int-snw-23649

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.938	1.18e-15	2.28e-03	3.78e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-23649 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
[ POLA2 ]	23649	1	0.014	0.938	88	-	-
RSL24D1	51187	36	1.300	1.020	59	Yes	-
EIF6	3692	14	0.700	1.013	267	Yes	-
POLA1	5422	2	0.593	0.938	69	Yes	-
RPL14	9045	42	1.250	1.113	143	Yes	-
RPL8	6132	9	0.778	0.967	218	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
HSPD1	3329	35	0.913	1.035	286	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (17)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
HSPD1	3329	RPSA	3921	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
RPL8	6132	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
PGD	5226	POLA2	23649	pp	--	int.I2D: BioGrid_Yeast
EIF6	3692	PGD	5226	pp	--	int.I2D: YeastLow
HSPD1	3329	POLA1	5422	pp	--	int.I2D: YeastLow
HSPD1	3329	EIF6	3692	pp	--	int.I2D: BioGrid_Yeast
RPL8	6132	POLA2	23649	pp	--	int.I2D: IntAct_Yeast
POLA1	5422	POLA2	23649	pp	--	int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BCI, BioGrid_Yeast, IntAct_Fly, IntAct_Mouse, IntAct_Yeast, MINT_Yeast, BioGrid, BioGrid_Fly, BIND_Fly, FlyLow, HPRD, IntAct, IntAct_Rat, Krogan_Core, MINT_Fly, YeastLow, Yu_GoldStd; int.HPRD: in vitro, in vivo
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
EIF6	3692	RPL8	6132	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
EIF6	3692	POLA2	23649	pp	--	int.I2D: BioGrid, HPRD, StelzlHigh; int.HPRD: yeast 2-hybrid
HSPD1	3329	POLA2	23649	pp	--	int.I2D: YeastLow
ACTB	60	HSPD1	3329	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, YeastLow
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
EIF6	3692	RSL24D1	51187	pp	--	int.I2D: BioGrid_Yeast, YeastLow

Related GO terms (189)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0016032	viral process	9.88e-07	1.42e-02	3.881	6	55	534
GO:0006413	translational initiation	2.04e-06	2.94e-02	5.323	4	17	131
GO:0005658	alpha DNA polymerase:primase complex	3.17e-06	4.57e-02	9.357	2	2	4
GO:0016071	mRNA metabolic process	1.69e-05	2.43e-01	4.556	4	31	223
GO:0016070	RNA metabolic process	2.52e-05	3.64e-01	4.408	4	32	247
GO:0019083	viral transcription	2.73e-05	3.93e-01	5.602	3	10	81
GO:0006415	translational termination	3.38e-05	4.87e-01	5.499	3	10	87
GO:0042273	ribosomal large subunit biogenesis	4.11e-05	5.92e-01	7.656	2	4	13
GO:0006414	translational elongation	4.13e-05	5.95e-01	5.402	3	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	5.76e-05	8.31e-01	5.241	3	10	104
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	7.58e-05	1.00e+00	5.109	3	11	114
GO:0019058	viral life cycle	7.78e-05	1.00e+00	5.096	3	13	115
GO:0032201	telomere maintenance via semi-conservative replication	1.10e-04	1.00e+00	6.964	2	5	21
GO:0006270	DNA replication initiation	1.21e-04	1.00e+00	6.897	2	6	22
GO:0003735	structural constituent of ribosome	1.31e-04	1.00e+00	4.844	3	10	137
GO:0000722	telomere maintenance via recombination	1.57e-04	1.00e+00	6.713	2	5	25
GO:0000082	G1/S transition of mitotic cell cycle	1.68e-04	1.00e+00	4.722	3	32	149
GO:0043022	ribosome binding	1.84e-04	1.00e+00	6.602	2	3	27
GO:0003887	DNA-directed DNA polymerase activity	1.98e-04	1.00e+00	6.549	2	3	28
GO:0006271	DNA strand elongation involved in DNA replication	2.27e-04	1.00e+00	6.450	2	7	30
GO:0044267	cellular protein metabolic process	3.16e-04	1.00e+00	3.468	4	29	474
GO:0006412	translation	6.01e-04	1.00e+00	4.096	3	20	230
GO:0022625	cytosolic large ribosomal subunit	6.10e-04	1.00e+00	5.742	2	6	49
GO:0070062	extracellular vesicular exosome	6.19e-04	1.00e+00	1.935	7	104	2400
GO:0016020	membrane	6.82e-04	1.00e+00	2.227	6	90	1681
GO:0002842	positive regulation of T cell mediated immune response to tumor cell	7.63e-04	1.00e+00	10.357	1	1	1
GO:0048291	isotype switching to IgG isotypes	7.63e-04	1.00e+00	10.357	1	1	1
GO:0019521	D-gluconate metabolic process	7.63e-04	1.00e+00	10.357	1	1	1
GO:0000054	ribosomal subunit export from nucleus	7.63e-04	1.00e+00	10.357	1	1	1
GO:0002368	B cell cytokine production	7.63e-04	1.00e+00	10.357	1	1	1
GO:0005829	cytosol	7.94e-04	1.00e+00	1.879	7	132	2496
GO:0000723	telomere maintenance	7.96e-04	1.00e+00	5.549	2	6	56
GO:0010467	gene expression	1.17e-03	1.00e+00	2.971	4	59	669
GO:0006272	leading strand elongation	1.52e-03	1.00e+00	9.357	1	2	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.52e-03	1.00e+00	9.357	1	1	2
GO:0019322	pentose biosynthetic process	1.52e-03	1.00e+00	9.357	1	2	2
GO:0005055	laminin receptor activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0006407	rRNA export from nucleus	1.52e-03	1.00e+00	9.357	1	1	2
GO:0006458	'de novo' protein folding	2.29e-03	1.00e+00	8.772	1	1	3
GO:0009051	pentose-phosphate shunt, oxidative branch	2.29e-03	1.00e+00	8.772	1	2	3
GO:0030135	coated vesicle	2.29e-03	1.00e+00	8.772	1	1	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	2.29e-03	1.00e+00	8.772	1	1	3
GO:0000278	mitotic cell cycle	2.77e-03	1.00e+00	3.331	3	48	391
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3.05e-03	1.00e+00	8.357	1	1	4
GO:0030686	90S preribosome	3.05e-03	1.00e+00	8.357	1	1	4
GO:0001882	nucleoside binding	3.05e-03	1.00e+00	8.357	1	1	4
GO:0006273	lagging strand elongation	3.05e-03	1.00e+00	8.357	1	1	4
GO:0003896	DNA primase activity	3.05e-03	1.00e+00	8.357	1	2	4
GO:0006260	DNA replication	3.65e-03	1.00e+00	4.438	2	9	121
GO:0006269	DNA replication, synthesis of RNA primer	3.81e-03	1.00e+00	8.035	1	2	5
GO:0042256	mature ribosome assembly	3.81e-03	1.00e+00	8.035	1	1	5
GO:0043248	proteasome assembly	3.81e-03	1.00e+00	8.035	1	1	5
GO:0046696	lipopolysaccharide receptor complex	3.81e-03	1.00e+00	8.035	1	1	5
GO:0005638	lamin filament	3.81e-03	1.00e+00	8.035	1	1	5
GO:0043023	ribosomal large subunit binding	3.81e-03	1.00e+00	8.035	1	1	5
GO:0003688	DNA replication origin binding	4.57e-03	1.00e+00	7.772	1	2	6
GO:0030957	Tat protein binding	4.57e-03	1.00e+00	7.772	1	3	6
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	4.57e-03	1.00e+00	7.772	1	1	6
GO:0000028	ribosomal small subunit assembly	5.33e-03	1.00e+00	7.549	1	1	7
GO:0070688	MLL5-L complex	6.09e-03	1.00e+00	7.357	1	1	8
GO:0051604	protein maturation	6.09e-03	1.00e+00	7.357	1	1	8
GO:0044822	poly(A) RNA binding	6.21e-03	1.00e+00	2.312	4	49	1056
GO:0005654	nucleoplasm	6.78e-03	1.00e+00	2.277	4	76	1082
GO:0006098	pentose-phosphate shunt	7.60e-03	1.00e+00	7.035	1	4	10
GO:0000731	DNA synthesis involved in DNA repair	7.60e-03	1.00e+00	7.035	1	1	10
GO:0043032	positive regulation of macrophage activation	7.60e-03	1.00e+00	7.035	1	1	10
GO:0019985	translesion synthesis	8.36e-03	1.00e+00	6.897	1	2	11
GO:0032727	positive regulation of interferon-alpha production	8.36e-03	1.00e+00	6.897	1	1	11
GO:0005838	proteasome regulatory particle	9.12e-03	1.00e+00	6.772	1	7	12
GO:0005737	cytoplasm	9.75e-03	1.00e+00	1.285	7	110	3767
GO:0001530	lipopolysaccharide binding	9.87e-03	1.00e+00	6.656	1	3	13
GO:0051131	chaperone-mediated protein complex assembly	9.87e-03	1.00e+00	6.656	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	1.06e-02	1.00e+00	6.549	1	4	14
GO:0042026	protein refolding	1.14e-02	1.00e+00	6.450	1	2	15
GO:0050998	nitric-oxide synthase binding	1.21e-02	1.00e+00	6.357	1	1	16
GO:0008408	3'-5' exonuclease activity	1.21e-02	1.00e+00	6.357	1	1	16
GO:0050870	positive regulation of T cell activation	1.29e-02	1.00e+00	6.269	1	1	17
GO:0022624	proteasome accessory complex	1.29e-02	1.00e+00	6.269	1	8	17
GO:0006303	double-strand break repair via nonhomologous end joining	1.36e-02	1.00e+00	6.187	1	2	18
GO:0032733	positive regulation of interleukin-10 production	1.44e-02	1.00e+00	6.109	1	1	19
GO:0048863	stem cell differentiation	1.44e-02	1.00e+00	6.109	1	1	19
GO:0042100	B cell proliferation	1.59e-02	1.00e+00	5.964	1	1	21
GO:0006297	nucleotide-excision repair, DNA gap filling	1.67e-02	1.00e+00	5.897	1	3	22
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	1.67e-02	1.00e+00	5.897	1	2	22
GO:0030863	cortical cytoskeleton	1.67e-02	1.00e+00	5.897	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.67e-02	1.00e+00	5.897	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.74e-02	1.00e+00	5.833	1	4	23
GO:0043236	laminin binding	1.74e-02	1.00e+00	5.833	1	1	23
GO:0000060	protein import into nucleus, translocation	1.82e-02	1.00e+00	5.772	1	5	24
GO:0042113	B cell activation	1.89e-02	1.00e+00	5.713	1	2	25
GO:0032735	positive regulation of interleukin-12 production	1.89e-02	1.00e+00	5.713	1	1	25
GO:0043234	protein complex	2.03e-02	1.00e+00	3.152	2	18	295
GO:0019843	rRNA binding	2.04e-02	1.00e+00	5.602	1	3	27
GO:0050661	NADP binding	2.04e-02	1.00e+00	5.602	1	2	27
GO:0031492	nucleosomal DNA binding	2.04e-02	1.00e+00	5.602	1	4	27
GO:0071897	DNA biosynthetic process	2.12e-02	1.00e+00	5.549	1	2	28
GO:0019894	kinesin binding	2.12e-02	1.00e+00	5.549	1	1	28
GO:0042254	ribosome biogenesis	2.27e-02	1.00e+00	5.450	1	1	30
GO:0019901	protein kinase binding	2.32e-02	1.00e+00	3.048	2	21	317
GO:0001895	retina homeostasis	2.56e-02	1.00e+00	5.269	1	1	34
GO:0051539	4 iron, 4 sulfur cluster binding	2.64e-02	1.00e+00	5.227	1	3	35
GO:0003723	RNA binding	2.68e-02	1.00e+00	2.939	2	20	342
GO:0034332	adherens junction organization	2.71e-02	1.00e+00	5.187	1	1	36
GO:0032755	positive regulation of interleukin-6 production	2.71e-02	1.00e+00	5.187	1	2	36
GO:0051084	'de novo' posttranslational protein folding	2.79e-02	1.00e+00	5.147	1	4	37
GO:0005730	nucleolus	2.86e-02	1.00e+00	1.676	4	69	1641
GO:0070527	platelet aggregation	2.86e-02	1.00e+00	5.109	1	2	38
GO:0032729	positive regulation of interferon-gamma production	2.94e-02	1.00e+00	5.071	1	2	39
GO:0022627	cytosolic small ribosomal subunit	2.94e-02	1.00e+00	5.071	1	4	39
GO:0005925	focal adhesion	3.04e-02	1.00e+00	2.841	2	19	366
GO:0042110	T cell activation	3.16e-02	1.00e+00	4.964	1	3	42
GO:0046982	protein heterodimerization activity	3.25e-02	1.00e+00	2.787	2	13	380
GO:0021762	substantia nigra development	3.31e-02	1.00e+00	4.897	1	2	44
GO:0003743	translation initiation factor activity	3.68e-02	1.00e+00	4.742	1	8	49
GO:0006521	regulation of cellular amino acid metabolic process	3.75e-02	1.00e+00	4.713	1	17	50
GO:0006986	response to unfolded protein	3.75e-02	1.00e+00	4.713	1	2	50
GO:0005905	coated pit	3.75e-02	1.00e+00	4.713	1	3	50
GO:0003725	double-stranded RNA binding	3.90e-02	1.00e+00	4.656	1	5	52
GO:0090305	nucleic acid phosphodiester bond hydrolysis	3.97e-02	1.00e+00	4.629	1	1	53
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.97e-02	1.00e+00	4.629	1	5	53
GO:0043066	negative regulation of apoptotic process	3.98e-02	1.00e+00	2.629	2	31	424
GO:0045216	cell-cell junction organization	4.04e-02	1.00e+00	4.602	1	2	54
GO:0002039	p53 binding	4.12e-02	1.00e+00	4.575	1	7	55
GO:0000502	proteasome complex	4.34e-02	1.00e+00	4.499	1	17	58
GO:0051087	chaperone binding	4.41e-02	1.00e+00	4.474	1	6	59
GO:0030141	secretory granule	4.63e-02	1.00e+00	4.402	1	2	62
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.78e-02	1.00e+00	4.357	1	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.85e-02	1.00e+00	4.334	1	22	65
GO:0034329	cell junction assembly	5.07e-02	1.00e+00	4.269	1	1	68
GO:0003697	single-stranded DNA binding	5.07e-02	1.00e+00	4.269	1	5	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.21e-02	1.00e+00	4.227	1	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	5.36e-02	1.00e+00	4.187	1	20	72
GO:0000785	chromatin	5.43e-02	1.00e+00	4.167	1	4	73
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.50e-02	1.00e+00	4.147	1	6	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.50e-02	1.00e+00	4.147	1	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	5.58e-02	1.00e+00	4.128	1	20	75
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	5.72e-02	1.00e+00	4.090	1	7	77
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	5.86e-02	1.00e+00	4.053	1	23	79
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	5.94e-02	1.00e+00	4.035	1	3	80
GO:0050821	protein stabilization	6.51e-02	1.00e+00	3.897	1	2	88
GO:0016363	nuclear matrix	6.73e-02	1.00e+00	3.849	1	12	91
GO:0006928	cellular component movement	6.73e-02	1.00e+00	3.849	1	7	91
GO:0005200	structural constituent of cytoskeleton	6.73e-02	1.00e+00	3.849	1	8	91
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	6.80e-02	1.00e+00	3.833	1	21	92
GO:0051082	unfolded protein binding	6.87e-02	1.00e+00	3.817	1	5	93
GO:0006364	rRNA processing	6.94e-02	1.00e+00	3.802	1	6	94
GO:0014069	postsynaptic density	7.73e-02	1.00e+00	3.642	1	3	105
GO:0072562	blood microparticle	8.15e-02	1.00e+00	3.562	1	3	111
GO:0030529	ribonucleoprotein complex	8.22e-02	1.00e+00	3.549	1	8	112
GO:0005635	nuclear envelope	8.29e-02	1.00e+00	3.536	1	6	113
GO:0000209	protein polyubiquitination	8.50e-02	1.00e+00	3.499	1	20	116
GO:0006325	chromatin organization	8.64e-02	1.00e+00	3.474	1	5	118
GO:0006511	ubiquitin-dependent protein catabolic process	9.20e-02	1.00e+00	3.379	1	5	126
GO:0000790	nuclear chromatin	9.41e-02	1.00e+00	3.345	1	9	129
GO:0005634	nucleus	9.78e-02	1.00e+00	0.787	6	136	4559
GO:0016887	ATPase activity	1.02e-01	1.00e+00	3.227	1	7	140
GO:0006457	protein folding	1.04e-01	1.00e+00	3.197	1	7	143
GO:0061024	membrane organization	1.05e-01	1.00e+00	3.177	1	7	145
GO:0042981	regulation of apoptotic process	1.09e-01	1.00e+00	3.128	1	24	150
GO:0005769	early endosome	1.10e-01	1.00e+00	3.109	1	2	152
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.19e-01	1.00e+00	2.990	1	7	165
GO:0030424	axon	1.20e-01	1.00e+00	2.982	1	4	166
GO:0005515	protein binding	1.23e-01	1.00e+00	0.608	7	184	6024
GO:0034641	cellular nitrogen compound metabolic process	1.23e-01	1.00e+00	2.939	1	20	171
GO:0005759	mitochondrial matrix	1.61e-01	1.00e+00	2.524	1	14	228
GO:0005615	extracellular space	1.63e-01	1.00e+00	1.454	2	17	957
GO:0005975	carbohydrate metabolic process	1.77e-01	1.00e+00	2.374	1	9	253
GO:0000166	nucleotide binding	1.81e-01	1.00e+00	2.340	1	5	259
GO:0006281	DNA repair	1.82e-01	1.00e+00	2.329	1	18	261
GO:0043065	positive regulation of apoptotic process	1.86e-01	1.00e+00	2.291	1	10	268
GO:0005743	mitochondrial inner membrane	1.92e-01	1.00e+00	2.243	1	8	277
GO:0005856	cytoskeleton	2.01e-01	1.00e+00	2.172	1	12	291
GO:0006200	ATP catabolic process	2.02e-01	1.00e+00	2.167	1	15	292
GO:0007411	axon guidance	2.18e-01	1.00e+00	2.039	1	13	319
GO:0003682	chromatin binding	2.23e-01	1.00e+00	2.004	1	11	327
GO:0008283	cell proliferation	2.24e-01	1.00e+00	1.999	1	14	328
GO:0044281	small molecule metabolic process	2.35e-01	1.00e+00	1.115	2	58	1211
GO:0003677	DNA binding	2.37e-01	1.00e+00	1.106	2	28	1218
GO:0007155	cell adhesion	2.48e-01	1.00e+00	1.829	1	6	369
GO:0005524	ATP binding	2.60e-01	1.00e+00	1.015	2	60	1298
GO:0009986	cell surface	2.67e-01	1.00e+00	1.706	1	11	402
GO:0055114	oxidation-reduction process	2.78e-01	1.00e+00	1.642	1	12	420
GO:0003674	molecular_function	2.91e-01	1.00e+00	1.562	1	4	444
GO:0007596	blood coagulation	2.97e-01	1.00e+00	1.527	1	18	455
GO:0006915	apoptotic process	3.51e-01	1.00e+00	1.240	1	33	555
GO:0045087	innate immune response	3.71e-01	1.00e+00	1.137	1	24	596
GO:0005739	mitochondrion	5.46e-01	1.00e+00	0.394	1	28	998
GO:0005886	plasma membrane	6.12e-01	1.00e+00	0.022	2	45	2582
GO:0046872	metal ion binding	6.48e-01	1.00e+00	0.005	1	25	1307

Wolf-ratios-Mammosphere-Adherent

int-snw-23649

Statistics

Genes (11)

Interactions (17)

Related GO terms (189)