int-snw-23203

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.936 1.48e-15 2.41e-03 3.94e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-23203 subnetwork

Genes (13)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
ACO2 50 501.0001.076191Yes-
EEF2 1938 270.8901.043301Yes-
PSMD13 5719 160.8481.029104Yes-
PSMA2 5683 601.0931.10689Yes-
PSMD3 5709 570.9861.106146Yes-
RRM1 6240 20.5870.98939Yes-
[ PMPCA ] 23203 10.0780.93635Yes-
PSMA1 5682 610.9961.052123Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
HSPD1 3329 350.9131.035286Yes-
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-

Interactions (33)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PSMD3 5709 PSMD13 5719 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, MINT_Yeast, YeastHigh, BioGrid, BioGrid_Yeast, IntAct_Yeast, Krogan_Core
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
PSMA1 5682 PSMA2 5683 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
EEF2 1938 PGD 5226 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
EEF2 1938 PMPCA 23203 pp -- int.I2D: YeastLow
PSMD11 5717 PSMD13 5719 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastHigh, BioGrid, INTEROLOG
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
HSPD1 3329 PMPCA 23203 pp -- int.I2D: IntAct_Yeast
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
ACO2 50 PSMD11 5717 pp -- int.I2D: YeastLow
EEF2 1938 HSPD1 3329 pp -- int.I2D: YeastLow, YeastMedium
HSPD1 3329 RPSA 3921 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
EEF2 1938 PSMD13 5719 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 EEF2 1938 pp -- int.I2D: YeastLow, IntAct_Yeast
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PGD 5226 PSMD3 5709 pp -- int.I2D: YeastLow
ACO2 50 PGD 5226 pp -- int.I2D: YeastLow
PSMA1 5682 PSMD13 5719 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: IntAct, YeastMedium, BioGrid, BioGrid_Yeast, IntAct_Yeast
ACO2 50 HSPD1 3329 pp -- int.I2D: IntAct_Yeast
PSMA2 5683 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMD13 5719 PMPCA 23203 pp -- int.I2D: YeastLow
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
EEF2 1938 PSMD3 5709 pp -- int.I2D: Krogan_NonCore
PSMD13 5719 RRM1 6240 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB 60 HSPD1 3329 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, YeastLow
ACTB 60 PSMD13 5719 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMD13 5719 pp -- int.I2D: YeastLow
RRM1 6240 PMPCA 23203 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast

Related GO terms (190)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0006521regulation of cellular amino acid metabolic process5.14e-107.41e-066.79451750
GO:0000502proteasome complex1.11e-091.60e-056.58051758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.84e-092.65e-056.43851964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.99e-092.87e-056.41552265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.91e-094.19e-056.30852270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent3.36e-094.84e-056.26852072
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.86e-095.57e-056.22852274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I4.14e-095.97e-056.20952075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process5.39e-097.78e-056.13452379
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.17e-081.69e-045.91452192
GO:0016071mRNA metabolic process2.00e-082.89e-044.900631223
GO:0016070RNA metabolic process3.68e-085.31e-044.752632247
GO:0000209protein polyubiquitination3.77e-085.44e-045.580520116
GO:0005838proteasome regulatory particle1.25e-071.81e-038.1163712
GO:0016032viral process1.30e-071.87e-033.862755534
GO:0000082G1/S transition of mitotic cell cycle1.32e-071.91e-035.218532149
GO:0042981regulation of apoptotic process1.37e-071.98e-035.209524150
GO:0070062extracellular vesicular exosome1.49e-072.15e-032.346111042400
GO:0005829cytosol2.26e-073.27e-032.290111322496
GO:0034641cellular nitrogen compound metabolic process2.63e-073.80e-035.020520171
GO:0022624proteasome accessory complex3.86e-075.57e-037.6133817
GO:0000278mitotic cell cycle5.58e-078.05e-034.090648391
GO:0010467gene expression6.02e-078.68e-033.537759669
GO:0043066negative regulation of apoptotic process8.97e-071.29e-023.973631424
GO:0044281small molecule metabolic process2.12e-063.06e-022.8748581211
GO:0005654nucleoplasm1.51e-052.17e-012.8447761082
GO:0019773proteasome core complex, alpha-subunit complex2.09e-053.02e-018.116248
GO:0006915apoptotic process8.25e-051.00e+003.321533555
GO:0005839proteasome core complex1.14e-041.00e+006.9462818
GO:0004298threonine-type endopeptidase activity1.27e-041.00e+006.8682819
GO:0005844polysome1.88e-041.00e+006.5922423
GO:0016020membrane2.61e-041.00e+002.2087901681
GO:0044267cellular protein metabolic process6.50e-041.00e+003.227429474
GO:0002842positive regulation of T cell mediated immune response to tumor cell9.01e-041.00e+0010.116111
GO:0048291isotype switching to IgG isotypes9.01e-041.00e+0010.116111
GO:0019521D-gluconate metabolic process9.01e-041.00e+0010.116111
GO:0002368B cell cytokine production9.01e-041.00e+0010.116111
GO:0005759mitochondrial matrix9.92e-041.00e+003.868314228
GO:00515383 iron, 4 sulfur cluster binding1.80e-031.00e+009.116112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.80e-031.00e+009.116112
GO:0019322pentose biosynthetic process1.80e-031.00e+009.116122
GO:0003994aconitate hydratase activity1.80e-031.00e+009.116112
GO:0005055laminin receptor activity1.80e-031.00e+009.116112
GO:0006407rRNA export from nucleus1.80e-031.00e+009.116112
GO:0007127meiosis I1.80e-031.00e+009.116112
GO:0009263deoxyribonucleotide biosynthetic process2.70e-031.00e+008.531113
GO:0006458'de novo' protein folding2.70e-031.00e+008.531113
GO:0009051pentose-phosphate shunt, oxidative branch2.70e-031.00e+008.531123
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor2.70e-031.00e+008.531113
GO:0030135coated vesicle2.70e-031.00e+008.531113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.70e-031.00e+008.531113
GO:0006414translational elongation3.06e-031.00e+004.57621393
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.60e-031.00e+008.116114
GO:003068690S preribosome3.60e-031.00e+008.116114
GO:0030529ribonucleoprotein complex4.41e-031.00e+004.30828112
GO:0043248proteasome assembly4.50e-031.00e+007.794115
GO:0046696lipopolysaccharide receptor complex4.50e-031.00e+007.794115
GO:0006102isocitrate metabolic process4.50e-031.00e+007.794115
GO:0003688DNA replication origin binding5.40e-031.00e+007.531126
GO:0030957Tat protein binding5.40e-031.00e+007.531136
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex5.40e-031.00e+007.531116
GO:0006101citrate metabolic process5.40e-031.00e+007.531116
GO:0005634nucleus5.94e-031.00e+001.13191364559
GO:0000028ribosomal small subunit assembly6.29e-031.00e+007.308117
GO:0070688MLL5-L complex7.19e-031.00e+007.116118
GO:0051604protein maturation7.19e-031.00e+007.116118
GO:0008494translation activator activity8.09e-031.00e+006.946119
GO:0006098pentose-phosphate shunt8.98e-031.00e+006.7941410
GO:0021846cell proliferation in forebrain8.98e-031.00e+006.7941110
GO:0043032positive regulation of macrophage activation8.98e-031.00e+006.7941110
GO:0032727positive regulation of interferon-alpha production9.87e-031.00e+006.6561111
GO:0051290protein heterotetramerization9.87e-031.00e+006.6561211
GO:0030234enzyme regulator activity1.17e-021.00e+006.4151313
GO:0001530lipopolysaccharide binding1.17e-021.00e+006.4151313
GO:0051131chaperone-mediated protein complex assembly1.17e-021.00e+006.4151113
GO:0035267NuA4 histone acetyltransferase complex1.26e-021.00e+006.3081414
GO:0042026protein refolding1.34e-021.00e+006.2091215
GO:0050998nitric-oxide synthase binding1.43e-021.00e+006.1161116
GO:0042176regulation of protein catabolic process1.43e-021.00e+006.1161316
GO:0050870positive regulation of T cell activation1.52e-021.00e+006.0281117
GO:0003746translation elongation factor activity1.52e-021.00e+006.0281317
GO:0015949nucleobase-containing small molecule interconversion1.61e-021.00e+005.9461118
GO:0032733positive regulation of interleukin-10 production1.70e-021.00e+005.8681119
GO:0048863stem cell differentiation1.70e-021.00e+005.8681119
GO:0006412translation1.76e-021.00e+003.270220230
GO:0042100B cell proliferation1.88e-021.00e+005.7231121
GO:0006206pyrimidine nucleobase metabolic process1.97e-021.00e+005.6561222
GO:0030863cortical cytoskeleton1.97e-021.00e+005.6561122
GO:0036464cytoplasmic ribonucleoprotein granule1.97e-021.00e+005.6561422
GO:0043044ATP-dependent chromatin remodeling2.05e-021.00e+005.5921423
GO:0043236laminin binding2.05e-021.00e+005.5921123
GO:0042113B cell activation2.23e-021.00e+005.4721225
GO:0032735positive regulation of interleukin-12 production2.23e-021.00e+005.4721125
GO:0043022ribosome binding2.41e-021.00e+005.3611327
GO:0050661NADP binding2.41e-021.00e+005.3611227
GO:0031492nucleosomal DNA binding2.41e-021.00e+005.3611427
GO:0005743mitochondrial inner membrane2.49e-021.00e+003.00228277
GO:0006099tricarboxylic acid cycle2.50e-021.00e+005.3081428
GO:0019894kinesin binding2.50e-021.00e+005.3081128
GO:0043234protein complex2.80e-021.00e+002.911218295
GO:0001895retina homeostasis3.02e-021.00e+005.0281134
GO:00515394 iron, 4 sulfur cluster binding3.11e-021.00e+004.9861335
GO:0034332adherens junction organization3.20e-021.00e+004.9461136
GO:0019901protein kinase binding3.20e-021.00e+002.807221317
GO:0032755positive regulation of interleukin-6 production3.20e-021.00e+004.9461236
GO:0051084'de novo' posttranslational protein folding3.29e-021.00e+004.9061437
GO:0070527platelet aggregation3.37e-021.00e+004.8681238
GO:0032729positive regulation of interferon-gamma production3.46e-021.00e+004.8301239
GO:0022627cytosolic small ribosomal subunit3.46e-021.00e+004.8301439
GO:0042110T cell activation3.72e-021.00e+004.7231342
GO:0010212response to ionizing radiation3.72e-021.00e+004.7231142
GO:0021762substantia nigra development3.90e-021.00e+004.6561244
GO:0006626protein targeting to mitochondrion3.90e-021.00e+004.6561144
GO:0045727positive regulation of translation3.90e-021.00e+004.6561344
GO:0006091generation of precursor metabolites and energy4.42e-021.00e+004.4721350
GO:0006986response to unfolded protein4.42e-021.00e+004.4721250
GO:0005905coated pit4.42e-021.00e+004.4721350
GO:0060041retina development in camera-type eye4.50e-021.00e+004.4431251
GO:0003725double-stranded RNA binding4.59e-021.00e+004.4151552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.68e-021.00e+004.3881553
GO:0002244hematopoietic progenitor cell differentiation4.76e-021.00e+004.3611154
GO:0045216cell-cell junction organization4.76e-021.00e+004.3611254
GO:0000932cytoplasmic mRNA processing body4.76e-021.00e+004.3611354
GO:0002039p53 binding4.85e-021.00e+004.3341755
GO:0005615extracellular space5.05e-021.00e+001.798317957
GO:0051087chaperone binding5.19e-021.00e+004.2331659
GO:0042995cell projection5.28e-021.00e+004.2091660
GO:0055114oxidation-reduction process5.34e-021.00e+002.401212420
GO:0030141secretory granule5.45e-021.00e+004.1611262
GO:0005739mitochondrion5.60e-021.00e+001.738328998
GO:0034329cell junction assembly5.96e-021.00e+004.0281168
GO:0003697single-stranded DNA binding5.96e-021.00e+004.0281568
GO:0055086nucleobase-containing small molecule metabolic process6.13e-021.00e+003.9861270
GO:0044822poly(A) RNA binding6.44e-021.00e+001.6563491056
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis6.47e-021.00e+003.9061674
GO:0008584male gonad development6.56e-021.00e+003.8871375
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process6.72e-021.00e+003.8491777
GO:0004222metalloendopeptidase activity6.72e-021.00e+003.8491177
GO:0002755MyD88-dependent toll-like receptor signaling pathway6.98e-021.00e+003.7941380
GO:0019083viral transcription7.06e-021.00e+003.77611081
GO:0006415translational termination7.57e-021.00e+003.67311087
GO:0050821protein stabilization7.65e-021.00e+003.6561288
GO:0006928cellular component movement7.90e-021.00e+003.6081791
GO:0005200structural constituent of cytoskeleton7.90e-021.00e+003.6081891
GO:0051082unfolded protein binding8.07e-021.00e+003.5761593
GO:0006614SRP-dependent cotranslational protein targeting to membrane8.98e-021.00e+003.415110104
GO:0014069postsynaptic density9.07e-021.00e+003.40113105
GO:0005506iron ion binding9.07e-021.00e+003.40114105
GO:0072562blood microparticle9.56e-021.00e+003.32113111
GO:0005635nuclear envelope9.72e-021.00e+003.29516113
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay9.81e-021.00e+003.283111114
GO:0019058viral life cycle9.89e-021.00e+003.270113115
GO:0044237cellular metabolic process1.01e-011.00e+003.24515117
GO:0006325chromatin organization1.01e-011.00e+003.23315118
GO:0006260DNA replication1.04e-011.00e+003.19719121
GO:0005524ATP binding1.05e-011.00e+001.3593601298
GO:0006511ubiquitin-dependent protein catabolic process1.08e-011.00e+003.13815126
GO:0009615response to virus1.08e-011.00e+003.13815126
GO:0000790nuclear chromatin1.10e-011.00e+003.10419129
GO:0006413translational initiation1.12e-011.00e+003.082117131
GO:0003735structural constituent of ribosome1.17e-011.00e+003.018110137
GO:0016887ATPase activity1.19e-011.00e+002.98617140
GO:0006457protein folding1.22e-011.00e+002.95617143
GO:0061024membrane organization1.23e-011.00e+002.93617145
GO:0005515protein binding1.23e-011.00e+000.55981846024
GO:0010628positive regulation of gene expression1.24e-011.00e+002.92615146
GO:0005769early endosome1.29e-011.00e+002.86812152
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.39e-011.00e+002.74917165
GO:0030424axon1.40e-011.00e+002.74114166
GO:0003924GTPase activity1.64e-011.00e+002.494112197
GO:0006184GTP catabolic process1.77e-011.00e+002.374112214
GO:0043025neuronal cell body2.00e-011.00e+002.17919245
GO:0005975carbohydrate metabolic process2.06e-011.00e+002.13319253
GO:0043065positive regulation of apoptotic process2.16e-011.00e+002.050110268
GO:0005856cytoskeleton2.33e-011.00e+001.931112291
GO:0006200ATP catabolic process2.34e-011.00e+001.926115292
GO:0005737cytoplasm2.35e-011.00e+000.55851103767
GO:0005525GTP binding2.46e-011.00e+001.840112310
GO:0007411axon guidance2.52e-011.00e+001.798113319
GO:0005813centrosome2.57e-011.00e+001.767114326
GO:0003723RNA binding2.68e-011.00e+001.698120342
GO:0005925focal adhesion2.84e-011.00e+001.600119366
GO:0007155cell adhesion2.86e-011.00e+001.58816369
GO:0006508proteolysis2.92e-011.00e+001.55319378
GO:0009986cell surface3.08e-011.00e+001.465111402
GO:0007596blood coagulation3.41e-011.00e+001.286118455
GO:0045087innate immune response4.22e-011.00e+000.896124596
GO:0005730nucleolus4.45e-011.00e+000.4352691641
GO:0005886plasma membrane7.05e-011.00e+00-0.2192452582
GO:0046872metal ion binding7.09e-011.00e+00-0.2361251307