int-snw-3659

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.922	5.08e-15	3.25e-03	4.88e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-3659 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
KEAP1	9817	3	0.580	0.981	63	Yes	-
POLR2K	5440	2	0.912	0.931	13	Yes	-
RBX1	9978	97	1.185	1.151	139	Yes	-
POLR2F	5435	1	0.891	0.922	21	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-
[ IRF1 ]	3659	1	-0.076	0.922	61	-	-

Interactions (7)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
IRF1	3659	POLR2F	5435	pp	--	int.I2D: INNATEDB_Mouse
KEAP1	9817	RBX1	9978	pp	--	int.I2D: BioGrid, BioGrid_Mouse
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
IRF1	3659	KEAP1	9817	pp	--	int.I2D: BioGrid
POLR2F	5435	POLR2K	5440	pp	--	int.I2D: BioGrid
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct

Related GO terms (179)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006283	transcription-coupled nucleotide-excision repair	1.68e-06	2.43e-02	6.877	3	7	46
GO:0032481	positive regulation of type I interferon production	3.97e-06	5.73e-02	6.470	3	6	61
GO:0005654	nucleoplasm	4.32e-06	6.23e-02	3.322	6	76	1082
GO:0006289	nucleotide-excision repair	5.52e-06	7.96e-02	6.314	3	11	68
GO:0006281	DNA repair	6.93e-06	9.99e-02	4.788	4	18	261
GO:0001055	RNA polymerase II activity	7.53e-06	1.09e-01	8.816	2	3	8
GO:0001054	RNA polymerase I activity	1.48e-05	2.13e-01	8.357	2	3	11
GO:0005736	DNA-directed RNA polymerase I complex	1.77e-05	2.56e-01	8.231	2	3	12
GO:0005829	cytosol	3.14e-05	4.52e-01	2.338	7	132	2496
GO:0005665	DNA-directed RNA polymerase II, core complex	3.22e-05	4.64e-01	7.816	2	4	16
GO:0001056	RNA polymerase III activity	3.22e-05	4.64e-01	7.816	2	3	16
GO:0005666	DNA-directed RNA polymerase III complex	3.65e-05	5.26e-01	7.729	2	3	17
GO:0006386	termination of RNA polymerase III transcription	4.10e-05	5.91e-01	7.646	2	3	18
GO:0006385	transcription elongation from RNA polymerase III promoter	4.10e-05	5.91e-01	7.646	2	3	18
GO:0031463	Cul3-RING ubiquitin ligase complex	6.77e-05	9.77e-01	7.293	2	3	23
GO:0016032	viral process	1.15e-04	1.00e+00	3.755	4	55	534
GO:0006360	transcription from RNA polymerase I promoter	1.16e-04	1.00e+00	6.909	2	5	30
GO:0006370	7-methylguanosine mRNA capping	1.16e-04	1.00e+00	6.909	2	5	30
GO:0006383	transcription from RNA polymerase III promoter	1.97e-04	1.00e+00	6.531	2	3	39
GO:0050434	positive regulation of viral transcription	2.52e-04	1.00e+00	6.357	2	6	44
GO:2000564	regulation of CD8-positive, alpha-beta T cell proliferation	5.55e-04	1.00e+00	10.816	1	1	1
GO:0006368	transcription elongation from RNA polymerase II promoter	5.85e-04	1.00e+00	5.750	2	6	67
GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway	1.11e-03	1.00e+00	9.816	1	1	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.11e-03	1.00e+00	9.816	1	1	2
GO:0005055	laminin receptor activity	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006407	rRNA export from nucleus	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006366	transcription from RNA polymerase II promoter	1.22e-03	1.00e+00	3.690	3	10	419
GO:0045590	negative regulation of regulatory T cell differentiation	1.66e-03	1.00e+00	9.231	1	1	3
GO:0045604	regulation of epidermal cell differentiation	1.66e-03	1.00e+00	9.231	1	1	3
GO:0000790	nuclear chromatin	2.15e-03	1.00e+00	4.805	2	9	129
GO:0010499	proteasomal ubiquitin-independent protein catabolic process	2.22e-03	1.00e+00	8.816	1	2	4
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.22e-03	1.00e+00	8.816	1	1	4
GO:0030686	90S preribosome	2.22e-03	1.00e+00	8.816	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	2.22e-03	1.00e+00	8.816	1	1	4
GO:0019788	NEDD8 ligase activity	2.22e-03	1.00e+00	8.816	1	1	4
GO:0043374	CD8-positive, alpha-beta T cell differentiation	2.22e-03	1.00e+00	8.816	1	1	4
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	2.77e-03	1.00e+00	8.494	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	2.77e-03	1.00e+00	8.494	1	1	5
GO:0030891	VCB complex	2.77e-03	1.00e+00	8.494	1	2	5
GO:0002819	regulation of adaptive immune response	2.77e-03	1.00e+00	8.494	1	1	5
GO:0000730	DNA recombinase assembly	2.77e-03	1.00e+00	8.494	1	1	5
GO:2000001	regulation of DNA damage checkpoint	2.77e-03	1.00e+00	8.494	1	1	5
GO:0030957	Tat protein binding	3.32e-03	1.00e+00	8.231	1	3	6
GO:0006356	regulation of transcription from RNA polymerase I promoter	3.32e-03	1.00e+00	8.231	1	2	6
GO:0031466	Cul5-RING ubiquitin ligase complex	3.32e-03	1.00e+00	8.231	1	1	6
GO:0045087	innate immune response	3.36e-03	1.00e+00	3.182	3	24	596
GO:0000398	mRNA splicing, via spliceosome	3.44e-03	1.00e+00	4.459	2	8	164
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	3.48e-03	1.00e+00	4.450	2	7	165
GO:0045084	positive regulation of interleukin-12 biosynthetic process	3.88e-03	1.00e+00	8.009	1	1	7
GO:0000028	ribosomal small subunit assembly	3.88e-03	1.00e+00	8.009	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	3.88e-03	1.00e+00	8.009	1	2	7
GO:0031625	ubiquitin protein ligase binding	4.04e-03	1.00e+00	4.340	2	14	178
GO:0006367	transcription initiation from RNA polymerase II promoter	4.31e-03	1.00e+00	4.293	2	8	184
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	4.43e-03	1.00e+00	7.816	1	2	8
GO:0070688	MLL5-L complex	4.43e-03	1.00e+00	7.816	1	1	8
GO:0045116	protein neddylation	4.43e-03	1.00e+00	7.816	1	2	8
GO:0010467	gene expression	4.67e-03	1.00e+00	3.015	3	59	669
GO:0010569	regulation of double-strand break repair via homologous recombination	5.53e-03	1.00e+00	7.494	1	1	10
GO:0035458	cellular response to interferon-beta	6.09e-03	1.00e+00	7.357	1	1	11
GO:0031571	mitotic G1 DNA damage checkpoint	6.09e-03	1.00e+00	7.357	1	4	11
GO:0008380	RNA splicing	6.54e-03	1.00e+00	3.983	2	11	228
GO:0005662	DNA replication factor A complex	7.19e-03	1.00e+00	7.116	1	1	13
GO:0045088	regulation of innate immune response	7.19e-03	1.00e+00	7.116	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	7.74e-03	1.00e+00	7.009	1	4	14
GO:0050998	nitric-oxide synthase binding	8.84e-03	1.00e+00	6.816	1	1	16
GO:0035861	site of double-strand break	9.94e-03	1.00e+00	6.646	1	1	18
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.05e-02	1.00e+00	6.568	1	1	19
GO:0016567	protein ubiquitination	1.08e-02	1.00e+00	3.612	2	5	295
GO:0071353	cellular response to interleukin-4	1.10e-02	1.00e+00	6.494	1	1	20
GO:0006298	mismatch repair	1.10e-02	1.00e+00	6.494	1	3	20
GO:0032201	telomere maintenance via semi-conservative replication	1.16e-02	1.00e+00	6.424	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.16e-02	1.00e+00	6.424	1	4	21
GO:0006297	nucleotide-excision repair, DNA gap filling	1.21e-02	1.00e+00	6.357	1	3	22
GO:0030863	cortical cytoskeleton	1.21e-02	1.00e+00	6.357	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.21e-02	1.00e+00	6.357	1	4	22
GO:0032728	positive regulation of interferon-beta production	1.21e-02	1.00e+00	6.357	1	1	22
GO:0043044	ATP-dependent chromatin remodeling	1.27e-02	1.00e+00	6.293	1	4	23
GO:0006362	transcription elongation from RNA polymerase I promoter	1.27e-02	1.00e+00	6.293	1	3	23
GO:0043236	laminin binding	1.27e-02	1.00e+00	6.293	1	1	23
GO:0006513	protein monoubiquitination	1.27e-02	1.00e+00	6.293	1	1	23
GO:0006363	termination of RNA polymerase I transcription	1.32e-02	1.00e+00	6.231	1	3	24
GO:0000722	telomere maintenance via recombination	1.38e-02	1.00e+00	6.172	1	5	25
GO:0006361	transcription initiation from RNA polymerase I promoter	1.43e-02	1.00e+00	6.116	1	3	26
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.43e-02	1.00e+00	6.116	1	3	26
GO:0043022	ribosome binding	1.49e-02	1.00e+00	6.061	1	3	27
GO:0031492	nucleosomal DNA binding	1.49e-02	1.00e+00	6.061	1	4	27
GO:0005634	nucleus	1.49e-02	1.00e+00	1.247	6	136	4559
GO:0019894	kinesin binding	1.54e-02	1.00e+00	6.009	1	1	28
GO:0019005	SCF ubiquitin ligase complex	1.60e-02	1.00e+00	5.958	1	1	29
GO:0006271	DNA strand elongation involved in DNA replication	1.65e-02	1.00e+00	5.909	1	7	30
GO:0001895	retina homeostasis	1.87e-02	1.00e+00	5.729	1	1	34
GO:0034332	adherens junction organization	1.98e-02	1.00e+00	5.646	1	1	36
GO:0051084	'de novo' posttranslational protein folding	2.03e-02	1.00e+00	5.607	1	4	37
GO:0006284	base-excision repair	2.03e-02	1.00e+00	5.607	1	3	37
GO:0070527	platelet aggregation	2.09e-02	1.00e+00	5.568	1	2	38
GO:0022627	cytosolic small ribosomal subunit	2.14e-02	1.00e+00	5.531	1	4	39
GO:0000781	chromosome, telomeric region	2.14e-02	1.00e+00	5.531	1	3	39
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	2.42e-02	1.00e+00	5.357	1	3	44
GO:0021762	substantia nigra development	2.42e-02	1.00e+00	5.357	1	2	44
GO:0003677	DNA binding	2.44e-02	1.00e+00	2.151	3	28	1218
GO:0007596	blood coagulation	2.45e-02	1.00e+00	2.986	2	18	455
GO:0044267	cellular protein metabolic process	2.65e-02	1.00e+00	2.927	2	29	474
GO:0003684	damaged DNA binding	2.69e-02	1.00e+00	5.201	1	7	49
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.90e-02	1.00e+00	5.088	1	5	53
GO:0045216	cell-cell junction organization	2.96e-02	1.00e+00	5.061	1	2	54
GO:0000724	double-strand break repair via homologous recombination	3.01e-02	1.00e+00	5.035	1	3	55
GO:0000723	telomere maintenance	3.06e-02	1.00e+00	5.009	1	6	56
GO:0060337	type I interferon signaling pathway	3.17e-02	1.00e+00	4.958	1	2	58
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	3.23e-02	1.00e+00	4.933	1	2	59
GO:0019903	protein phosphatase binding	3.39e-02	1.00e+00	4.862	1	4	62
GO:0060333	interferon-gamma-mediated signaling pathway	3.39e-02	1.00e+00	4.862	1	2	62
GO:0006302	double-strand break repair	3.39e-02	1.00e+00	4.862	1	4	62
GO:0071260	cellular response to mechanical stimulus	3.55e-02	1.00e+00	4.794	1	5	65
GO:0034329	cell junction assembly	3.71e-02	1.00e+00	4.729	1	1	68
GO:0003697	single-stranded DNA binding	3.71e-02	1.00e+00	4.729	1	5	68
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.03e-02	1.00e+00	4.607	1	6	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.09e-02	1.00e+00	4.587	1	2	75
GO:0019083	viral transcription	4.41e-02	1.00e+00	4.476	1	10	81
GO:0047485	protein N-terminus binding	4.67e-02	1.00e+00	4.390	1	5	86
GO:0006415	translational termination	4.73e-02	1.00e+00	4.373	1	10	87
GO:0016605	PML body	4.78e-02	1.00e+00	4.357	1	3	88
GO:0006928	cellular component movement	4.94e-02	1.00e+00	4.308	1	7	91
GO:0005200	structural constituent of cytoskeleton	4.94e-02	1.00e+00	4.308	1	8	91
GO:0071456	cellular response to hypoxia	4.99e-02	1.00e+00	4.293	1	6	92
GO:0006414	translational elongation	5.04e-02	1.00e+00	4.277	1	13	93
GO:0051726	regulation of cell cycle	5.26e-02	1.00e+00	4.216	1	5	97
GO:0005730	nucleolus	5.31e-02	1.00e+00	1.721	3	69	1641
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	5.63e-02	1.00e+00	4.116	1	10	104
GO:0014069	postsynaptic density	5.68e-02	1.00e+00	4.102	1	3	105
GO:0030496	midbody	5.84e-02	1.00e+00	4.061	1	5	108
GO:0005815	microtubule organizing center	5.89e-02	1.00e+00	4.048	1	5	109
GO:0072562	blood microparticle	5.99e-02	1.00e+00	4.022	1	3	111
GO:0030529	ribonucleoprotein complex	6.05e-02	1.00e+00	4.009	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6.15e-02	1.00e+00	3.983	1	11	114
GO:0005515	protein binding	6.16e-02	1.00e+00	0.845	6	184	6024
GO:0019058	viral life cycle	6.20e-02	1.00e+00	3.971	1	13	115
GO:0006325	chromatin organization	6.36e-02	1.00e+00	3.933	1	5	118
GO:0007219	Notch signaling pathway	6.47e-02	1.00e+00	3.909	1	5	120
GO:0006260	DNA replication	6.52e-02	1.00e+00	3.897	1	9	121
GO:0007050	cell cycle arrest	6.68e-02	1.00e+00	3.862	1	9	124
GO:0051607	defense response to virus	6.78e-02	1.00e+00	3.839	1	1	126
GO:0006413	translational initiation	7.04e-02	1.00e+00	3.783	1	17	131
GO:0003735	structural constituent of ribosome	7.35e-02	1.00e+00	3.718	1	10	137
GO:0006457	protein folding	7.66e-02	1.00e+00	3.656	1	7	143
GO:0061024	membrane organization	7.77e-02	1.00e+00	3.636	1	7	145
GO:0000082	G1/S transition of mitotic cell cycle	7.97e-02	1.00e+00	3.597	1	32	149
GO:0030424	axon	8.85e-02	1.00e+00	3.441	1	4	166
GO:0032403	protein complex binding	9.71e-02	1.00e+00	3.300	1	10	183
GO:0008270	zinc ion binding	1.01e-01	1.00e+00	1.855	2	12	997
GO:0001701	in utero embryonic development	1.06e-01	1.00e+00	3.165	1	8	201
GO:0019221	cytokine-mediated signaling pathway	1.16e-01	1.00e+00	3.028	1	9	221
GO:0016071	mRNA metabolic process	1.17e-01	1.00e+00	3.015	1	31	223
GO:0006412	translation	1.21e-01	1.00e+00	2.971	1	20	230
GO:0008134	transcription factor binding	1.27e-01	1.00e+00	2.897	1	8	242
GO:0016070	RNA metabolic process	1.29e-01	1.00e+00	2.868	1	32	247
GO:0005737	cytoplasm	1.30e-01	1.00e+00	0.937	4	110	3767
GO:0004842	ubiquitin-protein transferase activity	1.33e-01	1.00e+00	2.822	1	6	255
GO:0019899	enzyme binding	1.44e-01	1.00e+00	2.702	1	12	277
GO:0005856	cytoskeleton	1.50e-01	1.00e+00	2.631	1	12	291
GO:0043234	protein complex	1.52e-01	1.00e+00	2.612	1	18	295
GO:0019901	protein kinase binding	1.63e-01	1.00e+00	2.508	1	21	317
GO:0007411	axon guidance	1.64e-01	1.00e+00	2.499	1	13	319
GO:0008285	negative regulation of cell proliferation	1.80e-01	1.00e+00	2.353	1	11	353
GO:0005925	focal adhesion	1.86e-01	1.00e+00	2.300	1	19	366
GO:0007155	cell adhesion	1.87e-01	1.00e+00	2.289	1	6	369
GO:0000278	mitotic cell cycle	1.97e-01	1.00e+00	2.205	1	48	391
GO:0045892	negative regulation of transcription, DNA-templated	2.07e-01	1.00e+00	2.126	1	15	413
GO:0045893	positive regulation of transcription, DNA-templated	2.36e-01	1.00e+00	1.915	1	13	478
GO:0016020	membrane	2.37e-01	1.00e+00	1.101	2	90	1681
GO:0006915	apoptotic process	2.69e-01	1.00e+00	1.700	1	33	555
GO:0005783	endoplasmic reticulum	2.70e-01	1.00e+00	1.697	1	10	556
GO:0003700	sequence-specific DNA binding transcription factor activity	3.28e-01	1.00e+00	1.367	1	11	699
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	3.62e-01	1.00e+00	1.192	1	19	789
GO:0070062	extracellular vesicular exosome	3.95e-01	1.00e+00	0.587	2	104	2400
GO:0005615	extracellular space	4.23e-01	1.00e+00	0.914	1	17	957
GO:0044822	poly(A) RNA binding	4.56e-01	1.00e+00	0.772	1	49	1056
GO:0005524	ATP binding	5.30e-01	1.00e+00	0.474	1	60	1298
GO:0006351	transcription, DNA-templated	5.71e-01	1.00e+00	0.318	1	31	1446
GO:0005886	plasma membrane	7.94e-01	1.00e+00	-0.518	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-3659

Statistics

Genes (8)

Interactions (7)

Related GO terms (179)