int-snw-2271

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.923	4.69e-15	3.19e-03	4.81e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-2271 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
ACO2	50	50	1.000	1.076	191	Yes	-
RSL24D1	51187	36	1.300	1.020	59	Yes	-
EIF6	3692	14	0.700	1.013	267	Yes	-
RPS11	6205	36	0.993	1.113	175	Yes	-
[ FH ]	2271	1	0.095	0.923	86	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
HSPD1	3329	35	0.913	1.035	286	Yes	-
ATP6V1B2	526	44	0.881	1.076	278	-	-
DLST	1743	5	0.646	1.026	135	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (19)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
HSPD1	3329	EIF6	3692	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
ATP6V1B2	526	RPSA	3921	pp	--	int.I2D: IntAct_Yeast
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
FH	2271	EIF6	3692	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
DLST	1743	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast
EIF6	3692	RSL24D1	51187	pp	--	int.I2D: BioGrid_Yeast, YeastLow
EIF6	3692	PGD	5226	pp	--	int.I2D: YeastLow
DLST	1743	HSPD1	3329	pp	--	int.I2D: IntAct_Yeast, YeastLow
ACO2	50	EIF6	3692	pp	--	int.I2D: YeastLow
ACO2	50	PSMD11	5717	pp	--	int.I2D: YeastLow
DLST	1743	FH	2271	pp	--	int.I2D: BioGrid_Yeast
HSPD1	3329	RPSA	3921	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
DLST	1743	RPSA	3921	pp	--	int.I2D: IntAct_Yeast
ACO2	50	FH	2271	pp	--	int.I2D: BioGrid_Yeast
ACO2	50	PGD	5226	pp	--	int.I2D: YeastLow
ACO2	50	HSPD1	3329	pp	--	int.I2D: IntAct_Yeast
ATP6V1B2	526	DLST	1743	pp	--	int.I2D: IntAct_Yeast

Related GO terms (156)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006099	tricarboxylic acid cycle	1.07e-06	1.54e-02	7.134	3	4	28
GO:0070062	extracellular vesicular exosome	3.85e-06	5.55e-02	2.298	9	104	2400
GO:0005759	mitochondrial matrix	1.84e-05	2.65e-01	4.524	4	14	228
GO:0044237	cellular metabolic process	8.19e-05	1.00e+00	5.071	3	5	117
GO:0006413	translational initiation	1.15e-04	1.00e+00	4.908	3	17	131
GO:0043022	ribosome binding	1.84e-04	1.00e+00	6.602	2	3	27
GO:0022627	cytosolic small ribosomal subunit	3.86e-04	1.00e+00	6.071	2	4	39
GO:0016032	viral process	4.98e-04	1.00e+00	3.296	4	55	534
GO:0016071	mRNA metabolic process	5.49e-04	1.00e+00	4.141	3	31	223
GO:0006091	generation of precursor metabolites and energy	6.35e-04	1.00e+00	5.713	2	3	50
GO:0016070	RNA metabolic process	7.40e-04	1.00e+00	3.993	3	32	247
GO:0002842	positive regulation of T cell mediated immune response to tumor cell	7.63e-04	1.00e+00	10.357	1	1	1
GO:0045239	tricarboxylic acid cycle enzyme complex	7.63e-04	1.00e+00	10.357	1	1	1
GO:0004149	dihydrolipoyllysine-residue succinyltransferase activity	7.63e-04	1.00e+00	10.357	1	1	1
GO:0006106	fumarate metabolic process	7.63e-04	1.00e+00	10.357	1	1	1
GO:0048291	isotype switching to IgG isotypes	7.63e-04	1.00e+00	10.357	1	1	1
GO:0019521	D-gluconate metabolic process	7.63e-04	1.00e+00	10.357	1	1	1
GO:0000054	ribosomal subunit export from nucleus	7.63e-04	1.00e+00	10.357	1	1	1
GO:0004333	fumarate hydratase activity	7.63e-04	1.00e+00	10.357	1	1	1
GO:0002368	B cell cytokine production	7.63e-04	1.00e+00	10.357	1	1	1
GO:0044281	small molecule metabolic process	1.24e-03	1.00e+00	2.437	5	58	1211
GO:0045252	oxoglutarate dehydrogenase complex	1.52e-03	1.00e+00	9.357	1	2	2
GO:0051538	3 iron, 4 sulfur cluster binding	1.52e-03	1.00e+00	9.357	1	1	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.52e-03	1.00e+00	9.357	1	1	2
GO:0019322	pentose biosynthetic process	1.52e-03	1.00e+00	9.357	1	2	2
GO:0003994	aconitate hydratase activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0005055	laminin receptor activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0006407	rRNA export from nucleus	1.52e-03	1.00e+00	9.357	1	1	2
GO:0019083	viral transcription	1.66e-03	1.00e+00	5.017	2	10	81
GO:0006415	translational termination	1.91e-03	1.00e+00	4.914	2	10	87
GO:0006414	translational elongation	2.18e-03	1.00e+00	4.817	2	13	93
GO:0006458	'de novo' protein folding	2.29e-03	1.00e+00	8.772	1	1	3
GO:0009051	pentose-phosphate shunt, oxidative branch	2.29e-03	1.00e+00	8.772	1	2	3
GO:0033512	L-lysine catabolic process to acetyl-CoA via saccharopine	2.29e-03	1.00e+00	8.772	1	1	3
GO:0030135	coated vesicle	2.29e-03	1.00e+00	8.772	1	1	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	2.29e-03	1.00e+00	8.772	1	1	3
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	2.71e-03	1.00e+00	4.656	2	10	104
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3.05e-03	1.00e+00	8.357	1	1	4
GO:0030686	90S preribosome	3.05e-03	1.00e+00	8.357	1	1	4
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	3.25e-03	1.00e+00	4.524	2	11	114
GO:0019058	viral life cycle	3.31e-03	1.00e+00	4.511	2	13	115
GO:0042256	mature ribosome assembly	3.81e-03	1.00e+00	8.035	1	1	5
GO:0043248	proteasome assembly	3.81e-03	1.00e+00	8.035	1	1	5
GO:0046696	lipopolysaccharide receptor complex	3.81e-03	1.00e+00	8.035	1	1	5
GO:0006102	isocitrate metabolic process	3.81e-03	1.00e+00	8.035	1	1	5
GO:0005638	lamin filament	3.81e-03	1.00e+00	8.035	1	1	5
GO:0043023	ribosomal large subunit binding	3.81e-03	1.00e+00	8.035	1	1	5
GO:0003688	DNA replication origin binding	4.57e-03	1.00e+00	7.772	1	2	6
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	4.57e-03	1.00e+00	7.772	1	1	6
GO:0006101	citrate metabolic process	4.57e-03	1.00e+00	7.772	1	1	6
GO:0003735	structural constituent of ribosome	4.66e-03	1.00e+00	4.259	2	10	137
GO:0033180	proton-transporting V-type ATPase, V1 domain	5.33e-03	1.00e+00	7.549	1	2	7
GO:0000028	ribosomal small subunit assembly	5.33e-03	1.00e+00	7.549	1	1	7
GO:0016020	membrane	5.39e-03	1.00e+00	1.963	5	90	1681
GO:0005829	cytosol	5.58e-03	1.00e+00	1.656	6	132	2496
GO:0006554	lysine catabolic process	6.09e-03	1.00e+00	7.357	1	2	8
GO:0051604	protein maturation	6.09e-03	1.00e+00	7.357	1	1	8
GO:0034641	cellular nitrogen compound metabolic process	7.16e-03	1.00e+00	3.939	2	20	171
GO:0006098	pentose-phosphate shunt	7.60e-03	1.00e+00	7.035	1	4	10
GO:0043032	positive regulation of macrophage activation	7.60e-03	1.00e+00	7.035	1	1	10
GO:0032727	positive regulation of interferon-alpha production	8.36e-03	1.00e+00	6.897	1	1	11
GO:0005838	proteasome regulatory particle	9.12e-03	1.00e+00	6.772	1	7	12
GO:0042273	ribosomal large subunit biogenesis	9.87e-03	1.00e+00	6.656	1	4	13
GO:0001530	lipopolysaccharide binding	9.87e-03	1.00e+00	6.656	1	3	13
GO:0051131	chaperone-mediated protein complex assembly	9.87e-03	1.00e+00	6.656	1	1	13
GO:0046961	proton-transporting ATPase activity, rotational mechanism	1.14e-02	1.00e+00	6.450	1	3	15
GO:0042026	protein refolding	1.14e-02	1.00e+00	6.450	1	2	15
GO:0046034	ATP metabolic process	1.14e-02	1.00e+00	6.450	1	1	15
GO:0010467	gene expression	1.24e-02	1.00e+00	2.556	3	59	669
GO:0006412	translation	1.27e-02	1.00e+00	3.511	2	20	230
GO:0050870	positive regulation of T cell activation	1.29e-02	1.00e+00	6.269	1	1	17
GO:0022624	proteasome accessory complex	1.29e-02	1.00e+00	6.269	1	8	17
GO:0015078	hydrogen ion transmembrane transporter activity	1.44e-02	1.00e+00	6.109	1	3	19
GO:0032733	positive regulation of interleukin-10 production	1.44e-02	1.00e+00	6.109	1	1	19
GO:0048863	stem cell differentiation	1.44e-02	1.00e+00	6.109	1	1	19
GO:0048873	homeostasis of number of cells within a tissue	1.52e-02	1.00e+00	6.035	1	1	20
GO:0042100	B cell proliferation	1.59e-02	1.00e+00	5.964	1	1	21
GO:0043236	laminin binding	1.74e-02	1.00e+00	5.833	1	1	23
GO:0042113	B cell activation	1.89e-02	1.00e+00	5.713	1	2	25
GO:0032735	positive regulation of interleukin-12 production	1.89e-02	1.00e+00	5.713	1	1	25
GO:0015991	ATP hydrolysis coupled proton transport	1.97e-02	1.00e+00	5.656	1	4	26
GO:0019843	rRNA binding	2.04e-02	1.00e+00	5.602	1	3	27
GO:0050661	NADP binding	2.04e-02	1.00e+00	5.602	1	2	27
GO:0015992	proton transport	2.19e-02	1.00e+00	5.499	1	3	29
GO:0042254	ribosome biogenesis	2.27e-02	1.00e+00	5.450	1	1	30
GO:0033572	transferrin transport	2.27e-02	1.00e+00	5.450	1	5	30
GO:0051701	interaction with host	2.41e-02	1.00e+00	5.357	1	4	32
GO:0051539	4 iron, 4 sulfur cluster binding	2.64e-02	1.00e+00	5.227	1	3	35
GO:0090382	phagosome maturation	2.71e-02	1.00e+00	5.187	1	5	36
GO:0032755	positive regulation of interleukin-6 production	2.71e-02	1.00e+00	5.187	1	2	36
GO:0005902	microvillus	2.86e-02	1.00e+00	5.109	1	2	38
GO:0032729	positive regulation of interferon-gamma production	2.94e-02	1.00e+00	5.071	1	2	39
GO:0042110	T cell activation	3.16e-02	1.00e+00	4.964	1	3	42
GO:0005739	mitochondrion	3.58e-02	1.00e+00	1.979	3	28	998
GO:0003743	translation initiation factor activity	3.68e-02	1.00e+00	4.742	1	8	49
GO:0006521	regulation of cellular amino acid metabolic process	3.75e-02	1.00e+00	4.713	1	17	50
GO:0006986	response to unfolded protein	3.75e-02	1.00e+00	4.713	1	2	50
GO:0005905	coated pit	3.75e-02	1.00e+00	4.713	1	3	50
GO:0006879	cellular iron ion homeostasis	3.82e-02	1.00e+00	4.684	1	4	51
GO:0003725	double-stranded RNA binding	3.90e-02	1.00e+00	4.656	1	5	52
GO:0043066	negative regulation of apoptotic process	3.98e-02	1.00e+00	2.629	2	31	424
GO:0002039	p53 binding	4.12e-02	1.00e+00	4.575	1	7	55
GO:0044822	poly(A) RNA binding	4.14e-02	1.00e+00	1.897	3	49	1056
GO:0012505	endomembrane system	4.19e-02	1.00e+00	4.549	1	2	56
GO:0005840	ribosome	4.34e-02	1.00e+00	4.499	1	1	58
GO:0000502	proteasome complex	4.34e-02	1.00e+00	4.499	1	17	58
GO:0051087	chaperone binding	4.41e-02	1.00e+00	4.474	1	6	59
GO:0030141	secretory granule	4.63e-02	1.00e+00	4.402	1	2	62
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.78e-02	1.00e+00	4.357	1	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.85e-02	1.00e+00	4.334	1	22	65
GO:0044267	cellular protein metabolic process	4.87e-02	1.00e+00	2.468	2	29	474
GO:0003697	single-stranded DNA binding	5.07e-02	1.00e+00	4.269	1	5	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.21e-02	1.00e+00	4.227	1	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	5.36e-02	1.00e+00	4.187	1	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.50e-02	1.00e+00	4.147	1	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	5.58e-02	1.00e+00	4.128	1	20	75
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	5.72e-02	1.00e+00	4.090	1	7	77
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	5.86e-02	1.00e+00	4.053	1	23	79
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	5.94e-02	1.00e+00	4.035	1	3	80
GO:0001726	ruffle	5.94e-02	1.00e+00	4.035	1	4	80
GO:0050821	protein stabilization	6.51e-02	1.00e+00	3.897	1	2	88
GO:0042470	melanosome	6.73e-02	1.00e+00	3.849	1	9	91
GO:0001649	osteoblast differentiation	6.80e-02	1.00e+00	3.833	1	6	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	6.80e-02	1.00e+00	3.833	1	21	92
GO:0051082	unfolded protein binding	6.87e-02	1.00e+00	3.817	1	5	93
GO:0005506	iron ion binding	7.73e-02	1.00e+00	3.642	1	4	105
GO:0000209	protein polyubiquitination	8.50e-02	1.00e+00	3.499	1	20	116
GO:0006511	ubiquitin-dependent protein catabolic process	9.20e-02	1.00e+00	3.379	1	5	126
GO:0005634	nucleus	9.78e-02	1.00e+00	0.787	6	136	4559
GO:0016887	ATPase activity	1.02e-01	1.00e+00	3.227	1	7	140
GO:0008286	insulin receptor signaling pathway	1.03e-01	1.00e+00	3.207	1	7	142
GO:0000082	G1/S transition of mitotic cell cycle	1.08e-01	1.00e+00	3.137	1	32	149
GO:0042981	regulation of apoptotic process	1.09e-01	1.00e+00	3.128	1	24	150
GO:0005769	early endosome	1.10e-01	1.00e+00	3.109	1	2	152
GO:0005765	lysosomal membrane	1.44e-01	1.00e+00	2.691	1	5	203
GO:0005975	carbohydrate metabolic process	1.77e-01	1.00e+00	2.374	1	9	253
GO:0043065	positive regulation of apoptotic process	1.86e-01	1.00e+00	2.291	1	10	268
GO:0005743	mitochondrial inner membrane	1.92e-01	1.00e+00	2.243	1	8	277
GO:0006200	ATP catabolic process	2.02e-01	1.00e+00	2.167	1	15	292
GO:0043234	protein complex	2.03e-01	1.00e+00	2.152	1	18	295
GO:0043231	intracellular membrane-bounded organelle	2.18e-01	1.00e+00	2.044	1	9	318
GO:0005925	focal adhesion	2.46e-01	1.00e+00	1.841	1	19	366
GO:0007155	cell adhesion	2.48e-01	1.00e+00	1.829	1	6	369
GO:0005524	ATP binding	2.60e-01	1.00e+00	1.015	2	60	1298
GO:0000278	mitotic cell cycle	2.61e-01	1.00e+00	1.746	1	48	391
GO:0009986	cell surface	2.67e-01	1.00e+00	1.706	1	11	402
GO:0055114	oxidation-reduction process	2.78e-01	1.00e+00	1.642	1	12	420
GO:0055085	transmembrane transport	2.86e-01	1.00e+00	1.592	1	10	435
GO:0005886	plasma membrane	3.13e-01	1.00e+00	0.607	3	45	2582
GO:0005737	cytoplasm	3.18e-01	1.00e+00	0.477	4	110	3767
GO:0006915	apoptotic process	3.51e-01	1.00e+00	1.240	1	33	555
GO:0005730	nucleolus	3.61e-01	1.00e+00	0.676	2	69	1641
GO:0005515	protein binding	5.16e-01	1.00e+00	0.122	5	184	6024
GO:0005615	extracellular space	5.30e-01	1.00e+00	0.454	1	17	957
GO:0005654	nucleoplasm	5.76e-01	1.00e+00	0.277	1	76	1082
GO:0016021	integral component of membrane	8.03e-01	1.00e+00	-0.596	1	27	1982

Wolf-ratios-Mammosphere-Adherent

int-snw-2271

Statistics

Genes (11)

Interactions (19)

Related GO terms (156)