int-snw-3035

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.960	1.65e-16	1.41e-03	2.66e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-3035 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RSL24D1	51187	36	1.300	1.020	59	Yes	-
ACO2	50	50	1.000	1.076	191	Yes	-
EIF2S2	8894	27	1.075	1.138	81	Yes	-
[ HARS ]	3035	2	0.475	0.960	37	Yes	-
CLTC	1213	35	0.884	1.138	247	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
ATP6V1B2	526	44	0.881	1.076	278	-	-
CFL1	1072	12	0.674	1.020	203	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (11)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
CLTC	1213	HARS	3035	pp	--	int.I2D: IntAct_Worm
ACO2	50	CFL1	1072	pp	--	int.I2D: YeastLow
CFL1	1072	RSL24D1	51187	pp	--	int.I2D: YeastLow
ATP6V1B2	526	CLTC	1213	pp	--	int.I2D: IntAct_Yeast
CFL1	1072	HARS	3035	pp	--	int.I2D: BIND_Yeast, MINT_Yeast, MIPS, YeastLow, IntAct_Yeast
ACO2	50	PGD	5226	pp	--	int.I2D: YeastLow
CFL1	1072	PGD	5226	pp	--	int.I2D: YeastLow
ACTB	60	ATP6V1B2	526	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	CLTC	1213	pp	--	int.I2D: IntAct_Yeast
CLTC	1213	EIF2S2	8894	pp	--	int.I2D: YeastLow
ACTB	60	CFL1	1072	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, MINT_Yeast, MIPS, BioGrid, BIND_Yeast, HPRD, IntAct, IntAct_Yeast, MINT, VidalHuman_core, YeastLow, Yu_GoldStd; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid

Related GO terms (147)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0033572	transferrin transport	1.49e-04	1.00e+00	6.739	2	5	30
GO:0019521	D-gluconate metabolic process	6.24e-04	1.00e+00	10.646	1	1	1
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	9.13e-04	1.00e+00	5.437	2	6	74
GO:0005925	focal adhesion	1.21e-03	1.00e+00	3.715	3	19	366
GO:0006427	histidyl-tRNA aminoacylation	1.25e-03	1.00e+00	9.646	1	1	2
GO:0051538	3 iron, 4 sulfur cluster binding	1.25e-03	1.00e+00	9.646	1	1	2
GO:0002176	male germ cell proliferation	1.25e-03	1.00e+00	9.646	1	1	2
GO:0019322	pentose biosynthetic process	1.25e-03	1.00e+00	9.646	1	2	2
GO:0003994	aconitate hydratase activity	1.25e-03	1.00e+00	9.646	1	1	2
GO:0004821	histidine-tRNA ligase activity	1.25e-03	1.00e+00	9.646	1	1	2
GO:0042470	melanosome	1.38e-03	1.00e+00	5.138	2	9	91
GO:0005829	cytosol	1.39e-03	1.00e+00	1.946	6	132	2496
GO:0005850	eukaryotic translation initiation factor 2 complex	1.87e-03	1.00e+00	9.061	1	1	3
GO:0001842	neural fold formation	1.87e-03	1.00e+00	9.061	1	1	3
GO:1900126	negative regulation of hyaluronan biosynthetic process	1.87e-03	1.00e+00	9.061	1	2	3
GO:0009051	pentose-phosphate shunt, oxidative branch	1.87e-03	1.00e+00	9.061	1	2	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	1.87e-03	1.00e+00	9.061	1	1	3
GO:0071439	clathrin complex	1.87e-03	1.00e+00	9.061	1	2	3
GO:0032051	clathrin light chain binding	2.49e-03	1.00e+00	8.646	1	1	4
GO:1903077	negative regulation of protein localization to plasma membrane	2.49e-03	1.00e+00	8.646	1	1	4
GO:0031982	vesicle	2.83e-03	1.00e+00	4.613	2	9	131
GO:0006102	isocitrate metabolic process	3.12e-03	1.00e+00	8.324	1	1	5
GO:0061024	membrane organization	3.45e-03	1.00e+00	4.466	2	7	145
GO:0030130	clathrin coat of trans-Golgi network vesicle	3.74e-03	1.00e+00	8.061	1	3	6
GO:0030957	Tat protein binding	3.74e-03	1.00e+00	8.061	1	3	6
GO:0030836	positive regulation of actin filament depolymerization	3.74e-03	1.00e+00	8.061	1	2	6
GO:0006101	citrate metabolic process	3.74e-03	1.00e+00	8.061	1	1	6
GO:0030118	clathrin coat	3.74e-03	1.00e+00	8.061	1	2	6
GO:0033180	proton-transporting V-type ATPase, V1 domain	4.36e-03	1.00e+00	7.839	1	2	7
GO:0030132	clathrin coat of coated pit	4.36e-03	1.00e+00	7.839	1	2	7
GO:0070688	MLL5-L complex	4.98e-03	1.00e+00	7.646	1	1	8
GO:0030042	actin filament depolymerization	4.98e-03	1.00e+00	7.646	1	2	8
GO:0006098	pentose-phosphate shunt	6.22e-03	1.00e+00	7.324	1	4	10
GO:0061001	regulation of dendritic spine morphogenesis	6.85e-03	1.00e+00	7.187	1	2	11
GO:0006412	translation	8.47e-03	1.00e+00	3.801	2	20	230
GO:0035267	NuA4 histone acetyltransferase complex	8.70e-03	1.00e+00	6.839	1	4	14
GO:0070062	extracellular vesicular exosome	8.87e-03	1.00e+00	1.739	5	104	2400
GO:0046961	proton-transporting ATPase activity, rotational mechanism	9.32e-03	1.00e+00	6.739	1	3	15
GO:0046034	ATP metabolic process	9.32e-03	1.00e+00	6.739	1	1	15
GO:0050998	nitric-oxide synthase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0031258	lamellipodium membrane	9.94e-03	1.00e+00	6.646	1	2	16
GO:0022604	regulation of cell morphogenesis	9.94e-03	1.00e+00	6.646	1	1	16
GO:0015078	hydrogen ion transmembrane transporter activity	1.18e-02	1.00e+00	6.398	1	3	19
GO:0030010	establishment of cell polarity	1.30e-02	1.00e+00	6.254	1	2	21
GO:0000281	mitotic cytokinesis	1.30e-02	1.00e+00	6.254	1	1	21
GO:0030863	cortical cytoskeleton	1.36e-02	1.00e+00	6.187	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.36e-02	1.00e+00	6.187	1	4	22
GO:0043234	protein complex	1.37e-02	1.00e+00	3.442	2	18	295
GO:0043044	ATP-dependent chromatin remodeling	1.43e-02	1.00e+00	6.123	1	4	23
GO:0030864	cortical actin cytoskeleton	1.43e-02	1.00e+00	6.123	1	1	23
GO:0043200	response to amino acid	1.43e-02	1.00e+00	6.123	1	1	23
GO:0008135	translation factor activity, nucleic acid binding	1.49e-02	1.00e+00	6.061	1	7	24
GO:0019901	protein kinase binding	1.57e-02	1.00e+00	3.338	2	21	317
GO:0007411	axon guidance	1.58e-02	1.00e+00	3.329	2	13	319
GO:0015991	ATP hydrolysis coupled proton transport	1.61e-02	1.00e+00	5.946	1	4	26
GO:0050661	NADP binding	1.67e-02	1.00e+00	5.891	1	2	27
GO:0031492	nucleosomal DNA binding	1.67e-02	1.00e+00	5.891	1	4	27
GO:0001755	neural crest cell migration	1.73e-02	1.00e+00	5.839	1	2	28
GO:0006099	tricarboxylic acid cycle	1.73e-02	1.00e+00	5.839	1	4	28
GO:0030669	clathrin-coated endocytic vesicle membrane	1.73e-02	1.00e+00	5.839	1	4	28
GO:0019894	kinesin binding	1.73e-02	1.00e+00	5.839	1	1	28
GO:0015992	proton transport	1.80e-02	1.00e+00	5.788	1	3	29
GO:0042254	ribosome biogenesis	1.86e-02	1.00e+00	5.739	1	1	30
GO:0031623	receptor internalization	1.92e-02	1.00e+00	5.692	1	2	31
GO:0051701	interaction with host	1.98e-02	1.00e+00	5.646	1	4	32
GO:0032588	trans-Golgi network membrane	2.10e-02	1.00e+00	5.559	1	2	34
GO:0001895	retina homeostasis	2.10e-02	1.00e+00	5.559	1	1	34
GO:0051539	4 iron, 4 sulfur cluster binding	2.16e-02	1.00e+00	5.517	1	3	35
GO:0034332	adherens junction organization	2.22e-02	1.00e+00	5.476	1	1	36
GO:0090382	phagosome maturation	2.22e-02	1.00e+00	5.476	1	5	36
GO:0051084	'de novo' posttranslational protein folding	2.29e-02	1.00e+00	5.437	1	4	37
GO:0005902	microvillus	2.35e-02	1.00e+00	5.398	1	2	38
GO:0070527	platelet aggregation	2.35e-02	1.00e+00	5.398	1	2	38
GO:0030136	clathrin-coated vesicle	2.59e-02	1.00e+00	5.254	1	4	42
GO:0006418	tRNA aminoacylation for protein translation	2.59e-02	1.00e+00	5.254	1	9	42
GO:0006892	post-Golgi vesicle-mediated transport	2.65e-02	1.00e+00	5.220	1	3	43
GO:0021762	substantia nigra development	2.71e-02	1.00e+00	5.187	1	2	44
GO:0007266	Rho protein signal transduction	2.90e-02	1.00e+00	5.092	1	2	47
GO:0003743	translation initiation factor activity	3.02e-02	1.00e+00	5.031	1	8	49
GO:0006091	generation of precursor metabolites and energy	3.08e-02	1.00e+00	5.002	1	3	50
GO:0007596	blood coagulation	3.09e-02	1.00e+00	2.816	2	18	455
GO:0006879	cellular iron ion homeostasis	3.14e-02	1.00e+00	4.974	1	4	51
GO:0003725	double-stranded RNA binding	3.20e-02	1.00e+00	4.946	1	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.26e-02	1.00e+00	4.918	1	5	53
GO:0045216	cell-cell junction organization	3.32e-02	1.00e+00	4.891	1	2	54
GO:0044267	cellular protein metabolic process	3.33e-02	1.00e+00	2.757	2	29	474
GO:0012505	endomembrane system	3.44e-02	1.00e+00	4.839	1	2	56
GO:0005524	ATP binding	4.04e-02	1.00e+00	1.889	3	60	1298
GO:0034329	cell junction assembly	4.17e-02	1.00e+00	4.559	1	1	68
GO:0032587	ruffle membrane	4.29e-02	1.00e+00	4.517	1	3	70
GO:0008584	male gonad development	4.59e-02	1.00e+00	4.417	1	3	75
GO:0001726	ruffle	4.88e-02	1.00e+00	4.324	1	4	80
GO:0002576	platelet degranulation	5.00e-02	1.00e+00	4.289	1	4	82
GO:0045087	innate immune response	5.06e-02	1.00e+00	2.427	2	24	596
GO:0006898	receptor-mediated endocytosis	5.12e-02	1.00e+00	4.254	1	3	84
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	5.48e-02	1.00e+00	4.154	1	7	90
GO:0007010	cytoskeleton organization	5.54e-02	1.00e+00	4.138	1	1	91
GO:0016363	nuclear matrix	5.54e-02	1.00e+00	4.138	1	12	91
GO:0006928	cellular component movement	5.54e-02	1.00e+00	4.138	1	7	91
GO:0005200	structural constituent of cytoskeleton	5.54e-02	1.00e+00	4.138	1	8	91
GO:0001649	osteoblast differentiation	5.60e-02	1.00e+00	4.123	1	6	92
GO:0010467	gene expression	6.23e-02	1.00e+00	2.260	2	59	669
GO:0014069	postsynaptic density	6.37e-02	1.00e+00	3.932	1	3	105
GO:0005506	iron ion binding	6.37e-02	1.00e+00	3.932	1	4	105
GO:0072562	blood microparticle	6.72e-02	1.00e+00	3.852	1	3	111
GO:0030529	ribonucleoprotein complex	6.78e-02	1.00e+00	3.839	1	8	112
GO:0005819	spindle	6.78e-02	1.00e+00	3.839	1	7	112
GO:0044237	cellular metabolic process	7.07e-02	1.00e+00	3.776	1	5	117
GO:0006325	chromatin organization	7.13e-02	1.00e+00	3.764	1	5	118
GO:0030036	actin cytoskeleton organization	7.42e-02	1.00e+00	3.704	1	5	123
GO:0009615	response to virus	7.60e-02	1.00e+00	3.669	1	5	126
GO:0016020	membrane	7.75e-02	1.00e+00	1.516	3	90	1681
GO:0000790	nuclear chromatin	7.77e-02	1.00e+00	3.635	1	9	129
GO:0006413	translational initiation	7.89e-02	1.00e+00	3.613	1	17	131
GO:0005911	cell-cell junction	8.18e-02	1.00e+00	3.559	1	4	136
GO:0008286	insulin receptor signaling pathway	8.52e-02	1.00e+00	3.496	1	7	142
GO:0006457	protein folding	8.58e-02	1.00e+00	3.486	1	7	143
GO:0005198	structural molecule activity	8.98e-02	1.00e+00	3.417	1	5	150
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	9.84e-02	1.00e+00	3.280	1	7	165
GO:0030424	axon	9.90e-02	1.00e+00	3.271	1	4	166
GO:0006886	intracellular protein transport	1.02e-01	1.00e+00	3.228	1	5	171
GO:0005615	extracellular space	1.16e-01	1.00e+00	1.744	2	17	957
GO:0001701	in utero embryonic development	1.19e-01	1.00e+00	2.995	1	8	201
GO:0005765	lysosomal membrane	1.20e-01	1.00e+00	2.981	1	5	203
GO:0030168	platelet activation	1.21e-01	1.00e+00	2.967	1	10	205
GO:0007067	mitotic nuclear division	1.33e-01	1.00e+00	2.820	1	14	227
GO:0005759	mitochondrial matrix	1.34e-01	1.00e+00	2.813	1	14	228
GO:0044822	poly(A) RNA binding	1.37e-01	1.00e+00	1.602	2	49	1056
GO:0005975	carbohydrate metabolic process	1.47e-01	1.00e+00	2.663	1	9	253
GO:0003779	actin binding	1.54e-01	1.00e+00	2.591	1	12	266
GO:0005856	cytoskeleton	1.68e-01	1.00e+00	2.461	1	12	291
GO:0044281	small molecule metabolic process	1.71e-01	1.00e+00	1.404	2	58	1211
GO:0043231	intracellular membrane-bounded organelle	1.82e-01	1.00e+00	2.333	1	9	318
GO:0003723	RNA binding	1.94e-01	1.00e+00	2.228	1	20	342
GO:0055114	oxidation-reduction process	2.34e-01	1.00e+00	1.932	1	12	420
GO:0043066	negative regulation of apoptotic process	2.36e-01	1.00e+00	1.918	1	31	424
GO:0055085	transmembrane transport	2.41e-01	1.00e+00	1.881	1	10	435
GO:0006468	protein phosphorylation	2.53e-01	1.00e+00	1.801	1	18	460
GO:0005737	cytoplasm	4.31e-01	1.00e+00	0.352	3	110	3767
GO:0005739	mitochondrion	4.76e-01	1.00e+00	0.683	1	28	998
GO:0005886	plasma membrane	4.98e-01	1.00e+00	0.312	2	45	2582
GO:0005654	nucleoplasm	5.04e-01	1.00e+00	0.567	1	76	1082
GO:0005515	protein binding	5.61e-01	1.00e+00	0.090	4	184	6024
GO:0046872	metal ion binding	5.75e-01	1.00e+00	0.294	1	25	1307
GO:0005634	nucleus	5.79e-01	1.00e+00	0.077	3	136	4559
GO:0005730	nucleolus	6.63e-01	1.00e+00	-0.034	1	69	1641
GO:0016021	integral component of membrane	7.36e-01	1.00e+00	-0.307	1	27	1982

Wolf-ratios-Mammosphere-Adherent

int-snw-3035

Statistics

Genes (9)

Interactions (11)

Related GO terms (147)