int-snw-2890

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.962 1.37e-16 1.34e-03 2.57e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-2890 subnetwork

Genes (8)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
[ GRIA1 ] 2890 10.3250.96237--
EIF2S2 8894 271.0751.13881Yes-
CLTC 1213 350.8841.138247Yes-
ACTB 60 1671.1531.151587Yes-
ATP6V1B2 526 440.8811.076278--
CASP8 841 80.8041.041141--
RPSA 3921 1561.3271.151152Yes-

Interactions (9)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CLTC 1213 EIF2S2 8894 pp -- int.I2D: YeastLow
ATP6V1B2 526 CLTC 1213 pp -- int.I2D: IntAct_Yeast
ATP6V1B2 526 RPSA 3921 pp -- int.I2D: IntAct_Yeast
ACTB 60 ATP6V1B2 526 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
CLTC 1213 GRIA1 2890 pp -- int.I2D: IntAct_Mouse
CASP8 841 GRIA1 2890 pp -- int.I2D: HPRD;
int.HPRD: in vivo
ACTB 60 CLTC 1213 pp -- int.I2D: IntAct_Yeast

Related GO terms (243)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0033572transferrin transport1.16e-041.00e+006.9092530
GO:0031623receptor internalization1.24e-041.00e+006.8622231
GO:0005829cytosol5.44e-041.00e+002.11661322496
GO:0030690Noc1p-Noc2p complex5.55e-041.00e+0010.816111
GO:0070243regulation of thymocyte apoptotic process5.55e-041.00e+0010.816111
GO:0042470melanosome1.08e-031.00e+005.3082991
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.11e-031.00e+009.816112
GO:0002176male germ cell proliferation1.11e-031.00e+009.816112
GO:0097199cysteine-type endopeptidase activity involved in apoptotic signaling pathway1.11e-031.00e+009.816112
GO:0005055laminin receptor activity1.11e-031.00e+009.816112
GO:0006407rRNA export from nucleus1.11e-031.00e+009.816112
GO:0014069postsynaptic density1.43e-031.00e+005.10223105
GO:0005850eukaryotic translation initiation factor 2 complex1.66e-031.00e+009.231113
GO:1900126negative regulation of hyaluronan biosynthetic process1.66e-031.00e+009.231123
GO:0060715syncytiotrophoblast cell differentiation involved in labyrinthine layer development1.66e-031.00e+009.231113
GO:0036462TRAIL-activated apoptotic signaling pathway1.66e-031.00e+009.231113
GO:0044309neuron spine1.66e-031.00e+009.231113
GO:0071439clathrin complex1.66e-031.00e+009.231123
GO:0044308axonal spine1.66e-031.00e+009.231113
GO:0044267cellular protein metabolic process1.75e-031.00e+003.512329474
GO:0006413translational initiation2.21e-031.00e+004.783217131
GO:0004971alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity2.22e-031.00e+008.816114
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.22e-031.00e+008.816114
GO:003068690S preribosome2.22e-031.00e+008.816114
GO:0097153cysteine-type endopeptidase activity involved in apoptotic process2.22e-031.00e+008.816114
GO:0035877death effector domain binding2.22e-031.00e+008.816114
GO:0032051clathrin light chain binding2.22e-031.00e+008.816114
GO:1903077negative regulation of protein localization to plasma membrane2.22e-031.00e+008.816114
GO:0061024membrane organization2.70e-031.00e+004.63627145
GO:0000730DNA recombinase assembly2.77e-031.00e+008.494115
GO:2000001regulation of DNA damage checkpoint2.77e-031.00e+008.494115
GO:0032025response to cobalt ion2.77e-031.00e+008.494115
GO:0032591dendritic spine membrane2.77e-031.00e+008.494115
GO:0031265CD95 death-inducing signaling complex3.32e-031.00e+008.231116
GO:0030130clathrin coat of trans-Golgi network vesicle3.32e-031.00e+008.231136
GO:0030957Tat protein binding3.32e-031.00e+008.231136
GO:0031264death-inducing signaling complex3.32e-031.00e+008.231116
GO:0030118clathrin coat3.32e-031.00e+008.231126
GO:0060546negative regulation of necroptotic process3.88e-031.00e+008.009117
GO:0033180proton-transporting V-type ATPase, V1 domain3.88e-031.00e+008.009127
GO:0030132clathrin coat of coated pit3.88e-031.00e+008.009127
GO:0097342ripoptosome3.88e-031.00e+008.009117
GO:0000028ribosomal small subunit assembly3.88e-031.00e+008.009117
GO:0031625ubiquitin protein ligase binding4.04e-031.00e+004.340214178
GO:0097202activation of cysteine-type endopeptidase activity4.43e-031.00e+007.816118
GO:0070688MLL5-L complex4.43e-031.00e+007.816118
GO:0097284hepatocyte apoptotic process4.98e-031.00e+007.646139
GO:0001841neural tube formation5.53e-031.00e+007.4941110
GO:0010569regulation of double-strand break repair via homologous recombination5.53e-031.00e+007.4941110
GO:2001239regulation of extrinsic apoptotic signaling pathway in absence of ligand6.09e-031.00e+007.3571111
GO:0008066glutamate receptor activity6.09e-031.00e+007.3571111
GO:0031571mitotic G1 DNA damage checkpoint6.09e-031.00e+007.3571411
GO:0045651positive regulation of macrophage differentiation6.09e-031.00e+007.3571111
GO:0006412translation6.65e-031.00e+003.971220230
GO:0005662DNA replication factor A complex7.19e-031.00e+007.1161113
GO:0035267NuA4 histone acetyltransferase complex7.74e-031.00e+007.0091414
GO:0032590dendrite membrane7.74e-031.00e+007.0091114
GO:0046961proton-transporting ATPase activity, rotational mechanism8.29e-031.00e+006.9091315
GO:0046034ATP metabolic process8.29e-031.00e+006.9091115
GO:0030225macrophage differentiation8.29e-031.00e+006.9091115
GO:0005123death receptor binding8.29e-031.00e+006.9091115
GO:0050998nitric-oxide synthase binding8.84e-031.00e+006.8161116
GO:0030101natural killer cell activation8.84e-031.00e+006.8161116
GO:0032281alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex8.84e-031.00e+006.8161116
GO:0051603proteolysis involved in cellular protein catabolic process8.84e-031.00e+006.8161216
GO:0035861site of double-strand break9.94e-031.00e+006.6461118
GO:0005234extracellular-glutamate-gated ion channel activity9.94e-031.00e+006.6461118
GO:0015078hydrogen ion transmembrane transporter activity1.05e-021.00e+006.5681319
GO:0097194execution phase of apoptosis1.05e-021.00e+006.5681119
GO:0005856cytoskeleton1.05e-021.00e+003.631212291
GO:0043234protein complex1.08e-021.00e+003.612218295
GO:0006298mismatch repair1.10e-021.00e+006.4941320
GO:0005515protein binding1.12e-021.00e+001.06771846024
GO:0032201telomere maintenance via semi-conservative replication1.16e-021.00e+006.4241521
GO:0045862positive regulation of proteolysis1.16e-021.00e+006.4241121
GO:0000718nucleotide-excision repair, DNA damage removal1.16e-021.00e+006.4241421
GO:0006297nucleotide-excision repair, DNA gap filling1.21e-021.00e+006.3571322
GO:0030863cortical cytoskeleton1.21e-021.00e+006.3571122
GO:0036464cytoplasmic ribonucleoprotein granule1.21e-021.00e+006.3571422
GO:0019901protein kinase binding1.24e-021.00e+003.508221317
GO:0043044ATP-dependent chromatin remodeling1.27e-021.00e+006.2931423
GO:0043236laminin binding1.27e-021.00e+006.2931123
GO:0008135translation factor activity, nucleic acid binding1.32e-021.00e+006.2311724
GO:0035235ionotropic glutamate receptor signaling pathway1.32e-021.00e+006.2311124
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway1.38e-021.00e+006.1721325
GO:0000722telomere maintenance via recombination1.38e-021.00e+006.1721525
GO:0042113B cell activation1.38e-021.00e+006.1721225
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway1.43e-021.00e+006.1161426
GO:0015991ATP hydrolysis coupled proton transport1.43e-021.00e+006.1161426
GO:0009409response to cold1.43e-021.00e+006.1161226
GO:0043022ribosome binding1.49e-021.00e+006.0611327
GO:2001238positive regulation of extrinsic apoptotic signaling pathway1.49e-021.00e+006.0611227
GO:0034612response to tumor necrosis factor1.49e-021.00e+006.0611227
GO:0031492nucleosomal DNA binding1.49e-021.00e+006.0611427
GO:0007616long-term memory1.49e-021.00e+006.0611227
GO:0030669clathrin-coated endocytic vesicle membrane1.54e-021.00e+006.0091428
GO:0019894kinesin binding1.54e-021.00e+006.0091128
GO:0015992proton transport1.60e-021.00e+005.9581329
GO:0005925focal adhesion1.63e-021.00e+003.300219366
GO:0006271DNA strand elongation involved in DNA replication1.65e-021.00e+005.9091730
GO:0005164tumor necrosis factor receptor binding1.65e-021.00e+005.9091230
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling1.65e-021.00e+005.9091130
GO:0044822poly(A) RNA binding1.66e-021.00e+002.3573491056
GO:0046677response to antibiotic1.71e-021.00e+005.8621231
GO:0035249synaptic transmission, glutamatergic1.76e-021.00e+005.8161132
GO:0051701interaction with host1.76e-021.00e+005.8161432
GO:0032588trans-Golgi network membrane1.87e-021.00e+005.7291234
GO:0001895retina homeostasis1.87e-021.00e+005.7291134
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors1.87e-021.00e+005.7291234
GO:0097110scaffold protein binding1.87e-021.00e+005.7291334
GO:0034332adherens junction organization1.98e-021.00e+005.6461136
GO:0090382phagosome maturation1.98e-021.00e+005.6461536
GO:0008234cysteine-type peptidase activity2.03e-021.00e+005.6071337
GO:0051084'de novo' posttranslational protein folding2.03e-021.00e+005.6071437
GO:0006284base-excision repair2.03e-021.00e+005.6071337
GO:0005902microvillus2.09e-021.00e+005.5681238
GO:0097191extrinsic apoptotic signaling pathway2.09e-021.00e+005.5681338
GO:0071407cellular response to organic cyclic compound2.09e-021.00e+005.5681238
GO:0070527platelet aggregation2.09e-021.00e+005.5681238
GO:0022627cytosolic small ribosomal subunit2.14e-021.00e+005.5311439
GO:0000781chromosome, telomeric region2.14e-021.00e+005.5311339
GO:0042110T cell activation2.31e-021.00e+005.4241342
GO:0030136clathrin-coated vesicle2.31e-021.00e+005.4241442
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway2.36e-021.00e+005.3901443
GO:0006892post-Golgi vesicle-mediated transport2.36e-021.00e+005.3901343
GO:0021762substantia nigra development2.42e-021.00e+005.3571244
GO:0006283transcription-coupled nucleotide-excision repair2.52e-021.00e+005.2931746
GO:0044297cell body2.52e-021.00e+005.2931246
GO:0006921cellular component disassembly involved in execution phase of apoptosis2.58e-021.00e+005.2611547
GO:0003743translation initiation factor activity2.69e-021.00e+005.2011849
GO:0003684damaged DNA binding2.69e-021.00e+005.2011749
GO:0004197cysteine-type endopeptidase activity2.74e-021.00e+005.1721350
GO:0006879cellular iron ion homeostasis2.79e-021.00e+005.1441451
GO:0003725double-stranded RNA binding2.85e-021.00e+005.1161552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding2.90e-021.00e+005.0881553
GO:0030666endocytic vesicle membrane2.90e-021.00e+005.0881453
GO:0008233peptidase activity2.96e-021.00e+005.0611254
GO:0045216cell-cell junction organization2.96e-021.00e+005.0611254
GO:0097193intrinsic apoptotic signaling pathway3.01e-021.00e+005.0351655
GO:0000724double-strand break repair via homologous recombination3.01e-021.00e+005.0351355
GO:0070062extracellular vesicular exosome3.05e-021.00e+001.58741042400
GO:0051291protein heterooligomerization3.06e-021.00e+005.0091256
GO:0000723telomere maintenance3.06e-021.00e+005.0091656
GO:0012505endomembrane system3.06e-021.00e+005.0091256
GO:0016032viral process3.30e-021.00e+002.755255534
GO:0019903protein phosphatase binding3.39e-021.00e+004.8621462
GO:0006302double-strand break repair3.39e-021.00e+004.8621462
GO:0071260cellular response to mechanical stimulus3.55e-021.00e+004.7941565
GO:0006289nucleotide-excision repair3.71e-021.00e+004.72911168
GO:0034329cell junction assembly3.71e-021.00e+004.7291168
GO:0003697single-stranded DNA binding3.71e-021.00e+004.7291568
GO:0055037recycling endosome3.82e-021.00e+004.6871270
GO:0032355response to estradiol3.87e-021.00e+004.6661571
GO:0005886plasma membrane3.90e-021.00e+001.4824452582
GO:0008021synaptic vesicle3.98e-021.00e+004.6261273
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis4.03e-021.00e+004.6071674
GO:0045087innate immune response4.05e-021.00e+002.597224596
GO:0008584male gonad development4.09e-021.00e+004.5871375
GO:0035666TRIF-dependent toll-like receptor signaling pathway4.14e-021.00e+004.5681376
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process4.19e-021.00e+004.5491777
GO:0002756MyD88-independent toll-like receptor signaling pathway4.25e-021.00e+004.5311378
GO:0034138toll-like receptor 3 signaling pathway4.30e-021.00e+004.5121379
GO:0001726ruffle4.35e-021.00e+004.4941480
GO:0019083viral transcription4.41e-021.00e+004.47611081
GO:0043197dendritic spine4.46e-021.00e+004.4591382
GO:0006898receptor-mediated endocytosis4.57e-021.00e+004.4241384
GO:0047485protein N-terminus binding4.67e-021.00e+004.3901586
GO:0045471response to ethanol4.67e-021.00e+004.3901386
GO:0006415translational termination4.73e-021.00e+004.37311087
GO:0016605PML body4.78e-021.00e+004.3571388
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II4.89e-021.00e+004.3241790
GO:0006928cellular component movement4.94e-021.00e+004.3081791
GO:0005200structural constituent of cytoskeleton4.94e-021.00e+004.3081891
GO:0001649osteoblast differentiation4.99e-021.00e+004.2931692
GO:0010467gene expression4.99e-021.00e+002.430259669
GO:0006414translational elongation5.04e-021.00e+004.27711393
GO:0030165PDZ domain binding5.10e-021.00e+004.2611194
GO:0034142toll-like receptor 4 signaling pathway5.20e-021.00e+004.2311396
GO:0006614SRP-dependent cotranslational protein targeting to membrane5.63e-021.00e+004.116110104
GO:0016020membrane5.64e-021.00e+001.6863901681
GO:0005741mitochondrial outer membrane5.68e-021.00e+004.10217105
GO:0002224toll-like receptor signaling pathway5.89e-021.00e+004.04813109
GO:0005815microtubule organizing center5.89e-021.00e+004.04815109
GO:0072562blood microparticle5.99e-021.00e+004.02213111
GO:0030529ribonucleoprotein complex6.05e-021.00e+004.00918112
GO:0005819spindle6.05e-021.00e+004.00917112
GO:0097190apoptotic signaling pathway6.10e-021.00e+003.99616113
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay6.15e-021.00e+003.983111114
GO:0019058viral life cycle6.20e-021.00e+003.971113115
GO:0006325chromatin organization6.36e-021.00e+003.93315118
GO:0006260DNA replication6.52e-021.00e+003.89719121
GO:0032496response to lipopolysaccharide6.52e-021.00e+003.89714121
GO:0000790nuclear chromatin6.94e-021.00e+003.80519129
GO:0031982vesicle7.04e-021.00e+003.78319131
GO:0003735structural constituent of ribosome7.35e-021.00e+003.718110137
GO:0007507heart development7.46e-021.00e+003.69717139
GO:0008286insulin receptor signaling pathway7.61e-021.00e+003.66617142
GO:0006457protein folding7.66e-021.00e+003.65617143
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling7.77e-021.00e+003.63614145
GO:0034220ion transmembrane transport7.97e-021.00e+003.59714149
GO:0000082G1/S transition of mitotic cell cycle7.97e-021.00e+003.597132149
GO:0005198structural molecule activity8.03e-021.00e+003.58715150
GO:0045121membrane raft8.33e-021.00e+003.53118156
GO:0043005neuron projection8.39e-021.00e+003.52116157
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding8.80e-021.00e+003.45017165
GO:0030424axon8.85e-021.00e+003.44114166
GO:0045211postsynaptic membrane9.05e-021.00e+003.40711170
GO:0006886intracellular protein transport9.10e-021.00e+003.39815171
GO:0032403protein complex binding9.71e-021.00e+003.300110183
GO:0001525angiogenesis1.01e-011.00e+003.23914191
GO:0001701in utero embryonic development1.06e-011.00e+003.16518201
GO:0005765lysosomal membrane1.07e-011.00e+003.15115203
GO:0005654nucleoplasm1.16e-011.00e+001.7372761082
GO:0016071mRNA metabolic process1.17e-011.00e+003.015131223
GO:0007067mitotic nuclear division1.19e-011.00e+002.990114227
GO:0030425dendrite1.21e-011.00e+002.97113230
GO:0043025neuronal cell body1.28e-011.00e+002.87919245
GO:0016070RNA metabolic process1.29e-011.00e+002.868132247
GO:0006281DNA repair1.36e-011.00e+002.788118261
GO:0019899enzyme binding1.44e-011.00e+002.702112277
GO:0005524ATP binding1.58e-011.00e+001.4742601298
GO:0043231intracellular membrane-bounded organelle1.63e-011.00e+002.50319318
GO:0007411axon guidance1.64e-011.00e+002.499113319
GO:0007268synaptic transmission1.70e-011.00e+002.44116332
GO:0030054cell junction1.72e-011.00e+002.42415336
GO:0003723RNA binding1.75e-011.00e+002.398120342
GO:0007155cell adhesion1.87e-011.00e+002.28916369
GO:0006508proteolysis1.91e-011.00e+002.25419378
GO:0046982protein heterodimerization activity1.92e-011.00e+002.246113380
GO:0000278mitotic cell cycle1.97e-011.00e+002.205148391
GO:0009986cell surface2.02e-011.00e+002.165111402
GO:0055085transmembrane transport2.17e-011.00e+002.051110435
GO:0007596blood coagulation2.26e-011.00e+001.986118455
GO:0005730nucleolus2.29e-011.00e+001.1362691641
GO:0006915apoptotic process2.69e-011.00e+001.700133555
GO:0005789endoplasmic reticulum membrane2.76e-011.00e+001.661116570
GO:0005737cytoplasm3.49e-011.00e+000.52231103767
GO:0007165signal transduction4.05e-011.00e+000.991124907
GO:0005615extracellular space4.23e-011.00e+000.914117957
GO:0005739mitochondrion4.37e-011.00e+000.853128998
GO:0005634nucleus4.89e-011.00e+000.24731364559
GO:0046872metal ion binding5.32e-011.00e+000.4641251307
GO:0016021integral component of membrane6.94e-011.00e+00-0.1371271982