO:0045216cell-cell junction organization3.32e-021.00e+004.8911254
GO:0044267cellular protein metabolic process3.33e-021.00e+002.757229474
GO:0051592response to calcium ion3.38e-021.00e+004.8651355
GO:0000724double-strand break repair via homologous recombination3.38e-021.00e+004.8651355
GO:0002039p53 binding3.38e-021.00e+004.8651755
GO:0000723telomere maintenance3.44e-021.00e+004.8391656
GO:0051087chaperone binding3.62e-021.00e+004.7641659
GO:0019903protein phosphatase binding3.80e-021.00e+004.6921462
GO:0005901caveola3.80e-021.00e+004.6921562
GO:0006302double-strand break repair3.80e-021.00e+004.6921462
GO:0030141secretory granule3.80e-021.00e+004.6921262
GO:0006813potassium ion transport3.98e-021.00e+004.6241165
GO:0006310DNA recombination3.98e-021.00e+004.6241265
GO:0005524ATP binding4.04e-021.00e+001.8893601298
GO:0016032viral process4.14e-021.00e+002.585255534
GO:0006289nucleotide-excision repair4.17e-021.00e+004.55911168
GO:0034329cell junction assembly4.17e-021.00e+004.5591168
GO:0032587ruffle membrane4.29e-021.00e+004.5171370
GO:0006334nucleosome assembly4.41e-021.00e+004.4761272
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process4.70e-021.00e+004.3791777
GO:0002755MyD88-dependent toll-like receptor signaling pathway4.88e-021.00e+004.3241380
GO:0019083viral transcription4.94e-021.00e+004.30611081
GO:0002576platelet degranulation5.00e-021.00e+004.2891482
GO:0071805potassium ion transmembrane transport5.06e-021.00e+004.2711183
GO:0045087innate immune response5.06e-021.00e+002.427224596
GO:0047485protein N-terminus binding5.24e-021.00e+004.2201586
GO:0006415translational termination5.30e-021.00e+004.20311087
GO:0016605PML body5.36e-021.00e+004.1871388
GO:0050821protein stabilization5.36e-021.00e+004.1871288
GO:0007010cytoskeleton organization5.54e-021.00e+004.1381191
GO:0006928cellular component movement5.54e-021.00e+004.1381791
GO:0005200structural constituent of cytoskeleton5.54e-021.00e+004.1381891
GO:0006414translational elongation5.66e-021.00e+004.10711393
GO:0051082unfolded protein binding5.66e-021.00e+004.1071593
GO:0005737cytoplasm5.81e-021.00e+001.08951103767
GO:0034765regulation of ion transmembrane transport5.95e-021.00e+004.0311198
GO:0006614SRP-dependent cotranslational protein targeting to membrane6.31e-021.00e+003.946110104
GO:0014069postsynaptic density6.37e-021.00e+003.93213105
GO:0005506iron ion binding6.37e-021.00e+003.93214105
GO:0005815microtubule organizing center6.60e-021.00e+003.87815109
GO:0072562blood microparticle6.72e-021.00e+003.85213111
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay6.89e-021.00e+003.813111114
GO:0019058viral life cycle6.95e-021.00e+003.801113115
GO:0044237cellular metabolic process7.07e-021.00e+003.77615117
GO:0005730nucleolus7.30e-021.00e+001.5513691641
GO:0006260DNA replication7.30e-021.00e+003.72719121
GO:0030036actin cytoskeleton organization7.42e-021.00e+003.70415123
GO:0009615response to virus7.60e-021.00e+003.66915126
GO:0000790nuclear chromatin7.77e-021.00e+003.63519129
GO:0006413translational initiation7.89e-021.00e+003.613117131
GO:0031982vesicle7.89e-021.00e+003.61319131
GO:0005911cell-cell junction8.18e-021.00e+003.55914136
GO:0003735structural constituent of ribosome8.23e-021.00e+003.548110137
GO:0006457protein folding8.58e-021.00e+003.48617143
GO:0061024membrane organization8.69e-021.00e+003.46617145
GO:0001666response to hypoxia8.92e-021.00e+003.42715149
GO:0000082G1/S transition of mitotic cell cycle8.92e-021.00e+003.427132149
GO:0005769early endosome9.10e-021.00e+003.39812152
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding9.84e-021.00e+003.28017165
GO:0030424axon9.90e-021.00e+003.27114166
GO:0031625ubiquitin protein ligase binding1.06e-011.00e+003.170114178
GO:0016324apical plasma membrane1.18e-011.00e+003.01015199
GO:0005634nucleus1.20e-011.00e+000.81451364559
GO:0030168platelet activation1.21e-011.00e+002.967110205
GO:0005739mitochondrion1.25e-011.00e+001.683228998
GO:0016071mRNA metabolic process1.31e-011.00e+002.845131223
GO:0007067mitotic nuclear division1.33e-011.00e+002.820114227
GO:0006412translation1.35e-011.00e+002.801120230
GO:0044822poly(A) RNA binding1.37e-011.00e+001.6022491056
GO:0016070RNA metabolic process1.44e-011.00e+002.698132247
GO:0007283spermatogenesis1.52e-011.00e+002.61318262
GO:0006357regulation of transcription from RNA polymerase II promoter1.53e-011.00e+002.60218264
GO:0005743mitochondrial inner membrane1.60e-011.00e+002.53218277
GO:0019899enzyme binding1.60e-011.00e+002.532112277
GO:0005856cytoskeleton1.68e-011.00e+002.461112291
GO:0006200ATP catabolic process1.68e-011.00e+002.456115292
GO:0019901protein kinase binding1.81e-011.00e+002.338121317
GO:0043231intracellular membrane-bounded organelle1.82e-011.00e+002.33319318
GO:0007268synaptic transmission1.89e-011.00e+002.27116332
GO:0005829cytosol1.93e-011.00e+000.94631322496
GO:0007155cell adhesion2.08e-011.00e+002.11916369
GO:0005886plasma membrane2.08e-011.00e+000.8973452582
GO:0000278mitotic cell cycle2.19e-011.00e+002.035148391
GO:0009986cell surface2.25e-011.00e+001.995111402
GO:0006468protein phosphorylation2.53e-011.00e+001.801118460
GO:0005794Golgi apparatus3.22e-011.00e+001.393115610
GO:0010467gene expression3.48e-011.00e+001.260159669
GO:0044281small molecule metabolic process5.46e-011.00e+000.4041581211
GO:0046872metal ion binding5.75e-011.00e+000.2941251307
GO:0006351transcription, DNA-templated6.14e-011.00e+000.1481311446
GO:0016021integral component of membrane7.36e-011.00e+00-0.3071271982